Eileen M. Crimmins
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View article: Gene expression composite scores of cellular senescence predict aging health outcomes in the Health and Retirement Study
Gene expression composite scores of cellular senescence predict aging health outcomes in the Health and Retirement Study Open
View article: Living in historically redlined neighborhoods and biological aging among older adults
Living in historically redlined neighborhoods and biological aging among older adults Open
Living in historically redlined neighborhoods has deleterious effects on aging-related health outcomes, yet little is known about how historical redlining affects the physiological aging process and the role of current neighborhood socioec…
View article: Physiological health Age (PhysAge): a novel multi-system molecular timepiece predicts health and mortality in older adults
Physiological health Age (PhysAge): a novel multi-system molecular timepiece predicts health and mortality in older adults Open
The complexity of epigenetic changes that accompany aging has been distilled into a number of molecular timepieces—termed epigenetic clocks—that characterize the pace of biological aging to differing degrees. Here, we develop and validate …
View article: Association of blood-based neurodegenerative biomarkers with cognitive functioning and dementia in India (LASI-DAD) and the United States (HRS)
Association of blood-based neurodegenerative biomarkers with cognitive functioning and dementia in India (LASI-DAD) and the United States (HRS) Open
This study examines associations between blood-based neurodegenerative biomarkers and cognitive functioning in nationally representative samples of older adults in India and the United States. Using data from the Longitudinal Aging Study i…
View article: Prevalence, awareness, treatment, and control of diabetes in India: a nationally representative survey of adults aged 45 years and older
Prevalence, awareness, treatment, and control of diabetes in India: a nationally representative survey of adults aged 45 years and older Open
View article: Life Expectancy and Health Expectancy in the Twenty-first Century: The Unthinkable, the Inconceivable, and the Unknowable
Life Expectancy and Health Expectancy in the Twenty-first Century: The Unthinkable, the Inconceivable, and the Unknowable Open
The last century witnessed an unprecedented rise in life expectancy; however, in recent decades the “unthinkable” has occurred—life expectancy stagnation, a dramatic drop in the U.S. international life expectancy ranking, rising midlife de…
View article: Increasing Educational Inequality in Biological Aging Among U.S. Adults Aged 50–79 From 1988–1994 to 2015–2018
Increasing Educational Inequality in Biological Aging Among U.S. Adults Aged 50–79 From 1988–1994 to 2015–2018 Open
Educational inequality in health has been increasing in the United States. The growth in health inequality has not been limited to specific conditions but has been observed across a wide range of outcomes, including disability, multimorbid…
View article: Methodology of community-based venous blood specimen collection for the harmonized diagnostic assessment of dementia for the Longitudinal Aging Study in India (LASI-DAD): Wave 2
Methodology of community-based venous blood specimen collection for the harmonized diagnostic assessment of dementia for the Longitudinal Aging Study in India (LASI-DAD): Wave 2 Open
The prevalence of dementia is on the rise, with 60% of dementia cases existing in low- and middle-income countries. In India, the prevalence was reported to be 7.4%. Since the pathophysiology of dementia is multifactorial, the Harmonized L…
View article: Dynamics of multimorbidity, health expectancy, and survival in middle aged and older individuals
Dynamics of multimorbidity, health expectancy, and survival in middle aged and older individuals Open
Background Life expectancy has increased, but such increase has disproportionally expanded the period of life with diseases. Whether expanding health expectancy (HE), defined as years of life free of chronic diseases, could also affect rat…
View article: Risk and protective factors against cognitive decline in older adults from a nationally representative sample in India: Results from the LASI-DAD
Risk and protective factors against cognitive decline in older adults from a nationally representative sample in India: Results from the LASI-DAD Open
