Maha A. Hegazy
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View article: Chemometric-assisted spectrophotometric approach for stability assessment of safinamide and its synthetic precursor in antiparkinsonian formulation with sustainability profiling
Chemometric-assisted spectrophotometric approach for stability assessment of safinamide and its synthetic precursor in antiparkinsonian formulation with sustainability profiling Open
Parkinson’s disease (PD) is a significant health issue that affects older individuals. Safinamide mesylate (SAF) is a recently developed adjunct therapy increasingly employed in the management of PD. Ensuring the stability of new drug form…
View article: A sensitive green HPLC-fluorescence method for simultaneous analysis of sacubitril and valsartan in pure forms, pharmaceutical dosage form and human plasma
A sensitive green HPLC-fluorescence method for simultaneous analysis of sacubitril and valsartan in pure forms, pharmaceutical dosage form and human plasma Open
The development of green methods of analysis has recently become a global trend in analytical chemistry, especially in routine HPLC analysis. This study presents a sensitive and economic green HPLC method with fluorescence detection for th…
View article: Carbon dot based molecularly imprinted polymer for selective fluorometric determination of tetracycline and metronidazole in pharmaceuticals and human plasma
Carbon dot based molecularly imprinted polymer for selective fluorometric determination of tetracycline and metronidazole in pharmaceuticals and human plasma Open
View article: Biochemical studies on some common amino acids
Biochemical studies on some common amino acids Open
View article: An eco-friendly bioanalytical RP-HPLC method coupled with fluorescence detection for simultaneous estimation of felodipine and metoprolol
An eco-friendly bioanalytical RP-HPLC method coupled with fluorescence detection for simultaneous estimation of felodipine and metoprolol Open
View article: Correction: Kammoun et al. Etodolac Fortified Sodium Deoxycholate Stabilized Zein Nanoplatforms for Augmented Repositioning Profile in Human Hepatocellular Carcinoma: Assessment of Bioaccessibility, Anti-Proliferation, Pro-Apoptosis and Oxidant Potentials in HepG2 Cells. Pharmaceuticals 2022, 15, 916
Correction: Kammoun et al. Etodolac Fortified Sodium Deoxycholate Stabilized Zein Nanoplatforms for Augmented Repositioning Profile in Human Hepatocellular Carcinoma: Assessment of Bioaccessibility, Anti-Proliferation, Pro-Apoptosis and Oxidant Potentials in HepG2 Cells. Pharmaceuticals 2022, 15, 916 Open
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View article: Chemometric-assisted UV spectrophotometric methods for determination of miconazole nitrate and lidocaine hydrochloride along with potential impurity and dosage from preservatives
Chemometric-assisted UV spectrophotometric methods for determination of miconazole nitrate and lidocaine hydrochloride along with potential impurity and dosage from preservatives Open
Three accurate, simple, and precise chemometric techniques, principal component regression (PCR), partial least squares (PLS), and backward interval partial least squares (biPLS) were used to resolve the severely overlapped UV spectra of m…
View article: Stability-indicating spectrophotometric manipulations for the determination of Letrozole in the presence of its alkali-induced degradation products; towards whiteness and ChlorTox scale perspectives
Stability-indicating spectrophotometric manipulations for the determination of Letrozole in the presence of its alkali-induced degradation products; towards whiteness and ChlorTox scale perspectives Open
Letrozole (LTZ) is an established first hormonal treatment for breast cancer, yet it was found to be highly susceptible for degradation in alkaline medium due to the presence of cyano phenyl group. Consequently, three stability-indicating …
View article: A cutting-edge design of a novel electrochemical voltammetric nanosensor modified with molecularly imprinted polymer along with multi-walled carbon nanotubes for selective safinamide recognition
A cutting-edge design of a novel electrochemical voltammetric nanosensor modified with molecularly imprinted polymer along with multi-walled carbon nanotubes for selective safinamide recognition Open
View article: Green Assessment of Sensitive Spectrofluorimetric Methods for Simultaneous Estimation of Formoterol Fumarate and Fluticasone Propionate Using a Micelle-Mediated Approach
Green Assessment of Sensitive Spectrofluorimetric Methods for Simultaneous Estimation of Formoterol Fumarate and Fluticasone Propionate Using a Micelle-Mediated Approach Open
