Maria Elena Crespo‐López
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View article: A Brazilian Minamata disease? Neurologists must be aware of mercury exposure and intoxication
A Brazilian Minamata disease? Neurologists must be aware of mercury exposure and intoxication Open
Mercury intoxication poses a significant challenge and growing threat to public health, particularly in the Amazon region. Despite a known history of neurological damage, as evidenced by Japan's Minamata disease, mercury intoxication remai…
View article: A Scoping Review of Guidelines for Mercury Limits in Soil, Water, and Air: How Do Brazil’s Standards Compare to International and Developed Country Guidelines?
A Scoping Review of Guidelines for Mercury Limits in Soil, Water, and Air: How Do Brazil’s Standards Compare to International and Developed Country Guidelines? Open
View article: Raising awareness of riverine populations in the Brazilian Amazon about MeHg intoxication in APOE4 carriers: cardiovascular risk and potential benefit of native selenium diets
Raising awareness of riverine populations in the Brazilian Amazon about MeHg intoxication in APOE4 carriers: cardiovascular risk and potential benefit of native selenium diets Open
View article: Mercury Contamination and Co‑exposures in the Amazon Basin: At the Center of the Planetary Environmental Crisis
Mercury Contamination and Co‑exposures in the Amazon Basin: At the Center of the Planetary Environmental Crisis Open
Background: Mercury contamination remains a significant public health concern in the Amazon basin. This review synthesizes recent evidence on mercury exposure, health outcomes, and emerging co-exposures in the Amazon countries. Data…
View article: Environmental pollution challenges public health surveillance: the case of mercury exposure and intoxication in Brazil
Environmental pollution challenges public health surveillance: the case of mercury exposure and intoxication in Brazil Open
View article: Editorial: The outcomes of pollutants on glia
Editorial: The outcomes of pollutants on glia Open
Citation: Arrifano GP, Augusto-Oliveira M, Tremblay M-E and Crespo-Lopez ME (2024) Editorial: The outcomes of pollutants on glia. Front. Cell. Neurosci. 18:1444344. doi: 10.3389/fncel.2024.1444344
View article: Assessing the reaction to and efficacy of the Screener drug discovery and development board game as a pedagogical tool in postgraduate courses
Assessing the reaction to and efficacy of the Screener drug discovery and development board game as a pedagogical tool in postgraduate courses Open
Screener, a board game supplemented with online resources, was introduced and distributed by the Brazilian Society of Pharmacology and Experimental Therapeutics to postgraduate programs as an instructional tool for the process of drug disc…
View article: Revisiting Genetic Influence on Mercury Exposure and Intoxication in Humans: A Scoping Review
Revisiting Genetic Influence on Mercury Exposure and Intoxication in Humans: A Scoping Review Open
Human intoxication to mercury is a worldwide health problem. In addition to the type and length of exposure, the genetic background plays an important role in mercury poisoning. However, reviews on the genetic influence in mercury toxicity…
View article: Açaí juice (Euterpe oleraceae) prevents ethanol-induced motor impairments in adolescent female rats
Açaí juice (Euterpe oleraceae) prevents ethanol-induced motor impairments in adolescent female rats Open
Açaí (Euterpe oleracea), a natural species frequent in the Amazon biome is widely consumed by the inhabitants of the Amazon. Açaí juice presents high levels of antioxidant compounds, especially anthocyanins, which confer several pharmacolo…
View article: What We Know about Euterpe Genus and Neuroprotection: A Scoping Review
What We Know about Euterpe Genus and Neuroprotection: A Scoping Review Open
The Euterpe genus (mainly Euterpe oleracea Martius, Euterpe precatoria Martius, and Euterpe edulis Martius) has recently gained commercial and scientific notoriety due to the high nutritional value of its fruits, which are rich in polyphen…
View article: Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels: a concern for oral health
Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels: a concern for oral health Open
