Elena García‐Martín
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View article: Copy Number Variant Duplications Associated with Essential Tremor
Copy Number Variant Duplications Associated with Essential Tremor Open
Background Essential tremor (ET) is a complex neurological disorder with a strong genetic basis, yet there remains a disparity between the estimated heritability and the currently known genetic risk of ET. This missing heritability of ET h…
View article: Automatic identification of neurodegenerative diseases with 3D point cloud-based analysis using geometric deep learning in OCT retinal images
Automatic identification of neurodegenerative diseases with 3D point cloud-based analysis using geometric deep learning in OCT retinal images Open
View article: A Superpixel-Based Algorithm for Detecting Optical Density Changes in Choroidal Optical Coherence Tomography Images of Diabetic Patients
A Superpixel-Based Algorithm for Detecting Optical Density Changes in Choroidal Optical Coherence Tomography Images of Diabetic Patients Open
Background: This study explored the diagnostic potential of image-processing analysis in optical coherence tomography (OCT) images to detect systemic vascular changes in individuals with systemic diseases. Methods: Ocular OCT images from t…
View article: Ketorolac, melatonin and latanoprost tri-loaded PLGA microspheres for neuroprotection in glaucoma
Ketorolac, melatonin and latanoprost tri-loaded PLGA microspheres for neuroprotection in glaucoma Open
Glaucoma is a multifactorial neurodegenerative disease that affects the retina and optic nerve. The aim of this work was to reach different therapeutics targets by co-encapsulating three neuroprotective substances with hypotensive (latanop…
View article: A pain in the hip: the under-used potential of fascia iliaca compartment block in the prehospital setting
A pain in the hip: the under-used potential of fascia iliaca compartment block in the prehospital setting Open
View article: EoFTCNets: Efficient Solar Flare Nowcasting using 3D Temporal Convolutional Networks (3DTCN)
EoFTCNets: Efficient Solar Flare Nowcasting using 3D Temporal Convolutional Networks (3DTCN) Open
In the evolving landscape of 21st-century space science, forecasting space weather events such as solar flares and Coronal Mass Ejections (CMEs) are crucial yet challenging. Solar flares are intense bursts of radiation caused by the releas…
View article: Deep Learning-Based Postural Asymmetry Detection Through Pressure Mat
Deep Learning-Based Postural Asymmetry Detection Through Pressure Mat Open
Deep learning, a subfield of artificial intelligence that uses neural networks with multiple layers, is rapidly changing healthcare. Its ability to analyze large datasets and extract relevant information makes it a powerful tool for improv…
View article: Multi-loaded PLGA microspheres as neuroretinal therapy in a chronic glaucoma animal model
Multi-loaded PLGA microspheres as neuroretinal therapy in a chronic glaucoma animal model Open
View article: Individual Prognostication of Disease Activity and Disability Worsening in Multiple Sclerosis With Retinal Layer Thickness <i>z</i> Scores
Individual Prognostication of Disease Activity and Disability Worsening in Multiple Sclerosis With Retinal Layer Thickness <i>z</i> Scores Open
In conclusion, our work demonstrated reference cohort-based z scores that account for age, a major driver for disease progression in MS, to be a promising approach for creating OCT-derived measures useable across devices and toward …
View article: Multi-loaded PLGA microspheres as neuroretinal therapy in a chronic glaucoma animal model
Multi-loaded PLGA microspheres as neuroretinal therapy in a chronic glaucoma animal model Open
This work focused on the co-encapsulation and simultaneous co-delivery of three different neuroprotective drugs in PLGA (poly(lactic-co-glycolic acid) microspheres for the treatment of glaucoma. For formulation optimization, dexamethasone …
View article: Whipple's Disease in Older Adults
Whipple's Disease in Older Adults Open
Background: Whipple’s disease is a rare disease that has been described as a multisystem infectious disorder caused by Thropheryma whipplei, and characterized by joint problems, weight loss, diarrhea, and other symptoms that can clinically…
View article: Association between direct transport to a cardiac arrest centre and survival following out-of-hospital cardiac arrest: A propensity-matched Aotearoa New Zealand study
Association between direct transport to a cardiac arrest centre and survival following out-of-hospital cardiac arrest: A propensity-matched Aotearoa New Zealand study Open
View article: Are two shocks better than one? Aotearoa New Zealand emergency medical services implement a new defibrillation strategy: implications for around nine patients per week
Are two shocks better than one? Aotearoa New Zealand emergency medical services implement a new defibrillation strategy: implications for around nine patients per week Open
View article: Immune Analysis Using Vitreous Optical Coherence Tomography Imaging in Rats with Steroid-Induced Glaucoma
Immune Analysis Using Vitreous Optical Coherence Tomography Imaging in Rats with Steroid-Induced Glaucoma Open
Glaucoma is a multifactorial pathology involving the immune system. The subclinical immune response plays a homeostatic role in healthy situations, but in pathological situations, it produces imbalances. Optical coherence tomography detect…
View article: Diagnosis of multiple sclerosis using optical coherence tomography supported by explainable artificial intelligence
Diagnosis of multiple sclerosis using optical coherence tomography supported by explainable artificial intelligence Open
View article: Corrigendum to “Laponite for biomedical applications: An ophthalmological perspective” [Mater. Today Bio 24 (2024) 100935]
Corrigendum to “Laponite for biomedical applications: An ophthalmological perspective” [Mater. Today Bio 24 (2024) 100935] Open
[This corrects the article DOI: 10.1016/j.mtbio.2023.100935.].
