Ekaterini Domali
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View article: Bridging Andrology and Oncology: Prognostic Indicators of Cancer Among Infertile Men
Bridging Andrology and Oncology: Prognostic Indicators of Cancer Among Infertile Men Open
Approximately 7% of males globally suffer from male infertility, which is becoming more widely acknowledged as a clinical indicator of potential health hazards as well as a cause of reproductive failure. Among these, cancer has become a si…
View article: Genomic Analysis of Low-Grade Serous Ovarian Cancer: Clinical and Biological Insights
Genomic Analysis of Low-Grade Serous Ovarian Cancer: Clinical and Biological Insights Open
View article: MicroRNAs Regulating Oxidative Stress in Human Fertility: A Narrative Review of Mechanistic Insights and Clinical Potential
MicroRNAs Regulating Oxidative Stress in Human Fertility: A Narrative Review of Mechanistic Insights and Clinical Potential Open
Human infertility represents a multifaceted condition, with oxidative stress (OS) and microRNAs (miRNAs) emerging as key contributors to its pathophysiology. This comprehensive review explores the complex interplay between reactive oxygen …
View article: The Role of Angiogenetic Factors in Preeclampsia
The Role of Angiogenetic Factors in Preeclampsia Open
Preeclampsia (PE) occurs in approximately 2–8% of all pregnancies worldwide and represents one of the primary causes of maternal and fetal morbidity and mortality. Angiogenic growth factors such as placental growth factor (PlGF) and vascul…
View article: Prenatal Dietary Exposure to Endocrine Disruptors and Its Lasting Impact on Offspring Health
Prenatal Dietary Exposure to Endocrine Disruptors and Its Lasting Impact on Offspring Health Open
Environmental stressors during the crucial period of fetal development can have a substantial impact on long-term health outcomes. A major concern is dietary exposure to endocrine-disrupting chemicals (EDCs), which can readily cross the pl…
View article: Obesity and Pregnancy: Impact on Childbirth Timing, Delivery Mode, and Maternal Recovery: An Update
Obesity and Pregnancy: Impact on Childbirth Timing, Delivery Mode, and Maternal Recovery: An Update Open
This review explores the impact of maternal obesity on pregnancy outcomes, emphasizing its significant global health challenge and profound implications for both mothers and infants. It influences the timing and mode of childbirth, elevati…
View article: After the Shock: Impact of Ectopic Pregnancy on Subsequent Fertility and Parenthood
After the Shock: Impact of Ectopic Pregnancy on Subsequent Fertility and Parenthood Open
The potentially fatal condition known as ectopic pregnancy (EP) occurs when an embryo implants outside of the uterus, usually in the fallopian tube. It accounts for approximately 1–2% of all pregnancies and remains a leading cause of mater…
View article: Systemic Lupus Erythematosus in Pregnancy
Systemic Lupus Erythematosus in Pregnancy Open
Background/Objectives: The reciprocal relationship between Systemic Lupus Erythematosus (SLE) and pregnancy continues to elude the scientific community’s approaches for a clear understanding. Multiple studies have reached dissimilar result…
View article: Unmasking the Placenta–Heart Axis: A Comprehensive Review of Placental Abnormalities in Congenital Heart Disease
Unmasking the Placenta–Heart Axis: A Comprehensive Review of Placental Abnormalities in Congenital Heart Disease Open
Congenital heart disease (CHD), the most prevalent congenital abnormality, is becoming increasingly acknowledged as a component of a broad fetoplacental pathology. This systematic review summarizes recent imaging-based data linking CHD to …
View article: A Systematic Review on Biomarkers for Gestational Diabetes Mellitus Detection in Pregnancies Conceived Using Assisted Reproductive Technology: Current Trends and Future Directions
A Systematic Review on Biomarkers for Gestational Diabetes Mellitus Detection in Pregnancies Conceived Using Assisted Reproductive Technology: Current Trends and Future Directions Open
Gestational diabetes mellitus (GDM) is a frequently encountered medical complication during pregnancy that is increasing at a rapid pace globally, posing significant public health concerns. Similarly, there is a rising trend in the number …
View article: Artificial Intelligence in Assessing Reproductive Aging: Role of Mitochondria, Oxidative Stress, and Telomere Biology
Artificial Intelligence in Assessing Reproductive Aging: Role of Mitochondria, Oxidative Stress, and Telomere Biology Open
Fertility potential ever more diminishes due to the complex, multifactorial, and still not entirely clarified process of reproductive aging in women and men. Gamete quality and reproductive lifespan are compromised by biologic factors like…
View article: Hyperemesis in Pregnancy: Complications and Treatment.
