Eldon Spackman
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View article: Assessing the average causal effect of maternal postpartum depression diagnosis on subsequent child development at age five years: A causal analysis using the All Our Families cohort and administrative data in Alberta, Canada
Assessing the average causal effect of maternal postpartum depression diagnosis on subsequent child development at age five years: A causal analysis using the All Our Families cohort and administrative data in Alberta, Canada Open
Purpose Postpartum depression (PPD) is a prevalent public health issue impacting nearly 15% of mothers in the first year following childbirth. PPD has implications for the health and mental health of the mother and downstream effects for t…
View article: Identifying characteristics for a cost-effective psoriatic arthritis biomarker test: a development-focused health technology assessment
Identifying characteristics for a cost-effective psoriatic arthritis biomarker test: a development-focused health technology assessment Open
Objectives This study aimed to evaluate the required test characteristics that a psoriatic arthritis (PsA) biomarker test would need to achieve to be considered cost-effective. Methods We adapted an existing Markov model to compare a hypot…
View article: Cost-Effectiveness of Semaglutide in Patients With Obesity and Cardiovascular Disease
Cost-Effectiveness of Semaglutide in Patients With Obesity and Cardiovascular Disease Open
Semaglutide might be a cost-effective option for the publicly funded health care system contingent on initial pricing. Considering the candidate population-patients who are overweight or obese with preexisting cardiovascular disease-policy…
View article: Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT
Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT Open
Background Longitudinal observational studies suggest that patients who present early to secondary care with psoriatic arthritis have a better outcome. Outcome needs to be measured including domains important to patients. Objectives To ide…
View article: IPECAD Modeling Workshop 2023 Cross-Comparison Challenge on Cost-Effectiveness Models in Alzheimer’s Disease
IPECAD Modeling Workshop 2023 Cross-Comparison Challenge on Cost-Effectiveness Models in Alzheimer’s Disease Open
Trial data can be implemented in different ways across health-economic models leading to large variation in model predictions. We recommend (1) addressing the choice of outcome measure and treatment effectiveness assumptions in sensitivity…
View article: Do beta-amyloid-targeted interventions improve cognition, physical functioning, and overt behaviour of Alzheimer’s Disease (AD) patients: Protocol for meta-analysis of Phase 3 clinical trials both completed and terminated
Do beta-amyloid-targeted interventions improve cognition, physical functioning, and overt behaviour of Alzheimer’s Disease (AD) patients: Protocol for meta-analysis of Phase 3 clinical trials both completed and terminated Open
Accumulation of amyloid-beta (Aβ) in the brain has been explored as a primary cause of Alzheimer’s Disease (AD). Better known as the amyloid hypothesis, it has been the main target of researchers vying to bring their therapeutic interventi…
View article: Partial herd hoof trimming results in a higher economic net benefit than whole herd hoof trimming in dairy herds
Partial herd hoof trimming results in a higher economic net benefit than whole herd hoof trimming in dairy herds Open
Sole ulcers, a common cause of lameness is the costliest non-infectious foot lesion in dairy cows and one of the most prevalent non-infectious foot lesions in freestall housing systems. Costs associated with sole ulcers are treatment costs…
View article: Exploring the prospective acceptability of a healthy food incentive program from the perspective of people with type 2 diabetes and experiences of household food insecurity in Alberta, Canada
Exploring the prospective acceptability of a healthy food incentive program from the perspective of people with type 2 diabetes and experiences of household food insecurity in Alberta, Canada Open
Objective: FoodRx is a 12-month healthy food prescription incentive program for people with type 2 diabetes (T2DM) and experiences of household food insecurity. In this study, we aimed to explore potential users’ prospective acceptability …
View article: Logical Inconsistencies in the Health Years in Total and Equal Value of Life-Years Gained
Logical Inconsistencies in the Health Years in Total and Equal Value of Life-Years Gained Open
The HYT and evLYG approaches can result in logically inconsistent decisions. We recommend that decision makers avoid these approaches and that the logical consistency of any approaches proposed in future be thoroughly explored before consi…
View article: Examining the Relationship Between Screening for Postpartum Depression and Associated Child Health Service Utilization and Costs: A Study Using the All Our Families Cohort and Administrative Data
Examining the Relationship Between Screening for Postpartum Depression and Associated Child Health Service Utilization and Costs: A Study Using the All Our Families Cohort and Administrative Data Open
Introduction Despite a recognized association between maternal postpartum depression (PPD) and adverse child health outcomes, evidence examining the relationship between PPD symptoms and associated child health service utilization and cost…
View article: Neighbourhood deprivation, distance to nearest comprehensive stroke centre and access to endovascular thrombectomy for ischemic stroke: a population-based study
Neighbourhood deprivation, distance to nearest comprehensive stroke centre and access to endovascular thrombectomy for ischemic stroke: a population-based study Open
The results suggest that people from more deprived neighbourhoods in Alberta were less likely to be treated with EVT than those from less deprived neighbourhoods. Improving access to EVT for people living in remote locations may improve th…
