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View article: Production of antigenically stable enterovirus A71 virus-like particles in Pichia pastoris as a vaccine candidate
Production of antigenically stable enterovirus A71 virus-like particles in Pichia pastoris as a vaccine candidate Open
Enterovirus A71 (EVA71) causes widespread disease in young children with occasional fatal consequences. In common with other picornaviruses, both empty capsids (ECs) and infectious virions are produced during the viral lifecycle. While ini…
View article: Production of antigenically stable enterovirus A71 virus-like particles in<i>Pichia pastoris</i>as a vaccine candidate
Production of antigenically stable enterovirus A71 virus-like particles in<i>Pichia pastoris</i>as a vaccine candidate Open
Enterovirus A71 (EVA71) causes widespread disease in young children with occasional fatal consequences. In common with other picornaviruses, both empty capsids (ECs) and infectious virions are produced during the viral lifecycle. While ini…
View article: Detection of Enterovirus D68 in Wastewater Samples from the UK between July and November 2021
Detection of Enterovirus D68 in Wastewater Samples from the UK between July and November 2021 Open
Infection with enterovirus D68 (EV-D68) has been linked with severe neurological disease such as acute flaccid myelitis (AFM) in recent years. However, active surveillance for EV-D68 is lacking, which makes full assessment of this associat…
View article: Detection and Typing of Human Enteroviruses from Clinical Samples by Entire-Capsid Next Generation Sequencing
Detection and Typing of Human Enteroviruses from Clinical Samples by Entire-Capsid Next Generation Sequencing Open
There are increasing concerns of infections by enteroviruses (EVs) causing severe disease in humans. EV diagnostic laboratory methods show differences in sensitivity and specificity as well as the level of genetic information provided. We …
View article: Laboratory Growth and Genetic Manipulation of <i>Eimeria tenella</i>
Laboratory Growth and Genetic Manipulation of <i>Eimeria tenella</i> Open
Eimeria is a genus of apicomplexan parasites that contains a large number of species, most of which are absolutely host‐specific. Seven species have been recognized to infect chickens. Infection of susceptible chickens results in an intest…
View article: Differences in Antigenic Structure of Inactivated Polio Vaccines Made From Sabin Live-Attenuated and Wild-Type Poliovirus Strains: Impact on Vaccine Potency Assays
Differences in Antigenic Structure of Inactivated Polio Vaccines Made From Sabin Live-Attenuated and Wild-Type Poliovirus Strains: Impact on Vaccine Potency Assays Open
Homologous references are required to measure the antigen content of IPV products consistently. The first World Health Organization international standard for sIPV was established, with new, specific Sabin D-antigen units assigned.
View article: A newly described strain of Eimeria arloingi (strain A) belongs to the phylogenetic group of ruminant-infecting pathogenic species, which replicate in host endothelial cells in vivo
A newly described strain of Eimeria arloingi (strain A) belongs to the phylogenetic group of ruminant-infecting pathogenic species, which replicate in host endothelial cells in vivo Open
Coccidiosis caused by Eimeria species is an important disease worldwide, particularly in ruminants and poultry. Eimeria infection can result in significant economic losses due to costs associated with treatment and slower growth rates, or …
View article: Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis
Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis Open
Trypanosoma brucei relies on an essential Variant Surface Glycoprotein (VSG) coat for survival in the mammalian bloodstream. High VSG expression within an expression site body (ESB) is mediated by RNA polymerase I (Pol I), which in other e…
View article: Application of a new PCR-RFLP panel suggests a restricted population structure for Eimeria tenella in UK and Irish chickens
Application of a new PCR-RFLP panel suggests a restricted population structure for Eimeria tenella in UK and Irish chickens Open
•Eimeria tenella populations differ in genetic diversity between regions.•PCR-RFLP provides a robust tool to assess genetic diversity for Eimeria tenella.•Cost-effective genotyping can support expansion of population genetics for Eimeria.
View article: Viral proteins expressed in the protozoan parasite Eimeria tenella are detected by the chicken immune system
Viral proteins expressed in the protozoan parasite Eimeria tenella are detected by the chicken immune system Open