Elena Pinelli
YOU?
Author Swipe
View article: Early immune profiling reveals distinct inflammatory responses between children and adults few days after primary SARS-CoV-2 infection
Early immune profiling reveals distinct inflammatory responses between children and adults few days after primary SARS-CoV-2 infection Open
Background To date, it is still not clear why during the COVID-19 pandemic children generally developed no or milder symptoms compared to adults. As innate immune responses are crucial in the early defense against pathogens, we aimed at pr…
View article: Cytokine profiles, blood parasite load and clinical features of visceral leishmaniasis in West Pokot County, Kenya
Cytokine profiles, blood parasite load and clinical features of visceral leishmaniasis in West Pokot County, Kenya Open
Visceral leishmaniasis (VL) is a severe infectious disease caused by protozoan parasites of the Leishmania donovani complex. Blood cytokine concentrations in VL patients can inform us about underlying immunopathogenesis and may serve as a …
View article: Human Monocytes Exposed to SARS-CoV-2 Display Features of Innate Immune Memory Producing High Levels of CXCL10 upon Restimulation
Human Monocytes Exposed to SARS-CoV-2 Display Features of Innate Immune Memory Producing High Levels of CXCL10 upon Restimulation Open
Introduction: A role for innate immune memory in protection during COVID-19 infection or vaccination has been recently reported. However, no study so far has shown whether the severe acute respiratory syndrome coronavirus 2 (…
View article: Supplementary Material for: Human monocytes exposed to SARS-CoV-2 display features of innate immune memory producing high levels of CXCL10 upon restimulation
Supplementary Material for: Human monocytes exposed to SARS-CoV-2 display features of innate immune memory producing high levels of CXCL10 upon restimulation Open
Introduction A role for innate immune memory in protection during COVID-19 infection or vaccination has been recently reported. However, no study so far has shown whether SARS-CoV-2 can train innate immune cells. The aim of this study was …
View article: Long Lasting Antibodies From Convalescent Pertussis Patients Induce ROS Production and Bacterial Killing by Human Neutrophils
Long Lasting Antibodies From Convalescent Pertussis Patients Induce ROS Production and Bacterial Killing by Human Neutrophils Open
Pertussis is a respiratory infection caused by the Gram-negative bacterium Bordetella pertussis . Despite high vaccination coverage this disease remains a public health concern worldwide. A better understanding of the protective immune res…
View article: Bordetella pertussis-infected innate immune cells drive the anti-pertussis response of human airway epithelium
Bordetella pertussis-infected innate immune cells drive the anti-pertussis response of human airway epithelium Open
View article: Naturally circulating pertactin-deficient <i>Bordetella pertussis</i> strains induce distinct gene expression and inflammatory signatures in human dendritic cells
Naturally circulating pertactin-deficient <i>Bordetella pertussis</i> strains induce distinct gene expression and inflammatory signatures in human dendritic cells Open
Respiratory infections caused by Bordetella pertussis are reemerging despite high pertussis vaccination coverage. Since the introduction of the acellular pertussis vaccine in the late twentieth century, circulating B. pertussis
View article: DC-SIGN signalling induced by Trichinella spiralis products contributes to the tolerogenic signatures of human dendritic cells
DC-SIGN signalling induced by Trichinella spiralis products contributes to the tolerogenic signatures of human dendritic cells Open
Tolerogenic dendritic cells (tolDCs) are central players in the maintenance of immune tolerance and thereby have been identified as the most favourable candidates for cell therapy of autoimmune diseases. We have recently shown that excreto…
View article: Ex vivo innate responses to particulate matter from livestock farms in asthma patients and healthy individuals
Ex vivo innate responses to particulate matter from livestock farms in asthma patients and healthy individuals Open
View article: Interactions between helminths and tuberculosis infections: Implications for tuberculosis diagnosis and vaccination in Africa
Interactions between helminths and tuberculosis infections: Implications for tuberculosis diagnosis and vaccination in Africa Open
Africa is the second most populous continent and has perennial health challenges. Of the estimated 181 million school aged children in sub-Saharan Africa (SSA), nearly half suffer from ascariasis, trichuriasis, or a combination of these in…
View article: Livestock farm particulate matter enhances airway inflammation in mice with or without allergic airway disease
Livestock farm particulate matter enhances airway inflammation in mice with or without allergic airway disease Open
Effects of airborne biological particulate matter (BioPM; from livestock farms) on the pulmonary airways are not well studied. The aim of the present study was to investigate whether fine (<2.5 μm) BioPM derived from indoor animal stables …
View article: Airborne particulate matter from goat farm increases acute allergic airway responses in mice
Airborne particulate matter from goat farm increases acute allergic airway responses in mice Open
Background: Inhalation exposure to biological particulate matter (BioPM) from livestock farms may provoke exacerbations in subjects suffering from allergy and asthma. The aim of this study was to use a murine model of allergic asthm…
View article: Activation of Human NK Cells by Bordetella pertussis Requires Inflammasome Activation in Macrophages
Activation of Human NK Cells by Bordetella pertussis Requires Inflammasome Activation in Macrophages Open
