Elena Battaglioli
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View article: A comprehensive protocol for efficient differentiation of human NPCs into electrically competent neurons
A comprehensive protocol for efficient differentiation of human NPCs into electrically competent neurons Open
Our protocol provides clear instructions for generating reliable human neuronal cultures with defined electrophysiological properties to investigate neuronal differentiation and model diseases in vitro.
View article: LSD1/PRMT6-targeting gene therapy to attenuate androgen receptor toxic gain-of-function ameliorates spinobulbar muscular atrophy phenotypes in flies and mice
LSD1/PRMT6-targeting gene therapy to attenuate androgen receptor toxic gain-of-function ameliorates spinobulbar muscular atrophy phenotypes in flies and mice Open
View article: Violence against Women and Stress-Related Disorders: Seeking for Associated Epigenetic Signatures, a Pilot Study
Violence against Women and Stress-Related Disorders: Seeking for Associated Epigenetic Signatures, a Pilot Study Open
Background: Violence against women is a relevant health and social problem with negative consequences on women’s health. The interaction between genome and environmental factors, such as violence, represents one of the major challenges in …
View article: Preclinical and clinical evidence on the approach-avoidance conflict evaluation as an integrative tool for psychopathology – CORRIGENDUM
Preclinical and clinical evidence on the approach-avoidance conflict evaluation as an integrative tool for psychopathology – CORRIGENDUM Open
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View article: Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism
Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism Open
The histone demethylase KDM1A is a multi-faceted regulator of vital developmental processes, including mesodermal and cardiac tube formation during gastrulation. However, it is unknown whether the fine-tuning of KDM1A splicing isoforms, al…
View article: The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes
The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes Open
Protocadherin-19 (PCDH19) is a synaptic cell-adhesion molecule encoded by X-linked PCDH19, a gene linked with epilepsy. Here, we report a synapse-to-nucleus signaling pathway through which PCDH19 bridges neuronal activity with gene express…
View article: Sexual Dimorphism in the Brain Correlates of Adult-Onset Depression: A Pilot Structural and Functional 3T MRI Study
Sexual Dimorphism in the Brain Correlates of Adult-Onset Depression: A Pilot Structural and Functional 3T MRI Study Open
Major Depressive Disorder (MDD) is a disabling illness affecting more than 5% of the elderly population. Higher female prevalence and sex-specific symptomatology have been observed, suggesting that biologically-determined dimensions might …
View article: Preclinical and clinical evidence on the approach-avoidance conflict evaluation as an integrative tool for psychopathology
Preclinical and clinical evidence on the approach-avoidance conflict evaluation as an integrative tool for psychopathology Open
The approach-avoidance conflict (AAC), i.e. the competing tendencies to undertake goal-directed actions or to withdraw from everyday life challenges, stands at the basis of humans' existence defining behavioural and personality domains. Gr…
View article: The study of inhibitory control in elderly depression – an EEG-fMRI integrated study
The study of inhibitory control in elderly depression – an EEG-fMRI integrated study Open
View article: LSD1 is an environmental stress-sensitive negative modulator of the glutamatergic synapse
LSD1 is an environmental stress-sensitive negative modulator of the glutamatergic synapse Open
View article: Rationale, Relevance, and Limits of Stress-Induced Psychopathology in Rodents as Models for Psychiatry Research: An Introductory Overview
Rationale, Relevance, and Limits of Stress-Induced Psychopathology in Rodents as Models for Psychiatry Research: An Introductory Overview Open
Emotional and cognitive information processing represent higher-order brain functions. They require coordinated interaction of specialized brain areas via a complex spatial and temporal equilibrium among neuronal cell-autonomous, circuitry…
View article: Endocannabinoid-Epigenetic Cross-Talk: A Bridge toward Stress Coping
Endocannabinoid-Epigenetic Cross-Talk: A Bridge toward Stress Coping Open
There is no argument with regard to the physical and psychological stress-related nature of neuropsychiatric disorders. Yet, the mechanisms that facilitate disease onset starting from molecular stress responses are elusive. Environmental s…
View article: Psychiatric Disorders and lncRNAs: A Synaptic Match
Psychiatric Disorders and lncRNAs: A Synaptic Match Open
Psychiatric disorders represent a heterogeneous class of multifactorial mental diseases whose origin entails a pathogenic integration of genetic and environmental influences. Incidence of these pathologies is dangerously high, as more than…
View article: Termination of acute stress response by the endocannabinoid system is regulated through lysine‐specific demethylase 1‐mediated transcriptional repression of 2‐AG hydrolases ABHD6 and MAGL
Termination of acute stress response by the endocannabinoid system is regulated through lysine‐specific demethylase 1‐mediated transcriptional repression of 2‐AG hydrolases ABHD6 and MAGL Open
Acute environmental stress rarely implies long‐lasting neurophysiological and behavioral alterations. On the contrary, chronic stress exerts a potent toxic effect at the glutamatergic synapse whose altered physiology has been recognized as…
View article: SRF and SRFΔ5 Splicing Isoform Recruit Corepressor LSD1/KDM1A Modifying Structural Neuroplasticity and Environmental Stress Response
SRF and SRFΔ5 Splicing Isoform Recruit Corepressor LSD1/KDM1A Modifying Structural Neuroplasticity and Environmental Stress Response Open
View article: Multiple Layers of CDK5R1 Regulation in Alzheimer’s Disease Implicate Long Non-Coding RNAs
Multiple Layers of CDK5R1 Regulation in Alzheimer’s Disease Implicate Long Non-Coding RNAs Open
Cyclin-dependent kinase 5 regulatory subunit 1 (CDK5R1) gene encodes for p35, the main activator of Cyclin-dependent kinase 5 (CDK5). The active p35/CDK5 complex is involved in numerous aspects of brain development and function, and its de…
View article: Acute Stress-Induced Epigenetic Modulations and Their Potential Protective Role Toward Depression
Acute Stress-Induced Epigenetic Modulations and Their Potential Protective Role Toward Depression Open
Psychiatric disorders entail maladaptive processes impairing individuals' ability to appropriately interface with environment. Among them, depression is characterized by diverse debilitating symptoms including hopelessness and anhedonia, d…
View article: Adolescent THC exposure in female rats leads to cognitive deficits through a mechanism involving chromatin modifications in the prefrontal cortex
Adolescent THC exposure in female rats leads to cognitive deficits through a mechanism involving chromatin modifications in the prefrontal cortex Open
Background: Increasing cannabis consumption among adolescents, studies that link its early use with mental illnesses, and the political debate on cannabis legalization together call for an urgent need to study molecular underpinnings of ad…
View article: Epigenetic Etiology of Intellectual Disability
Epigenetic Etiology of Intellectual Disability Open
Intellectual disability (ID) is a prevailing neurodevelopmental condition associated with impaired cognitive and adaptive behaviors. Many chromatin-modifying enzymes and other epigenetic regulators have been genetically associated with ID …
View article: LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors
LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors Open
Genetic diseases often lead to rare and severe syndromes and the identification of the genetic and protein alterations responsible for the pathogenesis is essential to understand both the physiological and pathological role of the gene pro…
View article: LSD1 modulates stress-evoked transcription of immediate early genes and emotional behavior
LSD1 modulates stress-evoked transcription of immediate early genes and emotional behavior Open
Significance In mammals, different forms of stress, including psychosocial stress, can affect several aspects of health, fostering mood and anxiety disorders in humans. However, a lack of knowledge about the mechanisms underlying the brain…