View article: The comparative performance of three screening questionnaires for psoriatic arthritis in a primary care surveillance study
The comparative performance of three screening questionnaires for psoriatic arthritis in a primary care surveillance study Open
Objectives The objective of this study was to compare the performance of three PsA screening questionnaires in a primary care psoriasis surveillance study. Methods Participants with psoriasis, and not known to have PsA, were identified fro…
View article: The Association of Homelessness With Rates of Diabetes Complications: A Population-Based Cohort Study
The Association of Homelessness With Rates of Diabetes Complications: A Population-Based Cohort Study Open
OBJECTIVE To estimate the rates of diabetes complications and revascularization procedures among people with diabetes who have experienced homelessness compared with a matched cohort of nonhomeless control subjects. RESEARCH DESIGN AND MET…
View article: <strong>The association of homelessness with rates of diabetes complications: A population-based cohort study</strong>
<strong>The association of homelessness with rates of diabetes complications: A population-based cohort study</strong> Open
Objective: To estimate the rates of diabetes complications and revascularization procedures among people with diabetes who have experienced homelessness compared with a matched cohort of non-homeless controls. Research Design and Methods: …
View article: <strong>The association of homelessness with rates of diabetes complications: A population-based cohort study</strong>
<strong>The association of homelessness with rates of diabetes complications: A population-based cohort study</strong> Open
Objective: To estimate the rates of diabetes complications and revascularization procedures among people with diabetes who have experienced homelessness compared with a matched cohort of non-homeless controls. Research Design and Methods: …
View article: The Impact of Providing Material Benefits to Improve Access to Food on Clinical Parameters, Dietary Intake, and Household Food Insecurity in People with Diabetes: A Systematic Review with Narrative Synthesis
The Impact of Providing Material Benefits to Improve Access to Food on Clinical Parameters, Dietary Intake, and Household Food Insecurity in People with Diabetes: A Systematic Review with Narrative Synthesis Open
The high cost of healthy foods makes maintaining a healthy dietary pattern challenging, particularly among people with diabetes who are experiencing food insecurity. The objectives of this study were to: 1) review evidence on the impact of…
View article: A Better Way to Care for Long Term Care (LTC) residents in Times of Medical Urgency: Improving Acute Care transfers for LTC Residents.
A Better Way to Care for Long Term Care (LTC) residents in Times of Medical Urgency: Improving Acute Care transfers for LTC Residents. Open
Background: Prior to the pandemic, every day approximately 28 long term care (LTC) residents were transferred to an emergency department (ED) in Alberta. This was placing increasing strain on healthcare resources and potentially negatively…
View article: <i>Clostridioides difficile</i> Near-Patient Testing Versus Centralized Testing: A Pragmatic Cluster Randomized Crossover Trial
<i>Clostridioides difficile</i> Near-Patient Testing Versus Centralized Testing: A Pragmatic Cluster Randomized Crossover Trial Open
Background Management of suspected Clostridioides difficile infection (CDI) in the hospital setting typically results in patient isolation, laboratory testing, infection control, and presumptive treatment. We investigated whether implement…
View article: Observational evidence in support of screening for depression during pregnancy and the postpartum period
Observational evidence in support of screening for depression during pregnancy and the postpartum period Open
In their recently updated guideline for depression screening during pregnancy and the postpartum period, the Canadian Task Force on Preventive Health Care concluded that evidence is uncertain as to whether screening is beneficial relative …
View article: Cost‐effectiveness models for Alzheimer's disease and related dementias: IPECAD modeling workshop cross‐comparison challenge
Cost‐effectiveness models for Alzheimer's disease and related dementias: IPECAD modeling workshop cross‐comparison challenge Open
Introduction The credibility of model‐based economic evaluations of Alzheimer's disease (AD) interventions is central to appropriate decision‐making in a policy context. We report on the International PharmacoEconomic Collaboration on Alzh…
View article: Characteristics of People with Type I or Type II Diabetes with and without a History of Homelessness: A Population-based Cohort Study
Characteristics of People with Type I or Type II Diabetes with and without a History of Homelessness: A Population-based Cohort Study Open
Introduction Homelessness poses unique barriers to diabetes management. Population-level data on the risks of diabetes outcomes among people experiencing homelessness are needed to inform resource investment. The aim of this study was to c…
View article: A Healthy Food Prescription Incentive Program for Adults With Type 2 Diabetes Who Are Experiencing Food Insecurity: Protocol for a Longitudinal Qualitative Study
A Healthy Food Prescription Incentive Program for Adults With Type 2 Diabetes Who Are Experiencing Food Insecurity: Protocol for a Longitudinal Qualitative Study Open
Food insecurity is inadequate or insecure access to food due to financial constraints. Individuals experiencing food insecurity tend to have poorer diet quality compared to their food secure peers. Given the importance of maintaining healt…
View article: A Cost-Utility Analysis of the Syncope: Pacing or Recording in The Later Years (SPRITELY) Trial
A Cost-Utility Analysis of the Syncope: Pacing or Recording in The Later Years (SPRITELY) Trial Open
The PM strategy was dominant-that is, less costly and estimated to result in a greater number of QALYs. For patients with unexplained syncope, bifascicular block, and age > 50 years, a PM is more likely to be cost-effective than an ICM.