Elena S. Wall
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View article: Integrating biological knowledge for mechanistic inference in the host-associated microbiome
Integrating biological knowledge for mechanistic inference in the host-associated microbiome Open
Advances in high-throughput technologies have enhanced our ability to describe microbial communities as they relate to human health and disease. Alongside the growth in sequencing data has come an influx of resources that synthesize knowle…
View article: Complete Genome Sequence of a Staphylococcus epidermidis Isolate from Healthy Skin with Upregulation of Protease EcpA
Complete Genome Sequence of a Staphylococcus epidermidis Isolate from Healthy Skin with Upregulation of Protease EcpA Open
Staphylococcus epidermidis is a ubiquitous skin commensal that has the potential to become pathogenic and cause disease. Here, we report the complete genome sequence of a S. epidermidis strain isolated from adult healthy skin that shows hi…
View article: BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell mass
BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell mass Open
View article: A microbiota membrane disrupter disseminates to the pancreas and increases β-cell mass
A microbiota membrane disrupter disseminates to the pancreas and increases β-cell mass Open
Summary Microbiome dysbiosis is a feature of diabetes, but how microbial products influence insulin production is poorly understood. Here we report the mechanism of BefA, a microbiome-derived protein that increases proliferation of insulin…
View article: Enteric nervous system modulation of luminal pH modifies the microbial environment to promote intestinal health
Enteric nervous system modulation of luminal pH modifies the microbial environment to promote intestinal health Open
The enteric nervous system (ENS) controls many aspects of intestinal homeostasis, including parameters that shape the habitat of microbial residents. Previously we showed that zebrafish lacking an ENS, due to deficiency of the sox10 gene, …
View article: Enteric nervous system modulation of luminal pH modifies the microbial environment to promote intestinal health
Enteric nervous system modulation of luminal pH modifies the microbial environment to promote intestinal health Open
The enteric nervous system (ENS) controls many aspects of intestinal homeostasis, including parameters that shape the habitat of microbial residents. Previously we showed that zebrafish lacking an ENS, due to deficiency of the sox10 gene, …
View article: <i>Pseudocapillaria tomentosa</i> , <i>Mycoplasma</i> spp., and Intestinal Lesions in Experimentally Infected Zebrafish <i>Danio rerio</i>
<i>Pseudocapillaria tomentosa</i> , <i>Mycoplasma</i> spp., and Intestinal Lesions in Experimentally Infected Zebrafish <i>Danio rerio</i> Open
Intestinal neoplasms and preneoplastic lesions are common in zebrafish research facilities. Previous studies have demonstrated that these neoplasms are caused by a transmissible agent, and two candidate agents have been implicated: a My…
View article: <i>Pseudocapillaria tomentosa, Mycoplasma</i>spp., and intestinal lesions in experimentally infected zebrafish<i>Danio rerio</i>
<i>Pseudocapillaria tomentosa, Mycoplasma</i>spp., and intestinal lesions in experimentally infected zebrafish<i>Danio rerio</i> Open
Intestinal neoplasms and preneoplastic lesions are common in zebrafish research facilities. Previous studies have demonstrated that the neoplasms are caused by a transmissible agent, and two candidate agents have been implicated: a Mycopla…
View article: Swimming motility of a gut bacterial symbiont promotes resistance to intestinal expulsion and enhances inflammation
Swimming motility of a gut bacterial symbiont promotes resistance to intestinal expulsion and enhances inflammation Open
Some of the densest microbial ecosystems in nature thrive within the intestines of humans and other animals. To protect mucosal tissues and maintain immune tolerance, animal hosts actively sequester bacteria within the intestinal lumen. In…
View article: Sublethal antibiotics collapse gut bacterial populations by enhancing aggregation and expulsion
Sublethal antibiotics collapse gut bacterial populations by enhancing aggregation and expulsion Open
