Ekaterina Stroeva
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View article: Quantitative single-molecule analysis of assembly and Ca2+-dependent disassembly of synaptotagmin oligomers on lipid bilayers
Quantitative single-molecule analysis of assembly and Ca2+-dependent disassembly of synaptotagmin oligomers on lipid bilayers Open
Synaptotagmin-1 (Syt-1) self-assembles into ring-like oligomers, and genetic and biochemical evidence suggest that oligomerization is needed to clamp synaptic vesicles and stabilize them for Ca2+-evoked release. However, oligomerization ha…
View article: G-quadruplex Polymorphism: a Winding Road from Structure to Therapeutics
G-quadruplex Polymorphism: a Winding Road from Structure to Therapeutics Open
Structural and folding patterns of promoter regions (c-MYC, BCL) and telomeric (TTAGGG repeats) G-Quadruplexes were explored and their interactions with small molecules were tested. EAO-108 and MHI-21, symmetric heptamethine cyanines, were…
View article: Second Generation G-Quadruplex Stabilizing Trimethine Cyanines
Second Generation G-Quadruplex Stabilizing Trimethine Cyanines Open
G-quadruplex DNA has been recognized as a highly appealing target for the development of new selective chemotherapeutics, which could result in markedly reduced toxicity towards normal cells. In particular, the cyanine dyes that bind selec…
View article: Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis
Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis Open
Significance Synaptotagmin (Syt) is the primary calcium ion (Ca 2+ ) sensor for regulated exocytosis. It couples Ca 2+ binding to soluble N -ethylmaleimide–sensitive factor attachment protein receptor-catalyzed fusion, but how this happens…
View article: Imino proton NMR guides the reprogramming of A•T specific minor groove binders for mixed base pair recognition
Imino proton NMR guides the reprogramming of A•T specific minor groove binders for mixed base pair recognition Open
Sequence-specific binding to DNA is crucial for targeting transcription factor-DNA complexes to modulate gene expression. The heterocyclic diamidine, DB2277, specifically recognizes a single G•C base pair in the minor groove of mixed base …