INTRODUCTION We characterized modifiable risk and protective factors for cognitive decline in India. METHODS Using the first nationally representative population-based longitudinal sample of N=6,168 older adults in India, we evaluated asso…
View article: Development of a novel transcriptomic measure of aging: Transcriptomic Mortality-risk Age (TraMA)
Development of a novel transcriptomic measure of aging: Transcriptomic Mortality-risk Age (TraMA) Open
Increasingly, research suggests that aging is a coordinated multi-system decline in functioning that occurs at multiple biological levels. We developed and validated a transcriptomic (RNA-based) aging measure we call Transcriptomic Mortali…
View article: Early menopause, hysterectomy, and biological aging: Health and Retirement Study
Early menopause, hysterectomy, and biological aging: Health and Retirement Study Open
Objective: This study examines the association between the timing of menopause and hysterectomy and biological aging, focusing on epigenetic and physiological aging markers. Methods: Data were analyzed from women aged 56 and over in the na…
View article: Impaired lung function is associated with elevated blood biomarkers of AD/ADRD: Unraveling the interplay with risk of dementia
Impaired lung function is associated with elevated blood biomarkers of AD/ADRD: Unraveling the interplay with risk of dementia Open
Rationale We hypothesize that impaired lung function contributes to dementia risk via biological mechanisms reflected in AD/ADRD-related protein biomarkers, and aim to evaluate their role in mediating this relationship. Methods Serum p-Tau…
View article: The Joint Effects of Exposure to Ambient Long-term Air Pollution and Short-term Heat on Epigenetic Aging in the Health and Retirement Study
The Joint Effects of Exposure to Ambient Long-term Air Pollution and Short-term Heat on Epigenetic Aging in the Health and Retirement Study Open
Prior research has examined associations of exposure to air pollution and heat with epigenetic alterations separately; however, these 2 exposures commonly used to measure climate change typically co-occur. We examine joint effects of expos…
View article: The MIND Diet and Incidence of Alzheimer's Disease and Related Dementias Among Five Racial and Ethnic Groups in the Multiethnic Cohort Study
The MIND Diet and Incidence of Alzheimer's Disease and Related Dementias Among Five Racial and Ethnic Groups in the Multiethnic Cohort Study Open
View article: Sex variation in the relationship between <i>APOE</i> ε4, cognitive decline, and dementia
Sex variation in the relationship between <i>APOE</i> ε4, cognitive decline, and dementia Open
INTRODUCTION We examine if the relationship between apolipoprotein E ( APOE) ε4 and cognitive decline and dementia onset differs by sex in non‐Hispanic White and Black respondents from the Health and Retirement Study. METHODS We used race‐…
View article: Epigenetic Clocks Relate to 4 Age-related Health Outcomes Similarly Across 3 Countries
Epigenetic Clocks Relate to 4 Age-related Health Outcomes Similarly Across 3 Countries Open
Background Measures of epigenetic age have been linked to life circumstances and health outcomes in older populations. The similarity of these relationships across multiple populations in well-harmonized data has not been addressed. We exa…
View article: Assessing Metabolic Ageing via <scp>DNA</scp> Methylation Surrogate Markers: A Multicohort Study in Britain, Ireland and the <scp>USA</scp>
Assessing Metabolic Ageing via <span>DNA</span> Methylation Surrogate Markers: A Multicohort Study in Britain, Ireland and the <span>USA</span> Open
Metabolomics and epigenomics have been used to develop ‘ageing clocks’ that assess biological age and identify ‘accelerated ageing’. While metabolites are subject to short‐term variation, DNA methylation (DNAm) may capture longer‐term meta…
View article: Development of a novel transcriptomic measure of aging: Transcriptomic Mortality-risk Age (TraMA)
Development of a novel transcriptomic measure of aging: Transcriptomic Mortality-risk Age (TraMA) Open
Increasingly, research suggests that aging is a coordinated multi-system decline in functioning that occurs at multiple biological levels. We developed and validated a transcriptomic (RNA-based) aging measure we call Transcriptomic Mortali…
View article: Blood Omics Models for System-Specific Mortality Risk Estimation
Blood Omics Models for System-Specific Mortality Risk Estimation Open
Traditional blood-based aging clocks provide an estimate of a person’s overall biological age. However, physiological systems and organs age at different rates in an individual, and anti-aging interventions often target specific physiologi…
