Explanipedia

Changes in Gray Matter Morphology and White Matter Microstructure Across the Adult Lifespan in People With Temporal Lobe Epilepsy Open

Judy Chen, Alexander Ngo, Raúl Rodríguez‐Cruces, Jessica Royer, Maria Eugenia Caligiuri , et al. · 2025

This study highlights that patients with TLE exhibit more pronounced and widespread gray and white matter atrophy across the lifespan. The cross-sectional nature of our study limits definitive conclusions on whether the atrophy shown is pr…

Perioperative IDH inhibition in treatment-naive IDH-mutant glioma: a pilot trial Open

Katharine J. Drummond, M A Spiteri, Sarah Cain, Jordan Jones, Sammy Shaya , et al. · 2025

Associations between epilepsy-related polygenic risk and brain morphology in childhood Open

Alexander Ngo, L W Liu, Sara Larivière, Valeria Kebets, Serena Fett , et al. · 2025

Extensive neuroimaging research in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) has identified brain atrophy as a disease phenotype. While it is also related to a complex genetic architecture, the transition from genetic risk…

Relationship between brain atrophy and disability in a multi-site multiple sclerosis registry Open

Ai‐Lan Nguyen, Dana Horáková, Eva Havrdová, Michael Barnett, Maria Pia Sormani , et al. · 2025

Background In a retrospective multicentre cohort study, we explored the association between brain atrophy and multiple sclerosis (MS) disability using different MRI scanners and protocols at multiple sites. Methods Relapse-onset MS patient…

A Prospective, Multicentre Randomised Controlled Study of Angiographic and Clinical Outcomes in Total Arterial Coronary Bypass Grafting: The TA Trial Protocol Open

Alistair Royse, Justin Ren, Andrea Bowyer, Christopher M. Reid, Rinaldo Bellomo , et al. · 2025

The trial has been registered under the Australian New Zealand Clinical Trial Registry (registration number: ACTRN12623000864628). Dissemination of results: The analysed results will be published in a peer-reviewed journal on completion of…

The topography of infratentorial lesions in depression and anxiety in multiple sclerosis Open

Federica Giofrè, Alessandra Lugaresi, Flavia Baccari, Elaine Lui, Stefanie Roberts , et al. · 2025

Background Depression and anxiety are highly prevalent in multiple sclerosis and significantly impact patient outcomes. However, their link to specific areas of demyelination remains unclear. Objectives This study examines the association …

Associations between epilepsy-related polygenic risk and brain morphology in childhood Open

Alexander Ngo, L W Liu, Sara Larivière, Valeria Kebets, Serena Fett , et al. · 2025

A bstract Temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) is associated with a complex genetic architecture, but the translation from genetic risk factors to brain vulnerability remains unclear. Here, we examined associations be…

High variability in reporting of right ventricle contouring technique and body surface area methodology in cardiac magnetic resonance studies of patients with repaired tetralogy of Fallot: A systematic review Open

Abbey J Grbac, Phillip S. Naimo, Jeremy Russo, S. Fogarty, William Wilson , et al. · 2025

RV contouring technique and BSA methodology utilized in CMR studies of PVI in TOF is poorly reported. Given the importance of severity thresholds for RV volumes in triggering intervention in clinical practice, clear reporting and standardi…

Utility of icobrain for brain volumetry in multiple sclerosis clinical practice Open

Ai‐Lan Nguyen, Maria Pia Sormani, Dana Horáková, Eva Havrdová, Michael Barnett , et al. · 2024

Icobrain should be utilised for PBVC determination only on selected MRIs with the best alignment similarity. Applying strict selection criteria for the included MRI pairs and longitudinal imaging on the same scanner remain mandatory to red…

Amygdala enlargement in temporal lobe epilepsy: Histopathology and surgical outcomes Open

Lubna Shakhatreh, Benjamin Sinclair, Catriona McLean, Elaine Lui, Andrew Morokoff , et al. · 2024

Objectives Amygdala enlargement is detected on magnetic resonance imaging (MRI) in some patients with drug‐resistant temporal lobe epilepsy (TLE), but its clinical significance remains uncertain We aimed to assess if the presence of amygda…

A worldwide ENIGMA study on epilepsy-related gray and white matter compromise across the adult lifespan Open

Judy Chen, Alexander Ngo, Raúl Rodríguez‐Cruces, Jessica Royer, Maria Eugenia Caligiuri , et al. · 2024

Objectives Temporal lobe epilepsy (TLE) is commonly associated with mesiotemporal pathology and widespread alterations of grey and white matter structures. Evidence supports a progressive condition although the temporal evolution of TLE is…

Combining OPM and lesion mapping data for epilepsy surgery planning: a simulation study Open

Stephanie Mellor, Ryan C. Timms, George C. O’Neill, Tim M. Tierney, Meaghan Elizabeth Spedden , et al. · 2024

When planning for epilepsy surgery, multiple potential sites for resection may be identified through anatomical imaging. Magnetoencephalography (MEG) using optically pumped sensors (OP-MEG) is a non-invasive functional neuroimaging techniq…

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Ara Feb, Arun Abraham, Cherry Agustin, Sydney Ahern, Sydney Badawy , et al. · 2024

3T sodium-MRI as predictor of neurocognition in nondemented older adults: a cross sectional study Open

Elaine Lui, Vijay Venkatraman, Sue Finch, Michelle Chua, Tie‐Qiang Li , et al. · 2024

