Lorena Elena Meliţ
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View article: Maternal HIV Infection and Antiretroviral Therapy in Pregnancy: Implications for Vertical Transmission, Fetal Safety, and Long-Term Infant Outcomes
Maternal HIV Infection and Antiretroviral Therapy in Pregnancy: Implications for Vertical Transmission, Fetal Safety, and Long-Term Infant Outcomes Open
HIV mother-to-child transmission (MTCT) continues to pose a significant public health challenge, especially in regions with limited resources, although the worldwide distribution of antiretroviral therapy (ART) has drastically lowered the …
View article: Microbiota—A Rescuing Modulator in Children Struggling with Functional Constipation
Microbiota—A Rescuing Modulator in Children Struggling with Functional Constipation Open
Constipation affects around 30% of children and in 95% of cases is functional (FC), a consequence of alterations in digestive tract peristalsis, modulated by the immune and nervous systems, bile acid metabolism, and the gut microbiota. The…
View article: The impact of pandemics on education—“a nice monster of COVID-19”—Mini review
The impact of pandemics on education—“a nice monster of COVID-19”—Mini review Open
The medical world carries a major burden in terms of specialized human resource and infrastructure. The recent COVID-19 pandemics revealed an urgent need for specialized medical professionals in order to preempt future natural disasters. T…
View article: A rare case of peripheral facial paralysis associated with meningococcal meningitis - case report
A rare case of peripheral facial paralysis associated with meningococcal meningitis - case report Open
Introduction. Meningococcal meningitis is a severe form of bacterial meningitis caused by the bacterium Neisseria meningitidis (N. meningitidis). It is a medical emergency and requires prompt treatment to prevent severe complications or de…
View article: The Negative Impact of Maternal HIV Infection on Birth Outcomes—Myth or Reality?
The Negative Impact of Maternal HIV Infection on Birth Outcomes—Myth or Reality? Open
Human Immunodeficiency Virus (HIV) infection during pregnancy poses significant risks to both maternal and child health, with potential adverse effects on perinatal outcomes. This study aimed to compare perinatal outcomes, including birth …
View article: Cytomegalovirus, a “Friend” of SARS-CoV-2: A Case Report
Cytomegalovirus, a “Friend” of SARS-CoV-2: A Case Report Open
Introduction: Cytomegalovirus (CMV) infection is present in a latent state in 70–90% of the immunocompetent population, and its reactivation might be triggered by inflammatory conditions such as post-COVID multisystem inflammatory syndrome…
View article: Pediatric inflammatory multisystem syndrome or Kawasaki disease - continuous challenges in Pediatrics - case report
Pediatric inflammatory multisystem syndrome or Kawasaki disease - continuous challenges in Pediatrics - case report Open
Introduction. Kawasaki disease (KD) and pediatric inflammatory multisystem syndrome (PIMS) are similar vasculitis conditions affecting medium and small vessels, particularly the coronary arteries. This study aimed to highlight diagnostic a…
View article: Mycoplasma pneumoniae pneumonia – challenges related to diagnosis and treatment in children
Mycoplasma pneumoniae pneumonia – challenges related to diagnosis and treatment in children Open
Introduction. Pneumonia is a common infectious disease among children, very familiar to pediatricians and a major cause of hospitalization worldwide. Mycoplasma pneumoniae (M. pneumoniae) - atypical pathogen, is estimated to be responsible…
View article: The Most Recent Insights into the Roots of Gastric Cancer
The Most Recent Insights into the Roots of Gastric Cancer Open
Helicobacter pylori (H. pylori) is the most common bacterial infection worldwide, usually being acquired during childhood, and its persistence into adulthood represents one of the main contributors of gastric carcinogenesis. Based on these…
View article: Prebiotics, Probiotics, and Synbiotics—A Research Hotspot for Pediatric Obesity
Prebiotics, Probiotics, and Synbiotics—A Research Hotspot for Pediatric Obesity Open
Childhood obesity is a major public health problem worldwide with an increasing prevalence, associated not only with metabolic syndrome, insulin resistance, hypertension, dyslipidemia, and non-alcoholic fatty liver disease (NAFLD), but als…
