Eiichiro Ono
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View article: Parasitism-mediated horizontal transfer of a functional cytochrome P450 gene entails transposon colonization in newly gained introns
Parasitism-mediated horizontal transfer of a functional cytochrome P450 gene entails transposon colonization in newly gained introns Open
Plants produce a wide variety of specialized metabolites that are typically present only in specific lineages. However, some specialized metabolites are found sporadically across distantly related plant species. While the latter cases have…
View article: Chromosome-scale Genome Assemblies of Two Allopolyploid Cuscuta Species Uncover Genomic Signatures of Parasitic Lifestyle and Polyploid Evolution
Chromosome-scale Genome Assemblies of Two Allopolyploid Cuscuta Species Uncover Genomic Signatures of Parasitic Lifestyle and Polyploid Evolution Open
Dodders (Cuscuta spp.) is an obligated parasitic plant, which lost a large part of photosynthetic genes but gained host genes through parasitism-mediated horizontal gene transfer (HGT). Their migratory ecology across the world would contri…
View article: Non-radiate flowers are associated with truncation of the CYCLOIDEA gene in Scaevola aemula (Goodeniaceae)
Non-radiate flowers are associated with truncation of the CYCLOIDEA gene in Scaevola aemula (Goodeniaceae) Open
Floral morphology is a crucial trait that determines the commercial value of ornamental plants and pollinator preference. Scaevola aemula (Fan Flower) typically develops bilaterally symmetrical flowers, but a recessive mutant with a radial…
View article: Time-resolved transcriptomics of S. cerevisiae and S. pastorianus in response to plasma membrane stresses
Time-resolved transcriptomics of S. cerevisiae and S. pastorianus in response to plasma membrane stresses Open
Yeasts are beneficial microorganisms for human society and are utilized for academic and industrial purposes. For academic purposes, S. cerevisiae is a well-investigated model for studying eukaryotic cellular processes. For industrial purp…
View article: Dynamic patterns of repeats and retrotransposons in the centromeres of <i>Humulus lupulus</i> L.
Dynamic patterns of repeats and retrotransposons in the centromeres of <i>Humulus lupulus</i> L. Open
Summary The centromere has a conserved function across eukaryotes; however, the associated DNA sequences exhibit remarkable diversity in both size and structure. In plants, some species possess well‐defined centromeres dominated by tandem …
View article: Evolution and functioning of an X-A balance sex determination system in hops
Evolution and functioning of an X-A balance sex determination system in hops Open
Chromosomal sex determining systems with male heterogamety include actively male-determining-Y and X-A balance systems, both of which are found in animals and plants. The sex-determining genes have been identified in several active-Y plant…
View article: Centromeric repeat diversity underlies non-Mendelian segregation pattern in hop (<i>Humulus lupulus</i>)
Centromeric repeat diversity underlies non-Mendelian segregation pattern in hop (<i>Humulus lupulus</i>) Open
Summary Aberrant meiosis in plants often leads to aneuploidy, genetic instability, and sterility. This can occur due to several factors, including chromosome misalignment, defective synapsis or environmental factors that may result in unus…
View article: <i>Anthriscus sylvestris</i> Deoxypodophyllotoxin Synthase Involved in the Podophyllotoxin Biosynthesis
<i>Anthriscus sylvestris</i> Deoxypodophyllotoxin Synthase Involved in the Podophyllotoxin Biosynthesis Open
Tetrahydrofuran ring formation from dibenzylbutyrolactone lignans is a key step in the biosynthesis of aryltetralin lignans including deoxypodophyllotoxin and podophyllotoxin. Previously, Fe(II)- and 2-oxoglutarate-dependent dioxygenase (2…
View article: The apiosyltransferase celery UGT94AX1 catalyzes the biosynthesis of the flavone glycoside apiin
The apiosyltransferase celery UGT94AX1 catalyzes the biosynthesis of the flavone glycoside apiin Open