Although there are many studies on the health effects of methylmercury (MeHg) toxicity during in utero and early development, little is known about its effects on mineralized tissues present in the oral cavity, such as enamel structure. Th…
View article: Mercury in the Amazon: The danger of a single story
Mercury in the Amazon: The danger of a single story Open
Amazon conservation is essential for the global future. Mercury is currently among the worst global pollutants and most (78.5%) of the South-American emissions are from the Amazon. Current Brazilian legislation on mining activities and tra…
View article: Global Human Threat: The Potential Synergism between Mercury Intoxication and COVID-19
Global Human Threat: The Potential Synergism between Mercury Intoxication and COVID-19 Open
The COVID-19 pandemic affected billions of people worldwide, and exposure to toxic metals has emerged as an important risk factor for COVID-19 severity. Mercury is currently ranked as the third toxic substance of global concern for human h…
View article: Are Dental Caries Associated with Oxidative Stress in Saliva in Children and Adolescents? A Systematic Review
Are Dental Caries Associated with Oxidative Stress in Saliva in Children and Adolescents? A Systematic Review Open
This systematic review aimed to assess whether dental caries is associated with oxidative salivary stress. The searches were carried out in electronic databases, including PubMed, Scopus, Web of Science, the Cochrane Library, LILACS, OpenG…
View article: Deciphering the Global Proteomic Profile Involved in Methylmercury-Induced Cerebellar Neurodegeneration and Motor Dysfunction in Adult Rats
Deciphering the Global Proteomic Profile Involved in Methylmercury-Induced Cerebellar Neurodegeneration and Motor Dysfunction in Adult Rats Open
Mercury is a ubiquitous pollutant in the environment with potential neurotoxic effects. Several populations are susceptible to mercurial exposure, especially methylmercury (MeHg) at low doses for long periods through food consumption. Give…
View article: Toxicogenomics and Molecular Markers in Pollution
Toxicogenomics and Molecular Markers in Pollution Open
Pollution is defined as the presence in or introduction of a substance into the environment that has harmful or poisonous effects [...]
View article: The GABAergic System and Endocannabinoids in Epilepsy and Seizures: What Can We Expect from Plant Oils?
The GABAergic System and Endocannabinoids in Epilepsy and Seizures: What Can We Expect from Plant Oils? Open
Seizures and epilepsy are some of the most common serious neurological disorders, with approximately 80% of patients living in developing/underdeveloped countries. However, about one in three patients do not respond to currently available …
View article: Methylmercury Causes Neurodegeneration and Downregulation of Myelin Basic Protein in the Spinal Cord of Offspring Rats after Maternal Exposure
Methylmercury Causes Neurodegeneration and Downregulation of Myelin Basic Protein in the Spinal Cord of Offspring Rats after Maternal Exposure Open
Methylmercury (MeHg) is one of the most dangerous toxic pollutants spread throughout the earth. Chronic MeHg intoxication by contaminated food ingestion is the most common threat to human health, including impairment to the developing fetu…
View article: Salivary Glands after Prolonged Aluminum Exposure: Proteomic Approach Underlying Biochemical and Morphological Impairments in Rats
Salivary Glands after Prolonged Aluminum Exposure: Proteomic Approach Underlying Biochemical and Morphological Impairments in Rats Open
Aluminum (Al) is one of the most abundant elements on Earth, and its high extraction rate and industrial use make human exposure very common. As Al may be a human toxicant, it is important to investigate the effects of Al exposure, mainly …
View article: Methylmercury exposure during prenatal and postnatal neurodevelopment promotes oxidative stress associated with motor and cognitive damages in rats: an environmental-experimental toxicology study
Methylmercury exposure during prenatal and postnatal neurodevelopment promotes oxidative stress associated with motor and cognitive damages in rats: an environmental-experimental toxicology study Open
View article: From Molecules to Behavior in Long-Term Inorganic Mercury Intoxication: Unraveling Proteomic Features in Cerebellar Neurodegeneration of Rats
