Elah Pick
YOU?
Author Swipe
View article: Csn5 Depletion Reverses Mitochondrial Defects in GCN5-Null <i>Saccharomyces cerevisiae</i>.
Csn5 Depletion Reverses Mitochondrial Defects in GCN5-Null <i>Saccharomyces cerevisiae</i>. Open
In this study, we investigated the mitochondrial defects resulting from the deletion of GCN5, a lysine-acetyltransferase, in the yeast Saccharomyces cerevisiae. Gcn5 serves as the catalytic subunit of the SAGA acetylation complex and funct…
View article: Redox-driven control of Yuh1/UCHL3 impacts mitochondrial health via NEDD8/Rub1 pathway
Redox-driven control of Yuh1/UCHL3 impacts mitochondrial health via NEDD8/Rub1 pathway Open
The ubiquitin-like protein NEDD8/Rub1 undergoes processing by the enzyme Yuh1/UCHL3 to become functional. While the processed NEDD8/Rub1 modifies Cullin-RING E3 ligases (CRLs) among all studied organisms, its role in facilitating CRL-based…
View article: The Ubiquitin-like Proteins of Saccharomyces cerevisiae
The Ubiquitin-like Proteins of Saccharomyces cerevisiae Open
In this review, we present a comprehensive list of the ubiquitin-like modifiers (Ubls) of Saccharomyces cerevisiae, a common model organism used to study fundamental cellular processes that are conserved in complex multicellular organisms,…
View article: Data from Phosphatidylinositol-3-Kinase as a Therapeutic Target in Melanoma
Data from Phosphatidylinositol-3-Kinase as a Therapeutic Target in Melanoma Open
Purpose: Phosphatidylinositol-3 kinases (PI3K) are critical for malignant cellular processes including growth, proliferation, and survival, and are targets of drugs in clinical development. We assessed expression of PI3K in melanomas and n…
View article: Supplementary Data from Phosphatidylinositol-3-Kinase as a Therapeutic Target in Melanoma
Supplementary Data from Phosphatidylinositol-3-Kinase as a Therapeutic Target in Melanoma Open
Supplementary Data from Phosphatidylinositol-3-Kinase as a Therapeutic Target in Melanoma
View article: Supplementary Data from Phosphatidylinositol-3-Kinase as a Therapeutic Target in Melanoma
Supplementary Data from Phosphatidylinositol-3-Kinase as a Therapeutic Target in Melanoma Open
Supplementary Data from Phosphatidylinositol-3-Kinase as a Therapeutic Target in Melanoma
View article: Data from Phosphatidylinositol-3-Kinase as a Therapeutic Target in Melanoma
Data from Phosphatidylinositol-3-Kinase as a Therapeutic Target in Melanoma Open
Purpose: Phosphatidylinositol-3 kinases (PI3K) are critical for malignant cellular processes including growth, proliferation, and survival, and are targets of drugs in clinical development. We assessed expression of PI3K in melanomas and n…
View article: Saccharomyces cerevisiae as a Toolkit for COP9 Signalosome Research
Saccharomyces cerevisiae as a Toolkit for COP9 Signalosome Research Open
The COP9 signalosome (CSN) is a highly conserved eukaryotic multi-subunit enzyme, regulating cullin RING ligase activities and accordingly, substrate ubiquitination and degradation. We showed that the CSN complex of Saccharomyces cerevisia…
View article: The necessity of NEDD8/Rub1 for vitality and its association with mitochondria-derived oxidative stress
The necessity of NEDD8/Rub1 for vitality and its association with mitochondria-derived oxidative stress Open
Access of molecular oxygen to the respiratory electron transport chain at the mitochondria costs in the generation of reactive oxygen-derived species (ROS). ROS induces progressive damage to macromolecules in all living cells, hence, rapid…
View article: Rub1/NEDD8, a ubiquitin-like modifier, is also a ubiquitin modifier
Rub1/NEDD8, a ubiquitin-like modifier, is also a ubiquitin modifier Open
Of all ubiquitin-like small protein modifiers, Rub1/NEDD8 is the closest kin of ubiquitin in sequence and in structure. Despite their profound similarities, prevalence of ubiquitin and of Rub1 is starkly different: targets of ubiquitin mod…
View article: The COP9 signalosome mediates the Spt23 regulated fatty acid desaturation and ergosterol biosynthesis
The COP9 signalosome mediates the Spt23 regulated fatty acid desaturation and ergosterol biosynthesis Open
The COP9 signalosome (CSN) is a conserved eukaryotic complex, essential for vitality in all multicellular organisms and critical for the turnover of key cellular proteins through catalytic and non‐catalytic activities. Saccharomyces cerevi…
View article: Statins interfere with the attachment of <i>S. cerevisiae</i> mtDNA to the inner mitochondrial membrane
Statins interfere with the attachment of <i>S. cerevisiae</i> mtDNA to the inner mitochondrial membrane Open
The 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme of the mevalonate pathway for the synthesis of cholesterol in mammals (ergosterol in fungi), is inhibited by statins, a class of cholesterol lowering drugs. Indeed, statins are in …
View article: The Proteasome Lid Triggers COP9 Signalosome Activity during the Transition of Saccharomyces cerevisiae Cells into Quiescence
The Proteasome Lid Triggers COP9 Signalosome Activity during the Transition of Saccharomyces cerevisiae Cells into Quiescence Open
The class of Cullin–RING E3 ligases (CRLs) selectively ubiquitinate a large portion of proteins targeted for proteolysis by the 26S proteasome. Before degradation, ubiquitin molecules are removed from their conjugated proteins by deubiquit…
View article: A molecular switch for Cdc48 activity and localization during oxidative stress and aging
A molecular switch for Cdc48 activity and localization during oxidative stress and aging Open
Summary Control over a healthy proteome begins with the birth of the polypeptide chain and ends with coordinated protein degradation. One of the major players in eukaryotic protein degradation is the essential and highly conserved ATPase, …
View article: Yeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5
Yeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5 Open
The CSN complex plays a key role in various cellular pathways: through a metalloprotease activity of its Csn5 deneddylating enzyme, it regulates the activity of Cullin-RING ligases (CRLs). Indeed, Csn5 has been found amplified in many tumo…
View article: Base-CP proteasome can serve as a platform for stepwise lid formation
Base-CP proteasome can serve as a platform for stepwise lid formation Open
26S proteasome, a major regulatory protease in eukaryotes, consists of a 20S proteolytic core particle (CP) capped by a 19S regulatory particle (RP). The 19S RP is divisible into base and lid sub-complexes. Even within the lid, subunits ha…