Elena Morelli
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View article: Phagophores are formed from multilamellar organelles which originate from the outer mitochondrial membrane following mitochondrial fusion
Phagophores are formed from multilamellar organelles which originate from the outer mitochondrial membrane following mitochondrial fusion Open
The origin of phagophore membranes for macroautophagy remains unclear. We demonstrate that in mammalian cells and in yeast, starvation induces fusion of mitochondria and the formation of an excess of outer mitochondrial membrane (OMM), whi…
View article: Development and Validation of a High-Performance Liquid Chromatography Diode Array Detector Method to Measure Seven Neonicotinoids in Wheat
Development and Validation of a High-Performance Liquid Chromatography Diode Array Detector Method to Measure Seven Neonicotinoids in Wheat Open
Neonicotinoids (NEOs), used as insecticides against aphids, whiteflies, lepidopterans, and beetles, have numerous detrimental impacts on human health, including chronic illnesses, cancer, infertility, and birth anomalies. Monitoring the re…
View article: Phenylalanine Butyramide: A Butyrate Derivative as a Novel Inhibitor of Tyrosinase
Phenylalanine Butyramide: A Butyrate Derivative as a Novel Inhibitor of Tyrosinase Open
Metabolites resulting from the bacterial fermentation of dietary fibers, such as short-chain fatty acids, especially butyrate, play important roles in maintaining gut health and regulating various biological effects in the skin. However, b…
View article: Advancing Lip Augmentation: State-of-the-Art 2D and 3D Analysis for Assessing Volume Enhancement and Lip Line Redefinition
Advancing Lip Augmentation: State-of-the-Art 2D and 3D Analysis for Assessing Volume Enhancement and Lip Line Redefinition Open
Over the preceding five decades, there has been a noticeable surge in the pursuit of achieving voluminous and well-defined lips. This trend has prompted an escalating number of individuals to undergo lip augmentation procedures, aiming for…
View article: Multi-Mycotoxin Analysis in Italian Grains Using Ultra-High-Performance Chromatography Coupled to Quadrupole Orbitrap Mass Spectrometry
Multi-Mycotoxin Analysis in Italian Grains Using Ultra-High-Performance Chromatography Coupled to Quadrupole Orbitrap Mass Spectrometry Open
Mycotoxins are a major source of contamination in cereals, posing risks to human health and causing significant economic losses to the industry. A comprehensive strategy for the analysis of 21 mycotoxins in Italian cereal grain samples (n …
View article: Validation of an Eco-Friendly Automated Method for the Determination of Glucose and Fructose in Wines
Validation of an Eco-Friendly Automated Method for the Determination of Glucose and Fructose in Wines Open
Fermentable sugar dosage helps oenologists to establish a harvest’s moment and control the fermentation process of the musts. The official analyses recommended for their determination are long, laborious, and must be carried out by special…
View article: Antagonizing S1P3 Receptor with Cell-Penetrating Pepducins in Skeletal Muscle Fibrosis
Antagonizing S1P3 Receptor with Cell-Penetrating Pepducins in Skeletal Muscle Fibrosis Open
S1P is the final product of sphingolipid metabolism, which interacts with five widely expressed GPCRs (S1P1-5). Increasing numbers of studies have indicated the importance of S1P3 in various pathophysiological processes. Recently, we have …
View article: Nosological Differences in the Nature of Punctate White Matter Lesions in Preterm Infants
Nosological Differences in the Nature of Punctate White Matter Lesions in Preterm Infants Open
Background: The pathogenesis of punctuate white matter lesions (PWMLs), a mild form of white matter damage observed in preterm infants, is still a matter of debate. Susceptibility-weighted imaging (SWI) allows to differentiate PWMLs based …
View article: Activity of the SNARE Protein SNAP29 at the Endoplasmic Reticulum and Golgi Apparatus
Activity of the SNARE Protein SNAP29 at the Endoplasmic Reticulum and Golgi Apparatus Open
Snap29 is a conserved regulator of membrane fusion essential to complete autophagy and to support other cellular processes, including cell division. In humans, inactivating SNAP29 mutations causes CEDNIK syndrome, a rare multi-systemic dis…
View article: Exploring the Photodynamic Properties of Two Antiproliferative Benzodiazopyrrole Derivatives
Exploring the Photodynamic Properties of Two Antiproliferative Benzodiazopyrrole Derivatives Open
The identification of molecules whose biological activity can be properly modulated by light is a promising therapeutic approach aimed to improve drug selectivity and efficacy on the molecular target and to limit the side effects compared …
View article: Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration Open
Macroautophagy/autophagy, a defense mechanism against aberrant stresses, in neurons counteracts aggregate-prone misfolded protein toxicity. Autophagy induction might be beneficial in neurodegenerative diseases (NDs). The natural compound t…
View article: How to use a multipurpose SNARE: The emerging role of Snap29 in cellular health
How to use a multipurpose SNARE: The emerging role of Snap29 in cellular health Open
Despite extensive study, regulation of membrane trafficking is incompletely understood. In particular, the specific role of SNARE (Soluble NSF Attachment REceptor) proteins for distinct trafficking steps and their mechanism of action, beyo…
View article: Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration Open
Macroautophagy/autophagy, a defense mechanism against aberrant stresses, in neurons counteracts aggregate-prone misfolded protein toxicity. Autophagy induction might be beneficial in neurodegenerative diseases (NDs). The natural compound t…