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View article: Erythrocyte aggregation kinetics for studying the vascular phase of inflammation in patients with suspected acute coronary syndrome or acute stroke
Erythrocyte aggregation kinetics for studying the vascular phase of inflammation in patients with suspected acute coronary syndrome or acute stroke Open
Inflammation plays a complex role in the pathophysiology of both acute coronary syndrome (ACS) and acute stroke (AS). Erythrocyte aggregation is a physiological phenomenon. Its initial kinetics (EAK), measured at the point of care in 20s, …
View article: The effect of pre-stroke physical activity on the initial volume and growth of the brain infarct and the rate of recanalization: A post-hoc analysis of the rescue brain trial
The effect of pre-stroke physical activity on the initial volume and growth of the brain infarct and the rate of recanalization: A post-hoc analysis of the rescue brain trial Open
Background: – Pre-stroke physical activity is known to influence stroke severity and long-term outcomes. However, its effects on infarct volume and vascular recanalization remain unclear. Using data from the RESCUE BRAIN trial, we aimed to…
View article: Editorial: Cryptogenic ischemic stroke
Editorial: Cryptogenic ischemic stroke Open
View article: Transcranial ultrasound localization microscopy in moyamoya patients using a clinical ultrasound system
Transcranial ultrasound localization microscopy in moyamoya patients using a clinical ultrasound system Open
Background: Deep brain structures are supplied by perforating arteries, which are too thin to be observed with non-invasive and widely available clinical imaging methods. In moyamoya disease, main arteries in the base of the brain p…
View article: Transcranial Ultrasound Localization Microscopy in Moya Moya patients using a clinical ultrasound system
Transcranial Ultrasound Localization Microscopy in Moya Moya patients using a clinical ultrasound system Open
Background Deep brain structures are supplied by perforating arteries, these arteries are too thin to be observed with non-invasive and widely available clinical imaging methods. In Moya Moya disease, main arteries in the base of the brain…
View article: First‐ever acute ischemic strokes in <scp>HIV</scp>‐infected persons: A case–control study from stroke units
First‐ever acute ischemic strokes in <span>HIV</span>‐infected persons: A case–control study from stroke units Open
Objective The stroke risk for persons living with human immunodeficiency virus (PLHIVs) doubled compared to uninfected individuals. Stroke‐unit (SU)—access, acute reperfusion therapy—use and outcome data on PLHIVs admitted for acute ischem…
View article: Underlying Causes of TIA and Minor Ischemic Stroke and Risk of Major Vascular Events
Underlying Causes of TIA and Minor Ischemic Stroke and Risk of Major Vascular Events Open
Importance The coexistence of underlying causes in patients with transient ischemic attack (TIA) or minor ischemic stroke as well as their associated 5-year risks are not well known. Objective To apply the ASCOD (atherosclerosis, small ves…
View article: Editorial: Targeting inflammation to prevent complications in stroke
Editorial: Targeting inflammation to prevent complications in stroke Open
This Research Topic "Targeting inflammation to prevent complications in stroke" focuses on the 18 inflammatory response after stroke and other inflammatory diseases at the onset to prevent secondary 19 injuries that result in poor outcomes…
View article: Yield of Dual Therapy With Statin and Ezetimibe in the Treat Stroke to Target Trial
Yield of Dual Therapy With Statin and Ezetimibe in the Treat Stroke to Target Trial Open
Background: In atherosclerotic stroke, lipid-lowering treatment with a target LDL (low-density lipoprotein) cholesterol of <70 compared with 100±10 mg/dL reduced the risk of subsequent cardiovascular events. This post hoc analysis explored…
View article: European Stroke Organisation guidelines on treatment of patients with intracranial atherosclerotic disease
European Stroke Organisation guidelines on treatment of patients with intracranial atherosclerotic disease Open
The aim of the present European Stroke Organisation guideline is to provide clinically useful evidence-based recommendations on the management of patients with intracranial atherosclerotic disease (ICAD). The guidelines were prepared follo…
View article: Evaluating Rates of Recurrent Ischemic Stroke Among Young Adults With Embolic Stroke of Undetermined Source
Evaluating Rates of Recurrent Ischemic Stroke Among Young Adults With Embolic Stroke of Undetermined Source Open
In this large cohort of young adult patients with ESUS, there was a relatively low rate of subsequent ischemic stroke and a low frequency of new-onset AF. Most recurrent strokes also met the criteria for ESUS, suggesting the need for futur…
