Explanipedia

Berbamine as potential STING inhibitor For KRAS-mutant non-small cell lung cancer Open

Yan Han, Jumin Huang, Yuwei Wang, Yizhong Zhang, Wenkang Ren , et al. · 2025

Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality. Poor prognostic results in LUAD are frequently associated with KRAS mutations and drug resistance. KRAS mutations can induce STING activation by triggering DNA dama…

Taurine and proline promote lung tumour growth by co-regulating Azgp1/mTOR signalling pathway Open

Tu-Liang Liang, Ying Chen, Ningning Zhou, Xiao Zheng Shu, Jianing Mi , et al. · 2025

Cross‐tissue multi‐omics analyses reveal the gut microbiota's absence impacts organ morphology, immune homeostasis, bile acid and lipid metabolism Open

Juan Shen, Weiming Liang, Ruizhen Zhao, Yang Chen, Yanmin Liu , et al. · 2025

The gut microbiota influences host immunity and metabolism, and changes in its composition and function have been implicated in several non‐communicable diseases. Here, comparing germ‐free (GF) and specific pathogen‐free (SPF) mice using s…

Ginseng polysaccharides circumvent acquired resistance to anti-PD-1 immunotherapy in patients with non-small cell lung cancer Open

Jumin Huang, Ziming Wang, Feng Li, Huiting Wang, Yang Xiang , et al. · 2025

Selective utilization of medicinal polysaccharides by human gut Bacteroides and Parabacteroides species Open

Zepeng Qu, Hongbin Liu, Yang Ji, Linggang Zheng, Jumin Huang , et al. · 2025

Applications of bacteriophages in precision engineering of the human gut microbiome Open

Xiaoxian Kuang, Juntao Shen, Linggang Zheng, Yi Duan, Yingfei Ma , et al. · 2025

As our understanding of the role of the gut microbiome in human diseases deepens, precision engineering of the gut microbiome using bacteriophages has gained significant attention. Herein, we review the recent advances in bacteriophage-med…

Berbamine as Potential Sting Inhibitor for Kras-Mutant Non-Small Cell Lung Cancer Open

Haohao Yan, Jumin Huang, Yuwei Wang, Ying‐Chuang Zhang, Wenkang Ren , et al. · 2025

Targeting regulated cell death (RCD) with naturally derived sesquiterpene lactones in cancer therapy Open

Cong Xu, Shaodi Wen, Xiaoyue Du, Xinhua Zou, Elaine Lai‐Han Leung , et al. · 2024

Regulated cell death (RCD) is a type of cell death modulated by specific signal transduction pathways. Currently, known RCD types include apoptosis, autophagy, ferroptosis, necroptosis, cuproptosis, pyroptosis, and NETosis. Mutations in ca…

Serum taurine affects lung cancer progression by regulating tumor immune escape mediated by the immune microenvironment Open

Tu-Liang Liang, Hudan Pan, Peiyu Yan, Jianing Mi, Xiaocui Liu , et al. · 2024

Utilization of medicinal polysaccharides by human gut Bacteroides and Parabacteroides species Open

Elaine Lai‐Han Leung, Zepeng Qu, Hongbin Liu, Yang Ji, Linggang Zheng , et al. · 2024

Human gut Bacteroides and Parabacteroides species play crucial roles in human health and are known for their capacity to utilize diverse polysaccharides. Understanding how these bacteria utilize medicinal polysaccharides is foundational fo…

Dual inhibitors of DNMT and HDAC remodels the immune microenvironment of colorectal cancer and enhances the efficacy of anti-PD-L1 therapy Open

Zhanbo Yang, Bizhu Chu, Yao Tu, Lulu Li, Dawei Chen , et al. · 2024

Colorectal cancer is the second most prevalent and deadly cancer worldwide. The emergence of immune checkpoint therapy has provided a revolutionary strategy for the treatment of solid tumors. However, less than 5 % of colorectal cancer pat…

