Ejike Daniel Eze
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View article: Modulatory effects of Hibiscus sabdariffa extract on insulin receptor sensitivity, oxidative stress, inflammatory markers, and glucose homeostasis in a rat model of metabolic syndrome
Modulatory effects of Hibiscus sabdariffa extract on insulin receptor sensitivity, oxidative stress, inflammatory markers, and glucose homeostasis in a rat model of metabolic syndrome Open
Background The prevalence of metabolic syndrome (MS) continues to rise globally, fueled by sedentary lifestyles, poor dietary habits, and increasing rates of obesity. The underlying pathophysiology of MS involves a multifaceted interplay o…
View article: Evaluating The Knowledge of Breast Cancer Risk Factors and Screening Methods among Community Health Workers in Kicukiro District, Rwanda: A cross-sectional study
Evaluating The Knowledge of Breast Cancer Risk Factors and Screening Methods among Community Health Workers in Kicukiro District, Rwanda: A cross-sectional study Open
Background Globally, the burden of breast cancer is rising with high mortality and morbidity rates particularly in low- and middle-income countries (LMICs). Increasing public knowledge of breast cancer is crucial to achieve early detection…
View article: Factors associated with non-compliance to wound care guidelines among nurses working at the University Teaching Hospital of Kigali, Rwanda
Factors associated with non-compliance to wound care guidelines among nurses working at the University Teaching Hospital of Kigali, Rwanda Open
Background Wounds are a significant burden to the global health care since they are more common. Noncompliance to wound care guideline can cause many different effects. Aim To identify the factors associated with noncompliance to wound car…
View article: ETHANOL LEAF EXTRACT OF FICUS EXASPERATA ATTENUATES CHANGES IN ELECTROLYTES AND LIPID PROFILES IN A RAT MODEL OF OLANZAPINE-INDUCED OBESITY
ETHANOL LEAF EXTRACT OF FICUS EXASPERATA ATTENUATES CHANGES IN ELECTROLYTES AND LIPID PROFILES IN A RAT MODEL OF OLANZAPINE-INDUCED OBESITY Open
Obesity is a major public health concern characterized by excessive body fat, which increases the risk of numerous health conditions, including heart disease, diabetes, high blood pressure, and certain cancers. Addressing obesity is crucia…
View article: Stem extract from Costus afer (Bush cane) prevents ethanol-induced neuronal degeneration in mice via an antioxidant-inflammatory pathway
Stem extract from Costus afer (Bush cane) prevents ethanol-induced neuronal degeneration in mice via an antioxidant-inflammatory pathway Open
Background: Excessive alcohol consumption is associated with memory impairment and can lead to Alzheimer's disease-like dementia, contributing to the rising prevalence of dementia worldwide. Costus afer (Bush cane) is a medicinal plant wid…
View article: <i>Cucumeropsis mannii</i> seed oil (<scp>CMSO</scp>) restores testicular mitochondrial dysfunctions by modulating the activities of dysregulated testicular mitochondrial enzymes in male albino rats exposed to bisphenol A
<i>Cucumeropsis mannii</i> seed oil (<span>CMSO</span>) restores testicular mitochondrial dysfunctions by modulating the activities of dysregulated testicular mitochondrial enzymes in male albino rats exposed to bisphenol A Open
Bisphenol A, a traditional endocrine disruptor, has been implicated in male infertility. This study investigated the effect of Cucumeropsis mannii seed oil (CMSO) on bisphenol A (BPA)‐induced biochemical toxicity in the testicular mitochon…
View article: Cucumeropsis mannii seed oil mitigates bisphenol-A-induced sperm and hormonal damages in F1-generation of F0-exposed male rats: An in-vivo and in-silico analysis
Cucumeropsis mannii seed oil mitigates bisphenol-A-induced sperm and hormonal damages in F1-generation of F0-exposed male rats: An in-vivo and in-silico analysis Open
Exposure to endocrine-disrupting chemicals such as bisphenol A (BPA) has been linked to the sharp drop in male fertility observed worldwide. This study evaluates the protective benefits of Cucumeropsis mannii seed oil (CMSO) against BPA-in…
View article: Renoprotective effects of Cucumeropsis mannii seed oil on cisplatin-induced nephrotoxicity in Wistar rats
Renoprotective effects of Cucumeropsis mannii seed oil on cisplatin-induced nephrotoxicity in Wistar rats Open
Background: The growing prevalence of cancer and the concomitant rise in chemotherapy use have led to an increased incidence of kidney-related diseases, including nephrotoxicity. Cisplatin (CP) is a widely used and potent anticancer drug, …
