Ekta Pathak
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View article: A novel tamoxifen-inducible Mct8-CreERT2 mouse model for targeted studies of Mct8-expressing cells and thyroid hormone transport and function
A novel tamoxifen-inducible Mct8-CreERT2 mouse model for targeted studies of Mct8-expressing cells and thyroid hormone transport and function Open
Deficiency of the Monocarboxylate Transporter 8 (MCT8) severely impairs thyroid hormone (TH) transport into the brain, disrupting brain development as well as peripheral TH homeostasis. Studies assessing MCT8 expression patterns and tissue…
View article: A Novel Tamoxifen-Inducible Mct8-CreERT2 Mouse Model for Targeted Studies of Mct8-Expressing Cells and Thyroid Hormone Transport and Function
A Novel Tamoxifen-Inducible Mct8-CreERT2 Mouse Model for Targeted Studies of Mct8-Expressing Cells and Thyroid Hormone Transport and Function Open
Deficiency of the Monocarboxylate Transporter 8 (MCT8) severely impairs thyroid hormone (TH) transport into the brain, disrupting brain development as well as peripheral TH homeostasis. Studies assessing MCT8 expression patterns and tissue…
View article: Integrative Transcriptomic and miRNA Analysis Reveals Immune Suppression and Metabolic Reprogramming in FGFR3–TACC3 Fusion-Positive versus Fusion-Negative Bladder Cancer
Integrative Transcriptomic and miRNA Analysis Reveals Immune Suppression and Metabolic Reprogramming in FGFR3–TACC3 Fusion-Positive versus Fusion-Negative Bladder Cancer Open
FGFR3–TACC3 gene fusion drives a molecularly distinct subset of bladder cancer characterized by post-transcriptional immune evasion and metabolic rewiring. To elucidate the transcriptomic and regulatory consequences of this fusion, we perf…
View article: Esculin as a Novel Inhibitor of CCR1: Insights into Its Potential Role in Modulating Immune Responses
Esculin as a Novel Inhibitor of CCR1: Insights into Its Potential Role in Modulating Immune Responses Open
Background: Chemokine receptor CCR1 plays a pivotal role in regulating immune responses, including leukocyte migration and inflammatory signaling pathways. Dysregulation of CCR1 has been implicated in chronic inflammatory diseases, autoimm…
View article: Targeting SARS-CoV-2 Main Protease Variants: Investigating the Role of the P132H Mutation in Ligand Binding and the Potential of Withania somnifera Phytochemicals
Targeting SARS-CoV-2 Main Protease Variants: Investigating the Role of the P132H Mutation in Ligand Binding and the Potential of Withania somnifera Phytochemicals Open
Mutations in viral proteins, especially at allosteric sites, can profoundly influence therapeutic strategies by altering protein dynamics, stability, and ligand interactions. This study investigates how the P132H mutation in SARS-CoV-2 Mai…
View article: Breaking the habit: isolating nicotine-degrading bacteria in undergraduate microbiology teaching labs
Breaking the habit: isolating nicotine-degrading bacteria in undergraduate microbiology teaching labs Open
Nicotine is a major alkaloid in tobacco plants and an addictive component of tobacco products. Some bacteria grow on tobacco plants and have evolved the ability to metabolize nicotine. As part of our microbiology teaching lab, we used mini…
View article: Microglial phagolysosome dysfunction and altered neural communication amplify phenotypic severity in Prader-Willi Syndrome with larger deletion
Microglial phagolysosome dysfunction and altered neural communication amplify phenotypic severity in Prader-Willi Syndrome with larger deletion Open
Prader-Willi Syndrome (PWS) is a rare neurodevelopmental disorder of genetic etiology, characterized by paternal deletion of genes located at chromosome 15 in 70% of cases. Two distinct genetic subtypes of PWS deletions are characterized, …
View article: Naringenin-7-O-glucoside: Targeting SERPINE1, MMP7, and MMP1 for COVID-19 Lung Pathology and Immune Modulation
Naringenin-7-O-glucoside: Targeting SERPINE1, MMP7, and MMP1 for COVID-19 Lung Pathology and Immune Modulation Open
