Eilon Sherman
YOU?
Author Swipe
View article: NRas Nanoclusters Mediate Crosstalk Between BRAF/ERK and PI3K/AKT Signaling in Melanoma Cells
NRas Nanoclusters Mediate Crosstalk Between BRAF/ERK and PI3K/AKT Signaling in Melanoma Cells Open
Melanocyte signaling through the MAPK pathway is orchestrated by NRas and relayed downstream via multiple effectors, such as RAF, Ral, and PI3K. In spite of their significance, the molecular mechanisms of signaling relay by NRas, their dyn…
View article: Coupling Molecular and Cellular Dynamics in a Large-Scale Monte Carlo Simulation
Coupling Molecular and Cellular Dynamics in a Large-Scale Monte Carlo Simulation Open
Cells change their shape to survive, proliferate, and function. Such changes are both driven by stochastic molecular interactions and affect them in return. Recent Monte-Carlo simulations, such as MCell4, can explicitly capture the interac…
View article: NRas Nanoclusters Mediate Crosstalk Between BRAF/ERK and PI3K/AKT Signalling in Melanoma Cells
NRas Nanoclusters Mediate Crosstalk Between BRAF/ERK and PI3K/AKT Signalling in Melanoma Cells Open
Melanocyte signaling through the MAPK pathway is orchestrated by NRas and relayed downstream via multiple effectors, such as RAF, Ral, and PI3K. In spite of their significance, the molecular mechanisms of signaling relay by NRas, their dyn…
View article: Coupling Molecular and Cellular Dynamics in a Large‐Scale Monte Carlo Simulation
Coupling Molecular and Cellular Dynamics in a Large‐Scale Monte Carlo Simulation Open
Cells change their shape to survive, proliferate and function. Such changes are both driven by stochastic molecular interactions and affect them in return. Recent Monte-Carlo simulations, such as MCell4, can explicitly capture the interact…
View article: Tau Oligomerization Drives Neurodegeneration via Nuclear Membrane Invagination and Lamin B Receptor Binding in Alzheimer’s disease
Tau Oligomerization Drives Neurodegeneration via Nuclear Membrane Invagination and Lamin B Receptor Binding in Alzheimer’s disease Open
The microtubule-associated protein tau aggregates into oligomeric complexes that highly correlate with Alzheimer’s disease (AD) progression. Increasing evidence suggests that nuclear membrane disruption occurs in AD and related tauopathies…
View article: Bayesian metamodeling of early T-cell antigen receptor signaling accounts for its nanoscale activation patterns
Bayesian metamodeling of early T-cell antigen receptor signaling accounts for its nanoscale activation patterns Open
T cells respond swiftly, specifically, sensitively, and robustly to cognate antigens presented on the surface of antigen presenting cells. Existing microscopic models capture various aspects of early T-cell antigen receptor (TCR) signaling…
View article: Nanoscale CAR Organization at the Immune Synapse Correlates with CAR-T Effector Functions
Nanoscale CAR Organization at the Immune Synapse Correlates with CAR-T Effector Functions Open
T cells expressing chimeric antigen receptors (CARs) are at the forefront of clinical treatment of cancers. Still, the nanoscale organization of CARs at the interface of CAR-Ts with target cells, which is essential for TCR-mediated T cell …
View article: Cell Surface Vibrations Distinguish Malignant from Benign Cells
Cell Surface Vibrations Distinguish Malignant from Benign Cells Open
The mechanical properties of living cells, including their shape, rigidity, and internal dynamics play a crucial role in their physiology and pathology. Still, the relations between the physiological cell state and its rigidity and surface…
View article: Nanoscale CAR organization at the immune synapse correlates with CAR-T effector functions
Nanoscale CAR organization at the immune synapse correlates with CAR-T effector functions Open
Chimeric antigen receptors (CARs) are at the forefront of clinical treatment of cancers using adoptive transfer of CAR-T cells. Still, the nanoscale organization of CARs at the interface of CAR-Ts with target cells, which is essential for …
View article: Supplementary Data from MEK Inhibition Reverses Aberrant Signaling in Melanoma Cells through Reorganization of NRas and BRAF in Self Nanoclusters
Supplementary Data from MEK Inhibition Reverses Aberrant Signaling in Melanoma Cells through Reorganization of NRas and BRAF in Self Nanoclusters Open
All supp. figures and Supp. materials and methods
View article: Supplementary Data from MEK Inhibition Reverses Aberrant Signaling in Melanoma Cells through Reorganization of NRas and BRAF in Self Nanoclusters
Supplementary Data from MEK Inhibition Reverses Aberrant Signaling in Melanoma Cells through Reorganization of NRas and BRAF in Self Nanoclusters Open
Supplementary tables
View article: Supplementary Data from MEK Inhibition Reverses Aberrant Signaling in Melanoma Cells through Reorganization of NRas and BRAF in Self Nanoclusters
Supplementary Data from MEK Inhibition Reverses Aberrant Signaling in Melanoma Cells through Reorganization of NRas and BRAF in Self Nanoclusters Open
Supplementary tables
View article: Data from MEK Inhibition Reverses Aberrant Signaling in Melanoma Cells through Reorganization of NRas and BRAF in Self Nanoclusters
Data from MEK Inhibition Reverses Aberrant Signaling in Melanoma Cells through Reorganization of NRas and BRAF in Self Nanoclusters Open
Hotspot mutations of the oncogenes BRAF and NRas are the most common genetic alterations in cutaneous melanoma. Still, the nanoscale organization and signal coupling of these proteins remain incompletely understood, particularly upon expre…
View article: Data from MEK Inhibition Reverses Aberrant Signaling in Melanoma Cells through Reorganization of NRas and BRAF in Self Nanoclusters
Data from MEK Inhibition Reverses Aberrant Signaling in Melanoma Cells through Reorganization of NRas and BRAF in Self Nanoclusters Open
Hotspot mutations of the oncogenes BRAF and NRas are the most common genetic alterations in cutaneous melanoma. Still, the nanoscale organization and signal coupling of these proteins remain incompletely understood, particularly upon expre…
