Einat K. Brenner
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View article: Interactive effects of blood–brain barrier breakdown and Alzheimer's disease biomarker status on cognitive decline in older adults without dementia
Interactive effects of blood–brain barrier breakdown and Alzheimer's disease biomarker status on cognitive decline in older adults without dementia Open
INTRODUCTION Some research suggests that blood–brain barrier (BBB) integrity is altered in Alzheimer's disease (AD). Few studies have examined markers of BBB integrity and their interactions with AD risk factors on multi‐domain cognition. …
View article: Pulse pressure and APOE ε4 dose interact to affect cerebral blood flow in older adults without dementia
Pulse pressure and APOE ε4 dose interact to affect cerebral blood flow in older adults without dementia Open
This study assessed whether the effect of vascular risk on cerebral blood flow (CBF) varies by gene dose of apolipoprotein (APOE) ε4 alleles. 144 older adults without dementia from the Alzheimer's Disease Neuroimaging Initiative underwent …
View article: Sex moderates the association between age and myelin water fraction in the cingulum and fornix among older adults without dementia
Sex moderates the association between age and myelin water fraction in the cingulum and fornix among older adults without dementia Open
Background Decreasing white matter integrity in limbic pathways including the fornix and cingulum have been reported in Alzheimer’s disease (AD), although underlying mechanisms and potential sex differences remain understudied. We therefor…
View article: Sex Moderates the Association Between Age and Myelin Water Fraction in the Cingulum and Fornix among Older Adults Without Dementia:A Preliminary Study
Sex Moderates the Association Between Age and Myelin Water Fraction in the Cingulum and Fornix among Older Adults Without Dementia:A Preliminary Study Open
Background Cognitive decline in normal aging and Alzheimer’s disease (AD) has been associated with changes in cerebral white matter tracts. Although women are at higher risk of developing AD, studies investigating the effect of sex on whit…
View article: 17 Education Moderates the Association Between Hippocampal CBF and Memory in Women but Not Men
17 Education Moderates the Association Between Hippocampal CBF and Memory in Women but Not Men Open
Objective: Higher educational attainment is associated with reduced risk for Alzheimer's disease (AD) dementia, and its protective effect may act through alterations in cerebral blood flow (CBF) that allow for better coping with accumulati…
View article: 6 Pulse Pressure and APOE ε4 Dose Interact to Affect Cerebral Blood Flow in Older Adults Without Dementia
6 Pulse Pressure and APOE ε4 Dose Interact to Affect Cerebral Blood Flow in Older Adults Without Dementia Open
Objective: Alterations in cerebral blood flow (CBF) are associated with risk of cognitive decline and Alzheimer’s disease (AD). Although apolipoprotein E (APOE) ε4 and greater vascular risk burden have both been linked to reduced CBF in ol…
View article: Regional White Matter Hyperintensities Relate to Specific Cognitive Abilities in Older Adults Without Dementia
Regional White Matter Hyperintensities Relate to Specific Cognitive Abilities in Older Adults Without Dementia Open
Introduction: White matter hyperintensities (WMHs) are magnetic resonance imaging markers of small vessel cerebrovascular disease that are associated with cognitive decline and clinical Alzheimer disease. Previous studies have often focuse…
View article: White Matter Hyperintensity Volume and Amyloid-PET Synergistically Impact Memory Independent of Tau-PET in Older Adults Without Dementia
White Matter Hyperintensity Volume and Amyloid-PET Synergistically Impact Memory Independent of Tau-PET in Older Adults Without Dementia Open
Background: Alzheimer’s disease (AD) and cerebrovascular disease are common, co-existing pathologies in older adults. Whether the effects of cerebrovascular disease and AD biomarkers on cognition are additive or synergistic remains unclear…
View article: Brain Derived Neurotrophic Factor Interacts with White Matter Hyperintensities to Influence Processing Speed and Hippocampal Volume in Older Adults
Brain Derived Neurotrophic Factor Interacts with White Matter Hyperintensities to Influence Processing Speed and Hippocampal Volume in Older Adults Open