Antibiotics induce large and highly variable changes in the intestinal microbiome even at sublethal concentrations, through mechanisms that remain elusive. Using gnotobiotic zebrafish, which allow high-resolution examination of microbial d…
View article: Swimming motility and chemotaxis control the spatial organization, persistence, and inflammatory activity of a model intestinal pathobiont
Swimming motility and chemotaxis control the spatial organization, persistence, and inflammatory activity of a model intestinal pathobiont Open
SUMMARY Understanding the processes that spatially restrict resident gut bacteria and the mechanisms by which disease-causing pathobionts escape this control will open new avenues for microbiome-based therapies. Using live imaging and gene…
View article: Bacteria evoke alarm behaviour in zebrafish
Bacteria evoke alarm behaviour in zebrafish Open
View article: Low-dose antibiotics can collapse gut bacterial populations via a gelation transition
Low-dose antibiotics can collapse gut bacterial populations via a gelation transition Open
Antibiotics can profoundly alter the intestinal microbiome even at the sublethal concentrations often encountered through environmental contamination. The mechanisms by which low-dose antibiotics induce large yet highly variable changes in…
View article: Swimming Motility and Chemotaxis Control the Spatial Organization, Persistence, and Inflammatory Activity of a Model Intestinal Pathobiont
Swimming Motility and Chemotaxis Control the Spatial Organization, Persistence, and Inflammatory Activity of a Model Intestinal Pathobiont Open
View article: Bacterial Cohesion Predicts Spatial Distribution in the Larval Zebrafish Intestine
Bacterial Cohesion Predicts Spatial Distribution in the Larval Zebrafish Intestine Open
View article: Modernized Tools for Streamlined Genetic Manipulation and Comparative Study of Wild and Diverse Proteobacterial Lineages
Modernized Tools for Streamlined Genetic Manipulation and Comparative Study of Wild and Diverse Proteobacterial Lineages Open
A great challenge in microbiota research is the immense diversity of symbiotic bacteria with the capacity to impact the lives of plants and animals. Moving beyond correlative DNA sequencing-based studies to define the cellular and molecula…
View article: Bacterial cohesion predicts spatial distribution in the larval zebrafish intestine
Bacterial cohesion predicts spatial distribution in the larval zebrafish intestine Open
Are there general biophysical relationships governing the spatial organization of the gut microbiome? Despite growing realization that spatial structure is important for population stability, inter-bacterial competition, and host functions…
View article: Data S1. Excel spreadsheet containing data values plotted in main and supplemental figures.
Data S1. Excel spreadsheet containing data values plotted in main and supplemental figures. Open
Data S1. Excel spreadsheet containing data values plotted in main and supplemental figures.
View article: Table S1. Wild and Recombinant Bacteria.
Table S1. Wild and Recombinant Bacteria. Open
Table S1. Wild and Recombinant Bacteria.
View article: Table S2. Summary of traits exhibited by bacterial symbionts within the larval zebrafish intestine.
Table S2. Summary of traits exhibited by bacterial symbionts within the larval zebrafish intestine. Open
Table S2. Summary of traits exhibited by bacterial symbionts within the larval zebrafish intestine.
View article: File S1. E. coli strains and plasmids, plasmid construction details, nucleotide sequences of select genetic parts, and primers.
File S1. E. coli strains and plasmids, plasmid construction details, nucleotide sequences of select genetic parts, and primers. Open
File S1. E. coli strains and plasmids, plasmid construction details, nucleotide sequences of select genetic parts, and primers.
View article: File S2. attTn7 and 16S rRNA Nucleotide Sequences.
File S2. attTn7 and 16S rRNA Nucleotide Sequences. Open
File S2. attTn7 and 16S rRNA Nucleotide Sequences.
View article: Modernized Tools for Streamlined Genetic Manipulation of Wild and Diverse Symbiotic Bacteria
Modernized Tools for Streamlined Genetic Manipulation of Wild and Diverse Symbiotic Bacteria Open
The capacity to associate symbiotic bacteria with vital aspects of plant and animal biology is outpacing our understanding of the mechanisms shaping these interactions. A major barrier to mechanistic studies is the paucity of tools for gen…