Ehsanollah Ghaznavi‐Rad
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View article: LL37-rIb-AMP4 Hybrid Peptide as a Therapy for Systematic Infections of Acinetobacter baumannii, Pseudomonas aeruginosa, Vancomycin-resistant Enterococcus (VRE), and Methicillin-resistant Staphylococcus aureus (MRSA) cells in a mouse model.
LL37-rIb-AMP4 Hybrid Peptide as a Therapy for Systematic Infections of Acinetobacter baumannii, Pseudomonas aeruginosa, Vancomycin-resistant Enterococcus (VRE), and Methicillin-resistant Staphylococcus aureus (MRSA) cells in a mouse model. Open
LL37-rIb-AMP4 Hybrid Peptide as a Therapy for Systematic Infections of Acinetobacter baumannii, Pseudomonas aeruginosa, Vancomycin-resistant Enterococcus (VRE), and Methicillin-resistant Staphylococcus aureus (MRSA) cells in a mouse model.
View article: In Vitro and In Vivo Synergistic Antibacterial Functions of the Recombinant Ib-AMP4 and E50-52 Antimicrobial Peptides against Multidrug-Resistant Acinetobacter baumannii
In Vitro and In Vivo Synergistic Antibacterial Functions of the Recombinant Ib-AMP4 and E50-52 Antimicrobial Peptides against Multidrug-Resistant Acinetobacter baumannii Open
Background: Most Acinetobacter baumannii species have become resistant to all common antibiotics. Many antimicrobial peptides (AMPs) have been identified with efficient functions in infection management. E50-52 (UniProtKB: P85148) and Ib-A…
View article: In vivo efficiency of the produced recombinant lysostaphin antimicrobial peptide in treatment of methicillin-resistant Staphylococcus aureus (MRSA) skin infection in a mouse model
In vivo efficiency of the produced recombinant lysostaphin antimicrobial peptide in treatment of methicillin-resistant Staphylococcus aureus (MRSA) skin infection in a mouse model Open
Background and Objectives: Staphylococcus simulans secretes an antimicrobial compound called lysostaphin, which has bactericidal properties. It destroys staphylococci through the hydrolysis of peptidoglycan in the cell wall. Therefore, thi…
View article: High frequency of NDM-1 and OXA-48 carbapenemase genes among Klebsiella pneumoniae isolates in central Iran
High frequency of NDM-1 and OXA-48 carbapenemase genes among Klebsiella pneumoniae isolates in central Iran Open
Background The emergence and distribution of multidrug-resistant (MDR) and carbapenem-resistant Klebsiella pneumoniae (CRKP) has become a global health threat. Therefore, this study aimed to investigate the frequency and antibiotic resista…
View article: The significant role of Carbapenems-resistant Acinetobacter Baumannii in mortality rate of patients with COVID-19
The significant role of Carbapenems-resistant Acinetobacter Baumannii in mortality rate of patients with COVID-19 Open
View article: The significant role of Carbapenems-resistant Acinetobacter Baumannii in mortality rate of patients with COVID-19
The significant role of Carbapenems-resistant Acinetobacter Baumannii in mortality rate of patients with COVID-19 Open
View article: The importance of using routine laboratory tests in the diagnosis and prognosis of patients with coronavirus disease 2019: Shedding light on clinical laboratory data in <scp>COVID</scp>‐19
The importance of using routine laboratory tests in the diagnosis and prognosis of patients with coronavirus disease 2019: Shedding light on clinical laboratory data in <span>COVID</span>‐19 Open
Background Novel coronavirus (COVID‐19) pandemic has become a global concern and requires early detection, isolation, and treatment. Our purpose is to find some beneficial information by analyzing the COVID‐19 laboratory data to provide gu…
View article: PLGA-Based Nanoplatforms in Drug Delivery for Inhibition and Destruction of Microbial Biofilm
PLGA-Based Nanoplatforms in Drug Delivery for Inhibition and Destruction of Microbial Biofilm Open
The biofilm community of microorganisms has been identified as the dominant mode of microbial growth in nature and a common characteristic of different microorganisms such as Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcu…
View article: Isolation of a lytic bacteriophage against extensively drug‐resistant <i>Acinetobacter baumannii</i> infections and its dramatic effect in rat model of burn infection
Isolation of a lytic bacteriophage against extensively drug‐resistant <i>Acinetobacter baumannii</i> infections and its dramatic effect in rat model of burn infection Open
Objectives Acinetobacter Baumannii is an opportunistic nosocomial pathogen belonging to the Moraxellaceae family. The emergence of multidrug resistant strains of this pathogen caused many problems for hospitals and patients. The aim of the…
View article: SARS-CoV-2 Viral Shedding and Associated Factors among COVID-19 Inpatients and Outpatients
SARS-CoV-2 Viral Shedding and Associated Factors among COVID-19 Inpatients and Outpatients Open
Background. According to the contagious ability of the new virus, SARS-CoV-2, characterization of viral shedding duration in the period of infection is highly valuable in terms of providing quarantine guidelines and isolation policies. The…
View article: Ib-AMP4 antimicrobial peptide as a treatment for skin and systematic infection of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA).