Background: Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays an important role in regulating synaptic activity and plasticity. Objective: Given that type-2 diabetes (T2DM) increases the risk of cognitive decline, and s…
View article: Greater accelerometer-measured physical activity is associated with better cognition and cerebrovascular health in older adults
Greater accelerometer-measured physical activity is associated with better cognition and cerebrovascular health in older adults Open
Objectives: Physical activity (PA) may help maintain brain structure and function in aging. Since the intensity of PA needed to effect cognition and cerebrovascular health remains unknown, we examined associations between PA and cognition,…
View article: Cognitive reserve moderates the association between cerebral blood flow and language performance in older adults with mild cognitive impairment
Cognitive reserve moderates the association between cerebral blood flow and language performance in older adults with mild cognitive impairment Open
View article: Cognitive Reserve Moderates the Association Between Cerebral Blood Flow and Language Performance in Older Adults with Mild Cognitive Impairment
Cognitive Reserve Moderates the Association Between Cerebral Blood Flow and Language Performance in Older Adults with Mild Cognitive Impairment Open
Background It has consistently been demonstrated that individuals with higher cognitive reserve (CR) exhibit decreased risk for dementia, and differences in cerebral blood flow (CBF) among those with higher CR may offer a protective mechan…
View article: Longitudinal Intraindividual Cognitive Variability Is Associated With Reduction in Regional Cerebral Blood Flow Among Alzheimer’s Disease Biomarker-Positive Older Adults
Longitudinal Intraindividual Cognitive Variability Is Associated With Reduction in Regional Cerebral Blood Flow Among Alzheimer’s Disease Biomarker-Positive Older Adults Open
Intraindividual variability (IIV) across neuropsychological measures within a single testing session is a promising marker predictive of cognitive decline and development of Alzheimer’s disease (AD). We have previously shown that greater I…
View article: Cognitive Reserve Moderates the Association between Cerebral Blood Flow and Language Performance in Older Adults with Mild Cognitive Impairment
Cognitive Reserve Moderates the Association between Cerebral Blood Flow and Language Performance in Older Adults with Mild Cognitive Impairment Open
View article: Brain Derived Neurotrophic Factor Interacts with Diabetes Status to Influence Memory and Hippocampal Volume in Older Adults
Brain Derived Neurotrophic Factor Interacts with Diabetes Status to Influence Memory and Hippocampal Volume in Older Adults Open
View article: Diminished neural network dynamics after moderate and severe traumatic brain injury
Diminished neural network dynamics after moderate and severe traumatic brain injury Open
Over the past decade there has been increasing enthusiasm in the cognitive neurosciences around using network science to understand the system-level changes associated with brain disorders. A growing literature has used whole-brain fMRI an…
View article: Prefrontal gray matter volume predicts metacognitive accuracy following traumatic brain injury.
Prefrontal gray matter volume predicts metacognitive accuracy following traumatic brain injury. Open
These results are consistent with those of previous research on MC in the cognitive neurosciences, but this study demonstrates that injury may moderate the regional contributions to MC. (PsycINFO Database Record
View article: Corrigendum: Dedifferentiation Does Not Account for Hyperconnectivity after Traumatic Brain Injury
Corrigendum: Dedifferentiation Does Not Account for Hyperconnectivity after Traumatic Brain Injury Open
[This corrects the article on p. 297 in vol. 8, PMID: 28769858.].
View article: Dedifferentiation Does Not Account for Hyperconnectivity after Traumatic Brain Injury
Dedifferentiation Does Not Account for Hyperconnectivity after Traumatic Brain Injury Open
The primary hypothesis that hyperconnectivity occurs through dedifferentiation was not supported. [corrected]. Instead, enhanced connectivity post injury was observed within network. Results suggest that the relationship between increased …