Eizo Takashima
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View article: Pfs230 domain 12 is a potent malaria transmission–blocking vaccine candidate
Pfs230 domain 12 is a potent malaria transmission–blocking vaccine candidate Open
Malaria transmission–blocking vaccines (TBV) target sexual stage parasites that are transmitted to mosquitoes and are critical for spread of the pathogen. The clinically most advanced TBV candidate contains part of the Pro-domain (Pro) and…
View article: Increased Plasmodium falciparum EBA175RIII-V antibody titres despite a 13-month malaria mass testing, treatment, and tracking intervention in a high malaria endemic community in Ghana
Increased Plasmodium falciparum EBA175RIII-V antibody titres despite a 13-month malaria mass testing, treatment, and tracking intervention in a high malaria endemic community in Ghana Open
Higher anti-PfEBA175RIII-V titres were associated with infection. The 13-month MTTT exercise in a malaria hyper-endemic community did not significantly reduce the titres of PfEBA-175RIII-V antibodies, and thus had no significant effect on …
View article: <i>Plasmodium falciparum</i> diacylglycerol acyltransferase maintains phospholipid homeostasis to regulate sexual differentiation, ER stress, and cytoadhesion
<i>Plasmodium falciparum</i> diacylglycerol acyltransferase maintains phospholipid homeostasis to regulate sexual differentiation, ER stress, and cytoadhesion Open
Plasmodium falciparum is the causative agent of human malaria, a life-threating infectious disease that imposes a major global health burden. Lipid metabolism is indispensable for this parasite’s replication and survival, yet most of the m…
View article: Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity
Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity Open
The Pfs230:Pfs48/45 complex forms the basis for leading malaria transmission-blocking vaccine candidates, yet little is known about its molecular assembly. Here, we used cryo-electron microscopy to elucidate the structure of the endogenous…
View article: Plasmodium falciparum Liver Stage Antigen 3 plays a role in completing the final stages of merozoite invasion of red blood cells
Plasmodium falciparum Liver Stage Antigen 3 plays a role in completing the final stages of merozoite invasion of red blood cells Open
Understanding the red blood cell (RBC) invasion mechanism by Plasmodium falciparum, the causative agent of human malaria, is critical for developing blood-stage vaccines. Most research on the roles of parasite molecules during invasion int…
View article: Advances in transmission-blocking vaccines against <i>Plasmodium falciparum</i> and <i>Plasmodium vivax</i>
Advances in transmission-blocking vaccines against <i>Plasmodium falciparum</i> and <i>Plasmodium vivax</i> Open
After over 30 years of research and development, Pfs230 for P. falciparum and Pvs25 for P. vivax are the most advanced candidates for transmission-blocking vaccines.
View article: Corrigendum: Adeno-associated virus as an effective malaria booster vaccine following adenovirus priming
Corrigendum: Adeno-associated virus as an effective malaria booster vaccine following adenovirus priming Open
[This corrects the article DOI: 10.3389/fimmu.2019.00730.].
