Kan Liu
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View article: Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis
Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis Open
Amino acid sensing in the central nervous system plays a key role in regulating energy homeostasis. The anterior piriform cortex (APC) has been implicated in sensing amino acid deficiency and rapidly inducing an aversive response. However,…
View article: Bench Surgery with Robot-assisted Kidney Autotransplantation for Complex Kidney Tumors: Technique and Outcomes from a Single Center
Bench Surgery with Robot-assisted Kidney Autotransplantation for Complex Kidney Tumors: Technique and Outcomes from a Single Center Open
We evaluated the outcomes of bench surgery (BenS) with robot-assisted kidney autotransplantation (RAKAT), in which the diseased kidney is removed, undergo partial nephrectomy (PN) extracorporeally, and is transplanted back robotically. We …
View article: Asparagine drives immune evasion in bladder cancer via RIG-I stability and type I IFN signaling
Asparagine drives immune evasion in bladder cancer via RIG-I stability and type I IFN signaling Open
Tumor cells often employ many ways to restrain type I IFN signaling to evade immune surveillance. However, whether cellular amino acid metabolism regulates this process remains unclear, and its effects on antitumor immunity are relatively …
View article: Clinical Efficacy And Immunomodulatory Mechanism Of Budesonide Nasal Spray Combined With Mucus Promoter In Patients With Chronic Sinusitis
Clinical Efficacy And Immunomodulatory Mechanism Of Budesonide Nasal Spray Combined With Mucus Promoter In Patients With Chronic Sinusitis Open
Chronic rhinosinusitis (CR) seriously affects the patient’s life quality, and current clinical treatment faces certain challenges. This study observed the effects of budesonide nasal spray combined with mucus promoter on the clinical effic…
View article: ROS-mediated thylakoid membrane remodeling and triacylglycerol biosynthesis under nitrogen starvation in the alga Chlorella sorokiniana
ROS-mediated thylakoid membrane remodeling and triacylglycerol biosynthesis under nitrogen starvation in the alga Chlorella sorokiniana Open
Many microbes accumulate energy storage molecules such as triglycerides (TAG) and starch during nutrient limitation. In eukaryotic green algae grown under nitrogen-limiting conditions, triglyceride accumulation is coupled with chlorosis an…
View article: Excess PbI2 Management via Multimode Supramolecular Complex Engineering Enables High-Performance Perovskite Solar Cells
Excess PbI2 Management via Multimode Supramolecular Complex Engineering Enables High-Performance Perovskite Solar Cells Open
Excess PbI2 in perovskite film is an effective strategy for boosting perovskite solar cells (PSCs) performance. However, the presence of unreacted PbI2 is a critical source of intrinsic instability in perovskite under illumination, due to …
View article: Intestinal activating transcription factor 4 regulates stress-related behavioral alterations via paraventricular thalamus in male mice
Intestinal activating transcription factor 4 regulates stress-related behavioral alterations via paraventricular thalamus in male mice Open
Chronic stress induces depression- and anxiety-related behaviors, which are common mental disorders accompanied not only by dysfunction of the brain but also of the intestine. Activating transcription factor 4 (ATF4) is a stress-induced ge…
View article: Supplemental Table 1 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Supplemental Table 1 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1 Open
Antibodies and primers introduction
View article: Data from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Data from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1 Open
The transcription factor KLF6 has an essential role in the development and metastasis of multiple human cancers. Paradoxically, KLF6 expression was found to be attenuated in primary metastatic clear cell renal cell carcinoma (ccRCC), such …
View article: Supplemental Figure 2 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Supplemental Figure 2 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1 Open
The ranking ï¬,ow chart of the differentiated genes on the data set
View article: Supplemental Figure 2 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Supplemental Figure 2 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1 Open
The ranking ï¬,ow chart of the differentiated genes on the data set
View article: Supplemental Table 1 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Supplemental Table 1 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1 Open
Antibodies and primers introduction
View article: Supplemental Table 2 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Supplemental Table 2 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1 Open
The comparison of KLF6 expressions in Non-metastatic and Metastatic specimens by immunohistochemical staining.
