Eileen Dahlke
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View article: Lysosome stress response and mitochondria injury are the earliest detectable alteration in FSGS
Lysosome stress response and mitochondria injury are the earliest detectable alteration in FSGS Open
View article: Primidone: a clinically promising candidate for the treatment of psoriasis
Primidone: a clinically promising candidate for the treatment of psoriasis Open
Using clinically relevant animal models, we have recently demonstrated that the anticonvulsant primidone (Liskantin ® ), approved by the FDA for the treatment of various forms of epilepsy, can effectively block RIPK1 enzymatic activity, wh…
View article: Molecular signature of stem-like glioma cells (SLGCs) from human glioblastoma and gliosarcoma
Molecular signature of stem-like glioma cells (SLGCs) from human glioblastoma and gliosarcoma Open
Glioblastoma multiforme (GBM) and the GBM variant gliosarcoma (GS) are among the tumors with the highest morbidity and mortality, providing only palliation. Stem-like glioma cells (SLGCs) are involved in tumor initiation, progression, ther…
View article: Targeted deletion of von-Hippel-Lindau in the proximal tubule conditions the kidney against early diabetic kidney disease
Targeted deletion of von-Hippel-Lindau in the proximal tubule conditions the kidney against early diabetic kidney disease Open
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Glomerular hyperfiltration and albuminuria subject the proximal tubule (PT) to a subsequent elevation of workload, growth, and hypoxia. Hypoxia plays an ambiguo…
View article: Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis
Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis Open
The metalloproteases meprin α and meprin β are highly expressed in the healthy gut but significantly decreased in inflammatory bowel disease, implicating a protective role in mucosal homeostasis. In the colon, meprin α and meprin β form co…
View article: Megalin Orchestrates FcRn Endocytosis and Trafficking
Megalin Orchestrates FcRn Endocytosis and Trafficking Open
The neonatal Fc receptor (FcRn) is highly expressed in the renal proximal tubule and is important for the reclamation of albumin by cellular transcytosis to prevent its loss in the urine. The initial event of this transcellular transport m…
View article: VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney Open
The lipid kinase VPS34 orchestrates autophagy, endocytosis, and metabolism and is implicated in cancer and metabolic disease. The proximal tubule in the kidney is a key metabolic organ that controls reabsorption of nutrients such as fatty …
View article: Tubular IKKβ Deletion Alleviates Acute Ischemic Kidney Injury and Facilitates Tissue Regeneration
Tubular IKKβ Deletion Alleviates Acute Ischemic Kidney Injury and Facilitates Tissue Regeneration Open
Acute kidney injury (AKI) is a common renal injury leading to relevant morbidity and mortality worldwide. Most of the clinical cases of AKI are caused by ischemia reperfusion (I/R) injury with renal ischemia injury followed by reperfusion …
View article: Primidone blocks RIPK1-driven cell death and inflammation
Primidone blocks RIPK1-driven cell death and inflammation Open
View article: Cathepsin B increases ENaC activity leading to hypertension early in nephrotic syndrome
Cathepsin B increases ENaC activity leading to hypertension early in nephrotic syndrome Open
The NPHS2 gene, encoding the slit diaphragm protein podocin, accounts for genetic and sporadic forms of nephrotic syndrome (NS). Patients with NS often present symptoms of volume retention, such as oedema formation or hypertension. The pri…