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has been a defining global health crisis, marked by severe respiratory distress and high mortality rates. The search for effective treatments against this highly mutable virus has been…
View article: Computational exploration of the dual role of the phytochemical fortunellin: antiviral activities against SARS-CoV-2 and immunomodulatory abilities against the host
Computational exploration of the dual role of the phytochemical fortunellin: antiviral activities against SARS-CoV-2 and immunomodulatory abilities against the host Open
SARS-CoV-2 infection generates approximately one million virions per day, and the majority of available antivirals are ineffective against it due to the virus's inherent genetic mutability. This necessitates the investigation of concurrent…
View article: Endogenous pancreatic microRNAs differentially target the Delta, Omicron, and Wuhan SARS-CoV-2 genomes to upregulate the Diabetes-associated genes
Endogenous pancreatic microRNAs differentially target the Delta, Omicron, and Wuhan SARS-CoV-2 genomes to upregulate the Diabetes-associated genes Open
The SARS-CoV-2 viral genome is mutating and evolving into new variations, including the recently discovered Delta and Omicron. In this study, we used and evaluated our notion of differential targeting of SARS-CoV-2 variant genomes by micro…
View article: Structural analysis of the role of the two conserved motifs of the ECF41 family sigma factor in the autoregulation of its own promoter in Azospirillum brasilense Sp245
Structural analysis of the role of the two conserved motifs of the ECF41 family sigma factor in the autoregulation of its own promoter in Azospirillum brasilense Sp245 Open
In Azospirillum brasilense, an extra-cytoplasmic function sigma factor (RpoE10) shows the characteristic 119 amino acid long C-terminal extension found in ECF41-type sigma factors, which possesses three conserved motifs (WLPEP, DGGGR, and …
View article: Deciphering the role of the Pancreatic Secretome in Covid-19 associated Multi-Organ Dysfunctions
Deciphering the role of the Pancreatic Secretome in Covid-19 associated Multi-Organ Dysfunctions Open
Summary Emerging evidence indicates an intricate relationship between the SARS-CoV-2 infection and Multi-Organ Dysfunctions (MODs). Here, we have investigated the role of the Secretome of the SARS-CoV-2 infected pancreas and mechanisticall…
View article: Linking Diabetes mellitus to SARS-CoV-2 infection through differential targeting of the microRNAs in the Pancreas tissue
Linking Diabetes mellitus to SARS-CoV-2 infection through differential targeting of the microRNAs in the Pancreas tissue Open
Coronavirus Disease 2019 (COVID-19) severity and Diabetes mellitus affect each other bidirectionally. The plus-sense single-stranded RNA (+ssRNA) genome of the SARS-CoV-2 virus can be targeted and suppressed by the host cell’s microRNAs (m…
View article: Whole exome sequencing unveils a frameshift mutation in CNGB3 for cone dystrophy
Whole exome sequencing unveils a frameshift mutation in CNGB3 for cone dystrophy Open
We have identified a recurrent mutation c.1148delC (p.Thr383fs) in CNGB3 for autosomal recessive CD. The present report provides the first description of CNGB3 mutation from India. It is also the foremost investigation of familial CD in In…
View article: Deciphering the Role of microRNAs in BRD4-NUT Fusion Gene Induced NUT Midline Carcinoma
Deciphering the Role of microRNAs in BRD4-NUT Fusion Gene Induced NUT Midline Carcinoma Open
NUT midline carcinoma (NMC) is a very aggressive and lethal type of squamous epithelial cell cancer caused due to fusion of BRD4 and NUT genes. The gene fusion results into a new fusion protein that promotes oncogenesis. The detailed molec…
View article: Analysis of correlated mutations in Ras G-domain
Analysis of correlated mutations in Ras G-domain Open
Ras GTPases are most prevalent proto-oncogenes in human cancer. Mutations in Ras remain untreatable more than three decades after the initial discovery. At the amino acid level, some residues under physical or functional constraints exhibi…