View article: General anesthetic action profile on the human prefrontal cortex cells through comprehensive single-cell RNA-seq analysis
General anesthetic action profile on the human prefrontal cortex cells through comprehensive single-cell RNA-seq analysis Open
The cellular and molecular actions of general anesthetics to induce anesthesia state and also cellular signaling changes for subsequent potential "long term" effects remain largely elusive. General anesthetics were reported to act on volta…
View article: Supplemental figure legends from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Supplemental figure legends from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1 Open
detailed illustrations for Supplemental figure1-3
View article: Supplemental figure legends from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Supplemental figure legends from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1 Open
detailed illustrations for Supplemental figure1-3
View article: Supplemental Table 3 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Supplemental Table 3 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1 Open
Patients' clinical characteristics
View article: Supplemental Figure 1 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Supplemental Figure 1 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1 Open
CpG island of the KLF6 locus was predicted in plot and the primers were designed.
View article: Supplemental Figure 1 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Supplemental Figure 1 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1 Open
CpG island of the KLF6 locus was predicted in plot and the primers were designed.
View article: Supplemental Table 2 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Supplemental Table 2 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1 Open
The comparison of KLF6 expressions in Non-metastatic and Metastatic specimens by immunohistochemical staining.
View article: Supplemental Table 3 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Supplemental Table 3 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1 Open
Patients' clinical characteristics
View article: Data from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Data from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1 Open
The transcription factor KLF6 has an essential role in the development and metastasis of multiple human cancers. Paradoxically, KLF6 expression was found to be attenuated in primary metastatic clear cell renal cell carcinoma (ccRCC), such …
View article: SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2
SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2 Open
Lysosomal amino acid accumulation is implicated in several diseases, but its role in insulin resistance, the central mechanism to type 2 diabetes and many metabolic diseases, is unclear. In this study, we show the hepatic expression of lys…
View article: Preliminary study of a new-style terrain disturbance method based on gradient inhomogeneity in convection-allowing scale ensemble prediction system
Preliminary study of a new-style terrain disturbance method based on gradient inhomogeneity in convection-allowing scale ensemble prediction system Open
<p>Terrain with different shapes and ground surface properties has extremely complex impacts on atmospheric motion, and the forecast uncertainty and complexity caused by terrain brings great challenges to disaster prevention and miti…
View article: Performance and the Optimal Cut-Off Value of First-Trimester Fasting Plasma Glucose To Identify Gestational Diabetes Mellitus: A Retrospective Study From Southern China
Performance and the Optimal Cut-Off Value of First-Trimester Fasting Plasma Glucose To Identify Gestational Diabetes Mellitus: A Retrospective Study From Southern China Open
Purpose Previous studies have suggested that first-trimester fasting plasma glucose (FPG) is associated with gestational diabetes mellitus (GDM) and is a predictor of GDM. The aim of the present study was to explore whether first-trimester…
View article: Serrate‐Associated Protein 1, a splicing‐related protein, promotes miRNA biogenesis in Arabidopsis
Serrate‐Associated Protein 1, a splicing‐related protein, promotes miRNA biogenesis in Arabidopsis Open
Summary MicroRNAs (miRNAs) are essential regulators of gene expression in metazoans and plants. In plants, most miRNAs are generated from primary miRNA transcripts (pri‐miRNAs), which are processed by the Dicer‐like 1 (DCL1) complex along …
View article: Fasting plasma glucose in the first trimester is related to gestational diabetes mellitus and adverse pregnancy outcomes
Fasting plasma glucose in the first trimester is related to gestational diabetes mellitus and adverse pregnancy outcomes Open
Purpose To investigate and identify first-trimester fasting plasma glucose (FPG) is related to gestational diabetes mellitus (GDM) and other adverse pregnancy outcomes in Shenzhen population. Methods We used data of 48,444 pregnant women t…
View article: Wild emmer introgression alters root-to-shoot growth dynamics in durum wheat in response to water stress
Wild emmer introgression alters root-to-shoot growth dynamics in durum wheat in response to water stress Open
Water deficit during the early vegetative growth stages of wheat (Triticum) can limit shoot growth and ultimately impact grain productivity. Introducing diversity in wheat cultivars to enhance the range of phenotypic responses to water lim…
View article: Androgen Receptor, Although Not a Specific Marker For, Is a Novel Target to Suppress Glioma Stem Cells as a Therapeutic Strategy for Glioblastoma
Androgen Receptor, Although Not a Specific Marker For, Is a Novel Target to Suppress Glioma Stem Cells as a Therapeutic Strategy for Glioblastoma Open
Targeting androgen receptor (AR) has been shown to be promising in treating glioblastoma (GBM) in cell culture and flank implant models but the mechanisms remain unclear. AR antagonists including enzalutamide are available for treating pro…