Eija Könönen
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View article: Association of Subgingival Microbiota Composition With Risk, Severity, and Outcome of Cryptogenic Ischemic Stroke in Young Adults
Association of Subgingival Microbiota Composition With Risk, Severity, and Outcome of Cryptogenic Ischemic Stroke in Young Adults Open
Background Oral and gut dysbiosis has been linked to stroke pathogenesis and its prognosis. However, the relationship between the subgingival microbiota and cryptogenic ischemic stroke (CIS) remains unclear. We compared the subgingival mic…
View article: Oral Microbial Determinants of Saliva and Serum Lipopolysaccharide Activity
Oral Microbial Determinants of Saliva and Serum Lipopolysaccharide Activity Open
Lipopolysaccharide (LPS) is a virulence factor of gram-negative bacteria, and endotoxemia or translocation of LPS in serum plays a significant role in oral and systemic pathologies. The contribution of the oral microbiome composition to sa…
View article: The Association of Periodontitis With Risk of Prevalent and Incident Metabolic Syndrome
The Association of Periodontitis With Risk of Prevalent and Incident Metabolic Syndrome Open
Aim To investigate whether periodontitis is associated with prevalent and incident metabolic syndrome (MetS). Materials and Methods The baseline study included 4183 individuals from a population‐based survey (DILGOM) in 2007 and follow‐up …
View article: Oral microbiome dysbiosis in cryptogenic ischemic stroke patients with high-risk patent foramen ovale
Oral microbiome dysbiosis in cryptogenic ischemic stroke patients with high-risk patent foramen ovale Open
Patent foramen ovale (PFO) is the most common congenital heart abnormality of foetal origin and has been associated with cryptogenic ischemic stroke (CIS) through several mechanisms, with most theories supporting paradoxical embolism. Othe…
View article: Activation of cellular responses by cyclic dinucleotides and <i>Porphyromonas gingivalis</i> lipopolysaccharide: a proteomic study on gingival fibroblasts
Activation of cellular responses by cyclic dinucleotides and <i>Porphyromonas gingivalis</i> lipopolysaccharide: a proteomic study on gingival fibroblasts Open
Simultaneous exposure to CDNs and Pg LPS stimulates the periodontal immune response by activating the anti-microbial cellular responses of HGFs with some notable differences from individual exposures.
View article: Polymicrobial infections with specific <i>Actinomyces</i> and related organisms, using the current taxonomy
Polymicrobial infections with specific <i>Actinomyces</i> and related organisms, using the current taxonomy Open
Actinomyces organisms reside on mucosal surfaces of the oropharynx and the genitourinary tract. Polymicrobial infections with Actinomyces organisms are increasingly being reported in the literature. Since these infections differ from class…
View article: Periodontitis, Dental Procedures, and Young-Onset Cryptogenic Stroke
Periodontitis, Dental Procedures, and Young-Onset Cryptogenic Stroke Open
Periodontitis is associated with an increased risk of ischemic stroke, and the risk may be particularly high among young people with unexplained stroke etiology. Thus, we investigated in a case-control study whether periodontitis or recent…
View article: Shotgun metagenomic analysis of the oral microbiome in gingivitis: a nested case-control study
Shotgun metagenomic analysis of the oral microbiome in gingivitis: a nested case-control study Open
We observed distinct differences in the oral microbiome between the GG/IP and H/LG groups, indicating similar yet unique microbial profiles and emphasizing their potential role in progression of periodontal diseases.