View article: Electrochemical sensor doped with core-shell structured molecularly imprinted polymer proposed for therapeutic drug monitoring of trazodone hydrochloride
Electrochemical sensor doped with core-shell structured molecularly imprinted polymer proposed for therapeutic drug monitoring of trazodone hydrochloride Open
Currently, the global push for eco-friendly analytical techniques has altered the priorities of analytical methodologies in accordance with their level of adherence to the principles of green analytical chemistry. Herein, sustainable, sens…
View article: Students’ Perception Towards Applying Artificial Intelligence in Medical Field. A Cross-Sectional Study Among Medical Students, Cairo University
Students’ Perception Towards Applying Artificial Intelligence in Medical Field. A Cross-Sectional Study Among Medical Students, Cairo University Open
View article: Ecological multivariate assisted spectrophotometric methods for determination of antipyrine and benzocaine HCl in presence of antipyrine official impurity and benzocaine HCl degradant: toward greenness and whiteness
Ecological multivariate assisted spectrophotometric methods for determination of antipyrine and benzocaine HCl in presence of antipyrine official impurity and benzocaine HCl degradant: toward greenness and whiteness Open
View article: A novel stability-indicating chromatographic quantification of the antiparkinsonian drug safinamide in its pharmaceutical formulation employing HPTLC densitometry and ion-pair HPLC–DAD
A novel stability-indicating chromatographic quantification of the antiparkinsonian drug safinamide in its pharmaceutical formulation employing HPTLC densitometry and ion-pair HPLC–DAD Open
View article: Greenness assessment of a molecularly imprinted polymeric sensor based on a bio-inspired polymer
Greenness assessment of a molecularly imprinted polymeric sensor based on a bio-inspired polymer Open
Methyldopa, a synthesized dopamine substitute with phenolic, amine, and carboxylic groups, was used to create a selective molecular imprinted polymer (MIP) for detecting formoterol fumarate dihydrate (FFD), a long-acting beta2-agonist for …
View article: Pharmacokinetics of pulmonary indacaterol in rat lung using molecular imprinting solid-phase extraction coupled with RP-UPLC
Pharmacokinetics of pulmonary indacaterol in rat lung using molecular imprinting solid-phase extraction coupled with RP-UPLC Open
Indacaterol, a β 2 agonist prescribed for long-term management of patients with chronic obstructive pulmonary disease and asthma. In this study the first MISPE cartridges was developed using indacaterol as a template for its selective extr…
View article: Eco-Friendly Synchronous Spectrofluorimetric Method for Simultaneous Determination of Remdesivir and Acetyl Salicylic Acid in Spiked Human Plasma
Eco-Friendly Synchronous Spectrofluorimetric Method for Simultaneous Determination of Remdesivir and Acetyl Salicylic Acid in Spiked Human Plasma Open
Remdesivir and acetyl salicylic acid are often co-administered medications in the treatment of COVID-19, specifically targeting the viral infection and thromboembolism associated with the condition. Hence, it is essential to establish a te…
View article: Green analytical chemistry and quality by design: A combined approach towards simultaneous determination of Letrozole with its co-administered Zoledronic Acid for cancer patients
Green analytical chemistry and quality by design: A combined approach towards simultaneous determination of Letrozole with its co-administered Zoledronic Acid for cancer patients Open
Nowadays, breast cancer is the most affecting and globally diagnosed malignancy among women, yet Letrozole (LTZ) was considered the first-line treatment as hormonal anticancer drug. Unfortunately, LTZ develops osteoporosis as a main side e…
View article: Ecofriendly micellar mediated spectrofluorimetric method for ultrasensitive quantification of the antiparkinsonian drug safinamide in pharmaceutical formulation and spiked human plasma
Ecofriendly micellar mediated spectrofluorimetric method for ultrasensitive quantification of the antiparkinsonian drug safinamide in pharmaceutical formulation and spiked human plasma Open
View article: Therapeutic drug monitoring of six contraindicated/co-administered drugs by simple and green RP-HPLC-PDA; application to spiked human plasma
Therapeutic drug monitoring of six contraindicated/co-administered drugs by simple and green RP-HPLC-PDA; application to spiked human plasma Open
View article: A Molecularly Imprinted Polymeric Sensor Based on Poly(methyldopa) for Electrochemical Quantification of Formoterol in Raw Material and Pharmaceutical Dosage Form
