Explanipedia

The Prospective Physical Activity, Sitting, and Sleep consortium (ProPASS): addressing methodological and geographical barriers to inform global public health guidelines, interventions, and precision medicine (Preprint) Open

Emmanuel Stamatakis, Matthew Ahmadi, Nicholas A. Koemel, Ashley Atkins, John J. Mitchell , et al. · 2025

UNSTRUCTURED For decades, global guidance for sedentary behaviour and sleep has primarily been informed by studies that relied on self-report questionnaires to assess behaviours. However, it is widely recognised that self-reported data su…

The predictive power of brain-predicted age and leg strength on mobility decline in aging: findings from the Baltimore Longitudinal Study of Aging Open

Brooke A. Vaughan, Graciela Muñiz‐Terrera, Janet E. Simon, Dustin R. Grooms, Brian C. Clark , et al. · 2025

Muscle weakness and poor brain health both contribute to mobility limitations in older adults, but their respective contributions and interactions are not well understood. This study examines the relationship between magnetic resonance ima…

Family history of fracture and fracture risk: a meta-analysis to update the FRAX® risk assessment tool Open

Eugène McCloskey, Helena Johansson, Enwu Liu, Kristina Åkesson, Fred Anderson , et al. · 2025

A family history of fracture is confirmed as a significant BMD-independent predictor of future fracture risk. While parental hip fracture appears the strongest factor for future hip fracture, a family history of other fractures might be ap…

Sleep chart of biological aging clocks across organs and omics Open

Cliodhna Kate O’Toole, Zhiyuan Song, Filippos Anagnostakis, Zhijian Yang, Ye Tian , et al. · 2025

Optimal sleep plays a vital role in promoting healthy aging and enhancing longevity. This study proposes a Sleep Chart to assess the relationship between sleep duration and 23 biological aging clocks across 17 organ systems or tissues and …

Body mass index and subsequent fracture risk: a meta-analysis to update FRAX Open

Nicholas C. Harvey, Helena Johansson, Eugène McCloskey, Enwu Liu, Kristina Åkesson , et al. · 2025

The aim of this international meta-analysis was to quantify the predictive value of BMI for incident fracture and relationship of this risk with age, sex, follow-up time, and BMD. A total of 1 667 922 men and women from 32 countries (63 co…

Prognostic significance of the QuickSIN score for future hearing threshold deterioration Open

Jiayue Liu, Haotian Zou, Eleanor M. Simonsick, Joshua Stohl, Tobias Overath · 2025

Prediction of future aging-related slow gait and its determinants with deep learning and logistic regression Open

Alison Deatsch, Michael J. McKenna, Jonathan Palumbo, Qu Tian, Eleanor M. Simonsick , et al. · 2025

Background Identification of accelerated aging and its biomarkers can lead to more timely therapeutic interventions and decision-making. Therefore, we sought to predict aging-related slow gait, a known predictor of accelerated aging, and i…

Metabolic Markers Demonstrate the Heterogeneity of Walking Ability in Non-Disabled Community-Dwelling Older Adults Open

Shanshan Yao, Ziling Mao, Megan M. Marron, Eleanor M. Simonsick, Venkatesh L. Murthy , et al. · 2025

Background: Walking ability is important for the quality of life of older adults. A self-reported walking ability index (WAI) covering the difficulty and ease of walking captures a broader spectrum of walking ability in healthy older perso…

Narrow Walk, Condition II, Semi-Tandem, Tandem, and Single Leg Stance Test Failure Could Predict Falls in Older Adults Open

Colleen Brown, Marina Oktapodas Feiler, Eric R. Anson, Eleanor M. Simonsick · 2025

Current fall prevention guidelines are largely reactive to a history of falls and are thus an ineffective approach to primary fall prevention. This work aims to identify objective measures that predict fall risk to facilitate broader imple…

Correction to: Differential Associations of Cigar, Pipe, and Smokeless Tobacco Use Versus Combustible Cigarette Use With Subclinical Markers of Inflammation, Thrombosis, and Atherosclerosis: The Cross-Cohort Collaboration–Tobacco Working Group Open

Zhiqi Yao, Erfan Tasdighi, Zeina Dardari, Kunal Jha, Ngozi Osuji , et al. · 2025

Directionality between cognitive function and daily physical activity patterns Open

Francesca Marino, Jennifer A. Deal, Alden L. Gross, Yang An, Qu Tian , et al. · 2025