View article: An <i>in vivo</i> fitness gene of <i>Toxoplasma</i>, MIC11, is essential for PLP1-mediated egress from host cells
An <i>in vivo</i> fitness gene of <i>Toxoplasma</i>, MIC11, is essential for PLP1-mediated egress from host cells Open
Summary After invasion and replication, intracellular pathogens must egress from infected host cells . Toxoplasma gondii facilitates this process by permeabilizing host cells by releasing perforin-like protein 1 (PLP1) through induced micr…
View article: Antibody responses in Burkinabe children against P. falciparum proteins associated with reduced risk of clinical malaria
Antibody responses in Burkinabe children against P. falciparum proteins associated with reduced risk of clinical malaria Open
Individuals residing in malaria-endemic regions with high disease transmission can develop semi-immunity within five years of age. Although understanding the target of the IgGs in this age group helps discover novel blood-stage vaccine can…
View article: Structure of endogenous Pfs230:Pfs48/45 in complex with potent malaria transmission-blocking antibodies
Structure of endogenous Pfs230:Pfs48/45 in complex with potent malaria transmission-blocking antibodies Open
SUMMARY The Pfs230:Pfs48/45 complex forms the basis for leading malaria transmission-blocking vaccine candidates, yet li]le is known about its molecular assembly. Here, we used cryogenic electron microscopy to elucidate the structure of th…
View article: Pfs230 Domain 12 is a potent malaria transmission-blocking vaccine candidate
Pfs230 Domain 12 is a potent malaria transmission-blocking vaccine candidate Open
Malaria transmission-blocking vaccines (TBV) target sexual stage parasites that are transmitted to mosquitoes and critical for spread of the pathogen. The clinically most advanced TBV candidate contains part of the Pro-domain (Pro) and Dom…
View article: Ultrastructural expansion microscopy (U-ExM) visualization of malaria parasite dense granules using RESA as a representative marker protein
Ultrastructural expansion microscopy (U-ExM) visualization of malaria parasite dense granules using RESA as a representative marker protein Open
Dense granules (DG) are understudied apical organelles in merozoites, the malaria parasite stage that invades erythrocytes. Only six proteins have been identified which localize to DGs, despite that DG proteins play crucial roles in multip…
View article: A systems serology approach to identifying key antibody correlates of protection from cerebral malaria in Malawian children
A systems serology approach to identifying key antibody correlates of protection from cerebral malaria in Malawian children Open
View article: Direct Binding of Synaptopodin 2-Like Protein to Alpha-Actinin Contributes to Actin Bundle Formation in Cardiomyocytes
Direct Binding of Synaptopodin 2-Like Protein to Alpha-Actinin Contributes to Actin Bundle Formation in Cardiomyocytes Open
Synaptopodin 2-like protein (SYNPO2L) is localized in the sarcomere of cardiomyocytes and is involved in heart morphogenesis. However, the molecular function of SYNPO2L in the heart is not fully understood. We investigated the interaction …
View article: Direct Binding of Synaptopodin 2-Like Protein to Alpha-Actinin Contributes to Actin Bundle Formation in Cardiomyocytes
Direct Binding of Synaptopodin 2-Like Protein to Alpha-Actinin Contributes to Actin Bundle Formation in Cardiomyocytes Open
Synaptopodin 2-like protein (SYNPO2L) is localized in the sarcomere of cardiomyocytes and is involved in heart morphogenesis. However, the molecular function of SYNPO2L in the heart is not fully understood. We investigated the interaction …
View article: Author Correction: A Pvs25 mRNA vaccine induces complete and durable transmission-blocking immunity to Plasmodium vivax
Author Correction: A Pvs25 mRNA vaccine induces complete and durable transmission-blocking immunity to Plasmodium vivax Open
View article: The Need for Novel Asexual Blood-Stage Malaria Vaccine Candidates for Plasmodium falciparum
The Need for Novel Asexual Blood-Stage Malaria Vaccine Candidates for Plasmodium falciparum Open
Extensive control efforts have significantly reduced malaria cases and deaths over the past two decades, but in recent years, coupled with the COVID-19 pandemic, success has stalled. The WHO has urged the implementation of a number of inte…
View article: Ultrastructural Expansion Microscopy (U-Exm) Visualization of Malaria Parasite Dense Granules Using Resa as a Representative Marker Protein
Ultrastructural Expansion Microscopy (U-Exm) Visualization of Malaria Parasite Dense Granules Using Resa as a Representative Marker Protein Open
View article: A Pvs25 mRNA vaccine induces complete and durable transmission-blocking immunity to Plasmodium vivax
A Pvs25 mRNA vaccine induces complete and durable transmission-blocking immunity to Plasmodium vivax Open