View article: Preliminary monosodium glutamate-induced changes in mammary gland receptors and gene expression, water channel, oxidative stress, and some lactogenic biomarkers in lactating rats
Preliminary monosodium glutamate-induced changes in mammary gland receptors and gene expression, water channel, oxidative stress, and some lactogenic biomarkers in lactating rats Open
Background Changes induced by monosodium glutamate (MSG) can negatively impact milk production and secretion, among other adverse effects. This study aimed to investigate the effects of MSG consumption on receptor gene expression and quant…
View article: Bisphenol-A (BPA) Exposure as a Risk Factor for Non-Communicable Diseases
Bisphenol-A (BPA) Exposure as a Risk Factor for Non-Communicable Diseases Open
Bisphenol-A (BPA) is a widely used chemical compound in the production of consumer items and building materials. Over the years, concerns have been raised about its potential adverse effects on human health. This chapter aims to explore th…
View article: Ameliorative Potential of Pumpkin Seed Oil (<i>Cucurbita pepo</i> L.) Against Tramadol-Induced Oxidative Stress
Ameliorative Potential of Pumpkin Seed Oil (<i>Cucurbita pepo</i> L.) Against Tramadol-Induced Oxidative Stress Open
Background of the Study The increase in the therapeutic use of tramadol in the management of moderate to severe pains in some disease conditions and its unregulated access has led to its associated toxicity and there is little or no inform…
View article: <i>Cucumeropsis mannii</i> seed oil protects against bisphenol A-induced hepatotoxicity by mitigating inflammation and oxidative stress in rats
<i>Cucumeropsis mannii</i> seed oil protects against bisphenol A-induced hepatotoxicity by mitigating inflammation and oxidative stress in rats Open
Objectives This study looked at how Cucumeropsis mannii seed oil (CMSO) affected male Wistar albino rats’ liver damage caused by bisphenol A (BPA). Methods The standard HPLC method was used to assess the CMSO’s phenolic content. Then, six …
View article: Physicochemical and Fat-Soluble Vitamins Constituents of Fresh and Reused Vegetable Oil from Abakaliki Metropolis, Ebonyi State
Physicochemical and Fat-Soluble Vitamins Constituents of Fresh and Reused Vegetable Oil from Abakaliki Metropolis, Ebonyi State Open
This research work was designed to evaluate the physicochemical and fat-soluble vitamins constituents of fresh and reused vegetable oils from fast food vendors in Abakaliki Metropolis. The physicochemical constituents such as peroxide valu…
View article: Green tea silver nanoparticles improve physiological motor and cognitive function in BALB/c mice during inflammation
Green tea silver nanoparticles improve physiological motor and cognitive function in BALB/c mice during inflammation Open
Information on the basic changes associated with green tea small molecules in acute inflammation is deficient. The purpose of the study was to characterize and establish the effects of green tea silver nanoparticles (AgNPs) following infla…
View article: <i>Cucumeropsis mannii</i> seed oil protects against <scp>Bisphenol A</scp>‐induced testicular mitochondrial damages
<i>Cucumeropsis mannii</i> seed oil protects against <span>Bisphenol A</span>‐induced testicular mitochondrial damages Open
There has been increasing search for the ameliorative properties of seed oils against toxicants. bisphenol A acts as an estrogenic endocrine‐disrupting chemical capable of causing male infertility. This study aimed to explore Cucumeropsis …
View article: Hepatoprotective potential of Tamarindus indica following prenatal aluminum exposure in Wistar rat pups
Hepatoprotective potential of Tamarindus indica following prenatal aluminum exposure in Wistar rat pups Open
Over time, the use of plant-derived agents in the management of various human health conditions has gained a lot of attention. The study assessed the hepatoprotective potential of ethyl acetate fraction Tamarindus indica leaves (EFTI) duri…
View article: Behavioural Response To Self-Medication Practice Before and During Covid-19 Pandemic in Western Uganda
Behavioural Response To Self-Medication Practice Before and During Covid-19 Pandemic in Western Uganda Open
Our investigation showed adequate knowledge of self-medication and a high level of self-medication practice with a decrease in self-medication practices during the COVID-19 pandemic lockdown compared to the practice before the lockdown.
