Explanipedia

A micellar nanoprobe for fluorescence image-guided delineation of glioblastoma margins Open

Mohammad Ali, Koen T H van der Kuil, Pavlo Khodakivskyi, Peter de Bruijn, Stijn L.W. Koolen , et al. · 2025

Despite remarkable advancements in (neuro)-oncology, glioblastoma (GBM) remains the most aggressive primary brain tumor with a dismal overall survival of 14-17 months. A critical factor contributing to its poor prognosis is the high local …

Near-infrared fatty acid molecular probe for image-guided surgery of glioblastoma Open

Meedie Ali, Pavlo Khodakivskyi, Ioannis Ntafoulis, Koen T H van der Kuil, Kranthi M. Panth , et al. · 2025

Targeted intracellular delivery of molecular cargo to hypoxic human breast cancer stem cells Open

Ashley V. Makela, Anthony Tundo, Huiping Liu, Doug Schneider, Terry Hermiston , et al. · 2025

Fetal programming by the maternal microbiome of offspring behavior, and DNA methylation and gene expression within the hippocampus Open

Kevin L. Gustafson, Susheel Bhanu Busi, Zachary L. McAdams, Rachael E. McCorkle, Pavlo Khodakivskyi , et al. · 2024

The microorganisms colonizing the gastrointestinal tract of animals, collectively referred to as the gut microbiome, affect numerous host behaviors dependent on the central nervous system (CNS). Studies comparing germ-free mice to normally…

A fatty-acid based probe for near infrared fluorescence guided surgery of glioblastoma Open

Meedie Ali, Pavlo Khodakivskyi, Martine L.M. Lamfers, Clemens W.G.M. Löwik, Clemens M.F. Dirven , et al. · 2024

High-grade gliomas (HGG) are the most common and most aggressive primary tumors of the brain. Despite recent advances in neuro-oncology survival of these tumors remains around 12-15 months. The first-line of treatment is surgical resection…

Targeted intracellular delivery of molecular cargo to hypoxic human breast cancer stem cells Open

Ashley V. Makela, Anthony Tundo, Huiping Liu, Doug Schneider, Terry Hermiston , et al. · 2024

Cancer stem cells (CSCs) drive tumorigenesis, are responsible for metastasis, and resist conventional therapies thus posing significant treatment challenges. CSCs reside in hypoxic tumor regions and therefore, effective therapies must targ…

A New Cathepsin D Targeting Drug Delivery System Based on Immunoliposomes Functionalized with Lipidated Pepstatin A Open

Andreja Kozak, Georgy Mikhaylov, Pavlo Khodakivskyi, Elena A. Goun, Boris Turk , et al. · 2023

Cathepsin D is an aspartic protease and one of the most abundant proteases. It is overexpressed in many cancers and plays an important role in tumor development, progression, and metastasis. While it is a physiologically intracellular prot…

P07.02.B A FATTY-ACID BASED PROBE FOR NEAR INFRARED FLUORESCENCE GUIDED SURGERY OF GLIOBLASTOMA Open

Mohammad Ali, Pavlo Khodakivskyi, Elena A. Goun, Martine L.M. Lamfers, Clemens W.G.M. Löwik , et al. · 2023

BACKGROUND Glioblastoma (GBM) is the most aggressive primary tumor of the brain with a median survival of 15 months. Maximal safe resection is the initial standard-of-care, but resection is limited by the diffuse invasiveness of the tumor.…

A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link between metastasis and NAD+ metabolism Open

Tamara Maric, Arkadiy Bazhin, Pavlo Khodakivskyi, Georgy Mikhaylov, Ekaterina Solodnikova , et al. · 2022

Portable bioluminescent platform for in vivo monitoring of biological processes in non-transgenic animals Open

Aleksey Yevtodiyenko, Arkadiy Bazhin, Pavlo Khodakivskyi, Aurélien Godinat, Ghyslain Budin , et al. · 2021

Noninvasive imaging and quantification of bile salt hydrolase activity: From bacteria to humans Open

Pavlo Khodakivskyi, Christian L. Lauber, Aleksey Yevtodiyenko, Arkadiy Bazhin, Stephen J. Bruce , et al. · 2021

Novel optical probes allow quantification of bile salt hydrolase activity in bacteria, clinical fecal samples, mice, and humans.

Bioluminescent compositions and uses thereof Open

Elena A. Goun, Pavlo Khodakivskyi, Manuel Drefahl, Aleksey Yevtodiyenko, Hacer Karataş · 2021

Compositions and methods for non-invasively monitoring the intracellular processing of a biomolecule are provided. The compositions have a novel thio-luciferin moiety which can be conjugated to the biomolecule directly or via a linker such…

Mitochondrial copper depletion suppresses triple-negative breast cancer in mice Open

Liyang Cui, Arvin M. Gouw, Edward L. LaGory, Shenghao Guo, Nabeel Attarwala , et al. · 2020

A bioluminescent probe for longitudinal monitoring of mitochondrial membrane potential Open

Arkadiy Bazhin, Riccardo Sinisi, Umberto De Marchi, Aurélie Hermant, Nicolas Sambiagio , et al. · 2020

Real-Time Imaging and Quantification of Peptide Uptake <i>in Vitro</i> and <i>in Vivo</i> Open

Hacer Karataş, Tamara Maric, Pier Luca D’Alessandro, Aleksey Yevtodiyenko, Thomas Vorherr , et al. · 2019

Peptides constitute an important class of drugs for the treatment of multiple metabolic, oncological, and neurodegenerative diseases, and several hundred novel therapeutic peptides are currently in the preclinical and clinical stages of de…

Bioluminescent-based imaging and quantification of glucose uptake in vivo Open

Tamara Maric, Georgy Mikhaylov, Pavlo Khodakivskyi, Arkadiy Bazhin, Riccardo Sinisi , et al. · 2019

A Universal Assay for Aminopeptidase Activity and Its Application for Dipeptidyl Peptidase-4 Drug Discovery Open

Arkadiy Bazhin, Marc Chambon, J.-M. Vesin, Julien Bortoli Chapalay, James W. Collins , et al. · 2018

Aminopeptidases, such as dipeptidyl peptidase-4 (DPP-4, CD26), are potent therapeutic targets for pharmacological interventions because they play key roles in many important pathological pathways. To analyze aminopeptidase activity in vitr…

Prediction of Occult Lymph Node Metastasis in Head and Neck Cancer with CD31 Vessel Quantification Open

Maxime Mermod, Massimo Bongiovanni, Tatiana V. Petrova, Elena A. Goun, Christian Simon , et al. · 2018

Objective The management of occult lymph node metastasis (LNM) in head and neck squamous cell carcinoma has been a matter of controversy for decades. The vascular density within the tumor microenvironment, as an indicator of ongoing angiog…

Bioorthogonal chemistry in bioluminescence imaging Open

Aurélien Godinat, Arkadiy Bazhin, Elena A. Goun · 2018

In Vivo Molecular Bioluminescence Imaging: New Tools and Applications Open

Laura Mezzanotte, Moniek van ‘t Root, Hacer Karataş, Elena A. Goun, Clemens W.G.M. Löwik · 2017

Elena A. Goun YOU? Author Swipe