Eileen Handberg
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View article: Refractory angina in women with ischemia and no obstructive coronary artery disease — A report from the Women’s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction (WISE-CVD) study
Refractory angina in women with ischemia and no obstructive coronary artery disease — A report from the Women’s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction (WISE-CVD) study Open
View article: TIMI Frame Count and Coronary Function in Women With Suspected Ischemia and Nonobstructed Coronary Arteries
TIMI Frame Count and Coronary Function in Women With Suspected Ischemia and Nonobstructed Coronary Arteries Open
Among women with suspected INOCA, measuring the TFC poststress did not help in the identification of abnormal coronary physiology pathways. Other strategies should be developed to improve accessibility to coronary function testing in this …
View article: Coronary microvascular dysfunction and right ventricular structure and function
Coronary microvascular dysfunction and right ventricular structure and function Open
Previous studies have suggested associations between coronary microvascular dysfunction (CMD) and alterations in left ventricular (LV) structure and function Data are however scarce regarding the right ventricular (RV). In the context of C…
View article: QUIET WARRIOR – Rationale and design: An ancillary study to the Women's IschemiA TRial to Reduce Events in Nonobstructive CAD (WARRIOR)
QUIET WARRIOR – Rationale and design: An ancillary study to the Women's IschemiA TRial to Reduce Events in Nonobstructive CAD (WARRIOR) Open
The QUIET WARRIOR sub-study will advance the understanding of INOCA in women, integrating clinical, imaging, and socioeconomic data to enhance risk prediction and guide personalized therapeutic strategies. This research will address critic…
View article: Through the lens of Good Participatory Practice: Findings and lessons learned from the healthcare worker subcommittee of the COVID-19 Healthcare Worker Exposure Response and Outcomes Registry
Through the lens of Good Participatory Practice: Findings and lessons learned from the healthcare worker subcommittee of the COVID-19 Healthcare Worker Exposure Response and Outcomes Registry Open
Participant representation, including the Good Participatory Practice guidelines, in the design and execution of clinical research can profoundly affect research structure and process. Early in the COVID-19 pandemic, an online registry cal…
View article: Contributors to high left ventricular ejection fraction in women with ischemia and no obstructive coronary artery disease: Results from the Women's Ischemia Syndrome Evaluation—Coronary Vascular Dysfunction (WISE-CVD) Study
Contributors to high left ventricular ejection fraction in women with ischemia and no obstructive coronary artery disease: Results from the Women's Ischemia Syndrome Evaluation—Coronary Vascular Dysfunction (WISE-CVD) Study Open
NCT02582021.
View article: Impact of epicardial fat on coronary vascular function, cardiac morphology, and cardiac function in women with suspected INOCA
Impact of epicardial fat on coronary vascular function, cardiac morphology, and cardiac function in women with suspected INOCA Open
Aims Epicardial fat is a metabolically active adipose tissue depot situated between the myocardium and visceral pericardium that covers ∼80% of the heart surface. While epicardial fat has been associated with the development of atheroscler…
View article: Endogenous androgens, coronary atheroma and remodeling in women with suspected ischemic heart disease: A report from the Women's Ischemia Syndrome Evaluation (WISE) study
Endogenous androgens, coronary atheroma and remodeling in women with suspected ischemic heart disease: A report from the Women's Ischemia Syndrome Evaluation (WISE) study Open
View article: Arterial stiffness assessment in coronary microvascular dysfunction and heart failure with preserved ejection fraction: An initial report from the WISE-CVD continuation study
Arterial stiffness assessment in coronary microvascular dysfunction and heart failure with preserved ejection fraction: An initial report from the WISE-CVD continuation study Open
HFpEF participants exhibit greater arterial stiffness and lower myocardial perfusion reserve, with lower LVEF albeit not remodeling, compared to suspected CMD participants. These findings suggest arterial stiffness may contribute to progre…
View article: Comparison of risk profiles of participants in the Women's IschemiA TRial to Reduce events In non-ObstRuctive CAD (WARRIOR) trial, using Coronary Computed Tomography Angiography vs Invasive Coronary Angiography
Comparison of risk profiles of participants in the Women's IschemiA TRial to Reduce events In non-ObstRuctive CAD (WARRIOR) trial, using Coronary Computed Tomography Angiography vs Invasive Coronary Angiography Open
View article: Elevated high-density lipoprotein cholesterol and adverse outcomes in women with symptoms of ischemic heart disease
Elevated high-density lipoprotein cholesterol and adverse outcomes in women with symptoms of ischemic heart disease Open
View article: Towards real-time myocardial infarction diagnosis: a convergence of machine learning and ion-exchange membrane technologies leveraging miRNA signatures
Towards real-time myocardial infarction diagnosis: a convergence of machine learning and ion-exchange membrane technologies leveraging miRNA signatures Open
Rapid diagnosis of acute myocardial infarction (AMI) is crucial for optimal patient management.
