Elena A. Nicu
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View article: Oral bacterial community dynamics during induction of gingival inflammation
Oral bacterial community dynamics during induction of gingival inflammation Open
Introduction The human oral cavity is a complex and dynamic microbial ecosystem integral to oral and overall health. While the specific roles of microbial communities in health and disease are not fully understood, dysbiosis of the oral mi…
View article: Periodontitis and Platelets Status: A Systematic Review With Meta‐Analysis and Trial Sequential Analysis
Periodontitis and Platelets Status: A Systematic Review With Meta‐Analysis and Trial Sequential Analysis Open
Aim Circulating platelets are essential in hemostasis, thrombosis, and immune responses. Modifications in platelet function may impact immunological reactions to dental biofilm and cardiovascular health. Understanding changes in platelet s…
View article: The evidence for placental microbiome and its composition in healthy pregnancies: A systematic review
The evidence for placental microbiome and its composition in healthy pregnancies: A systematic review Open
The results support the existence of a low biomass placental microbiota in healthy pregnancies. Some of the microbial taxa found in the placenta might have an oral origin. The high risk of quality bias for the majority of the included stud…
View article: Comparing periodontitis biomarkers in saliva, oral rinse and gingival crevicular fluid: A pilot study
Comparing periodontitis biomarkers in saliva, oral rinse and gingival crevicular fluid: A pilot study Open
Aim To explore the feasibility of screening for periodontitis by measuring biomarkers, namely total proteolytic activity (TPA), matrix metalloproteinase (MMP)‐8, chitinase, lysozyme or their combination, in saliva, oral rinse and gingival …
View article: Periodontal therapy increases neutrophil extracellular trap degradation
Periodontal therapy increases neutrophil extracellular trap degradation Open
In periodontitis, polymorphonuclear leucocytes (PMNs) are activated. They entrap and eliminate pathogens by releasing neutrophil extracellular traps (NETs). Abnormal NET degradation is part of a pro-inflammatory status, affecting co-morbid…
View article: The Possible Role of Neutrophils in the Induction of Osteoclastogenesis
The Possible Role of Neutrophils in the Induction of Osteoclastogenesis Open
The ligand of the receptor activator of NF- κ B (RANKL) is a key molecule in the formation of osteoclasts, the key cells that cause the disease-associated alveolar bone resorption in periodontitis. We hypothesized that polymorphonuclear le…
View article: A rapid, non-invasive tool for periodontitis screening in a medical care setting
A rapid, non-invasive tool for periodontitis screening in a medical care setting Open
View article: Oral Neutrophils Characterized: Chemotactic, Phagocytic, and Neutrophil Extracellular Trap (NET) Formation Properties
Oral Neutrophils Characterized: Chemotactic, Phagocytic, and Neutrophil Extracellular Trap (NET) Formation Properties Open
Maintenance of oral health is in part managed by the immune-surveillance and antimicrobial functions of polymorphonuclear leukocytes (PMNs), which migrate from the circulatory system through the oral mucosal tissues as oral PMNs (oPMNs). I…
View article: Oral Polymorphonuclear Neutrophil Contributes to Oral Health
Oral Polymorphonuclear Neutrophil Contributes to Oral Health Open
View article: Characterization of oral polymorphonuclear neutrophils in periodontitis patients: a case-control study
Characterization of oral polymorphonuclear neutrophils in periodontitis patients: a case-control study Open
View article: Survival, Retention, and Selective Proliferation of Lymphocytes Is Mediated by Gingival Fibroblasts
Survival, Retention, and Selective Proliferation of Lymphocytes Is Mediated by Gingival Fibroblasts Open
Periodontitis, a chronic inflammatory disease of the periodontium, is characterized by osteoclast-mediated alveolar bone destruction. Gingival fibroblasts (GFs) present in the bone-lining mucosa have the capacity to activate the formation …
View article: Emerging Concepts in the Resolution of Periodontal Inflammation: A Role for Resolvin E1
Emerging Concepts in the Resolution of Periodontal Inflammation: A Role for Resolvin E1 Open
Inflammatory response is a protective biological process intended to eliminate the harmful effect of the insulting influx. Resolution of inflammation constitutes an active sequence of overlapping events mediated by specialized proresolving…
View article: Genes Critical for Developing Periodontitis: Lessons from Mouse Models
Genes Critical for Developing Periodontitis: Lessons from Mouse Models Open
Since the etiology of periodontitis in humans is not fully understood, genetic mouse models may pinpoint indispensable genes for optimal immunological protection of the periodontium against tissue destruction. This review describes the cur…
View article: Impaired polymorphonuclear neutrophils in the oral cavity of edentulous individuals
Impaired polymorphonuclear neutrophils in the oral cavity of edentulous individuals Open
Oral health is characterized by functional oral polymorphonuclear neutrophils ( oPMN s). Edentulism might be associated with a loss of oPMN s because these cells enter the oral cavity primarily through the gingival crevices. The main aim o…
View article: Reduced platelet hyper-reactivity and platelet-leukocyte aggregation after periodontal therapy
Reduced platelet hyper-reactivity and platelet-leukocyte aggregation after periodontal therapy Open
View article: On the ecosystemic network of saliva in healthy young adults
On the ecosystemic network of saliva in healthy young adults Open
A dysbiotic state is believed to be a key factor in the onset of oral disease. Although oral diseases have been studied for decades, our understanding of oral health, the boundaries of a healthy oral ecosystem and ecological shift toward d…
View article: Oral polymorphonuclear neutrophil characteristics in relation to oral health: a cross-sectional, observational clinical study
Oral polymorphonuclear neutrophil characteristics in relation to oral health: a cross-sectional, observational clinical study Open