View article: Cyberbullying in teenagers – a true burden in the era of online socialization
Cyberbullying in teenagers – a true burden in the era of online socialization Open
Cyberbullying represents a major concern worldwide, especially among teenagers with major negative psychological impact. We performed a prospective online questionnaire-based study on 316 teenagers in order to assess the prevalence of cybe…
View article: COVID-19 and Cardiac Implications—Still a Mystery in Clinical Practice
COVID-19 and Cardiac Implications—Still a Mystery in Clinical Practice Open
Although initially the evolution of Coronavirus disease 2019 (COVID-19) seemed less severe in pediatric patients, in the three years since the beginning of the pandemics, several severe cases have been described, pediatric inflammatory mul…
View article: Current Worldwide Trends in Pediatric Helicobacter pylori Antimicrobial Resistance
Current Worldwide Trends in Pediatric Helicobacter pylori Antimicrobial Resistance Open
Helicobacter pylori (H. pylori) has acquired several resistance mechanisms in order to escape the currently used eradication regimens such as mutations that impair the replication, recombination, and transcription of DNA; the antibiotics c…
View article: Helicobacter pylori—The Bridge between Local and Systemic Inflammation in Children
Helicobacter pylori—The Bridge between Local and Systemic Inflammation in Children Open
Helicobacter pylori (H. pylori)-associated inflammatory status is no longer a debatable topic in children. The aim of our study was to to compare the inflammatory status in pediatric patients with H. pylori gastritis and non-H. pylori gast…
View article: Not Every Dyspepsia Is Related to Helicobacter pylori—A Case of Esophageal Inlet Patch in a Female Teenager
Not Every Dyspepsia Is Related to Helicobacter pylori—A Case of Esophageal Inlet Patch in a Female Teenager Open
Helicobacter pylori infection is one of the main causes of dyspepsia, but it is not the only cause. Esophageal inlet patches are areas of heterotopic gastric mucosa within the esophagus and are commonly located in the cervical part of the …
View article: Pathogen-Specific Benefits of Probiotic and Synbiotic Use in Childhood Acute Gastroenteritis: An Updated Review of the Literature
Pathogen-Specific Benefits of Probiotic and Synbiotic Use in Childhood Acute Gastroenteritis: An Updated Review of the Literature Open
Probiotics represent viable microorganisms which are found within the normal gut microbiota, that exert strain-specific benefits in the management of several gastrointestinal disorders in children, including acute gastroenteritis. This rev…
View article: Old and New Aspects of H. pylori-Associated Inflammation and Gastric Cancer
Old and New Aspects of H. pylori-Associated Inflammation and Gastric Cancer Open
H. pylori is involved in the development of 80% of gastric cancers and 5.5% of all malignant conditions worldwide.Its persistence within the host's stomach causes chronic inflammation, which is a well-known hallmark of carcinogenesis.A wid…
View article: Worldwide Prevalence and Risk Factors of Helicobacter pylori Infection in Children
Worldwide Prevalence and Risk Factors of Helicobacter pylori Infection in Children Open
Helicobacter pylori is usually acquired during childhood.The reports from the last two decades pointed out a decrease in H. pylori prevalence across geographical areas worldwide compared to previously reported data.Most of the studies perf…
View article: Traditional and Modern Diagnostic Approaches in Diagnosing Pediatric Helicobacter pylori Infection
Traditional and Modern Diagnostic Approaches in Diagnosing Pediatric Helicobacter pylori Infection Open
Helicobacter pylori (H.pylori) is the most common bacterial infection worldwide, is usually acquired during childhood and is related to gastric carcinogenesis during adulthood.Therefore, its early proper diagnosis and subsequent successful…
View article: Cardiological Monitoring – A Cornerstone for Pediatric Inflammatory Multisystem Syndrome Temporally Associated with COVID-19 Outcome: A Case Report and a Review from the Literature
Cardiological Monitoring – A Cornerstone for Pediatric Inflammatory Multisystem Syndrome Temporally Associated with COVID-19 Outcome: A Case Report and a Review from the Literature Open