Evolution of resistance to KRASG12C inhibitor in a non-small cell lung cancer responder Open

Elaine Lai‐Han Leung, Jiahui Xu, Shijia Wang, Ziming Wang, Jumin Huang , et al. · 2024

Despite initial therapeutic successes, most patients with non-small cell lung cancer (NSCLC) who carry the KRAS^G12C mutation ultimately exhibit resistance to targeted treatments. To improve our comprehension of how acquired resi…

Paris saponin VII reverses resistance to PARP inhibitors by regulating ovarian cancer tumor angiogenesis and glycolysis through the RORα/ECM1/VEGFR2 signaling axis Open

Mengfei Wang, Chenyue Yuan, Zong Wu, Meng Xu, Ziqi Chen , et al. · 2024

The emergence of Poly (ADP-ribose) polymerase inhibitors (PARPi) has marked the beginning of a precise targeted therapy era for ovarian cancer. However, an increasing number of patients are experiencing primary or acquired resistance to PA…

Evolution of resistance to KRASG12Cinhibitor in a non-small cell lung cancer responder Open

Jiahui Xu, Shijia Wang, Ziming Wang, Jumin Huang, Chun Xie , et al. · 2023

Despite initial therapeutic successes, most patients with non-small cell lung cancer (NSCLC) who carry the KRAS G12C mutation ultimately exhibit resistance to targeted treatments. To improve our comprehension of how acquired resistance dev…

Harnessing natural product polysaccharides against lung cancer and revisit its novel mechanism Open

Wangqi Tian, Jumin Huang, Weitong Zhang, Yifan Wang, Ruyi Jin , et al. · 2023

The incidence and mortality of lung cancer are on the rise worldwide. However, the benefit of clinical treatment in lung cancer is limited. Owning to important sources of drug development, natural products have received constant attention …

Predicting and managing postoperative pneumonia in thoracic surgery patients: the role of age, cancer type, and risk factors Open

Runze Li, Lin-lin Cai, Wenwen Hu, Li-Rong Lian, Wei-Yu Meng , et al. · 2023

Aims: To assess the influence of age, cancer type, and diverse risk factors on the occurrence of postoperative pulmonary infection (PPI) in patients undergoing thoracic surgery. Methods: The study encompassed a cohort of 231 patients who u…

Natural Anticancer Molecules and Their Therapeutic Potential Open

Junmin Zhang, Elaine Lai‐Han Leung · 2023

Cancer poses a significant global public health challenge [...]

Longitudinal high-dimensional analysis identifies immune features associating with response to anti-PD-1 immunotherapy Open

Elaine Lai‐Han Leung, Runze Li, Xing‐Xing Fan, Lily Yan Wang, Yan Wang , et al. · 2023

Response to immunotherapy widely varies among cancer patients and identification of parameters associating with favourable outcome is of great interest. Here we show longitudinal monitoring of peripheral blood samples of non-small cell lun…

CERS4 predicts positive anti-PD-1 response and promotes immunomodulation through Rhob-mediated suppression of CD8+Tim3+ exhausted T cells in non-small cell lung cancer Open

Jian Wang, Runze Li, Wenjun Wang, Hudan Pan, Chun Xie , et al. · 2023

Non-small cell lung cancer (NSCLC) is one of the main malignant tumors with high mortality and short survival time. Immunotherapy has become the standard treatment for advanced NSCLC, but it has the problems of drug resistance and low resp…

Longitudinal high-dimensional analysis identifies immune features associating with response to anti-PD-1 immunotherapy Open

Elaine Lai‐Han Leung, Runze Li · 2023

Longitudinal high-dimensional analysis identifies immune features associating with response to anti-PD-1 immunotherapy

Editorial: Progress of programmed cell death in antitumor immunity Open

Fangfang Yan, Chao Mao, Elaine Lai‐Han Leung, Lianxiang Luo · 2023

EDITORIAL article Front. Immunol., 12 June 2023Sec. Molecular Innate Immunity Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1230490

Supplementary methods from CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma Open