Ib-AMP4 antimicrobial peptide as a treatment for skin and systematic infection of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). Open
The results confirmed the rapid antibacterial potential of the produced recombinant Ib-AMP4 to be used for efficient treatment of MRSA infection.
View article: Low Frequency of Adenovirus, Rotavirus, and Norovirus in Pediatric Diarrheal Samples from Central Iran
Low Frequency of Adenovirus, Rotavirus, and Norovirus in Pediatric Diarrheal Samples from Central Iran Open
Background: Acute viral gastroenteritis is a disorder that affects children globally but mostly in developing countries. Adenoviruses, rotaviruses, and noroviruses are the leading viral causes of childhood gastroenteritis. Objectives: This…
View article: Association between colorectal cancer and Fusobacterium nucleatum and Bacteroides fragilis bacteria in Iranian patients: a preliminary study
Association between colorectal cancer and Fusobacterium nucleatum and Bacteroides fragilis bacteria in Iranian patients: a preliminary study Open
View article: Investigation into antibacterial and wound healing properties of platelets lysate against Acinetobacter baumannii and Klebsiella pneumoniae burn wound infections
Investigation into antibacterial and wound healing properties of platelets lysate against Acinetobacter baumannii and Klebsiella pneumoniae burn wound infections Open
View article: Quinolone resistant Salmonella species isolated from pediatric patients with diarrhea in central Iran
Quinolone resistant Salmonella species isolated from pediatric patients with diarrhea in central Iran Open
Background This study aimed to investigate the frequency and the antibiotic resistance patterns of Salmonella species that were isolated from infectious diarrhea samples taken from pediatric patients in central Iran. Methods The study anal…
View article: Frequency of Cardiovascular Complications and Its Association with Prognosis of COVID‐19 Patients
Frequency of Cardiovascular Complications and Its Association with Prognosis of COVID‐19 Patients Open
Coronavirus disease 2019 (COVID‐19) may lead to acute respiratory disease; cardiovascular, gastrointestinal, and coagulation complications; and even death. One of the major complications is cardiovascular disorders, including arrhythmias, …
View article: Prevalence and molecular epidemiology of ceftaroline non-susceptible methicillin-resistant Staphylococcus aureus isolates, first clinical report from Iran
Prevalence and molecular epidemiology of ceftaroline non-susceptible methicillin-resistant Staphylococcus aureus isolates, first clinical report from Iran Open
Background Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major pathogens in Iran with a high prevalence and a high level of antibiotic resistance. Ceftaroline is a fifth generation cephalosporin binding and inhibiting pe…
View article: Accuracy of Indirect ELISA Prepared from Recombinant Bp26 Gene of Brucella melitensis in Diagnosis of Human Brucellosis
Accuracy of Indirect ELISA Prepared from Recombinant Bp26 Gene of Brucella melitensis in Diagnosis of Human Brucellosis Open
Accuracy of Indirect ELISA Prepared from Recombinant Bp26 Gene of Brucella melitensis in Diagnosis of Human Brucellosis
View article: Evaluation of Blood Biomaterials Efficacy in the Treatment of Leishmania Lesions
Evaluation of Blood Biomaterials Efficacy in the Treatment of Leishmania Lesions Open
Background & objective: The aim of this study was to evaluate the therapeutic effect of platelets lysate on leishmaniasis lesions. Materials & methods: In this study, we used hamster as an animal model and Leishmania major to create an inf…
View article: Recombinant Oncorhyncin II Effect on the Treatment of Methicillin-Resistant Staphylococcus aureus Skin Infection
Recombinant Oncorhyncin II Effect on the Treatment of Methicillin-Resistant Staphylococcus aureus Skin Infection Open
Background: Methicillin-resistant Staphylococcus aureus (MRSA) is known to be one of the most potentially pathogenic organisms in the world. Skin infections are one of the significant infections of S. aureus. Therefore, therapeutic constra…
View article: <p>Multi-Drug-Resistant Diarrheagenic <em>Escherichia coli</em> Pathotypes in Pediatric Patients with Gastroenteritis from Central Iran</p>
Multi-Drug-Resistant Diarrheagenic <em>Escherichia coli</em> Pathotypes in Pediatric Patients with Gastroenteritis from Central Iran Open
Compared to the previous study, DEC appeared to be the second-most abundant agent of diarrhea in pediatric patients after Campylobacter jejuni, with frequent MDR and ESBL presence.