View article: 3D Point Cloud Analysis via Transformer-Based Graph Learning for Multiple Sclerosis Screening in OCT Images
3D Point Cloud Analysis via Transformer-Based Graph Learning for Multiple Sclerosis Screening in OCT Images Open
View article: Laponite for biomedical applications: An ophthalmological perspective
Laponite for biomedical applications: An ophthalmological perspective Open
Clay minerals have been applied in biomedicine for thousands of years. Laponite is a nanostructured synthetic clay with the capacity to retain and progressively release drugs. In recent years there has been a resurgence of interest in Lapo…
View article: Chronic Glaucoma Induced in Rats by a Single Injection of Fibronectin-Loaded PLGA Microspheres: IOP-Dependent and IOP-Independent Neurodegeneration
Chronic Glaucoma Induced in Rats by a Single Injection of Fibronectin-Loaded PLGA Microspheres: IOP-Dependent and IOP-Independent Neurodegeneration Open
To evaluate a new animal model of chronic glaucoma induced using a single injection of fibronectin-loaded biodegradable PLGA microspheres (Ms) to test prolonged therapies. 30 rats received a single injection of fibronectin-PLGA-Ms suspensi…
View article: Differential Study of Retinal Thicknesses in the Eyes of Alzheimer’s Patients, Multiple Sclerosis Patients and Healthy Subjects
Differential Study of Retinal Thicknesses in the Eyes of Alzheimer’s Patients, Multiple Sclerosis Patients and Healthy Subjects Open
Multiple sclerosis (MS) and Alzheimer’s disease (AD) cause retinal thinning that is detectable in vivo using optical coherence tomography (OCT). To date, no papers have compared the two diseases in terms of the structural differences they …
View article: Detecting Structural Changes in the Choroidal Layer of the Eye in Neurodegenerative Disease Patients through Optical Coherence Tomography Image Processing
Detecting Structural Changes in the Choroidal Layer of the Eye in Neurodegenerative Disease Patients through Optical Coherence Tomography Image Processing Open
Purpose: To evaluate alterations of the choroid in patients with a neurodegenerative disease versus healthy controls, a custom algorithm based on superpixel segmentation was used. Design: A cross-sectional study was conducted on data obtai…
View article: The OSCAR-MP Consensus Criteria for Quality Assessment of Retinal Optical Coherence Tomography Angiography
The OSCAR-MP Consensus Criteria for Quality Assessment of Retinal Optical Coherence Tomography Angiography Open
We propose a 3-step approach for standardized quality control: (1) To define a specific ROI, (2) to assess the occurrence of OCTA artifacts according to the OSCAR-MP criteria, and (3) to evaluate OCTA quality based on the occurrence of dif…
View article: Automatic Segmentation of Retinal Layers in Multiple Neurodegenerative Disorder Scenarios
Automatic Segmentation of Retinal Layers in Multiple Neurodegenerative Disorder Scenarios Open
Retinal Optical Coherence Tomography (OCT) allows the non-invasive direct observation of the central nervous system, enabling the measurement and extraction of biomarkers from neural tissue that can be helpful in the assessment of ocular, …
View article: Diagnosis of Multiple Sclerosis using Optical Coherence Tomography Supported by Explainable Artificial Intelligence
Diagnosis of Multiple Sclerosis using Optical Coherence Tomography Supported by Explainable Artificial Intelligence Open
Background/Objectives: Study of retinal structure based on optical coherence tomography (OCT) data can facilitate early diagnosis of relapsing-remitting multiple sclerosis (RRMS). Although artificial intelligence can provide highly reliabl…
View article: Explainable artificial intelligence toward usable and trustworthy computer-aided diagnosis of multiple sclerosis from Optical Coherence Tomography
Explainable artificial intelligence toward usable and trustworthy computer-aided diagnosis of multiple sclerosis from Optical Coherence Tomography Open
Background Several studies indicate that the anterior visual pathway provides information about the dynamics of axonal degeneration in Multiple Sclerosis (MS). Current research in the field is focused on the quest for the most discriminati…
View article: Evaluation of multiple sclerosis severity using a new OCT tool
Evaluation of multiple sclerosis severity using a new OCT tool Open
Purpose To assess the ability of a new posterior pole protocol to detect areas with significant differences in retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness in patients with multiple sclerosis versus healthy cont…
View article: The macular retinal ganglion cell layer as a biomarker for diagnosis and prognosis in multiple sclerosis: A deep learning approach
The macular retinal ganglion cell layer as a biomarker for diagnosis and prognosis in multiple sclerosis: A deep learning approach Open
Purpose The macular ganglion cell layer (mGCL) is a strong potential biomarker of axonal degeneration in multiple sclerosis (MS). For this reason, this study aims to develop a computer‐aided method to facilitate diagnosis and prognosis in …
View article: Diagnosis of multiple sclerosis using optical coherence tomography supported by artificial intelligence
Diagnosis of multiple sclerosis using optical coherence tomography supported by artificial intelligence Open
View article: Detecting Structural changes in the retina of neurodegenerative patients through OCT supervised segmentation
Detecting Structural changes in the retina of neurodegenerative patients through OCT supervised segmentation Open
Background To evaluate alterations of the choroid in neurodegenerative disease patients versus healthy controls using a custom supervised algorithm based on superpixel segmentation. Methods The prospective study protocol and procedures wer…