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View article: Hippocampal reelin and GAD67 gene expression and methylation in the GFAP.HMOX1 mouse model of schizophrenia
Hippocampal reelin and GAD67 gene expression and methylation in the GFAP.HMOX1 mouse model of schizophrenia Open
Schizophrenia is a complex neuropsychiatric disorder featuring enhanced brain oxidative stress and deficient reelin protein. GFAP.HMOX10-12m mice that overexpress heme oxygenase-1 (HO-1) in astrocytes manifest a schizophrenia-like neuroche…
View article: Poly ADP-ribosylation regulates<i>Arc</i>expression and promotes adaptive stress-coping
Poly ADP-ribosylation regulates<i>Arc</i>expression and promotes adaptive stress-coping Open
Rapid adaptation to stressful events is essential for survival and requires acute stress response and stress-coping strategy. Yet, the molecular mechanisms that govern this coping strategy have to be fully discovered. Poly ADP-ribosylation…
View article: DNA Methylation as a Therapeutic and Diagnostic Target in Major Depressive Disorder
DNA Methylation as a Therapeutic and Diagnostic Target in Major Depressive Disorder Open
OPINION article Front. Behav. Neurosci., 30 March 2022Sec. Emotion Regulation and Processing https://doi.org/10.3389/fnbeh.2022.759052
View article: The methyl donor S-adenosyl methionine reverses the DNA methylation signature of chronic neuropathic pain in mouse frontal cortex
The methyl donor S-adenosyl methionine reverses the DNA methylation signature of chronic neuropathic pain in mouse frontal cortex Open
Introduction: Chronic pain is associated with persistent but reversible structural and functional changes in the prefrontal cortex (PFC). This stable yet malleable plasticity implicates epigenetic mechanisms, including DNA methylation, as …
View article: The transition from acute to chronic pain: dynamic epigenetic reprogramming of the mouse prefrontal cortex up to 1 year after nerve injury
The transition from acute to chronic pain: dynamic epigenetic reprogramming of the mouse prefrontal cortex up to 1 year after nerve injury Open
Chronic pain is associated with persistent structural and functional changes throughout the neuroaxis, including in the prefrontal cortex (PFC). The PFC is important in the integration of sensory, cognitive, and emotional information and i…
View article: The Transition from Acute to Chronic Pain: Dynamic Epigenetic Reprogramming of the Mouse Prefrontal Cortex up to One Year Following Nerve Injury
The Transition from Acute to Chronic Pain: Dynamic Epigenetic Reprogramming of the Mouse Prefrontal Cortex up to One Year Following Nerve Injury Open
Chronic pain is associated with persistent structural and functional changes throughout the neuroaxis, including in the prefrontal cortex (PFC). The PFC is important in the integration of sensory, cognitive and emotional information and in…
View article: Dnmt3a2 in the Nucleus Accumbens Shell Mediates Cue-Induced Cocaine-Seeking Behavior
Dnmt3a2 in the Nucleus Accumbens Shell Mediates Cue-Induced Cocaine-Seeking Behavior Open
One of the main obstacles in treating drug addiction is the high rates of relapse even after prolonged periods of abstinence. Neuronal adaptions play a major role in drug craving and relapse ([Kalivas and Volkow, 2005][1]). Many of these a…
View article: A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention
A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention Open
Previous studies in animal models of cocaine craving have delineated broad changes in DNA methylation profiles in the nucleus accumbens. A crucial factor for progress in behavioral and mental health epigenetics is the discovery of epigenet…
View article: Methyl-CpG binding domain 2 (Mbd2) is an Epigenetic Regulator of Autism-Risk Genes and Cognition
Methyl-CpG binding domain 2 (Mbd2) is an Epigenetic Regulator of Autism-Risk Genes and Cognition Open
The Methyl-CpG-Binding Domain Protein family has been implicated in neurodevelopmental disorders. The Methyl-CpG-binding domain 2 (Mbd2) binds methylated DNA and was shown to play an important role in cancer and immunity. Some evidence lin…
View article: Adult Neural Stem Cell Multipotency and Differentiation Are Directed by the Methyl-CpG-Binding Protein MBD1
Adult Neural Stem Cell Multipotency and Differentiation Are Directed by the Methyl-CpG-Binding Protein MBD1 Open
The generation of new neurons in the subventricular zone of the dentate gyrus during adulthood is indispensable to hippocampal-dependent learning and memory formation ([Gonçalves et al., 2016][1]). A decrease in neurogenesis is associated …