View article: Supplementary Data from MEK Inhibition Reverses Aberrant Signaling in Melanoma Cells through Reorganization of NRas and BRAF in Self Nanoclusters
Supplementary Data from MEK Inhibition Reverses Aberrant Signaling in Melanoma Cells through Reorganization of NRas and BRAF in Self Nanoclusters Open
All supp. figures and Supp. materials and methods
View article: Nano-scale architecture of blood-brain barrier tight-junctions
Nano-scale architecture of blood-brain barrier tight-junctions Open
Tight junctions (TJs) between blood-brain barrier (BBB) endothelial cells construct a robust physical barrier, whose damage underlies BBB dysfunctions related to several neurodegenerative diseases. What makes these highly specialized BBB-T…
View article: Reducing Myosin II and ATP-Dependent Mechanical Activity Increases Order and Stability of Intracellular Organelles
Reducing Myosin II and ATP-Dependent Mechanical Activity Increases Order and Stability of Intracellular Organelles Open
Organization of intracellular content is affected by multiple simultaneous processes, including diffusion in a viscoelastic and structured environment, intracellular mechanical work and vibrations. The combined effects of these processes o…
View article: Author response: Nano-scale architecture of blood-brain barrier tight-junctions
Author response: Nano-scale architecture of blood-brain barrier tight-junctions Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Tight junctions (TJs) …
View article: Nano-scale Architecture of Blood-Brain Barrier Tight-Junctions
Nano-scale Architecture of Blood-Brain Barrier Tight-Junctions Open
Tight junctions (TJs) between blood-brain barrier (BBB) endothelial cells construct a robust physical barrier, whose damage underlies BBB dysfunctions related to several neurodegenerative diseases. What makes these highly specialized BBB-T…
View article: Spectral Analysis of ATP-Dependent Mechanical Vibrations in T Cells
Spectral Analysis of ATP-Dependent Mechanical Vibrations in T Cells Open
Mechanical vibrations affect multiple cell properties, including its diffusivity, entropy, internal content organization, and thus—function. Here, we used Differential Interference Contrast (DIC), confocal, and Total Internal Reflection Fl…
View article: Adhering interacting cells to two opposing coverslips allows super-resolution imaging of cell-cell interfaces
Adhering interacting cells to two opposing coverslips allows super-resolution imaging of cell-cell interfaces Open
Cell-cell interfaces convey mechanical and chemical information in multicellular systems. Microscopy has revealed intricate structure of such interfaces, yet typically with limited resolution due to diffraction and unfavourable orthogonal …
View article: MEK Inhibition Reverses Aberrant Signaling in Melanoma Cells through Reorganization of NRas and BRAF in Self Nanoclusters
MEK Inhibition Reverses Aberrant Signaling in Melanoma Cells through Reorganization of NRas and BRAF in Self Nanoclusters Open
Hotspot mutations of the oncogenes BRAF and NRas are the most common genetic alterations in cutaneous melanoma. Still, the nanoscale organization and signal coupling of these proteins remain incompletely understood, particularly upon expre…
View article: Fluctuations in the Homogeneity of Cell Medium Distinguish Benign from Malignant Lymphocytes in a Cellular Model of Acute T Cells Leukemia
Fluctuations in the Homogeneity of Cell Medium Distinguish Benign from Malignant Lymphocytes in a Cellular Model of Acute T Cells Leukemia Open
Intracellular mechanical work facilitates multiple cell functions, such as material transport, cell motility, etc., and is indicative of the cell’s physiological condition. Still, the characterization of intracellular mechanical work and r…
View article: Time-correlated single molecule localization microscopy enhances resolution and fidelity
Time-correlated single molecule localization microscopy enhances resolution and fidelity Open
Single-molecule-localization-microscopy (SMLM) enables superresolution imaging of biological samples down to ~ 10–20 nm and in single molecule detail. However, common SMLM reconstruction largely disregards information embedded in the entir…
View article: T Cell Activation through Isolated Tight Contacts
T Cell Activation through Isolated Tight Contacts Open
T cells engage antigen-presenting cells in search for cognate antigens via dynamic cell protrusions before forming a tight immune synapse. The spatiotemporal events that may lead to rapid TCR triggering and signal amplification in microvil…
View article: ATP-Dependent Diffusion Entropy and Homogeneity in Living Cells
ATP-Dependent Diffusion Entropy and Homogeneity in Living Cells Open
Intracellular dynamics is highly complex, and includes diffusion of poly-dispersed objects in a non-homogeneous, out-of-equilibrium medium. Assuming non-equilibrium steady-state, we developed a framework that relates non-equilibrium fluctu…
View article: InterCells: A Generic Monte-Carlo Simulation of Intercellular Interfaces Captures Nanoscale Patterning at the Immune Synapse
InterCells: A Generic Monte-Carlo Simulation of Intercellular Interfaces Captures Nanoscale Patterning at the Immune Synapse Open
Molecular interactions across intercellular interfaces serve to convey information between cells and to trigger appropriate cell functions. Examples include cell development and growth in tissues, neuronal and immune synapses (ISs). Here, …
View article: Synergizing superresolution optical fluctuation imaging with single molecule localization microscopy
Synergizing superresolution optical fluctuation imaging with single molecule localization microscopy Open
Single molecule localization microscopy (SMLM) techniques enable imaging biological samples well beyond the diffraction limit of light, but they vary significantly in their spatial and temporal resolutions. High-order statistical analysis …