View article: Object recognition memory and anti-anxiety potentials of stem-bark extract of Nauclea latifolia (African peach), taurine and vitamin E on Albino rats exposed to water immobilisation stress
Object recognition memory and anti-anxiety potentials of stem-bark extract of Nauclea latifolia (African peach), taurine and vitamin E on Albino rats exposed to water immobilisation stress Open
Memory loss is a typical symptom of generalized anxiety disorder, a condition that affects millions of individuals. Memory loss with anxiety can be quite distressing, but if you can find strategies to address the anxiety, your memory may i…
View article: Cerebral Cortical Activity During Academic Stress Amongst Undergraduate Medical Students at Kampala International University (Uganda)
Cerebral Cortical Activity During Academic Stress Amongst Undergraduate Medical Students at Kampala International University (Uganda) Open
Background Stress among medical students is related to their academic lifespan; however, information on brain health among medical students from developing countries continues to be scarce. The objective of this study was to establish perc…
View article: Effect of Ethanol Leaf Extract of Khat (Catha edulis forsk) on Prefrontal Cortex Oxidative Markers and Hematological Profile of Wistar Rats
Effect of Ethanol Leaf Extract of Khat (Catha edulis forsk) on Prefrontal Cortex Oxidative Markers and Hematological Profile of Wistar Rats Open
Aim: This study evaluated the effect of ethanol leaf extract of Catha edulis on the prefrontal cortex oxidative markers and hematological profile of Wistar rats.
Study Design: The study design was experimental.
Place and Duration of Stud…
View article: High-Prevalence Stunting in Preschool Children (1–5 Years) Attending Selected Health Centers in a Food Rich Area-Bushenyi District Southwestern Uganda
High-Prevalence Stunting in Preschool Children (1–5 Years) Attending Selected Health Centers in a Food Rich Area-Bushenyi District Southwestern Uganda Open
The prevalence of stunting among children in Uganda and Sub-Saharan Africa is still high, and if Uganda is to achieve the food-related Sustainable Development Goals (SDGs), it must urgently invest in improving nutrition and sanitation. In …
View article: ANTI-MALARIAL EFFECTS OF FIVE TRADITIONAL NIGERIAN MEDICINAL PLANT EXTRACTS ON PLASMODIUM BERGHEI-INFECTED RATS
ANTI-MALARIAL EFFECTS OF FIVE TRADITIONAL NIGERIAN MEDICINAL PLANT EXTRACTS ON PLASMODIUM BERGHEI-INFECTED RATS Open
This work focusses on comparative determination of the effects of plant extracts: bitter leaf (BL), sour lime (SL), grape (G), pawpaw (PP) and unripe pineapple (UPA) in female rats induced into malaria with Plasmodium berghei. Thirty femal…
View article: Allium Cepa (Onion) Extract Enhances and Protects Testicular Function and Architecture against Paraquat Induced Oxidative Damage.
Allium Cepa (Onion) Extract Enhances and Protects Testicular Function and Architecture against Paraquat Induced Oxidative Damage. Open
Allium cepa (A. cepa) is consumed for its health benefits. This study investigated the therapeutic potentials of ethanolic extract of A. cepa bulbs against paraquat-induced testicular toxicity in animal model. Thirty Wistar rats were split…
View article: COVID-19 Pandemic and Behavioural Response to Self-Medication Practice in Western Uganda
COVID-19 Pandemic and Behavioural Response to Self-Medication Practice in Western Uganda Open
Background Self-medication has become is a serious public health problem globally posing great risks, especially with the increasing number of cases of COVID-19 disease in Uganda. This is may be partly because of the absence of a recognize…
View article: An analysis of heavy metals contamination and estimating the daily intakes of vegetables from Uganda
An analysis of heavy metals contamination and estimating the daily intakes of vegetables from Uganda Open
Background: Environmental contamination with elevated levels of copper (Cu), cobalt (Co), iron (Fe), zinc (Zn), lead (Pb), chromium (Cr 6+ ), cadmium (Cd), and nickel (Ni)—all states of which are found in Uganda—raises health risk to the p…