Explanipedia

Butterfly glioblastoma: trends in therapeutic modalities, extent of resection and survival in the temozolomide era. a SEER-based study Open

Yosef Laviv, Ekkehard M. Kasper · 2025

Butterfly glioblastoma (bGBM) is a rare type of GBM, thought to have extremely poor outcome and is generally considered “inoperable”. The aim of this study was to investigate survival outcomes in bGBM over a long period, and to look for po…

Iliopsoas Abscesses: Whose Problem is it? Insights Gained by an Institutional 100-Patient Consecutive Case Series Open

Youssef J. Hamade, Elizabeth Ogando‐Rivas, Zachary Tataryn, Matías Costa, Kenan Alkhalili , et al. · 2025

First-line treatment for IPA includes antibiotics and PCD, with surgery reserved for complex cases, gas formation, neurological involvement, proximity to vertebrae or spinal hardware, or failure of initial treatment.

Preventing Wrong-Level Spine Surgery Open

James Paul Agolia, Scott Robertson, Keki E. Turel, Ekkehard M. Kasper · 2024

Importance : Wrong-level spine surgery (WLSS), a medical error in which a surgeon operates at an unintended vertebral level, is considered a “never event.” However, it continues to be a problem in spine surgery today despite the implementa…

Effect of neurosurgical residency programs on neurosurgical patient outcomes in a single health care system: a cohort study Open

Shervin Taslimi, Susan B. Brogly, Wenbin Li, Jillian Rodger, Ekkehard M. Kasper , et al. · 2024

Hospitals with neurosurgical residents had longer operative times with similar to better outcomes. Most, but not all, of the differences between hospitals with and without residency programs were explained by hospital-level variables rathe…

From amaurotic idiocy to biochemically defined lipid storage diseases: the first identification of GM1-Gangliosidosis Open

Burkhard S. Kasper, Christian Thomas, Anne Albers, Ekkehard M. Kasper, Konrad Sandhoff · 2023

On February 23rd 1936, a boy-child (“Kn”) died in an asylum near Munich after years of severe congenital dis-ease, which had profoundly impaired his development leading to inability to walk, talk and see as well as to severe epilepsy. Whil…

An update on multimodal management of craniopharyngioma in children Open

Laura‐Nanna Lohkamp, Ekkehard M. Kasper, Alexandra Espinosa Pousa, Ute Bartels · 2023

Craniopharyngioma (CP) represent 1.2-4.6% of all intracranial tumors in children and carry a significant morbidity due to their lesional intimacy with structures involved in neurological, visual, and endocrinological functions. Variable tr…

UBE3A and transsynaptic complex NRXN1-CBLN1-GluD1 in a hypothalamic VMHvl-arcuate feedback circuit regulates aggression Open

Yi Nong, David C. Stoppel, Mark Johnson, Morgane Boillot, Jelena Todorović , et al. · 2023

The circuit origins of aggression in autism spectrum disorder remain undefined. Here we report Tac1 -expressing glutamatergic neurons in ventrolateral division of ventromedial hypothalamus (VMHvl) drive intermale aggression. Aggression is …

Efficacy and Safety of Primary Stereotactic Radiosurgery in Patients With Intraventricular Meningiomas Open

Sebastian M. Christ, Dara S. Farhadi, Sun Junzhao, Anand Mahadevan, Maximilian Thormann , et al. · 2022

Forging the Frontiers of Image-Guided Neurosurgery—The Emerging Uses of Theranostics in Neurosurgical Oncology Open

Fred C. Lam, Uyanga Tsedev, Ekkehard M. Kasper, Angela M. Belcher · 2022

OPINION article Front. Bioeng. Biotechnol., 12 July 2022Sec. Nanobiotechnology https://doi.org/10.3389/fbioe.2022.857093

The Emerging Applications of Nanotechnology in Neuroimaging: A Comprehensive Review Open

Khunza Faiz, Fred C. Lam, Jay Chen, Ekkehard M. Kasper, Fateme Salehi · 2022

Neuroimaging modalities such as computer tomography and magnetic resonance imaging have greatly improved in their ability to achieve higher spatial resolution of neurovascular and soft tissue neuroanatomy, allowing for increased accuracy i…

Correction to: Tumor-Derived Cell Culture Model for the Investigation of Meningioma Biology Open

Erik J. Uhlmann, Rosalia Rabinovsky, Hemant Varma, Rachid El Fatimy, Ekkehard M. Kasper , et al. · 2022

Integrating Nanotechnology in Neurosurgery, Neuroradiology, and Neuro-Oncology Practice—The Clinicians’ Perspective Open

Fred C. Lam, Fateme Salehi, Ekkehard M. Kasper · 2022

OPINION article Front. Bioeng. Biotechnol., 09 February 2022 | https://doi.org/10.3389/fbioe.2022.801822

Tumor-Derived Cell Culture Model for the Investigation of Meningioma Biology Open

Erik J. Uhlmann, Rosalia Rabinovsky, Hemant Varma, Rachid El Fatimy, Ekkehard M. Kasper , et al. · 2021

Meningioma is the most common primary central nervous system tumor. Although mostly nonmalignant, meningioma can cause serious complications by mass effect and vasogenic edema. While surgery and radiation improve outcomes, not all cases ca…

Pre-Surgical and Surgical Planning in Neurosurgical Oncology - A Case-Based Approach to Maximal Safe Surgical Resection in Neurosurgery Open