View article: Dietary Composition, Angiographic Coronary Disease, and Cardiovascular Outcomes in the WISE Study (Women’s Ischemia Syndrome Evaluation)
Dietary Composition, Angiographic Coronary Disease, and Cardiovascular Outcomes in the WISE Study (Women’s Ischemia Syndrome Evaluation) Open
Background: Studies relating diet to angiographic coronary artery disease (CAD) and subsequent major adverse cardiac events (MACE) in women are limited. Information on diet was collected in the Women’s Ischemia Syndrome Evaluation (WISE), …
View article: Intravenous administration of umbilical cord lining stem cells in left ventricular assist device recipients: Results of the uSTOP LVAD BLEED pilot study
Intravenous administration of umbilical cord lining stem cells in left ventricular assist device recipients: Results of the uSTOP LVAD BLEED pilot study Open
In this first-ever IV administration of ULSCs in LVAD patients, infusion was noted to be safe and tolerable and did not cause immune sensitization. Half of the patients were noted to have angiogenic stabilization, and there was a trend tow…
View article: Association of abnormal electrocardiography response on dobutamine stress echocardiogram with longer-term major adverse cardiovascular events in women with symptoms of ischemic heart disease
Association of abnormal electrocardiography response on dobutamine stress echocardiogram with longer-term major adverse cardiovascular events in women with symptoms of ischemic heart disease Open
Abnormal stress ECG findings on dobutamine stress testing with a negative DSE should be viewed as an indicator of longer-term risk in women with signs and symptoms of ischemia.
View article: RELATIVE AND ABSOLUTE METABOLIC COST OF DAILY PHYSICAL ACTIVITIES ACROSS THE LIFESPAN
RELATIVE AND ABSOLUTE METABOLIC COST OF DAILY PHYSICAL ACTIVITIES ACROSS THE LIFESPAN Open
Americans spend over 90% of their activity related energy expenditure performing common daily activities. However, there is a gap in knowledge pertaining to potential age-related differences in the metabolic cost of performing these activi…
View article: High levels of high-density lipoprotein cholesterol (HDL-C) and major adverse cardiovascular events and 10-year all-cause mortality:results from Women's Ischemia Syndrome Evaluation (WISE) study
High levels of high-density lipoprotein cholesterol (HDL-C) and major adverse cardiovascular events and 10-year all-cause mortality:results from Women's Ischemia Syndrome Evaluation (WISE) study Open
Background High and low levels of high-density lipoprotein cholesterol (HDL-C) are associated with lower and higher cardiovascular risk, respectively. Emerging data in the general population and those with coronary artery disease have show…
View article: Acute electrophysiological effects of energy drink, energy gum and coffee: a double-blind randomized placebo-controlled crossover study
Acute electrophysiological effects of energy drink, energy gum and coffee: a double-blind randomized placebo-controlled crossover study Open
Background Energy drink consumption is highly prevalent in young adults, especially in males, and has been associated with adverse cardiovascular events, including QT prolongation and atherothrombosis. A proposed mechanism underlying these…
View article: Epicardial fat is associated with adverse ventricular remodeling and diastolic dysfunction in women with ischemia but no obstructive coronary artery disease
Epicardial fat is associated with adverse ventricular remodeling and diastolic dysfunction in women with ischemia but no obstructive coronary artery disease Open
Background Epicardial fat is a metabolically active adipose tissue depot located between the myocardium and visceral pericardium. Increased epicardial fat is associated with the development of atherosclerosis and obstructive coronary arter…
View article: High sensitivity cardiac troponin I in response to handgrip in women with signs and symptoms of ischemia with no obstructive coronary arteries
High sensitivity cardiac troponin I in response to handgrip in women with signs and symptoms of ischemia with no obstructive coronary arteries Open
Background Women with signs and symptoms of ischemia and no obstructive coronary arteries (INOCA) are suspected to have myocardial ischemia, ∼10% have prior myocardial scar often in the absence of acute myocardial infarction (AMI) diagnosi…
View article: Ventricular arterial coupling in patients with ischemia but no obstructive coronary artery disease: novel insight into heart failure progression
Ventricular arterial coupling in patients with ischemia but no obstructive coronary artery disease: novel insight into heart failure progression Open