Hyperemesis in Pregnancy: Complications and Treatment. Open
HG requires a comprehensive and individualized management approach. While doxylamine-pyridoxine remains the cornerstone of therapy, other pharmacologic and supportive measures may offer additional benefit. Continued research is essential t…
View article: The Detrimental Impact of Bisphenol S (BPS) on Trophoblastic Cells and the Ishikawa Cell Lines: An In Vitro Model of Cytotoxic Effect and Molecular Interactions
The Detrimental Impact of Bisphenol S (BPS) on Trophoblastic Cells and the Ishikawa Cell Lines: An In Vitro Model of Cytotoxic Effect and Molecular Interactions Open
Background/Objectives: Bisphenols (BPs) and especially bisphenol S (BPS), an analog of bisphenol A (BPA), are widely used and induce oxidative stress, resulting in the inhibition of cell proliferation and induction of apoptosis which all a…
View article: Unraveling the Core of Endometriosis: The Impact of Endocrine Disruptors
Unraveling the Core of Endometriosis: The Impact of Endocrine Disruptors Open
Globally, endometriosis affects almost 10% of reproductive-aged women, leading to chronic pain and discomfort. Endocrine-disrupting compounds (EDCs) seem to play a pivotal role as a causal factor. The current manuscript aims to explain pot…
View article: The Impact of Endocrine Disruptors on the Female Genital Tract Microbiome: A Narrative Review
The Impact of Endocrine Disruptors on the Female Genital Tract Microbiome: A Narrative Review Open
Background/Objectives: Endocrine disruptors (EDs) are xenobiotic chemicals that disrupt hormone signaling and homeostasis within the human body. Accumulative evidence proposes that EDs could affect systemic hormone balance and local microb…
View article: Long-Read Sequencing and Structural Variant Detection: Unlocking the Hidden Genome in Rare Genetic Disorders
Long-Read Sequencing and Structural Variant Detection: Unlocking the Hidden Genome in Rare Genetic Disorders Open
Rare genetic diseases are often caused by structural variants (SVs), such as insertions, deletions, duplications, inversions, and complex rearrangements. However, due to the technical limitations of short-read sequencing, these variants re…
View article: Role of the Bishop Score in Predicting Successful Induction of Vaginal Delivery: A Systematic Review of Current Evidence
Role of the Bishop Score in Predicting Successful Induction of Vaginal Delivery: A Systematic Review of Current Evidence Open
Labor induction is a common obstetric intervention, and the Bishop score remains a widely used clinical tool for predicting its success by assessing cervical readiness. This systematic review synthesizes evidence from 36 studies published …
View article: Calcium Supplementation in Pregnancy: A Systematic Review of Clinical Studies
Calcium Supplementation in Pregnancy: A Systematic Review of Clinical Studies Open
Background and Objectives: Calcium is an essential mineral that plays a vital role in fetal development and maternal health during pregnancy. The World Health Organization recommends a daily calcium intake of 1.5–2 g for pregnant adult wom…
View article: Scoping Review of Letrozole in Assisted Reproductive Cycles: Efficacy and Outcomes Across Infertility Causes
Scoping Review of Letrozole in Assisted Reproductive Cycles: Efficacy and Outcomes Across Infertility Causes Open
Background: Infertility affects 8–12% of couples globally, with causes including hormonal and structural abnormalities. Letrozole, an aromatase inhibitor, is commonly used for ovulation induction, but its role in various assisted reproduct…
View article: Association of Pre-Implantation Uterine Artery Doppler with Clinical Pregnancy in Assisted Reproductive Technology: A Systematic Review and Meta-Analysis
Association of Pre-Implantation Uterine Artery Doppler with Clinical Pregnancy in Assisted Reproductive Technology: A Systematic Review and Meta-Analysis Open
Background and Objectives: This meta-analysis aimed to determine whether pre-implantation uterine artery (UtA) Doppler measurements are associated with clinical pregnancy in women undergoing assisted reproductive technologies (ART). Materi…
View article: A Systematic Review on Biomarkers for Gestational Diabetes Mellitus Detection in ART Pregnancies: Current Trends and Future Directions
A Systematic Review on Biomarkers for Gestational Diabetes Mellitus Detection in ART Pregnancies: Current Trends and Future Directions Open