View article: Low Endemic Frequency of Adenovirus, Rotavirus and Norovirus in Pediatric Diarrhea Samples from Central Iran
Low Endemic Frequency of Adenovirus, Rotavirus and Norovirus in Pediatric Diarrhea Samples from Central Iran Open
Background: Acute viral gastroenteritis is a disorder that affects children on a worldwide scale but mostly in developing countries. Adenoviruses, rotaviruses, and noroviruses are the major viral cause of childhood gastroenteritis. This st…
View article: The Frequency of the Intestinal Parasites Giardia Lamblia and Entamoeba Histolytica in Pediatric Diarrhea Specimens from Central Iran
The Frequency of the Intestinal Parasites Giardia Lamblia and Entamoeba Histolytica in Pediatric Diarrhea Specimens from Central Iran Open
Introduction: Intestinal parasitic infections, particularly those caused by Giardia lamblia , are among the major health problems that exist worldwide, especially in developing countries. This study aimed to investigate the prevalence of t…
View article: Procalcitonin as a Guide of Antibiotics Administration in Lower Respiratory Tract Infection
Procalcitonin as a Guide of Antibiotics Administration in Lower Respiratory Tract Infection Open
Background: Pneumonia is one of the common infection-related death. Recently use of biomarkers in diagnostic and therapeutic approach to pneumonia has been considered. The aim of our study is to evaluate the length of antibiotic treatment,…
View article: Determination Antimicrobial Resistance Profile and Prevalence of Class 1 and 2 Integron Resistance Gene Cassettes in Pseudomonas aeruginosa Strains Isolated from Hospitalized Patients in Markazi Province, Iran
Determination Antimicrobial Resistance Profile and Prevalence of Class 1 and 2 Integron Resistance Gene Cassettes in Pseudomonas aeruginosa Strains Isolated from Hospitalized Patients in Markazi Province, Iran Open
Background: Pseudomonas aeruginosa is recognized as a serious opportunistic pathogen that causes infections in hospitalized patients and shows a high level of antibiotic resistance. Objectives: The current study aimed at investigating the …
View article: Efficacy of colistin and rifampin combination for treatment of ventilator\nassociated pneumonia caused by carbapenem resistant Acinetobacter\nbaumannii: brief report
Efficacy of colistin and rifampin combination for treatment of ventilator\nassociated pneumonia caused by carbapenem resistant Acinetobacter\nbaumannii: brief report Open
Background: It is difficult to treat infections caused by Acinetobacter baumannii due to multiple drug resistance. The aim of this study was to determine the efficacy of combination therapy with two broad-spectrum antibiotics colistin and …
View article: Wound healing properties and antimicrobial activity of platelet-derived biomaterials
Wound healing properties and antimicrobial activity of platelet-derived biomaterials Open
We analyzed the potential antibacterial effects of two different PdB against methicillin-resistant S. aureus and P. aeruginosa . The third-degree burn wound healing effects of PdB was also studied. Blood samples were obtained from 10 healt…
View article: Multi-drug-resistant diarrheagenic Escherichia coli pathotypes in pediatric patients with gastroenteritis from central Iran
Multi-drug-resistant diarrheagenic Escherichia coli pathotypes in pediatric patients with gastroenteritis from central Iran Open
Background Diarrheagenic Escherichia coli (DEC) is a significant cause of gastroenteritis and a major public health problem. This study investigates the prevalence and the antibiotic resistance patterns of DEC that were isolated from infec…
View article: Biodegradation of heavy oily sludge by a two-step inoculation composting process using synergistic effect of indigenous isolated bacteria
Biodegradation of heavy oily sludge by a two-step inoculation composting process using synergistic effect of indigenous isolated bacteria Open
View article: Detection of qacEΔ1, qacG, qacE, qacF resistance genes in Escherichia coli producing broad-spectrum beta-lactamases to benzalkonium chloride
Detection of qacEΔ1, qacG, qacE, qacF resistance genes in Escherichia coli producing broad-spectrum beta-lactamases to benzalkonium chloride Open
BACKGROUND AND OBJECTIVE: The resistance genes of quaternary ammonium compounds(qac) play an important role in the resistance of gram-negative bacteria producing broad-spectrum beta-lactamases to disinfectants. The aim of this study was de…