Plasmodium vivax ( P. vivax ) is the major malaria parasite outside of Africa and no vaccine is available against it. A vaccine that interrupts parasite transmission (transmission-blocking vaccine, TBV) is considered highly desirable to re…
View article: Pfs230 Domain 7 is targeted by a potent malaria transmission-blocking monoclonal antibody
Pfs230 Domain 7 is targeted by a potent malaria transmission-blocking monoclonal antibody Open
View article: Identification of novel Plasmodium vivax proteins associated with protection against clinical malaria
Identification of novel Plasmodium vivax proteins associated with protection against clinical malaria Open
As progress towards malaria elimination continues, the challenge posed by the parasite species Plasmodium vivax has become more evident. In many regions co-endemic for P. vivax and Plasmodium falciparum , as transmission has declined the p…
View article: Autoantibodies Inhibit&nbsp;Plasmodium falciparum&nbsp;Growth and Associate with Protection from Clinical Malaria
Autoantibodies Inhibit Plasmodium falciparum Growth and Associate with Protection from Clinical Malaria Open
View article: A Systems Serology Approach to Identifying Key Antibody Correlates of Protection from Cerebral Malaria in Malawian Children
A Systems Serology Approach to Identifying Key Antibody Correlates of Protection from Cerebral Malaria in Malawian Children Open
View article: GATS Tag System for Protein Analysis with Biotin Labelling Methods
GATS Tag System for Protein Analysis with Biotin Labelling Methods Open
Polypeptide tags and biotin labelling technologies are widely used for protein analyses in biochemistry and cell biology. Although biotin labelling reacts with a lysine residue, many peptide tag epitopes have lysine residue(s). Here, we pr…
View article: Identification of novel<i>Plasmodium vivax</i>proteins associated with protection against clinical malaria
Identification of novel<i>Plasmodium vivax</i>proteins associated with protection against clinical malaria Open
As progress towards malaria elimination continues, the challenge posed by the parasite species Plasmodium vivax has become more evident. In many regions co-endemic for P. vivax and Plasmodium falciparum , as transmission has declined the p…
View article: Assessment of IgG3 as a serological exposure marker for Plasmodium vivax in areas with moderate–high malaria transmission intensity
Assessment of IgG3 as a serological exposure marker for Plasmodium vivax in areas with moderate–high malaria transmission intensity Open
A more sensitive surveillance tool is needed to identify Plasmodium vivax infections for treatment and to accelerate malaria elimination efforts. To address this challenge, our laboratory has developed an eight-antigen panel that detects t…
View article: Comparison of Antibody Responses and Parasite Clearance in Artemisinin Therapeutic Efficacy Studies in the Democratic Republic of Congo and Asia
Comparison of Antibody Responses and Parasite Clearance in Artemisinin Therapeutic Efficacy Studies in the Democratic Republic of Congo and Asia Open
Background Understanding the effect of immunity on Plasmodium falciparum clearance is essential for interpreting therapeutic efficacy studies designed to monitor emergence of artemisinin drug resistance. In low-transmission areas of Southe…
View article: Meta-Analysis of Human Antibodies Against Plasmodium falciparum Variable Surface and Merozoite Stage Antigens
Meta-Analysis of Human Antibodies Against Plasmodium falciparum Variable Surface and Merozoite Stage Antigens Open
Concerted efforts to fight malaria have caused significant reductions in global malaria cases and mortality. Sustaining this will be critical to avoid rebound and outbreaks of seasonal malaria. Identifying predictive attributes that define…
View article: Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P. knowlesi
Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P. knowlesi Open
Serological markers are a promising tool for surveillance and targeted interventions for Plasmodium vivax malaria. P. vivax is closely related to the zoonotic parasite P. knowlesi, which also infects humans. P. vivax and P. knowlesi are co…
View article: Additional file 2 of Comparison of total immunoglobulin G antibody responses to different protein fragments of Plasmodium vivax Reticulocyte binding protein 2b
Additional file 2 of Comparison of total immunoglobulin G antibody responses to different protein fragments of Plasmodium vivax Reticulocyte binding protein 2b Open
Additional file 2. Supplementary data supporting results. Sheet 1. Relative Antibody Units (RAU) for individuals in the 12-month longitudinal cohort conducted in Thailand. Sheet 2. Relative Antibody Units (RAU) for individuals in the sympt…