Hanan Al-Gethami, Fred C. Lam, Rafael Rojas, Ekkehard M. Kasper · 2021

Use of functional neuroimaging capabilities such as fMRI, DTI, MRP, MRS, AS-PET-CT, SPECT, and TMS as noninvasive tools to visualize intrinsic brain and spine morphology in relation to function have developed over the past 30 years. Amongs…

Correction to: on the need of creating multicenter registries for more suitable matched cohort studies to elucidate best multidisciplinary care strategies for patients with Chiari malformations Open

Ekkehard M. Kasper · 2021

A Review of the Neurosurgical Management of Brain Metastases During Pregnancy Open

Phileas J. Proskynitopoulos, Fred C. Lam, Sunjay Sharma, Brett C. Young, Yosef Laviv , et al. · 2020

Objective: Patients with pregnancy-associated secondary brain tumors (PASBT) are challenging to manage. Because no guidelines for the management of such patients currently exist, we performed a systematic review of the literature using PRI…

BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage Open

Fred C. Lam, Yi Wen Kong, Qiuying Huang, Tu-Lan Vu Han, Amanda Maffa , et al. · 2020

Correction to: Clinical Chiari syndrome or anatomical Chiari malformation? A conundrum revisited Open

Ekkehard M. Kasper, Tiit Mathiesen, Andreas K. Demetriades · 2020

Indications, feasibility, safety, and efficacy of CyberKnife radiotherapy for the treatment of olfactory groove meningiomas: a single institutional retrospective series Open

Jianmin Liu, Rafael Rojas, Fred C. Lam, Farhan A. Mirza, Anand Mahadevan , et al. · 2020

Emerging Medical Treatments for Meningioma in the Molecular Era Open

Fares Nigim, Hiroaki Wakimoto, Ekkehard M. Kasper, Linda Ackermans, Yasin Temel · 2018

Meningiomas are the most common type of primary central nervous system tumors. Approximately, 80% of meningiomas are classified by the World Health Organization (WHO) as grade I, and 20% of these tumors are grade II and III, considered hig…

Factors predicting reoperation of chronic subdural hematoma following primary surgical evacuation Open

Rouzbeh Motiei-Langroudi, Martina Stippler, Siyu Shi, Nimer Adeeb, Raghav Gupta , et al. · 2017

OBJECTIVE Chronic subdural hematoma (CSDH) is commonly encountered in neurosurgical practice. However, surgical evacuation remains complicated by a high rate of reoperation. The optimal surgical approach to reduce the reoperation rate has …

Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1 Open

Vaishnav Krishnan, David C. Stoppel, Yi Nong, Mark A. Johnson, Monica J. S. Nadler , et al. · 2017

The Effect of Positive End-Expiratory Pressure on Intracranial Pressure and Cerebral Hemodynamics Open

Myles D. Boone, Sayuri P. Jinadasa, Ariel Mueller, Shahzad Shaefi, Ekkehard M. Kasper , et al. · 2016

Post-traumatic anosmia in patients with mild traumatic brain injury (mTBI): A systematic and illustrated review Open

Phileas J. Proskynitopoulos, Martina Stippler, Ekkehard M. Kasper · 2016

According to our search results, we conclude that OD is a prevalent but underdiagnosed problem in mTBI. Because OD is associated with a significant decrease in quality of life, we think that neurosurgical teams need to asses olfactory func…

Hypervascular glioblastoma multiforme or arteriovenous malformation associated Glioma? A diagnostic and therapeutic challenge: A case report Open

Laura‐Nanna Lohkamp, Christian Strong, Rafael Rojas, Matthew P. Anderson, Yosef Laviv , et al. · 2016

The coincidental presentation of vascular lesions such as AVM and malignant glioma is rare and presents a major challenge when establishing a diagnosis. The respective treatment decision is complicated by the fact that available treatment …

Exploring the Virchow-Robin spaces function: A unified theory of brain diseases Open

Iype Cherian, Margarita Beltran, Ekkehard M. Kasper, Binod Bhattarai, Sunil Munokami , et al. · 2016

The new insights into the physiology of the CSF circulation may have important clinical relevance for understanding the mechanisms underlying brain pathologies and their cure.

Preoperative Embolization of Extra-axial Hypervascular Tumors with Onyx Open

Matthew R. Fusco, Mohamed M. Salem, Bradley A. Gross, Arra S. Reddy, Christopher S. Ogilvy , et al. · 2016

This series augments the expanding literature confirming the safety and efficacy of Onyx in the preoperative embolization of extra-axial tumors, underscoring its advantage of being able to attain extensive devascularization via only one su…

Iatrogenic spinal hematoma as a complication of lumbar puncture: What is the risk and best management plan? Open

Merritt Brown, Tülin Serap Yilmaz, Ekkehard M. Kasper · 2016

We found a significant correlation between preexisting coagulopathy and poor neurological outcome irrespective of intervention. However, outcomes for these patients may be confounded by comorbidities including underlying conditions contrib…

Chronic Q-Fever (Coxiella burnetii) Causing Abdominal Aortic Aneurysm and Lumbar Osteomyelitis: A Case Report Open

P. Alexander Leahey, Steven R. Tahan, Ekkehard M. Kasper, Mary Albrecht · 2015

Coxiella burnetii is a rare cause of chronic infection that most frequently presents as endocarditis. We report a case of C burnetii causing an infected abdominal aortic aneurysm with contiguous lumbar osteomyelitis resulting in spinal cor…

Dosimetric analysis of the alopecia preventing effect of hippocampus sparing whole brain radiation therapy Open

Anand Mahadevan, Carrie Sampson, Salvatore A. Larosa, Scott Floyd, Eric T. Wong , et al. · 2015

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