A Molecularly Imprinted Polymeric Sensor Based on Poly(methyldopa) for Electrochemical Quantification of Formoterol in Raw Material and Pharmaceutical Dosage Form Open
Catechol amine-derived polymers, which include dopamine and its natural analogues, reveal desirable adhesion characteristics, great biocompatibility, and an achievable antifouling surface, by manipulating electro-polymerization procedures.…
View article: Eco-friendly HPTLC Determination of Paracetamol, Caffeine, Drotaverine HCl and Two of their Official Impurities; Application to Assay and Content Uniformity Testing of Tablet Dosage Form
Eco-friendly HPTLC Determination of Paracetamol, Caffeine, Drotaverine HCl and Two of their Official Impurities; Application to Assay and Content Uniformity Testing of Tablet Dosage Form Open
View article: Stability-indicating UPLC assay coupled with mass spectrometry for the analysis of vilanterol degradation products in human urine
Stability-indicating UPLC assay coupled with mass spectrometry for the analysis of vilanterol degradation products in human urine Open
Vilanterol is a once-daily dose inhaler prescribed for asthma and chronic obstructive pulmonary disease. This study involved an investigation of vilanterol stability under acidic, basic, oxidative, thermal, and photolytic stress conditions…
View article: Application of multivariate chemometrics tools for spectrophotometric determination of naphazoline HCl, pheniramine maleate and three official impurities in their eye drops
Application of multivariate chemometrics tools for spectrophotometric determination of naphazoline HCl, pheniramine maleate and three official impurities in their eye drops Open
This work is concerned with exploiting the power of chemometrics in the assay and purity determination of naphazoline HCl (NZ) and pheniramine maleate (PN) in their combined eye drops. Partial least squares (PLS) and artificial neural netw…
View article: Green chromatographic methods for determination of co-formulated lidocaine hydrochloride and miconazole nitrate along with an endocrine disruptor preservative and potential impurity
Green chromatographic methods for determination of co-formulated lidocaine hydrochloride and miconazole nitrate along with an endocrine disruptor preservative and potential impurity Open
View article: Effect of Different Levels of Undegradable Protein on Performance, Reproductive Activity and Rumen Fermentation in Ewes during Flushing Period
Effect of Different Levels of Undegradable Protein on Performance, Reproductive Activity and Rumen Fermentation in Ewes during Flushing Period Open
View article: Effect of Different Levels of Undegradable Protein on Performance, Blood Parameters, Colostrum Composition and Lamb Birth Weight in Pregnant Ewes
Effect of Different Levels of Undegradable Protein on Performance, Blood Parameters, Colostrum Composition and Lamb Birth Weight in Pregnant Ewes Open
Ewe productivity is one of the most important factors that determine the profitability of small stock farming.One of the key factors that directly affects agricultural animals' productivity and reproductivity is the quality of their nutrit…
View article: Smart chemometrics-assisted spectrophotometric methods for efficient resolution and simultaneous determination of paracetamol, caffeine, drotaverine HCl along with three of their corresponding related impurities
Smart chemometrics-assisted spectrophotometric methods for efficient resolution and simultaneous determination of paracetamol, caffeine, drotaverine HCl along with three of their corresponding related impurities Open
View article: Spectrophotometric determination of favipiravir in presence of its acid hydrolysis product
Spectrophotometric determination of favipiravir in presence of its acid hydrolysis product Open
Favipiravir (FAV) has been approved as an antiviral drug used in pandemic corona virus to treat covid-19. It has an amide moiety susceptible to hydrolysis and degradation in acid medium. Therefore, four simple, sensitive, and accurate stab…
View article: Experimental Design Approach for Development of HPLC Method for Simultaneous Analysis of Triamcinolone, Nystatin, and Gramicidin in Industrial Wastewater
Experimental Design Approach for Development of HPLC Method for Simultaneous Analysis of Triamcinolone, Nystatin, and Gramicidin in Industrial Wastewater Open
This study used an experimental design approach to optimize an HPLC method for the simultaneous determination of three pharmaceutical residues (triamcinolone, nystatin, and gramicidin) in industrial wastewater samples. The goal of using an…