Apiose is a unique branched-chain pentose found in plant glycosides and a key component of the cell wall polysaccharide pectin and other specialized metabolites. More than 1,200 plant-specialized metabolites contain apiose residues, repres…
View article: Exploring the Evolvability of Plant Specialized Metabolism: Uniqueness Out Of Uniformity and Uniqueness Behind Uniformity
Exploring the Evolvability of Plant Specialized Metabolism: Uniqueness Out Of Uniformity and Uniqueness Behind Uniformity Open
The huge structural diversity exhibited by plant specialized metabolites has primarily been considered to result from the catalytic specificity of their biosynthetic enzymes. Accordingly, enzyme gene multiplication and functional different…
View article: Discovery of the apiosyltransferase, celery UGT94AX1 that catalyzes the biosynthesis of a flavone glycoside, apiin
Discovery of the apiosyltransferase, celery UGT94AX1 that catalyzes the biosynthesis of a flavone glycoside, apiin Open
Apiose is a unique branched-chain pentose found in plant glycosides and a key component of the cell wall-polysaccharide pectin and other specialized metabolites. More than 1,200 plant-specialized metabolites contain apiose residues, repres…
View article: Transgenic Forsythia plants expressing sesame cytochrome P450 produce beneficial lignans
Transgenic Forsythia plants expressing sesame cytochrome P450 produce beneficial lignans Open
Lignans are widely distributed plant secondary metabolites that have received attention for their benefits to human health. Sesamin is a furofran lignan that is conventionally extracted from Sesamum seeds and shows anti-oxidant and anti-in…
View article: Functional diversity and plasticity in the sugar preferences of <i>Saccharomyces</i> MALT transporters in domesticated yeasts
Functional diversity and plasticity in the sugar preferences of <i>Saccharomyces</i> MALT transporters in domesticated yeasts Open
Maltose and maltotriose, together with glucose, are the major carbohydrates found in malts. Thus, brewing yeasts grown in malt-based brewing processes with serial re-pitching have likely increased their ability to uptake these sugars durin…
View article: Parasitism-evoked horizontal gene transfer between plants as a novel trigger for specialized metabolism evolution
Parasitism-evoked horizontal gene transfer between plants as a novel trigger for specialized metabolism evolution Open
Recent genomic studies of parasitic plants have revealed that there are numerous footprints indicative of horizontal gene transfer (HGT) to the parasites from their host plants. However, the molecular mechanisms and biological impacts of t…
View article: Seed-coat protective neolignans are produced by the dirigent protein AtDP1 and the laccase AtLAC5 in Arabidopsis
Seed-coat protective neolignans are produced by the dirigent protein AtDP1 and the laccase AtLAC5 in Arabidopsis Open
Lignans/neolignans are generally synthesized from coniferyl alcohol (CA) in the cinnamate/monolignol pathway by oxidation to generate the corresponding radicals with subsequent stereoselective dimerization aided by dirigent proteins (DIRs)…
View article: (+)‐Sesamin‐oxidising CYP92B14 shapes specialised lignan metabolism in sesame
(+)‐Sesamin‐oxidising CYP92B14 shapes specialised lignan metabolism in sesame Open
Summary Sesamum spp. (sesame) are known to accumulate a variety of lignans in a lineage‐specific manner. In cultivated sesame ( Sesamum indicum ), (+)‐sesamin, (+)‐sesamolin and (+)‐sesaminol triglucoside are the three major lignans found …
View article: Author Correction: Identification of a binding protein for sesamin and characterization of its roles in plant growth
Author Correction: Identification of a binding protein for sesamin and characterization of its roles in plant growth Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Glycoside‐specific glycosyltransferases catalyze regio‐selective sequential glucosylations for a sesame lignan, sesaminol triglucoside