INTRODUCTION Physical activity is a modifiable risk factor for dementia, but cognitive function is also important for physical activity engagement. This study evaluated the directionality of associations between daily physical activity and…

Physical activity complexity, cognition, and risk of cognitive impairment and dementia in the Baltimore Longitudinal Study of Aging Open

Yurun Cai, Junhong Zhou, Paul Scott, Qu Tian, Amal A. Wanigatunga , et al. · 2025

INTRODUCTION Studies on physical activity (PA) and dementia mainly focus on activity quantity or intensity. Yet PA requires neuro‐coordination of movement, and it is unclear whether complexity of daily activity varies by cognitive status. …

Small Integrin binding Ligand N-linked Glycoproteins, prostate-specific antigen and time to prostate cancer diagnosis Open

Alka Jain, Ying Ni, Dou Zhang, Eleanor M. Simonsick, E. Jeffrey Metter , et al. · 2025

These observations support SIBLINGs as biomarkers that associate with DFS and OS in prediagnosis samples.

Pet Attachment and Influence as Moderators of the Relationships of Psychological Factors to Physical Function in Community-Residing Older Adults Open

Lincy Koodaly, Erika Friedmann, Nancy R. Gee, Eleanor M. Simonsick, Barbara Resnick , et al. · 2025

Background: The growth of the older adult population calls for innovative and cost-effective ways of promoting their physical, psychological, and cognitive health. Human–animal interaction, including pet ownership, is related to positive a…

Healthy Aging Metabolomic and Proteomic Signatures Across Multiple Physiological Compartments Open

Ruin Moaddel, Julián Candia, Ceereena Ubaida‐Mohien, Toshiko Tanaka, Ann Zenobia Moore , et al. · 2025

The study of biomarkers in biofluids and tissues expanded our understanding of the biological processes that drive physiological and functional manifestations of aging. However, most of these studies were limited to examining one biologica…

The association of previous and current non-chronic low back pain with daily physical activity in middle- and older-aged adults Open

Tatiana Rehder Gonçalves, Diana Barbosa Cunha, Mauro Felippe Felix Mediano, Amal A. Wanigatunga, Eleanor M. Simonsick , et al. · 2025

Cigar, Pipe, and Smokeless Tobacco Use and Cardiovascular Outcomes From Cross Cohort Collaboration Open

Erfan Tasdighi, Zhiqi Yao, Kunal Jha, Zeina Dardari, Ngozi Osuji , et al. · 2025

Importance Cardiovascular health outcomes associated with noncigarette tobacco products (cigar, pipe, and smokeless tobacco) remain unclear, yet such data are required for evidence-based regulation. Objective To investigate the association…

Olfaction and diabetes among older adults Open

Jiangwei Xia, Yaqun Yuan, Chenxi Li, Anna Kucharska‐Newton, Qu Tian , et al. · 2025

Both poor olfaction and diabetes are common in older adults. It is biologically plausible that they may be related and interact to affect the health of older adults. We examined the association between poor olfaction and diabetes and their…

ASSOCIATION OF KIDNEY MARKERS AND DUAL TRAJECTORIES OF COGNITIVE AND PHYSICAL FUNCTION Open

Aman Shrestha, Michelle Shardell, Chixiang Chen, Stephen L. Seliger, Charles Ginsberg , et al. · 2024

The interplay between kidney health and cognitive-physical function has garnered increased attention. Dual trajectories consider simultaneous longitudinal changes in cognitive-physical function. Among participants in the Health, Aging and …

BODY COMPOSITION CHANGE AND PHYSICAL FUNCTION AFTER INTENSIVE BEHAVIORAL WEIGHT LOSS INTERVENTION Open

Kacey Chae, Amie F. Bettencourt, Denise K. Houston, Eleanor M. Simonsick, Luigi Ferrucci , et al. · 2024

The LookAHEAD trial, an RCT of adults with obesity and diabetes, has demonstrated weight loss (WL) efficacy through intensive lifestyle intervention (ILI), but also a decline in lean mass (LM) after ILI. One potential concern with LM reduc…

OLFACTION AND COGNITIVE FUNCTION IN NONDEMENTED OLDER ADULTS: FINDINGS FROM HEALTH ABC Open

Yaqun Yuan, Keran W. Chamberlin, Chenxi Li, Zhehui Luo, Anna Kucharska‐Newton , et al. · 2024

We examined olfaction in relation to longitudinal change in cognitive function among 1987 community-dwelling participants of the Health, Aging and Body Composition study (aged 71-82 years, 52.8% women, and 33.1% Black race), free of dement…