From Molecules to Behavior in Long-Term Inorganic Mercury Intoxication: Unraveling Proteomic Features in Cerebellar Neurodegeneration of Rats Open
Mercury is a severe environmental pollutant with neurotoxic effects, especially when exposed for long periods. Although there are several evidences regarding mercury toxicity, little is known about inorganic mercury (IHg) species and cereb…
View article: A systematic review of the mental health risks and resilience among pollution-exposed adolescents
A systematic review of the mental health risks and resilience among pollution-exposed adolescents Open
View article: Maternal methylmercury exposure changes the proteomic profile of the offspring’s salivary glands: Prospects on translational toxicology
Maternal methylmercury exposure changes the proteomic profile of the offspring’s salivary glands: Prospects on translational toxicology Open
Background Methylmercury (MeHg) remains a public health issue since developing organisms are particularly vulnerable to this environmental contaminant. This study investigated the effect of maternal MeHg exposure on the modulation of prote…
View article: Contributing to Understand the Crosstalk between Brain and Periphery in Methylmercury Intoxication: Neurotoxicity and Extracellular Vesicles
Contributing to Understand the Crosstalk between Brain and Periphery in Methylmercury Intoxication: Neurotoxicity and Extracellular Vesicles Open
Human exposure to methylmercury (MeHg) is currently high in regions such as the Amazon. Understanding the molecular changes associated with MeHg-induced neurotoxicity and the crosstalk with the periphery is essential to support early diagn…
View article: Living in the Southern Hemisphere: Metabolic Syndrome and Its Components in Amazonian Riverine Populations
Living in the Southern Hemisphere: Metabolic Syndrome and Its Components in Amazonian Riverine Populations Open
The metabolic syndrome (MetS) epidemic is a global challenge. Although developing countries (including Brazil, India, and South Africa) present a higher proportion of deaths by cardiovascular diseases than developed countries, most of our …
View article: Eating in the Amazon: Nutritional Status of the Riverine Populations and Possible Nudge Interventions
Eating in the Amazon: Nutritional Status of the Riverine Populations and Possible Nudge Interventions Open
The Amazon is the largest tropical forest in the world and a source of healthy food, such as fruits and fish. Surprisingly, the Amazonian riverine population present an increased prevalence (as high as 58%) of non-communicable diseases, su…
View article: Effects of pollution on adolescent mental health: a systematic review protocol
Effects of pollution on adolescent mental health: a systematic review protocol Open
View article: Lead‐Induced Motor Dysfunction Is Associated with Oxidative Stress, Proteome Modulation, and Neurodegeneration in Motor Cortex of Rats
Lead‐Induced Motor Dysfunction Is Associated with Oxidative Stress, Proteome Modulation, and Neurodegeneration in Motor Cortex of Rats Open
Lead (Pb) is a toxic metal with great neurotoxic potential. The aim of this study was to investigate the effects of a long‐term Pb intoxication on the global proteomic profile, oxidative biochemistry and neuronal density in motor cortex of…
View article: Maternal methylmercury exposure changes the proteomic profile of the offspring’s salivary glands: Prospects on translational toxicology
Maternal methylmercury exposure changes the proteomic profile of the offspring’s salivary glands: Prospects on translational toxicology Open
Background Methylmercury (MeHg) remains a public health issue since developing organisms are particularly vulnerable to this environmental contaminant. This study investigated the effect of maternal MeHg exposure on the modulation of prote…
View article: Human neurotoxicity of mercury in the Amazon: A scoping review with insights and critical considerations
Human neurotoxicity of mercury in the Amazon: A scoping review with insights and critical considerations Open
Human exposure to mercury is a major public health concern, causing neurological outcomes such as motor and visual impairment and learning disabilities. Currently, human exposure in the Amazon is among the highest in the world. A recent sy…