View article: Cerebello-Motor Paired Associative Stimulation and Motor Recovery in Stroke: a Randomized, Sham-Controlled, Double-Blind Pilot Trial
Cerebello-Motor Paired Associative Stimulation and Motor Recovery in Stroke: a Randomized, Sham-Controlled, Double-Blind Pilot Trial Open
View article: Intracranial Hemorrhage in the TST Trial
Intracranial Hemorrhage in the TST Trial Open
Background and Purpose: Although statins are effective in secondary prevention of ischemic stroke, they are also associated with an increase risk of intracranial hemorrhage (ICH) in certain conditions. In the TST trial (Treat Stroke to Tar…
View article: Impact of Lower vs Higher LDL Cholesterol Targets on Cardiovascular Events After Ischemic Stroke in Diabetic Patients
Impact of Lower vs Higher LDL Cholesterol Targets on Cardiovascular Events After Ischemic Stroke in Diabetic Patients Open
After an ischemic stroke with evidence of atherosclerosis, lipid lowering treatment with a target LDL cholesterol of less than 70 mg/dL compared to 100±10 mg/dL, reduced the risk of subsequent cardiovascular events. In this analysis, we ex…
View article: Impact of Lower Versus Higher LDL Cholesterol Targets on Cardiovascular Events After Ischemic Stroke in Patients With Diabetes
Impact of Lower Versus Higher LDL Cholesterol Targets on Cardiovascular Events After Ischemic Stroke in Patients With Diabetes Open
After an ischemic stroke with evidence of atherosclerosis, lipid-lowering treatment with a target LDL cholesterol of P = 0.016). In patients without diabetes, the HR was 0.87 (95% CI 0.66-1.14; P = 0.31; interaction P = 0…
View article: Impact of Lower vs Higher LDL Cholesterol Targets on Cardiovascular Events After Ischemic Stroke in Diabetic Patients
Impact of Lower vs Higher LDL Cholesterol Targets on Cardiovascular Events After Ischemic Stroke in Diabetic Patients Open
After an ischemic stroke with evidence of atherosclerosis, lipid lowering treatment with a target LDL cholesterol of less than 70 mg/dL compared to 100±10 mg/dL, reduced the risk of subsequent cardiovascular events. In this analysis, we ex…
View article: Aortic Sources of Embolism
Aortic Sources of Embolism Open
Aortic arch atheroma is a frequent finding in ischemic stroke patients. Its role as a source of cerebral emboli or a marker of atherosclerosis is unclear. Transesophageal echography is considered the gold standard for its detection, wherea…
View article: Osteopontin Predicts Three-Month Outcome in Stroke Patients Treated by Reperfusion Therapies
Osteopontin Predicts Three-Month Outcome in Stroke Patients Treated by Reperfusion Therapies Open
Establishing a prognosis at hospital admission after stroke is a major challenge. Inflammatory processes, hemostasis, vascular injury, and tissue remodeling are all involved in the early response to stroke. This study analyzes whether 22 s…
View article: Large vessel stroke in six patients following SARS‐CoV‐2 infection: a retrospective case study series of acute thrombotic complications on stable underlying atherosclerotic disease
Large vessel stroke in six patients following SARS‐CoV‐2 infection: a retrospective case study series of acute thrombotic complications on stable underlying atherosclerotic disease Open
Background and purpose Ischaemic stroke has been described in association with COVID‐19. Several pathophysiological mechanisms have been suggested, i.e. prothrombotic state, cardiac injury etc. It was sought to assess the potential associa…
View article: Changes in High-Density Lipoproteins Related to Outcomes in Patients with Acute Stroke
Changes in High-Density Lipoproteins Related to Outcomes in Patients with Acute Stroke Open
Modifications in high-density lipoprotein (HDL) particle sizes and HDL-binding proteins have been reported in stroke patients. We evaluated whether the lipoprotein profile, HDL composition and functionality were altered in stroke patients …
View article: Carotid Atherosclerosis Evolution When Targeting a Low-Density Lipoprotein Cholesterol Concentration <70 mg/dL After an Ischemic Stroke of Atherosclerotic Origin
Carotid Atherosclerosis Evolution When Targeting a Low-Density Lipoprotein Cholesterol Concentration <70 mg/dL After an Ischemic Stroke of Atherosclerotic Origin Open
Background: The TST trial (Treat Stroke to Target) showed the benefit of targeting a low-density lipoprotein cholesterol (LDL-C) concentration of <70 mg/dL in terms of reducing the risk of major cardiovascular events in 2860 patients with …
View article: Effect of In-Hospital Remote Ischemic Perconditioning on Brain Infarction Growth and Clinical Outcomes in Patients With Acute Ischemic Stroke
Effect of In-Hospital Remote Ischemic Perconditioning on Brain Infarction Growth and Clinical Outcomes in Patients With Acute Ischemic Stroke Open
ClinicalTrials.gov Identifier: NCT02189928.