SKELETAL MUSCLE OXIDATIVE CAPACITY AND LIFE COURSE PHYSICAL ACTIVITY IN PARTICIPANTS OF THE BLSA Open

Ann Zenobia Moore, Teresa Tian, Eleanor M. Simonsick, Luigi Ferrucci · 2024

Physical activity has been associated with measures of mitochondrial quality and mitochondrial dysfunction and is connected to many aging processes. However, most studies relating physical activity to mitochondrial measures only capture ph…

PET ATTACHMENT AND RETAINED PHYSICAL FUNCTION IN COMMUNITY RESIDING OLDER ADULT PET OWNERS Open

Erika Friedmann, Nancy R. Gee, Eleanor M. Simonsick, Barbara Resnick, Merve Gurlu , et al. · 2024

Pet ownership has been associated with slower deterioration in cardiorespiratory fitness (400-M walk time), gait speed, overall functional performance and physical well-being independent of age and comorbidities in older adults with increa…

ASSOCIATIONS OF CIRCADIAN REST/ACTIVITY RHYTHMS WITH METABOLIC SYNDROME IN MIDDLE-AGED AND OLDER ADULTS Open

Yiwei Yue, Jill A. Rabinowitz, Yang An, Marc Kaizi-Lutu, Chun‐Yu Liu , et al. · 2024

Circadian rhythm disturbances often co-occur with adverse cardiometabolic outcomes, including high blood pressure, obesity, and diabetes. However, the links between disrupted circadian rhythms and metabolic syndrome (MetS) are understudied…

RED BLOOD CELL DISTRIBUTION WIDTH: FURTHER INSIGHTS Open

Matt T. Oberdier, Marta Zampino, Michelle Shardell, Majd AlGhatrif, Edward G. Lakatta , et al. · 2024

Red blood cell distribution width (RDW) measures erythrocyte size variability and strongly predicts cardiovascular disease (CVD) morbidity and mortality. Our prior cross-sectional analysis showed that inflammation, metabolic rate, and body…

INFLUENZA VACCINATION AND OLFACTION IN OLDER ADULTS: FINDINGS FROM HEALTH ABC Open

Yaqun Yuan, Keran W. Chamberlin, Chenxi Li, Zhehui Luo, T. Tian , et al. · 2024

Olfactory impairment is common in older adults and is likely associated with multiple adverse health outcomes. However, few risk or protective factors for olfactory impairment in older adults have been identified. We examined the cross-sec…

LINKS OF SLEEP WITH CHANGES IN CARDIORESPIRATORY FITNESS AND ENERGETIC EFFICIENCY IN MIDDLE-AGED AND OLDER ADULTS Open

Yiwei Yue, Daniel D. Callow, Idiatou Diallo, Jill A. Rabinowitz, Sarah Wanigatunga , et al. · 2024

Sleep disturbances are linked to cardiovascular disease in middle-aged and older adults, but little is known about the associations of poor sleep with cardiovascular fitness and energetic measures in this population. We investigated cross-…

ALGORITHMICALLY DEFINED SENSORIMOTOR FUNCTION AND RISK OF MILD COGNITIVE IMPAIRMENT Open

Amal A. Wanigatunga, Hang Wang, Anis Davoudi, Ryan J. Dougherty, Qu Tian , et al. · 2024

Early detection of persons at risk for, or living with, mild cognitive impairment (MCI) is a public health priority. Sensorimotor functioning—the integration of sensory information with motor function signaling to perform tasks and interac…

Multi-ancestry genome-wide association study reveals novel genetic signals for lung function decline Open

Bonnie Patchen, Jingwen Zhang, Nathan Gaddis, Traci M. Bartz, Jing Chen , et al. · 2024

Rationale Accelerated decline in lung function contributes to the development of chronic respiratory disease. Despite evidence for a genetic component, few genetic associations with lung function decline have been identified. Objectives To…

Body Mass Index and Diabetes Incidence Across the Adult Lifespan: The Baltimore Longitudinal Study of Aging Open

Noemi Malandrino, E. Jeffrey Metter, Eleanor M. Simonsick, Josephine M. Egan, Chee W. Chia , et al. · 2024

Context Body composition and glucose metabolism change with aging. Whether different levels of body-mass-index (BMI) are needed to define diabetes risk across the adult lifespan is unknown. Objective This work aimed to investigate whether …

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