Ehsan Habibi
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View article: Methylome profiling of SetDB1 deficient ESCs reveals diverse epigenetic cross-talk during pluripotency
Methylome profiling of SetDB1 deficient ESCs reveals diverse epigenetic cross-talk during pluripotency Open
SetDB1 is best known as a chromatin modifier catalyzing H3K9me3. However, recent studies show that SetDB1 can promote H3K27me3-deposition and CTCF-binding, and potentially recruit de novo DNA methyltransferases. Given the tight connection …
View article: Expansion<i>in situ</i>genome sequencing links nuclear abnormalities to hotspots of aberrant euchromatin repression
Expansion<i>in situ</i>genome sequencing links nuclear abnormalities to hotspots of aberrant euchromatin repression Open
Microscopy and genomics are both used to characterize cell function, but approaches to connect the two types of information are lacking, particularly at subnuclear resolution. While emerging multiplexed imaging methods can simultaneously l…
View article: Systemic inflammation impairs human myelopoiesis and interferon I responses
Systemic inflammation impairs human myelopoiesis and interferon I responses Open
Systemic inflammation (SI) plays a detrimental role in various conditions with high mortality rates 1–4 . SI manifests an acute hyperinflammation followed by long-lasting immunosuppression, increasing patients’ risks for secondary infectio…
View article: Urate-induced epigenetic modifications in myeloid cells
Urate-induced epigenetic modifications in myeloid cells Open
Objectives Hyperuricemia is a metabolic condition central to gout pathogenesis. Urate exposure primes human monocytes towards a higher capacity to produce and release IL-1β. In this study, we assessed the epigenetic processes associated to…
View article: Simultaneous single cell measurements of intranuclear proteins and gene expression
Simultaneous single cell measurements of intranuclear proteins and gene expression Open
Identifying gene regulatory targets of nuclear proteins in tissues remains a challenge. Here we describe in tranuclear C ellular I ndexing of T ranscriptomes and E pitopes (inCITE-seq), a scalable method for measuring multiplexed intranucl…
View article: Molecular Logic of Cellular Diversification in the Mammalian Cerebral Cortex
Molecular Logic of Cellular Diversification in the Mammalian Cerebral Cortex Open
The neocortex has an unparalleled diversity of cell types, which are generated during development through a series of temporally orchestrated events that are under tight evolutionary constraint and are critical for proper cortical assembly…
View article: Identification Prevalence of Musculoskeletal Disorders and its Related Factors among Street Cleaners of Isfahan Municipality
Identification Prevalence of Musculoskeletal Disorders and its Related Factors among Street Cleaners of Isfahan Municipality Open
Background: Musculoskeletal disorders are one of the major work-related diseases resulting from repetitive motions, awkward postures and exertion of excessive force on joints or an acute trauma. The present study was an attempt to determin…
View article: Compressed sensing for imaging transcriptomics
Compressed sensing for imaging transcriptomics Open
Tissue and organ function rely on the organization of cells and molecules in specific spatial structures. In order to understand these structures and how they relate to tissue function in health and disease, we would ideally be able to rap…
View article: The alarmin S100A9 hampers osteoclast differentiation from human circulating precursors by reducing the expression of RANK
The alarmin S100A9 hampers osteoclast differentiation from human circulating precursors by reducing the expression of RANK Open
The alarmin S100A8/A9 is implicated in sterile inflammation‐induced bone resorption and has been shown to increase the bone‐resorptive capacity of mature osteoclasts. Here, we investigated the effects of S100A9 on osteoclast differentiatio…
View article: The Investigation Relationship between Mental Workload and Occupational Fatigue in the Administrative Staffs of a Communications Service Company
The Investigation Relationship between Mental Workload and Occupational Fatigue in the Administrative Staffs of a Communications Service Company Open
Mental workload reflects the level of attention resources required to meet both objective and subjective performance criteria, which may be affected by task demand, external support and past experience. Mental workload and occupational fat…
View article: Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia
Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia Open
Epigenomic alterations have been associated with both pathogenesis and progression of cancer. Here, we analyzed the epigenome of two high-risk APL (hrAPL) patients and compared it to non-high-risk APL cases. Despite the lack of common gene…
View article: Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia
Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia Open
Epigenomic alterations have been associated with both pathogenesis and progression of cancer. Here, we analyzed the epigenome of two high-risk APL (hrAPL) patients and compared it to non-high-risk APL cases. Despite the lack of common gene…
View article: Epigenomic and functional dynamics of human bone marrow myeloid differentiation to mature blood neutrophils
Epigenomic and functional dynamics of human bone marrow myeloid differentiation to mature blood neutrophils Open
Summary Neutrophils are short-lived blood cells that play a critical role in host defense against infections. To better comprehend neutrophil functions and their regulation, we provide a complete epigenetic and functional overview of their…
View article: Increased H3K9 methylation and impaired expression of Protocadherins are associated with the cognitive dysfunctions of the Kleefstra syndrome
Increased H3K9 methylation and impaired expression of Protocadherins are associated with the cognitive dysfunctions of the Kleefstra syndrome Open
Kleefstra syndrome, a disease with intellectual disability, autism spectrum disorders and other developmental defects is caused in humans by haploinsufficiency of EHMT1. Although EHMT1 and its paralog EHMT2 were shown to be histone methylt…
View article: The Impact of Heat on the Accuracy and Pace of Working by Tests of Job Skill Assessment
The Impact of Heat on the Accuracy and Pace of Working by Tests of Job Skill Assessment Open
Harmful physical factors in workplace including temperature may affect the cognitive performance of human. This study was conducted to determine the impact of the intervention of heat on the accuracy and pace of working in men. This interv…
View article: Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells
Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells Open
Characterizing the multifaceted contribution of genetic and epigenetic factors to disease phenotypes is a major challenge in human genetics and medicine. We carried out high-resolution genetic, epigenetic, and transcriptomic profiling in t…
View article: Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells
Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells Open
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