View article: Factors affecting the quality and reproducibility of MALDI-TOF MS identification for human Capnocytophaga species
Factors affecting the quality and reproducibility of MALDI-TOF MS identification for human Capnocytophaga species Open
Reproducibility and quality of MALDI-TOF MS spectra are critical in the identification process, however, information on the factors affecting the identification scores are scarce. Here, we studied the influence of various factors during th…
View article: Quantitative Evaluation of NFE2L2/NRF2 and Cytokine Response Induced by Porphyromonas Gingivalis Lipopolysaccharide and Nicotine in a Titanium-Oral Mucosa Model
Quantitative Evaluation of NFE2L2/NRF2 and Cytokine Response Induced by Porphyromonas Gingivalis Lipopolysaccharide and Nicotine in a Titanium-Oral Mucosa Model Open
Objective: Titanium can alter peri-implant mucosa cytokine response to microbiological and chemical stresses. This work used organotypic titanium-oral mucosa model to evaluate oxidant resistance and cytokine response to Porphyromonas gingi…
View article: Multikingdom oral microbiome interactions in early-onset cryptogenic ischemic stroke
Multikingdom oral microbiome interactions in early-onset cryptogenic ischemic stroke Open
Although knowledge of the role of the oral microbiome in ischemic stroke is steadily increasing, little is known about the multikingdom microbiota interactions and their consequences. We enrolled participants from a prospective multicentre…
View article: Dietary inflammatory index in relation to salivary cytokine concentrations and periodontitis: A cross‐sectional analysis
Dietary inflammatory index in relation to salivary cytokine concentrations and periodontitis: A cross‐sectional analysis Open
Aim To examine the associations of dietary inflammatory index (DII) with salivary cytokine concentrations and periodontitis after controlling for body mass index (BMI), socio‐demographic factors and lifestyle. Materials and Methods Subgrou…
View article: Salivary Human β-Defensin 1-3 and Human α-Defensin-1 Levels in Relation to the Extent of Periodontal Disease and Tooth Loss in the Elderly
Salivary Human β-Defensin 1-3 and Human α-Defensin-1 Levels in Relation to the Extent of Periodontal Disease and Tooth Loss in the Elderly Open
The oral innate immune response may diminish with aging. In the present study, the aim was to examine human β-defensin (hBD) 1-3 and human neutrophil peptide (HNP)-1 levels in the saliva of an elderly population to establish the extent of …
View article: Periodontal microbiology and microbial etiology of periodontal diseases: Historical concepts and contemporary perspectives
Periodontal microbiology and microbial etiology of periodontal diseases: Historical concepts and contemporary perspectives Open
This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate t…
View article: Toll‐like receptor‐1, ‐2, and ‐6 genotypes in relation to salivary human beta‐defensin‐1, ‐2, ‐3 and human neutrophilic peptide‐1
Toll‐like receptor‐1, ‐2, and ‐6 genotypes in relation to salivary human beta‐defensin‐1, ‐2, ‐3 and human neutrophilic peptide‐1 Open
Aim To examine whether functional gene polymorphisms of toll‐like receptor ( TLR ) 1 , TLR2 , and TLR6 are related to the salivary concentrations of human beta‐defensins (hBDs)‐1, ‐2, ‐3, and human neutrophilic peptide (HNP)‐1. Materials a…
View article: <i>Prevotella</i> species as oral residents and infectious agents with potential impact on systemic conditions
<i>Prevotella</i> species as oral residents and infectious agents with potential impact on systemic conditions Open
Oral Prevotella are known as anaerobic commensals on oral mucosae and in dental plaques from early life onwards, including pigmented P. melaninogenica, P. nigrescens, and P. pallens and non-pigmented Prevotella species. Many Prevotella spe…
View article: Recommendations by the European Federation of Periodontology and guidelines in Nordic countries
Recommendations by the European Federation of Periodontology and guidelines in Nordic countries Open
The recent clinical practice guidelines by the European Federation of Periodontology (EFP) are based on the best available evidence to be used in decision-making when treating stage I-III periodontitis patients with the intention to improv…
View article: Anbefalinger fra European Federation of Periodontology og retningslinjer i de nordiske lande
Anbefalinger fra European Federation of Periodontology og retningslinjer i de nordiske lande Open
English summary Surgical therapy in the management of periodontitis – recommendations by the european federation of periodontology and guidelines in nordic countries Nor Tannlegeforen Tid. 2022; 132: 34–41. The recently published clinical …
View article: Oral Prevotella Species and Their Connection to Events of Clinical Relevance in Gastrointestinal and Respiratory Tracts
Oral Prevotella Species and Their Connection to Events of Clinical Relevance in Gastrointestinal and Respiratory Tracts Open
Prevotella is recognized as one of the core anaerobic genera in the oral microbiome. In addition, members of this genus belong to microbial communities of the gastrointestinal and respiratory tracts. Several novel Prevotella species, most …
View article: Global proteomics of fibroblast cells treated with bacterial cyclic dinucleotides, c-di-GMP and c-di-AMP
Global proteomics of fibroblast cells treated with bacterial cyclic dinucleotides, c-di-GMP and c-di-AMP Open
This study has added to the increasing appreciation that beyond the regulation of cytokine production via STING, cyclic dinucleotides also broadly affect many critical processes in human cells.
