Egor Veselovsky
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View article: Neoantigen-Driven Immunotherapy in Triple-Negative Breast Cancer: Emerging Strategies and Clinical Potential
Neoantigen-Driven Immunotherapy in Triple-Negative Breast Cancer: Emerging Strategies and Clinical Potential Open
Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer (BC), comprising approximately 20% of newly diagnosed BC cases. The poor prognosis, high recurrence rates, and inefficacy of hormone-based therapi…
View article: Adaptation of PCR-based library preparation for MGI platform for cancer mutation testing in clinical setting
Adaptation of PCR-based library preparation for MGI platform for cancer mutation testing in clinical setting Open
MGI platforms hold promise to become a widespread instrument for various clinical next-generation sequencing applications, from whole genome sequencing to COVID-19 genotyping. However, in the clinical oncology setting it is still restricte…
View article: The Role of MSI Testing Methodology and Its Heterogeneity in Predicting Colorectal Cancer Immunotherapy Response
The Role of MSI Testing Methodology and Its Heterogeneity in Predicting Colorectal Cancer Immunotherapy Response Open
MSI is a crucial biomarker for selecting CRC patients for immunotherapy. Here, we analyze the first results from the observational prospective trial BLOOMSI (NCT06414304), which investigated the impact of MSI/dMMR testing methods and basel…
View article: Analytical and Clinical Validation of Solo‐Test Driver: A Targeted Amplicon‐Based <scp>NGS</scp> Test‐System for <scp>FFPE</scp> and <scp>cfDNA</scp> Analysis in Clinical Oncology Setting
Analytical and Clinical Validation of Solo‐Test Driver: A Targeted Amplicon‐Based <span>NGS</span> Test‐System for <span>FFPE</span> and <span>cfDNA</span> Analysis in Clinical Oncology Setting Open
Background Next‐generation sequencing (NGS) is increasingly integrated into cancer patient management, necessitating cost‐effective, reliable tests for companion diagnostics. We present the validation of the Solo‐test Driver panel, a custo…
View article: NGS as an auxiliary tool for differential diagnosis of solid tumors: a clinical case and literature review
NGS as an auxiliary tool for differential diagnosis of solid tumors: a clinical case and literature review Open
Molecular genetic profiling of solid tumors by next generation sequencing (NGS) is widely used to select targeted therapy. At the same time, with rare exceptions, NGS has not proven to be a reliable tool for differential diagnosis of disea…
View article: NGS as an auxiliary tool for differential diagnosis of solid tumors: a clinical case and literature review
NGS as an auxiliary tool for differential diagnosis of solid tumors: a clinical case and literature review Open
Molecular genetic profiling of solid tumors by next-generation sequencing (NGS) is widely used to select targeted therapy. At the same time, with rare exceptions, NGS has not proven to be a reliable tool for differential diagnosis of disea…
View article: Dynamics of blood microsatellite instability (bMSI) burden predicts outcome of a patient treated with immune checkpoint inhibitors: a case report of hyperprogressive disease
Dynamics of blood microsatellite instability (bMSI) burden predicts outcome of a patient treated with immune checkpoint inhibitors: a case report of hyperprogressive disease Open
Microsatellite instability (MSI) is a widely studied molecular signature, which is associated with long-term benefit in patients treated with immune checkpoint inhibitor therapy. This approach has been proven to be effective in the treatme…
View article: Biomarkers of resistance to anti-EGFR therapy in patients with left-sided colorectal cancer: a retrospective NGS analysis
Biomarkers of resistance to anti-EGFR therapy in patients with left-sided colorectal cancer: a retrospective NGS analysis Open
Background : Routine analysis of KRAS, NRAS, BRAF V600 mutations, as well as MSI and HER2 guides treatment selection in colorectal cancer (CRC). Recent findings from the PRESSING and PARADIGM trials have demonstrated that the negative hype…
View article: Evaluation of blood MSI burden dynamics to trace immune checkpoint inhibitor therapy efficacy through the course of treatment
Evaluation of blood MSI burden dynamics to trace immune checkpoint inhibitor therapy efficacy through the course of treatment Open
Analysis of serial liquid biopsy (LB) samples has been found to be a promising approach for the monitoring of tumor dynamics in the course of therapy for patients with colorectal cancer (CRC). Currently, somatic mutations are used for trac…
View article: 67P Multi-institutional evaluation of interrater agreement of biomarker-drug pair rankings based on the ESMO scale for clinical actionability of molecular targets (ESCAT) and sources of discordance
67P Multi-institutional evaluation of interrater agreement of biomarker-drug pair rankings based on the ESMO scale for clinical actionability of molecular targets (ESCAT) and sources of discordance Open
View article: Untapped Potential of Poly(ADP-Ribose) Polymerase Inhibitors: Lessons Learned From the Real-World Clinical Homologous Recombination Repair Mutation Testing
Untapped Potential of Poly(ADP-Ribose) Polymerase Inhibitors: Lessons Learned From the Real-World Clinical Homologous Recombination Repair Mutation Testing Open
Our study represents one of the first reports about the incidence of DV and VUS in HRR genes, including genes beyond BRCA1/2, identified in cancer patients from Russia, assessed by NGS. In silico predictions of the observed HRR gene…
View article: Evidence blocks for effective presentation of genomic findings at molecular tumor boards: Single institution experience
Evidence blocks for effective presentation of genomic findings at molecular tumor boards: Single institution experience Open
Genomic profiling, or molecular profiling of the tumor, is becoming a key component of therapeutic decision making in clinical oncology, and is typically carried out via next generation sequencing. However, the interpretation of the result…
View article: 103P MSI detection by NGS using tumor samples and liquid biopsy for patients with solid tumors: A single institution experience
103P MSI detection by NGS using tumor samples and liquid biopsy for patients with solid tumors: A single institution experience Open
Microsatellite instability (MSI) is a powerful predictor for the efficacy of immune checkpoint inhibitor (ICI) therapy across tumor types. Although conventional MSI testing strategies are widely used, NGS represents a promising tool for MS…
View article: Microsatellite Instability: A Review of Molecular Epidemiology and Implications for Immune Checkpoint Inhibitor Therapy
Microsatellite Instability: A Review of Molecular Epidemiology and Implications for Immune Checkpoint Inhibitor Therapy Open
Microsatellite instability (MSI) is one of the most important molecular characteristics of a tumor, which occurs among various tumor types. In this review article, we examine the molecular characteristics of MSI tumors, both sporadic and L…
View article: CRAC (Clinical Relevance of Alterations in Cancer): a Knowledge Base for the Selection of Molecularly Matched Therapy for Solid Tumors
CRAC (Clinical Relevance of Alterations in Cancer): a Knowledge Base for the Selection of Molecularly Matched Therapy for Solid Tumors Open
Multigene testing using NGS (next-generation sequencing) provides a large amount of information and can detect multiple molecular alterations. Subsequent clinical interpretation is a time-consuming process necessary to select a treatment s…
View article: 111P Leveraging in silico signatures to predict clinically actionable variants in oncogenes
111P Leveraging in silico signatures to predict clinically actionable variants in oncogenes Open