Introduction Pediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) is a rare life-threatening condition requiring a complex management and multidisciplinary approach, whose outcome depends on the early d…
View article: New insights regarding Helicobacter pylori infection in children
New insights regarding Helicobacter pylori infection in children Open
Helicobacter pylori (H. pylori) are one of the most common infections during childhood, and if left untreated it might persist lifelong resulting in severe complications such as gastric malignancies. The epidemiology of this infection has …
View article: The Crosstalk between Vitamin D and Pediatric Digestive Disorders
The Crosstalk between Vitamin D and Pediatric Digestive Disorders Open
Vitamin D is a cyclopentane polyhydrophenanthrene compound involved mainly in bone health and calcium metabolism but also autophagy, modulation of the gut microbiota, cell proliferation, immune functions and intestinal barrier integrity. T…
View article: Worldwide Prevalence and Risk Factors of Helicobacter pylori Infection in Children
Worldwide Prevalence and Risk Factors of Helicobacter pylori Infection in Children Open
Helicobacter pylori is usually acquired during childhood. The reports from the last two decades pointed out a decrease in H. pylori prevalence across geographical areas worldwide compared to previously reported data. Most of the studies pe…
View article: Helicobacter pylori-Related Extraintestinal Manifestations—Myth or Reality
Helicobacter pylori-Related Extraintestinal Manifestations—Myth or Reality Open
It is well documented that Helicobacter pylori (H. pylori) can cause both gastrointestinal and extraintestinal manifestations. The latter one represents a major burden in terms of diagnosis and treatment. H. pylori-associated systemic subc…
View article: COVID-19 and PIMS—Two Different Entities, but the Same Trigger
COVID-19 and PIMS—Two Different Entities, but the Same Trigger Open
COVID-19 and PIMS represent two novel pathologies that have challenged the medical world during the last two years on account of their being very similar, but yet very different. Our aim was to comparatively assess children with SARS-CoV-2…
View article: Liver Disease Assessment in Children with Fontan and Glenn Surgeries for Univentricular Hearts—The Role of Elastography and Biochemical Fibrosis Markers
Liver Disease Assessment in Children with Fontan and Glenn Surgeries for Univentricular Hearts—The Role of Elastography and Biochemical Fibrosis Markers Open
Background: Children born with single-ventricle hearts require surgery in order to survive. Liver fibrosis is a known complication of Fontan surgery for univentricular hearts. Methods: In this study on 13 post-Fontan and 21 post-Glenn pati…
View article: Old and New Aspects of H. pylori-Associated Inflammation and Gastric Cancer
Old and New Aspects of H. pylori-Associated Inflammation and Gastric Cancer Open
H. pylori is involved in the development of 80% of gastric cancers and 5.5% of all malignant conditions worldwide. Its persistence within the host’s stomach causes chronic inflammation, which is a well-known hallmark of carcinogenesis. A w…
View article: Traditional and Modern Diagnostic Approaches in Diagnosing Pediatric Helicobacter pylori Infection
Traditional and Modern Diagnostic Approaches in Diagnosing Pediatric Helicobacter pylori Infection Open
Helicobacter pylori (H. pylori) is the most common bacterial infection worldwide, is usually acquired during childhood and is related to gastric carcinogenesis during adulthood. Therefore, its early proper diagnosis and subsequent successf…
View article: The importance of SARS-CoV-2 testing in pediatric population
The importance of SARS-CoV-2 testing in pediatric population Open
Pediatric population associates multiple peculiarities in terms of SARS-CoV-2 regarding the differences of symptoms in comparison to adults, but also the higher incidence of asymptomatic cases. The aim of these case reports is to underline…
View article: The Challenges of Eradicating Pediatric Helicobacter pylori Infection in the Era of Probiotics
The Challenges of Eradicating Pediatric Helicobacter pylori Infection in the Era of Probiotics Open
Helicobacter pylori (H. pylori), the most common infection of childhood, results in life-threatening complications during adulthood if left untreated. Most of these complications are related to H. pylori-induced chronic inflammation. The d…