Egor Pavlenko
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View article: Interaction with AK2A links AIFM1 to cellular energy metabolism
Interaction with AK2A links AIFM1 to cellular energy metabolism Open
Apoptosis-inducing factor 1 (AIFM1) is a flavoprotein essential for mitochondrial function and biogenesis. Its interaction with MIA40/CHCHD4, the central component of the mitochondrial disulfide relay, accounts for some, but not all, aspec…
View article: Activation of automethylated PRC2 by dimerization on chromatin
Activation of automethylated PRC2 by dimerization on chromatin Open
Polycomb repressive complex 2 (PRC2) is an epigenetic regulator that trimethylates lysine 27 of histone 3 (H3K27me3) and is essential for embryonic development and cellular differentiation. H3K27me3 is associated with transcriptionally rep…
View article: Remodeling of the endothelial cell transcriptional program via paracrine and DNA-binding activities of MPO
Remodeling of the endothelial cell transcriptional program via paracrine and DNA-binding activities of MPO Open
View article: Activation of automethylated PRC2 by dimerization on chromatin
Activation of automethylated PRC2 by dimerization on chromatin Open
Summary Polycomb Repressive Complex 2 (PRC2) is an epigenetic regulator that trimethylates lysine 27 of histone 3 (H3K27me3) and is essential for embryonic development and cellular differentiation. H3K27me3 is associated with transcription…
View article: Automethylated PRC2 dimer bound to nucleosome
Automethylated PRC2 dimer bound to nucleosome Open
View article: Remodelling of the endothelial cell transcriptional program via paracrine and DNA-binding activities of MPO
Remodelling of the endothelial cell transcriptional program via paracrine and DNA-binding activities of MPO Open
Myeloperoxidase (MPO) is an enzyme that functions in host defence by catalysing the formation of reactive oxygen intermediates. Synthesized majorly by myeloid progenitor cell types and neutrophils, MPO is released into the vascular lumen d…
View article: Functions and Interactions of Mammalian KDM5 Demethylases
Functions and Interactions of Mammalian KDM5 Demethylases Open
Mammalian histone demethylases of the KDM5 family are mediators of gene expression dynamics during developmental, cellular differentiation, and other nuclear processes. They belong to the large group of JmjC domain containing, 2-oxoglutara…
View article: Rescue of α-synuclein aggregation in Parkinson’s patient neurons by synergistic enhancement of ER proteostasis and protein trafficking
Rescue of α-synuclein aggregation in Parkinson’s patient neurons by synergistic enhancement of ER proteostasis and protein trafficking Open
View article: Cell Surface Processing of CD109 by Meprin β Leads to the Release of Soluble Fragments and Reduced Expression on Extracellular Vesicles
Cell Surface Processing of CD109 by Meprin β Leads to the Release of Soluble Fragments and Reduced Expression on Extracellular Vesicles Open
Cluster of differentiation 109 (CD109) is a glycosylphosphatidylinositol (GPI)-anchored protein expressed on primitive hematopoietic stem cells, activated platelets, CD4 + and CD8 + T cells, and keratinocytes. In recent years, CD109 was al…
View article: Functional Characterization of Colon-Cancer-Associated Variants in ADAM17 Affecting the Catalytic Domain
Functional Characterization of Colon-Cancer-Associated Variants in ADAM17 Affecting the Catalytic Domain Open
Although extensively investigated, cancer is still one of the most devastating and lethal diseases in the modern world. Among different types, colorectal cancer (CRC) is most prevalent and mortal, making it an important subject of research…
View article: Functional Characterization of Colon Cancer-Associated Mutations in ADAM17: Modifications in the Pro-Domain Interfere with Trafficking and Maturation
Functional Characterization of Colon Cancer-Associated Mutations in ADAM17: Modifications in the Pro-Domain Interfere with Trafficking and Maturation Open
Colorectal cancer is one of the most commonly diagnosed malignancies in the Western world and is associated with elevated expression and activity of epidermal growth factor receptors (EGF-R). The metalloproteinase ADAM17 is involved in EGF…
View article: Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells
Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells Open
A disintegrin and metalloproteinase (ADAM) 17 has been implicated in many shedding processes. Major substrates of ADAM17 are TNF-α, IL-6R, and ligands of the epidermal growth factor receptor. The essential role of the protease is emphasize…