Eleftheria Diakogiannaki
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View article: Dysregulation of Hnf1b Gene Expression in Cultured Beta-Cells in Response to Cytotoxic Fatty Acid
Dysregulation of Hnf1b Gene Expression in Cultured Beta-Cells in Response to Cytotoxic Fatty Acid Open
Context Increased levels of circulating fatty acids deriving from over-nutrition are thought to contribute to the progressive beta-cell failure associated with type 2 diabetes. Pancreatic beta-cells in culture are sensitive to exposure to …
View article: Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells
Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells Open
GPR119 ligands strongly enhanced GLP-1 release from colonic cultures, reflecting the high proportion of colonic L-cells that exhibited cAMP responses to GPR119 agonists. Less GPR119-dependence could be demonstrated in the upper small intes…
View article: Stimulation of GLP-1 Secretion Downstream of the Ligand-Gated Ion Channel TRPA1
Stimulation of GLP-1 Secretion Downstream of the Ligand-Gated Ion Channel TRPA1 Open
Stimulus-coupled incretin secretion from enteroendocrine cells plays a fundamental role in glucose homeostasis and could be targeted for the treatment of type 2 diabetes. Here, we investigated the expression and function of transient recep…
View article: Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein–Coupled Receptor FFAR2
Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein–Coupled Receptor FFAR2 Open
Interest in how the gut microbiome can influence the metabolic state of the host has recently heightened. One postulated link is bacterial fermentation of “indigestible” prebiotics to short-chain fatty acids (SCFAs), which in turn modulate…
View article: Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic β-cells
Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic β-cells Open
Long-chain saturated and monounsaturated fatty acids differ in their propensity to induce β-cell death in vitro with palmitate (C16:0) being cytotoxic, whereas palmitoleate (C16:1n-7) is cytoprotective. We now show that this cytoprotective…