Background Ischemia with no obstructive coronary artery disease (INOCA) is prevalent in women and is associated with increased risk of developing heart failure with preserved ejection fraction (HFpEF). While the exact mechanism contributin…
View article: Reprograming of transcriptional profile of colonic organoids from patients with high blood pressure by minocycline
Reprograming of transcriptional profile of colonic organoids from patients with high blood pressure by minocycline Open
Minocycline, an anti-inflammatory antibiotic drug, rebalances impaired gut microbiota, attenuates neuroinflammation and lowers high blood pressure in animal models of hypertension and in hypertensive patients. Our objective in this study w…
View article: Symptom Presentation among Women with Suspected Ischemia and No Obstructive Coronary Artery Disease (INOCA)
Symptom Presentation among Women with Suspected Ischemia and No Obstructive Coronary Artery Disease (INOCA) Open
Identifying ischemic heart disease (IHD) in women based on symptoms is challenging. Women are more likely to endorse non-cardiac symptoms. More than 50% of women with suspected ischemia have no obstructive coronary disease (and thus, INOCA…
View article: Longitudinal cardiac remodeling in collegiate American football players as assessed by echocardiography during their collegiate career
Longitudinal cardiac remodeling in collegiate American football players as assessed by echocardiography during their collegiate career Open
Background Studies on the longitudinal effects of intense physical training on cardiac remodeling are limited, especially in American collegiate football players. Hypothesis College‐level American football training will result in remodelin…
View article: Association of Coronary Artery Dominance With Long-term Outcomes in Female Patients With Suspected Ischemia but Nonobstructive Coronary Artery Disease
Association of Coronary Artery Dominance With Long-term Outcomes in Female Patients With Suspected Ischemia but Nonobstructive Coronary Artery Disease Open
Coronary artery dominance, referring to the arterial supply of the posterior descending artery (PDA), significantly impacts clinical outcomes in cardiac patients. Typically, the PDA originates from the right coronary artery in the right-do…
View article: Left ventricular ejection fraction and long-term outcomes in women presenting with signs and symptoms of ischaemia
Left ventricular ejection fraction and long-term outcomes in women presenting with signs and symptoms of ischaemia Open
Background Although women are known to have a relatively higher left ventricular ejection fraction (LVEF) compared with men, a sex-neutral LVEF threshold continues to be used for clinical management. We sought to investigate the relationsh…
View article: Autoimmune rheumatic diseases in women with coronary microvascular dysfunction: a report from the Women's Ischemia Syndrome Evaluation—Coronary Vascular Dysfunction (WISE-CVD) project
Autoimmune rheumatic diseases in women with coronary microvascular dysfunction: a report from the Women's Ischemia Syndrome Evaluation—Coronary Vascular Dysfunction (WISE-CVD) project Open
Background While autoimmune rheumatic diseases (ARDs) have been linked with coronary microvascular dysfunction (CMD), the relationship between ARD and CMD in women with signs and symptoms of ischemia and no obstructive arteries (INOCA) are…
View article: Clinically stable covid-19 patients presenting to acute unscheduled episodic care venues have increased risk of hospitalization: secondary analysis of a randomized control trial
Clinically stable covid-19 patients presenting to acute unscheduled episodic care venues have increased risk of hospitalization: secondary analysis of a randomized control trial Open
View article: Fitness attenuates long-term cardiovascular outcomes in women with ischemic heart disease and metabolic syndrome
Fitness attenuates long-term cardiovascular outcomes in women with ischemic heart disease and metabolic syndrome Open
https://www.clinicaltrials.gov/ct2/show/NCT00000554 (NCT00000554).
View article: Latest from the WISE: Contributions to the Understanding of Ischemia and Heart Failure among Women with No Obstructive Coronary Arteries
Latest from the WISE: Contributions to the Understanding of Ischemia and Heart Failure among Women with No Obstructive Coronary Arteries Open
Since 1996, the National Heart, Lung, and Blood Institute-sponsored Women’s Ischemia Syndrome Evaluation (WISE) has been investigating pathophysiological processes underlying ischemic heart disease in women and related outcomes. Recent fin…