View article: Benefit of Targeting a LDL (Low-Density Lipoprotein) Cholesterol <70 mg/dL During 5 Years After Ischemic Stroke
Benefit of Targeting a LDL (Low-Density Lipoprotein) Cholesterol <70 mg/dL During 5 Years After Ischemic Stroke Open
Background and Purpose— The TST trial (Treat Stroke to Target) evaluated the benefit of targeting a LDL (low-density lipoprotein) cholesterol of 4 mm, in a French and Korean population. The follow-up lasted a median of 5.3 years in French …
View article: Atrial Cardiopathy and Nonstenosing Large Artery Plaque in Patients With Embolic Stroke of Undetermined Source
Atrial Cardiopathy and Nonstenosing Large Artery Plaque in Patients With Embolic Stroke of Undetermined Source Open
Background and Purpose— Atrial cardiopathy and atherosclerotic plaque are two potential mechanisms underlying embolic strokes of undetermined source (ESUS). The relationship between these two mechanisms among ESUS patients remains unclear.…
View article: Twelve-month outcome in patients with stroke and atrial fibrillation not suitable to oral anticoagulant strategy: the WATCH-AF registry
Twelve-month outcome in patients with stroke and atrial fibrillation not suitable to oral anticoagulant strategy: the WATCH-AF registry Open
Aims Long-term oral anticoagulant (LTOAC) reduces ischaemic stroke recurrences. Because of bleeding history, frailty, cognitive impairment, comorbidities or patient refusal, many cannot be discharged from stroke unit on LTOAC. Proportion a…
View article: A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke
A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke Open
After an ischemic stroke or TIA with evidence of atherosclerosis, patients who had a target LDL cholesterol level of less than 70 mg per deciliter had a lower risk of subsequent cardiovascular events than those who had a target range of 90…
View article: Elucidating the Structural and Functional Correlates of Upper-Limb Poststroke Motor Impairment
Elucidating the Structural and Functional Correlates of Upper-Limb Poststroke Motor Impairment Open
Background and Purpose— Many studies have attempted to bring to light the neural correlates of poststroke motor impairment, but few have used multimodal approach to explain it. The aim of this study was to elucidate neural structural and f…
View article: Aortic Arch Atherosclerosis in Patients With Embolic Stroke of Undetermined Source
Aortic Arch Atherosclerosis in Patients With Embolic Stroke of Undetermined Source Open
Background and Purpose— Aortic arch atherosclerosis (AAA) is a possible source of embolism in patients with embolic stroke of undetermined source. Previous studies reported high rates of embolic events in patients with AAA, especially thos…
View article: Efficacy and Safety of Rivaroxaban Versus Aspirin in Embolic Stroke of Undetermined Source and Carotid Atherosclerosis
Efficacy and Safety of Rivaroxaban Versus Aspirin in Embolic Stroke of Undetermined Source and Carotid Atherosclerosis Open
Background and Purpose— The sources of emboli in patients with embolic stroke of undetermined source (ESUS) are multiple and may not respond uniformly to anticoagulation. In this exploratory subgroup analysis of patients with carotid ather…
View article: P305Value of aortic TBR measured on FDG-PET for the prediction of atherothrombotic events in a cohort of patients with overt coronary and carotid atherosclerotic disease
P305Value of aortic TBR measured on FDG-PET for the prediction of atherothrombotic events in a cohort of patients with overt coronary and carotid atherosclerotic disease Open
Introduction.In patients imaged for oncological indications, high vascular FDG uptake in the ascending aortic on FDG-PET was associated with an increased rate of cardiovascular events during follow-up.Whether the results observed in patien…