Elena Vasyutina
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View article: Vesicular Release and Uptake of Circular LSD1-RNAs from Non-Cancer and Cancer Lung Cells
Vesicular Release and Uptake of Circular LSD1-RNAs from Non-Cancer and Cancer Lung Cells Open
Lysine-specific demethylase 1 (LSD1) is highly expressed in many cancer types and strongly associated with cancer progression and metastasis. Circular RNAs (circRNAs) are produced by back-splicing and influence the interactive RNA network …
View article: Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia
Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia Open
In chronic lymphocytic leukemia (CLL), epigenetic alterations are considered to centrally shape the transcriptional signatures that drive disease evolution and that underlie its biological and clinical subsets. Characterizations of epigene…
View article: Data from A Novel Recombinant Anti-CD22 Immunokinase Delivers Proapoptotic Activity of Death-Associated Protein Kinase (DAPK) and Mediates Cytotoxicity in Neoplastic B Cells
Data from A Novel Recombinant Anti-CD22 Immunokinase Delivers Proapoptotic Activity of Death-Associated Protein Kinase (DAPK) and Mediates Cytotoxicity in Neoplastic B Cells Open
The serine/threonine death-associated protein kinases (DAPK) provide pro-death signals in response to (oncogenic) cellular stresses. Lost DAPK expression due to (epi)genetic silencing is found in a broad spectrum of cancers. Within B-cell …
View article: Lilienthal N et al., Immunokinase-based B-lymphotoxic delivery of activated DAPK1; Supplements from A Novel Recombinant Anti-CD22 Immunokinase Delivers Proapoptotic Activity of Death-Associated Protein Kinase (DAPK) and Mediates Cytotoxicity in Neoplastic B Cells
Lilienthal N et al., Immunokinase-based B-lymphotoxic delivery of activated DAPK1; Supplements from A Novel Recombinant Anti-CD22 Immunokinase Delivers Proapoptotic Activity of Death-Associated Protein Kinase (DAPK) and Mediates Cytotoxicity in Neoplastic B Cells Open
Table S1: Expression of DAPK1 (a) and surface CD22 (b) in various cell lines; Table S2: Characteristics of CLL patients from whom samples were analyzed including for DAPK1/2 expression and responses to DK1KD-SGIII;Figure S1: Analysis of DA…
View article: Data from A Novel Recombinant Anti-CD22 Immunokinase Delivers Proapoptotic Activity of Death-Associated Protein Kinase (DAPK) and Mediates Cytotoxicity in Neoplastic B Cells
Data from A Novel Recombinant Anti-CD22 Immunokinase Delivers Proapoptotic Activity of Death-Associated Protein Kinase (DAPK) and Mediates Cytotoxicity in Neoplastic B Cells Open
The serine/threonine death-associated protein kinases (DAPK) provide pro-death signals in response to (oncogenic) cellular stresses. Lost DAPK expression due to (epi)genetic silencing is found in a broad spectrum of cancers. Within B-cell …
View article: Lilienthal N et al., Immunokinase-based B-lymphotoxic delivery of activated DAPK1; Supplements from A Novel Recombinant Anti-CD22 Immunokinase Delivers Proapoptotic Activity of Death-Associated Protein Kinase (DAPK) and Mediates Cytotoxicity in Neoplastic B Cells
Lilienthal N et al., Immunokinase-based B-lymphotoxic delivery of activated DAPK1; Supplements from A Novel Recombinant Anti-CD22 Immunokinase Delivers Proapoptotic Activity of Death-Associated Protein Kinase (DAPK) and Mediates Cytotoxicity in Neoplastic B Cells Open
Table S1: Expression of DAPK1 (a) and surface CD22 (b) in various cell lines; Table S2: Characteristics of CLL patients from whom samples were analyzed including for DAPK1/2 expression and responses to DK1KD-SGIII;Figure S1: Analysis of DA…
View article: The proto-oncogene TCL1A deregulates cell cycle and genomic stability in CLL
The proto-oncogene TCL1A deregulates cell cycle and genomic stability in CLL Open
Upregulation of the proto-oncogene T-cell leukemia/lymphoma 1A (TCL1A) is causally implicated in various B-cell and T-cell malignancies. High-level TCL1A correlates with aggressive disease features and inferior clinical outcomes. However, …
View article: Extracellular vesicles released from chronic lymphocytic leukemia cells exhibit a disease relevant mRNA signature and transfer mRNA to bystander cells
Extracellular vesicles released from chronic lymphocytic leukemia cells exhibit a disease relevant mRNA signature and transfer mRNA to bystander cells Open
B-cell chronic lymphocytic leukemia (CLL) is characterized by the clonal accumulation of mature apoptosis-resistant tumor cells in lymphoid tissues and the peripheral blood. Recently genetic and epigenetic aberrations associated with the p…
View article: A Novel Recombinant Anti-CD22 Immunokinase Delivers Proapoptotic Activity of Death-Associated Protein Kinase (DAPK) and Mediates Cytotoxicity in Neoplastic B Cells
A Novel Recombinant Anti-CD22 Immunokinase Delivers Proapoptotic Activity of Death-Associated Protein Kinase (DAPK) and Mediates Cytotoxicity in Neoplastic B Cells Open
The serine/threonine death-associated protein kinases (DAPK) provide pro-death signals in response to (oncogenic) cellular stresses. Lost DAPK expression due to (epi)genetic silencing is found in a broad spectrum of cancers. Within B-cell …