Elena Petukhova
YOU?
Author Swipe
View article: DriveLEDs: software for synchronous control and video acquisition of fluorescent signals
DriveLEDs: software for synchronous control and video acquisition of fluorescent signals Open
Current research uses various fluorescent biosensors to measure ion concentrations, neuronal activity, or cellular components in biological preparations. Several free solutions are available to researchers for recording or analysing fluore…
View article: Dependence of the xanthan exopolysaccharide synthesis on the composition of the nutritional medium
Dependence of the xanthan exopolysaccharide synthesis on the composition of the nutritional medium Open
The possibility of changing the composition of the feed by replacing glucose with equivalent amounts of sucrose, starch, maltose was investigated. It was found that in the case of using sucrose, the kinematic viscosity of the culture liqui…
View article: Action of the Photochrome Glyght on GABAergic Synaptic Transmission in Mouse Brain Slices
Action of the Photochrome Glyght on GABAergic Synaptic Transmission in Mouse Brain Slices Open
Glyght is a new photochromic compound described as an effective modulator of glycine receptors at heterologous expression, in brain slices and in zebrafish larvae. Glyght also caused weak inhibition of GABAA-mediated currents in a cell lin…
View article: Simultaneous Monitoring of pH and Chloride (Cl−) in Brain Slices of Transgenic Mice
Simultaneous Monitoring of pH and Chloride (Cl−) in Brain Slices of Transgenic Mice Open
Optosensorics is the direction of research possessing the possibility of non-invasive monitoring of the concentration of intracellular ions or activity of intracellular components using specific biosensors. In recent years, genetically enc…
View article: Subunit-Specific Photocontrol of Glycine Receptors by Azobenzene-Nitrazepam Photoswitcher
Subunit-Specific Photocontrol of Glycine Receptors by Azobenzene-Nitrazepam Photoswitcher Open
Photopharmacology is a unique approach that through a combination of photochemistry methods and advanced life science techniques allows the study and control of specific biological processes, ranging from intracellular pathways to brain ci…
View article: Analysis of efficacy of combined therapy of amyotrophic lateral sclerosis in mSOD1 transgenic mice model
Analysis of efficacy of combined therapy of amyotrophic lateral sclerosis in mSOD1 transgenic mice model Open
Amyotrophic lateral sclerosis is a progressive, fatal neurode-generative disease characterized by damage of the motor neurons of the brain and spinal cord. The lack of effective methods of therapy of amyotrophic lateral sclerosis is one of…
View article: Novel Acetylcholinesterase Inhibitors Based on Uracil Moiety for Possible Treatment of Alzheimer Disease
Novel Acetylcholinesterase Inhibitors Based on Uracil Moiety for Possible Treatment of Alzheimer Disease Open
In this study, novel derivatives based on 6-methyluracil and condensed uracil were synthesized, namely, 2,4-quinazoline-2,4-dione with ω-(ortho-nitrilebenzylethylamino) alkyl chains at the N atoms of the pyrimidine ring. In this series of …
View article: A photoswitchable GABA receptor channel blocker
A photoswitchable GABA receptor channel blocker Open
Background and Purpose Anion‐selective Cys‐loop receptors (GABA and glycine receptors) provide the main inhibitory drive in the CNS. Both types of receptor operate via chloride‐selective ion channels, though with different kinetics, pharma…
View article: Developmental Changes in the Inhibition of Glycinergic Synaptic Currents by Niflumic Acid in Hypoglossal Motoneurons
Developmental Changes in the Inhibition of Glycinergic Synaptic Currents by Niflumic Acid in Hypoglossal Motoneurons Open
Mammalian brainstem hypoglossal motoneurones (HMs) receive powerful synaptic glycinergic inputs and are involved in a variety of motor functions, including respiration, chewing, sucking, swallowing, and phonation. During the early postnata…
View article: Transcriptional Analysis of Blood Lymphocytes and Skin Fibroblasts, Keratinocytes, and Endothelial Cells as a Potential Biomarker for Alzheimer’s Disease
Transcriptional Analysis of Blood Lymphocytes and Skin Fibroblasts, Keratinocytes, and Endothelial Cells as a Potential Biomarker for Alzheimer’s Disease Open
Alzheimer’s disease (AD) is a devastating and progressive form of dementia that is typically associated with a build-up of amyloid-β plaques and hyperphosphorylated and misfolded tau protein in the brain. Presently, there is no single test…