Eileen Carry
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View article: Expecting medication misuse: a proactive approach to drug discovery to prevent fatal overdose
Expecting medication misuse: a proactive approach to drug discovery to prevent fatal overdose Open
Misuse of central nervous system (CNS) depressants (alprazolam, fentanyl, etc.) is a major cause of fatal overdose, with a high prevalence of deaths involving polydrug interactions from the victim's own prescriptions. Thus, there is an urg…
View article: Identification of Dihydromyricetin and Metabolites in Serum and Brain Associated with Acute Anti-Ethanol Intoxicating Effects in Mice
Identification of Dihydromyricetin and Metabolites in Serum and Brain Associated with Acute Anti-Ethanol Intoxicating Effects in Mice Open
Dihydromyricetin is a natural bioactive flavonoid with unique GABAA receptor activity with a putative mechanism of action to reduce the intoxication effects of ethanol. Although dihydromyricetin’s poor oral bioavailability limits clinical …
View article: A Novel Dual Drug Approach That Combines Ivermectin and Dihydromyricetin (DHM) to Reduce Alcohol Drinking and Preference in Mice
A Novel Dual Drug Approach That Combines Ivermectin and Dihydromyricetin (DHM) to Reduce Alcohol Drinking and Preference in Mice Open
Alcohol use disorder (AUD) affects over 18 million people in the US. Unfortunately, pharmacotherapies available for AUD have limited clinical success and are under prescribed. Previously, we established that avermectin compounds (ivermecti…
View article: Targeting positive modulation and inhibition of ethanol-induced GABAA receptor potentiation as a novel mechanism for alcohol use disorder
Targeting positive modulation and inhibition of ethanol-induced GABAA receptor potentiation as a novel mechanism for alcohol use disorder Open
Alcohol use disorder (AUD) is the most common substance use disorder (SUD) giving rise to major socioeconomic and health consequences, with an estimated 208 million people affected worldwide. Current pharmacotherapies are minimally ineffec…
View article: Inhibition of EtOH-induced GABAAR potentiation as a Novel mechanism for the treatment of Alcohol Use Disorder
Inhibition of EtOH-induced GABAAR potentiation as a Novel mechanism for the treatment of Alcohol Use Disorder Open
Current pharmacotherapies for the treatment of alcohol use disorder are largely ineffective and/or associated with major side effects. There are currently no treatment options that target the direct neurological effects of ethanol, despite…
View article: Insights into bioavailability and microbial catabolism of grape polyphenols in mice using an efficient UPLC-Triple quadrupole-MS/MS method
Insights into bioavailability and microbial catabolism of grape polyphenols in mice using an efficient UPLC-Triple quadrupole-MS/MS method Open
Background: Polyphenol-rich foods, such as grape-derived products, contain a wide array of bioactive phenolic compounds. These phenolic compounds are promising chemo-preventative agents, which can be acquired naturally through diet. A sma…
View article: A Comprehensive Database and Analysis Framework To Incorporate Multiscale Data Types and Enable Integrated Analysis of Bioactive Polyphenols
A Comprehensive Database and Analysis Framework To Incorporate Multiscale Data Types and Enable Integrated Analysis of Bioactive Polyphenols Open
The development of a given botanical preparation for eventual clinical application requires extensive, detailed characterizations of the chemical composition, as well as the biological availability, biological activity, and safety profiles…