View article: Platelet-Rich Plasma (PRP) in Reproductive Medicine: A Critical Review of PRP Therapy in Low-Reserve and Premature Ovarian Insufficiency
Platelet-Rich Plasma (PRP) in Reproductive Medicine: A Critical Review of PRP Therapy in Low-Reserve and Premature Ovarian Insufficiency Open
Background: Intraovarian platelet-rich plasma (PRP) has emerged as a novel intervention at the intersection of reproductive medicine and regenerative biology. As women with diminished ovarian reserve (DOR), poor response to stimulation, or…
View article: The Association of Placental Grading with Perinatal Outcomes: A Systematic Review and Meta-Analysis
The Association of Placental Grading with Perinatal Outcomes: A Systematic Review and Meta-Analysis Open
Objective: Premature placental calcification (PPC) has been implicated in adverse perinatal outcomes, yet its clinical significance remains controversial. This meta-analysis aimed to quantitatively synthesize current data on the associatio…
View article: Long-Term Effects of COVID-19 on Women’s Reproductive Health and Its Association with Autoimmune Diseases, Including Multiple Sclerosis
Long-Term Effects of COVID-19 on Women’s Reproductive Health and Its Association with Autoimmune Diseases, Including Multiple Sclerosis Open
Concern over COVID-19’s long-term influence on women’s reproductive health is growing, with emerging research suggesting potential links to ovarian dysfunction, menstrual irregularities, fertility challenges, and adverse pregnancy outcomes…
View article: Exploring the Potential Impact of SERPINE Gene Expression in Cumulus Cells During Fertility Treatments: A Single Center Study
Exploring the Potential Impact of SERPINE Gene Expression in Cumulus Cells During Fertility Treatments: A Single Center Study Open
Background/Objectives: Cumulus cells have been proposed to be indicators of oocyte quality. In this study, oocyte cumulus cells were analyzed for SERPINE gene expression. High SERPINE gene expression in cumulus cells is associated with red…
View article: miR-27a rs895819 Polymorphism and Recurrent Pregnancy Loss in Caucasian Women: A Novel Genetic Risk Factor in a Challenging Fertility Dilemma
miR-27a rs895819 Polymorphism and Recurrent Pregnancy Loss in Caucasian Women: A Novel Genetic Risk Factor in a Challenging Fertility Dilemma Open
Background: This case–control study investigates whether miR-27a rs895819 A>G polymorphism is associated with an increased risk of recurrent pregnancy loss (RPL) in Caucasian Greek women. Methods: This study included 93 women with at least…
View article: From Inflammation to Infertility: How Oxidative Stress and Infections Disrupt Male Reproductive Health
From Inflammation to Infertility: How Oxidative Stress and Infections Disrupt Male Reproductive Health Open
Background/Objectives: Inflammation, infections, and oxidative stress (OS) all have an impact on male infertility, which is a complicated, multifaceted illness. OS affects motility and fertilization capability. It accomplishes this through…
View article: Genetic Variations in Vascular Endothelial Growth Factor and Their Impact on Preeclampsia: Insights into Risk, Severity, and Pregnancy Outcomes
Genetic Variations in Vascular Endothelial Growth Factor and Their Impact on Preeclampsia: Insights into Risk, Severity, and Pregnancy Outcomes Open
Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis and placental development, which are vital for a healthy pregnancy. Preeclampsia (PE), a hypertension condition that can cause major difficulties for both the m…
View article: MicroRNAs in Preeclampsia: Bridging Diagnosis and Treatment
MicroRNAs in Preeclampsia: Bridging Diagnosis and Treatment Open
Preeclampsia (PE) is a multifactorial hypertensive disorder that typically manifests after the twentieth week of pregnancy, significantly impacting perinatal mortality and neonatal morbidity. Its development is influenced by immunological …
View article: Impact of Placental Grading on Pregnancy Outcomes: A Retrospective Cohort Study
Impact of Placental Grading on Pregnancy Outcomes: A Retrospective Cohort Study Open
Background: Placental grading remains underutilized in clinical practice despite its potential prognostic value. This study aimed to elucidate the relationship between premature placental calcification (PPC) and relevant perinatal outcomes…