Eleanor J. Ward
YOU?
Author Swipe
View article: Placental Inflammation Leads to Abnormal Embryonic Heart Development
Placental Inflammation Leads to Abnormal Embryonic Heart Development Open
Background: Placental heart development and embryonic heart development occur in parallel, and these organs have been proposed to exert reciprocal regulation during gestation. Poor placentation has been associated with congenital heart dis…
View article: Loss of voltage-gated hydrogen channel 1 expression reveals heterogeneous metabolic adaptation to intracellular acidification by T cells
Loss of voltage-gated hydrogen channel 1 expression reveals heterogeneous metabolic adaptation to intracellular acidification by T cells Open
Voltage-gated hydrogen channel 1 (Hvcn1) is a voltage-gated proton channel, which reduces cytosol acidification and facilitates the production of ROS. The increased expression of this channel in some cancers has led to proposing Hvcn1 anta…
View article: Placental inflammation leads to abnormal embryonic heart development
Placental inflammation leads to abnormal embryonic heart development Open
Placental and embryonic heart development occurs in parallel, and these organs have been proposed to exert reciprocal regulation during gestation. Poor placentation has been associated with congenital heart disease (CHD), an important caus…
View article: Prognostic impact of chromosomal abnormalities and copy number alterations in adult B-cell precursor acute lymphoblastic leukaemia: a UKALL14 study
Prognostic impact of chromosomal abnormalities and copy number alterations in adult B-cell precursor acute lymphoblastic leukaemia: a UKALL14 study Open
View article: Neutrophils in pregnancy: New insights into innate and adaptive immune regulation
Neutrophils in pregnancy: New insights into innate and adaptive immune regulation Open
The immunology of pregnancy has been the focus of many studies to better understand how the mother is able to tolerate the presence of a semi‐allogeneic fetus. Far from the initial view of pregnancy as a state of immunosuppression, success…
View article: Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions
Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions Open
Autoantibody-mediated diseases are currently treated with intravenous immunoglobulin, which is thought to act in part via blockade of Fc gamma receptors, thereby inhibiting autoantibody effector functions and subsequent pathology. We aimed…
View article: Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment <i>in Vivo</i>
Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment <i>in Vivo</i> Open
The primary target of a novel series of immunosuppressive 7-piperazin-1-ylthiazolo[5,4- d]pyrimidin-5-amines was identified as the lipid kinase, PI4KIIIβ. Evaluation of the series highlighted their poor solubility and unwanted off-target a…
View article: Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis
Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis Open
(Immunity 47, 875–889, November 21, 2017). Main Text: The authors have noticed a reversal of labels identifying experimental treatment of samples analyzed by flow cytometry in Figure 3G. The left hand panels should have been labeled as IsC…
View article: Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis
Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis Open
View article: Mechanisms of T cell organotropism
Mechanisms of T cell organotropism Open