View article: Bacterial Cyclic Dinucleotides and the cGAS–cGAMP–STING Pathway: A Role in Periodontitis?
Bacterial Cyclic Dinucleotides and the cGAS–cGAMP–STING Pathway: A Role in Periodontitis? Open
Host cells can recognize cytosolic double-stranded DNAs and endogenous second messengers as cyclic dinucleotides—including c-di-GMP, c-di-AMP, and cGAMP—of invading microbes via the critical and essential innate immune signaling adaptor mo…
View article: Activation of Gingival Fibroblasts by Bacterial Cyclic Dinucleotides and Lipopolysaccharide
Activation of Gingival Fibroblasts by Bacterial Cyclic Dinucleotides and Lipopolysaccharide Open
Human gingival fibroblasts (HGFs) recognize microbe-associated molecular patterns (MAMPs) and respond with inflammatory proteins. Simultaneous impacts of bacterial cyclic di-guanosine monophosphate (c-di-GMP), cyclic di-adenosine monophosp…
View article: Elevated Baseline Salivary Protease Activity May Predict the Steadiness of Gingival Inflammation During Periodontal Healing: A 12-Week Follow-Up Study on Adults
Elevated Baseline Salivary Protease Activity May Predict the Steadiness of Gingival Inflammation During Periodontal Healing: A 12-Week Follow-Up Study on Adults Open
Aim was to profile salivary total protease, Porphyromonas gingivalis gingipain, and neutrophil elastase activities in relation to the resolution of periodontal inflammation, salivary macrophage-derived chemokine (MDC), and macrophage infla…
View article: Immunological and Microbiological Profiling of Cumulative Risk Score for Periodontitis
Immunological and Microbiological Profiling of Cumulative Risk Score for Periodontitis Open
The cumulative risk score (CRS) is a mathematical salivary diagnostic model to define an individual’s risk of having periodontitis. In order to further validate this salivary biomarker, we investigated how periodontal bacteria, lipopolysac…
View article: An Oral Rinse Active Matrix Metalloproteinase-8 Point-of-Care Immunotest May Be Less Accurate in Patients with Crohn’s Disease
An Oral Rinse Active Matrix Metalloproteinase-8 Point-of-Care Immunotest May Be Less Accurate in Patients with Crohn’s Disease Open
The diagnostic accuracy of point-of-care (PoC) applications may be compromised in individuals with additional inflammatory conditions. This cross-sectional study examined the performance of a commercial oral rinse active matrix metalloprot…
View article: Salivary cytokine biomarker concentrations in relation to obesity and periodontitis
Salivary cytokine biomarker concentrations in relation to obesity and periodontitis Open
Systemic low-grade inflammation is associated with obesity. Aim of this study was to examine the association between obesity and salivary biomarkers of periodontitis. Salivary interleukin (IL)-1-receptor antagonist (IL-1Ra), IL-6, IL-8, IL…
View article: Oral health of children and adolescents – factors of concern in the future
Oral health of children and adolescents – factors of concern in the future Open
Oral health of children and adolescents -factors of concern in the future In children, oral health is an integral part of general health.Good oral health contributes to normal growth and development as well as good quality of life.Professi…
View article: Salivary concentrations of macrophage activation-related chemokines are influenced by non-surgical periodontal treatment: a 12-week follow-up study
Salivary concentrations of macrophage activation-related chemokines are influenced by non-surgical periodontal treatment: a 12-week follow-up study Open
Background: During periodontal inflammation, bacteria induces chemokine expression and migration of various inflammatory cells. The aim of the study was to learn if periodontal treatment alters salivary concentrations of macrophage activat…
View article: Salivary Cytokine Biomarker Concentrations in Relation to Obesity and Periodontitis
Salivary Cytokine Biomarker Concentrations in Relation to Obesity and Periodontitis Open
Systemic low-grade inflammation is associated with obesity. Our aim was to examine the association between obesity and salivary biomarkers of periodontitis. Salivary interleukin (IL)-1-receptor antagonist (IL-1Ra), IL-6, IL-8, IL-10, and t…
View article: Gingival tissue human beta‐defensin levels in relation to infection and inflammation
Gingival tissue human beta‐defensin levels in relation to infection and inflammation Open
Aim To profile gingival tissue levels of human beta‐defensin (hBD)‐2 and hBD‐3 in relation to gingival inflammation, Th17‐related cytokine concentrations, Porphyromonas gingivalis counts, and gingipain and total protease activities. Materi…