Pertussis is a highly contagious respiratory infection caused by the bacterium Bordetella pertussis. Humans are the only known natural reservoir of B. pertussis. In mice, macrophages and NK cells have a key role in confining …
View article: Microbiome composition of airborne particulate matter from livestock farms and their effect on innate immune receptors and cells
Microbiome composition of airborne particulate matter from livestock farms and their effect on innate immune receptors and cells Open
View article: <i>Bordetella pertussis</i> pertactin knock-out strains reveal immunomodulatory properties of this virulence factor
<i>Bordetella pertussis</i> pertactin knock-out strains reveal immunomodulatory properties of this virulence factor Open
Whooping cough, caused by Bordetella pertussis, has resurged and presents a global health burden worldwide. B. pertussis strains unable to produce the acellular pertussis vaccine component pertactin (Prn), have been emerging …
View article: The National Immunisation Programme in the Netherlands : Surveillance and developments in 2017-2018
The National Immunisation Programme in the Netherlands : Surveillance and developments in 2017-2018 Open
In 2017, about 760,000 children aged 0 to 19 years received a total of 2,140,000 vaccinations within the National Immunisation Programme (NIP). Participation in the NIP was high among children under 10 years of age, despite the drop by aro…
View article: Detection of opsonizing antibodies directed against a recently circulating Bordetella pertussis strain in paired plasma samples from symptomatic and recovered pertussis patients
Detection of opsonizing antibodies directed against a recently circulating Bordetella pertussis strain in paired plasma samples from symptomatic and recovered pertussis patients Open
View article: Virulence Associated Gene 8 of Bordetella pertussis Enhances Contact System Activity by Inhibiting the Regulatory Function of Complement Regulator C1 Inhibitor
Virulence Associated Gene 8 of Bordetella pertussis Enhances Contact System Activity by Inhibiting the Regulatory Function of Complement Regulator C1 Inhibitor Open
Bordetella pertussis is a Gram-negative bacterium and the causative agent of whooping cough. Whooping cough is currently re-emerging worldwide and, therefore, still poses a continuous global health threat. B. pertussis expres…
View article: <i>Bordetella pertussis</i> pertactin knock-out strains reveal immunomodulatory properties of this virulence factor
<i>Bordetella pertussis</i> pertactin knock-out strains reveal immunomodulatory properties of this virulence factor Open
Whooping cough, caused by Bordetella pertussis, has resurged and presents a global health burden worldwide. B. pertussis strains unable to produce the acellular pertussis vaccine component pertactin (Prn), have been emerging and in some co…
View article: Trichinella spiralis Excretory–Secretory Products Induce Tolerogenic Properties in Human Dendritic Cells via Toll-Like Receptors 2 and 4
Trichinella spiralis Excretory–Secretory Products Induce Tolerogenic Properties in Human Dendritic Cells via Toll-Like Receptors 2 and 4 Open
Trichinella spiralis, as well as its muscle larvae excretory-secretory products (ES L1), given either alone or via dendritic cells (DCs), induce a tolerogenic immune microenvironment in inbred rodents and successfully amelior…
View article: Acquisition of C1 inhibitor by Bordetella pertussis virulence associated gene 8 results in C2 and C4 consumption away from the bacterial surface
Acquisition of C1 inhibitor by Bordetella pertussis virulence associated gene 8 results in C2 and C4 consumption away from the bacterial surface Open
Whooping cough, or pertussis, is a contagious disease of the respiratory tract that is re-emerging worldwide despite high vaccination coverage. The causative agent of this disease is the Gram-negative Bordetella pertussis. Knowledge on com…
View article: Emerging Bordetella pertussis Strains Induce Enhanced Signaling of Human Pattern Recognition Receptors TLR2, NOD2 and Secretion of IL-10 by Dendritic Cells
Emerging Bordetella pertussis Strains Induce Enhanced Signaling of Human Pattern Recognition Receptors TLR2, NOD2 and Secretion of IL-10 by Dendritic Cells Open
Vaccines against pertussis have been available for more than 60 years. Nonetheless, this highly contagious disease is reemerging even in countries with high vaccination coverage. Genetic changes of Bordetella pertussis over time have been …
View article: Diagnosis of intestinal parasites in a rural community of Venezuela: Advantages and disadvantages of using microscopy or RT-PCR
Diagnosis of intestinal parasites in a rural community of Venezuela: Advantages and disadvantages of using microscopy or RT-PCR Open
View article: Complement evasion by Bordetella pertussis: implications for improving current vaccines
Complement evasion by Bordetella pertussis: implications for improving current vaccines Open
View article: SEROPOSITIVITY FOR ASCARIOSIS AND TOXOCARIOSIS AND CYTOKINE EXPRESSION AMONG THE INDIGENOUS PEOPLE IN THE VENEZUELAN DELTA REGION
SEROPOSITIVITY FOR ASCARIOSIS AND TOXOCARIOSIS AND CYTOKINE EXPRESSION AMONG THE INDIGENOUS PEOPLE IN THE VENEZUELAN DELTA REGION Open
The present study aimed at measuring seropositivities for infection by Ascaris suum and Toxocara canis using the excretory/secretory (E/S) antigens from Ascaris suum (AES) and Toxocara canis (TES) within an indigenous population. In additi…
View article: Secretory Products of<i>Trichinella spiralis</i>Muscle Larvae and Immunomodulation: Implication for Autoimmune Diseases, Allergies, and Malignancies
Secretory Products of<i>Trichinella spiralis</i>Muscle Larvae and Immunomodulation: Implication for Autoimmune Diseases, Allergies, and Malignancies Open
Trichinella spiralis has the unique ability to make itself “at home” by creating and hiding in a new type of cell in the host body that is the nurse cell. From this immunologically privileged place, the parasite orchestrates a long-lasting…