View article: THE JOINT EFFECTS OF EXPOSURE TO AIR POLLUTION AND HEAT ON EPIGENETIC AGING IN THE HEALTH AND RETIREMENT STUDY
THE JOINT EFFECTS OF EXPOSURE TO AIR POLLUTION AND HEAT ON EPIGENETIC AGING IN THE HEALTH AND RETIREMENT STUDY Open
Prior research shows independent associations of exposure to air pollution and heat on epigenetic alterations. However, less is known about the combined effects of long-term air pollution (PM2.5) and acute heat events. We examine joint eff…
View article: A NOVEL DNA METHYLATION-BASED SURROGATE BIOMARKER FOR LATENT SYSTEMIC INFLAMMATION
A NOVEL DNA METHYLATION-BASED SURROGATE BIOMARKER FOR LATENT SYSTEMIC INFLAMMATION Open
Chronic low-grade systemic inflammation is a risk factor for chronic diseases and mortality and is an important biomarker in health research. DNA methylation (DNAm) surrogate biomarkers are valuable exposure, risk factor and health outcome…
View article: Lung function and plasma biomarkers: Unraveling the interplay with Alzheimer’s Disease and Related Dementias
Lung function and plasma biomarkers: Unraveling the interplay with Alzheimer’s Disease and Related Dementias Open
Background With the emerging role of the blood biomarkers in Alzheimer’s Disease (AD) clinical practice and trials, it is crucial to identify and address factors influencing the concentrations of these biomarkers in circulation for enhance…
View article: BIOMARKERS HELP US UNDERSTAND HOW CELLULAR AND SYSTEMIC AGING CONTRIBUTE TO MORTALITY
BIOMARKERS HELP US UNDERSTAND HOW CELLULAR AND SYSTEMIC AGING CONTRIBUTE TO MORTALITY Open
Research suggests aging is a coordinated decline occurring in multiple systems and at multiple biological levels. However, it is largely unknown how general biological aging and specific systemic aging co-occur and influence one another to…
View article: ADHD GENETIC BURDEN ASSOCIATES WITH COGNITIVE DECLINE AND ALZHEIMER DISEASE MARKERS IN OLDER ADULTS
ADHD GENETIC BURDEN ASSOCIATES WITH COGNITIVE DECLINE AND ALZHEIMER DISEASE MARKERS IN OLDER ADULTS Open
Attention deficit hyperactivity disorder (ADHD) is associated with greater risk for Alzheimer disease and related dementias (ADRD). Genetic liability for ADHD, via a well-characterized polygenic score, has shown associations with cognitive…
View article: RNA-based Indicators of Cellular Senescence Predict Aging Health Outcomes in the Health and Retirement Study
RNA-based Indicators of Cellular Senescence Predict Aging Health Outcomes in the Health and Retirement Study Open
Cellular senescence, a hallmark of aging, can be quantified through the expression levels of genes related to cell cycle arrest (CCA), macromolecular damage (MD), and the senescence-associated secretory phenotype (SASP). How cellular senes…
View article: The role of Southern context in shaping life course exposures linked to dementia incidence for Black and White older adults in the United States
The role of Southern context in shaping life course exposures linked to dementia incidence for Black and White older adults in the United States Open
View article: A novel DNA methylation-based surrogate biomarker for chronic systemic inflammation (InfLaMeS): results from the Health and Retirement Study
A novel DNA methylation-based surrogate biomarker for chronic systemic inflammation (InfLaMeS): results from the Health and Retirement Study Open
Chronic low-grade systemic inflammation is a risk factor for chronic diseases and mortality and is an important biomarker in health research. DNA methylation (DNAm) surrogate biomarkers are valuable exposure, risk factor and health outcome…
View article: Psychosocial Disadvantage During Childhood and Midlife Health
Psychosocial Disadvantage During Childhood and Midlife Health Open
Importance Low childhood socioeconomic status (SES) is a social hallmark of aging that contributes to adult health disparities and earlier morbidity and mortality. Childhood perceptions of stress are associated with child health outcomes a…
View article: Generations of epigenetic clocks and their links to socioeconomic status in the Health and Retirement Study
Generations of epigenetic clocks and their links to socioeconomic status in the Health and Retirement Study Open
Aim: This is a brief description of links between nine epigenetic clocks related to human aging and socioeconomic and behavioral characteristics as well as health outcomes.Materials & methods: We estimate frequently used and …