Dementia is a burgeoning global problem. Novel magnetic resonance imaging (MRI) metrics beyond volumetry may bring new insight and aid clinical trial evaluation of interventions early in the Alzheimer’s disease course to complement existin…

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A. Lüttringhaus jun, Arun Abraham, Cherry Agustin, Sydney Ahern, Sydney Badawy , et al. · 2023

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Ara Apr, Arun Abraham, Cherry Agustin, Sydney Ahern, Sydney Badawy , et al. · 2023

Impact of Different Artificial Intelligence User Interfaces on Lung Nodule and Mass Detection on Chest Radiographs Open

Jennifer S. N. Tang, Jeffrey Lai, J. Bui, Wayland Wang, Paul Simkin , et al. · 2023

Text-only UI output significantly improved radiologist performance compared with no AI in the detection of lung nodules and masses on chest radiographs, but user preference did not correspond with user performance.Keywords: Artifici…

Three Zone Scanning Protocol For Lung Ultrasound: An Anatomical Basis Open

Alistair Royse, Elaine Lui, Dayu Gai, Ximena Cid‐Serra, David Canty , et al. · 2022

Interpretable surface-based detection of focal cortical dysplasias: a Multi-centre Epilepsy Lesion Detection study Open

Hannah Spitzer, Mathilde Ripart, Kirstie Whitaker, Felice D’Arco, Kshitij Mankad , et al. · 2022

One outstanding challenge for machine learning in diagnostic biomedical imaging is algorithm interpretability. A key application is the identification of subtle epileptogenic focal cortical dysplasias (FCDs) from structural MRI. FCDs are d…

Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression Open

Sara Larivière, Jessica Royer, Raúl Rodríguez‐Cruces, Casey Paquola, Maria Eugenia Caligiuri , et al. · 2022

Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations, but associations between neurobiological mechanisms and macroscale connectomics remain unclear. This multisite ENIGMA-Epilepsy study examined who…

Event‐based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross‐sectional data Open

Seymour M. Lopez, Leon Aksman, Neil P. Oxtoby, Sjoerd B. Vos, Jun Rao , et al. · 2022

Objective Recent work has shown that people with common epilepsies have characteristic patterns of cortical thinning, and that these changes may be progressive over time. Leveraging a large multicenter cross‐sectional cohort, we investigat…

Synthetic Haematocrit Formula at 3T Field Strength for the Assessment of Extracellular Volume on Cardiac MRI Open

S. Fogarty, M. Rosa, J. Bui, M. McCusker, A. Agostinelli , et al. · 2022

Interpretable surface-based detection of focal cortical dysplasias: a MELD study Open

Hannah Spitzer, Mathilde Ripart, Kirstie Whitaker, Antonio Napolitano, Luca De Palma , et al. · 2021

Introduction One outstanding challenge for machine learning in diagnostic biomedical imaging is algorithm interpretability. A key application is the identification of subtle epileptogenic focal cortical dysplasias (FCDs) from structural MR…

Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia: A MELD study Open

Konrad Wagstyl, Kirstie Whitaker, Armin Raznahan, Jakob Seidlitz, Petra E. Vértes , et al. · 2021

Objective Drug‐resistant focal epilepsy is often caused by focal cortical dysplasias (FCDs). The distribution of these lesions across the cerebral cortex and the impact of lesion location on clinical presentation and surgical outcome are l…

Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy Open

Bo‐yong Park, Sara Larivière, Raúl Rodríguez‐Cruces, Jessica Royer, Shahin Tavakol , et al. · 2021

Temporal lobe epilepsy, a common drug-resistant epilepsy in adults, is primarily a limbic network disorder associated with predominant unilateral hippocampal pathology. Structural MRI has provided an in vivo window into whole-brain grey ma…

Structural network alterations in focal and generalized epilepsy follow axes of epilepsy risk gene expression: An ENIGMA study Open

Sara Larivière, Jessica Royer, Raúl Rodríguez‐Cruces, Maria Eugenia Caligiuri, Antonio Gambardella , et al. · 2021

Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations, but associations between neurobiological mechanisms and macroscale connectomics remain unclear. This multisite ENIGMA-Epilepsy study examined who…

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Arun Abraham, Cherry Agustin, Sydney Ahern, Sydney Christen Barras, Adelaide Bartlett , et al. · 2021

7T Magnetic Resonance Imaging Quantification of Brain Glutamate in Acute Ischaemic Stroke Open

John-Paul Nicolo, Bradford A. Moffat, David Wright, Benjamin Sinclair, Andrew Neal , et al. · 2021

Topographic Divergence of Atypical Cortical Asymmetry and Regional Atrophy Patterns in Temporal Lobe Epilepsy: A Worldwide ENIGMA Study Open

Bo‐yong Park, Sara Larivière, Raúl Rodríguez‐Cruces, Jessica Royer, Shahin Tavakol , et al. · 2021

A bstract Temporal lobe epilepsy (TLE), a common drug-resistant epilepsy in adults, is primarily a limbic network disorder associated with predominant unilateral hippocampal pathology. Structural MRI has provided an in vivo window into who…

Aortic root measurement on CT: linear dimensions, aortic root area and comparison with echocardiography. A retrospective cross sectional study Open

Kai’En Leong, Henry Knipe, S. Binny, Heather Pascoe, Nathan Better , et al. · 2021

Objective: We sought to assess the different CT aortic root measurements and determine their relationship to transthoracic echocardiography (TTE). Methods: TTE and ECG-gated CT images were reviewed from 70 consecutive patients (mean age 54…

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