Glycoside‐specific glycosyltransferases catalyze regio‐selective sequential glucosylations for a sesame lignan, sesaminol triglucoside Open
Summary Sesame ( Sesamum indicum ) seeds contain a large number of lignans, phenylpropanoid‐related plant specialized metabolites. (+)‐Sesamin and (+)‐sesamolin are major hydrophobic lignans, whereas (+)‐sesaminol primarily accumulates as …
View article: Functional specialization of <scp>UDP</scp>‐glycosyltransferase 73P12 in licorice to produce a sweet triterpenoid saponin, glycyrrhizin
Functional specialization of <span>UDP</span>‐glycosyltransferase 73P12 in licorice to produce a sweet triterpenoid saponin, glycyrrhizin Open
Summary Glycyrrhizin, a sweet triterpenoid saponin found in the roots and stolons of Glycyrrhiza species (licorice), is an important active ingredient in traditional herbal medicine. We previously identified two cytochrome P450 monooxygena…
View article: Open Sesame! A Long-Time Enigma of Sesame Lignan Oxidation Steps, Deciphered
Open Sesame! A Long-Time Enigma of Sesame Lignan Oxidation Steps, Deciphered Open
主要な油糧作物であるゴマ（Sesamum indicum）の種子は，古くから体に良い食べ物として食用あるいは薬用として利用されている(1)．近年，その有効成分が，ゴマ種子に高蓄積される特有のリグナン類（(+)-セサミン，(+)-セサモリン，(+)-セサミノール）であるという研究が多数報告され，健康機能成分としてのリグナン類のさまざまな生理作用が注目されている(2, 3)．またゴマ油がほかの食用油と比較して傷みにくいのは，(+)-セサモリンの分解により生成する抗酸化成分，セサ…
View article: Formation of a Methylenedioxy Bridge in (+)-Epipinoresinol by CYP81Q3 Corroborates with Diastereomeric Specialization in Sesame Lignans
Formation of a Methylenedioxy Bridge in (+)-Epipinoresinol by CYP81Q3 Corroborates with Diastereomeric Specialization in Sesame Lignans Open
Plant specialized metabolites are often found as lineage-specific diastereomeric isomers. For example, Sesamum alatum accumulates the specialized metabolite (+)-2-episesalatin, a furofuran-type lignan with a characteristic diastereomeric c…
MAL73, a novel regulator of maltose fermentation, is functionally impaired by single nucleotide polymorphism in sake brewing yeast Open
For maltose fermentation, budding yeast Saccharomyces cerevisiae operates a mechanism that involves transporters (MALT), maltases (MALS) and regulators (MALR) collectively known as MAL genes. However, functional relevance of MAL genes duri…
View article: Author Correction: Oxidative rearrangement of (+)-sesamin by CYP92B14 co-generates twin dietary lignans in sesame
Author Correction: Oxidative rearrangement of (+)-sesamin by CYP92B14 co-generates twin dietary lignans in sesame Open
The original version of of the Supplementary Information associated with this Article inadvertently omitted oligonucleotide primer sequences from Supplementary Table 3 and Supplementary Methods describing the molecular cloning of CYP92B14,…
View article: Oxidative rearrangement of (+)-sesamin by CYP92B14 co-generates twin dietary lignans in sesame
Oxidative rearrangement of (+)-sesamin by CYP92B14 co-generates twin dietary lignans in sesame Open
(+)-Sesamin, (+)-sesamolin, and (+)-sesaminol glucosides are phenylpropanoid-derived specialized metabolites called lignans, and are rich in sesame ( Sesamum indicum ) seed. Despite their renowned anti-oxidative and health-promoting proper…
View article: De Novo Transcriptomes of Forsythia koreana Using a Novel Assembly Method: Insight into Tissue- and Species-Specific Expression of Lignan Biosynthesis-Related Gene
De Novo Transcriptomes of Forsythia koreana Using a Novel Assembly Method: Insight into Tissue- and Species-Specific Expression of Lignan Biosynthesis-Related Gene Open
Forsythia spp. are perennial woody plants which are one of the most extensively used medicinal sources of Chinese medicines and functional diets owing to their lignan contents. Lignans have received widespread attention as leading compound…
View article: Diversity and Evolution of 2-Oxoglutarate Dependent Dioxygenase
Diversity and Evolution of 2-Oxoglutarate Dependent Dioxygenase Open
2-オキソグルタル酸依存性ジオキシゲナーゼ（2OGD）は二価鉄を含む水溶性のジオキシゲナーゼであり，低分子化合物からタンパク質やDNAまで様々な生体分子に対して水酸化や脱メチル化など多彩な酸化反応を触媒する．2OGDは細菌から植物，動物まで広く存在しており，ヒトには約60個，各植物種のゲノムには0.5%を占める2OGD遺伝子が存在しているが，進化系統解析に基づく分類命名法は確立されていない．本解説では，生物界全体の2OGDを比較解析し，2OGDの進化と多様性，および代謝活性…