Explanipedia

Elevated gamma activity in left frontotemporal regions preceding sleep signals emotional arousal in Bipolar Disorders: Insights from a high-density EEG investigation Open

Renata del Giudice, Riccardo Stefanelli, Francesco Donati, Veronica Nisticò, Cecilia Casetta , et al. · 2025

Our findings suggest an alteration in sleep onset, efficiency, and REM density in euthymic BD patients, in the context of a preserved sleep duration. Some of these changes may be associated with a neural signature of cortical arousal that …

Valproate discontinuation in girls and women of childbearing age with epilepsy: An Italian multicenter retrospective study on prescribing patterns and outcomes Open

Roberta Esposto, Giovanni Falcicchio, Elena Zambrelli, Emanuele Cerulli Irelli, Giulia Monti , et al. · 2025

Objective This study aimed to identify prescribing behaviors in women of childbearing potential (WOCP) with epilepsy already taking valproate (VPA), and to investigate the relationship between VPA maintenance, substitution, reduction, or w…

A machine learning model to predict the risk of perinatal depression: Psychosocial and sleep-related factors in the Life-ON study cohort Open

Corrado Garbazza, Francesca Mangili, Tatiana Adele D'Onofrio, Daniele Malpetti, Silvia Riccardi , et al. · 2024

Risk of Major Congenital Malformations and Exposure to Antiseizure Medication Monotherapy Open

Dina Battino, Torbjörn Tomson, Erminio Bonizzoni, John Craig, Emilio Perucca , et al. · 2024

Importance Women with epilepsy (WWE) require treatment with antiseizure medications (ASMs) during pregnancy, which may be associated with an increased risk of major congenital malformations (MCMs) in their offspring. Objective To investiga…

Optimal risk and diagnosis assessment strategies in perinatal depression: A machine learning approach from the life-ON study cohort Open

Armando D’Agostino, Corrado Garbazza, Daniele Malpetti, Laura Azzimonti, Francesca Mangili , et al. · 2023

This study aimed to assess the concordance of various psychometric scales in detecting Perinatal Depression (PND) risk and diagnosis. A cohort of 432 women was assessed at 10-15th and 23-25th gestational weeks, 33-40 days and 180-195 days …

Living with Epilepsy in Adolescence in Italy: Psychological and Behavioral Impact Open

Katherine Turner, Francesca La Briola, Aglaia Vignoli, Elena Zambrelli, Valentina Chiesa , et al. · 2023

Background: People with epilepsy have a higher prevalence of behavioral and neuropsychiatric comorbidities compared to the general population and those with other chronic medical conditions, although the underlying clinical features remain…

Psychobiological personality traits of children and adolescents with disorders of arousal Open

Katherine Turner, Anna Castelnovo, Lampros Perogamvros, Robert Cloninger, Andrea Galbiati , et al. · 2022

Influence of chronotype on the incidence and severity of perinatal depression in the “Life-ON” study Open

Corrado Garbazza, Sandra Hackethal, Enrica Migliore, Armando D’Agostino, Chiara Serrati , et al. · 2022

Pregnant evening chronotypes show unhealthy lifestyle habits and sociodemographic characteristics commonly associated with a higher risk for PND. They also have a higher risk of developing PND symptoms in the first month after delivery. Ch…

Sleep disorders and mental health in hospital workers during the COVID-19 pandemic: a cross-sectional multicenter study in Northern Italy Open

Paola Proserpio, Elena Zambrelli, Andrea Lanza, Ambra Dominese, Roberta Di Giacomo , et al. · 2022

Psychobiological personality traits of children and adolescents with disorders of arousal Open

Anna Castelnovo, Katherine Turner, Lampros Perogamvros, Robert Cloninger, Alessia Bertolotti , et al. · 2022

Disorders of arousal (DOA) are Non-Rem Sleep (NREM) parasomnias that emerge from incomplete arousal out of deep sleep and lead to a broad variety of emotional and motor behaviours. Increasing evidence supports the hypothesis that specific …

Sleep disorders and mental health in hospital workers during the COVID-19 pandemic: a cross-sectional multicenter study in Northern Italy Open

Paola Proserpio, Elena Zambrelli, Andrea Lanza, Ambra Dominese, Roberta Di Giacomo , et al. · 2022

Effects of Supplementation With Antioxidant Agents on Sleep in Autism Spectrum Disorder: A Review Open

Elena Zambrelli, Althea Lividini, Sofia Spadavecchia, Katherine Turner, Maria Paola Canevini · 2021

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition, whose etiology remains poorly understood in most cases. Several genetic, epigenetic and environmental factors have been implicated in ASD pathogenesis and nume…

Epilepsy in adult patients with tuberous sclerosis complex Open

Aglaia Vignoli, Francesca La Briola, Katherine Turner, Angela Peron, Chiara Vannicola , et al. · 2021

Epilepsy in TSC can be a lifelong disorder, but one-third of individuals reach seizure freedom by early adulthood. In the long term, age at epilepsy onset has a crucial role in drug resistance and in developing intellectual disability, bot…

Alternatives to valproate in girls and women of childbearing potential with Idiopathic Generalized Epilepsies: state of the art and guidance for the clinician proposed by the Epilepsy and Gender Commission of the Italian League Against Epilepsy (LICE) Open

Barbara Mostacci, Federica Ranzato, Loretta Giuliano, Angela La Neve, Umberto Aguglia , et al. · 2020

De novo ARHGEF9 missense variants associated with neurodevelopmental disorder in females: expanding the genotypic and phenotypic spectrum of ARHGEF9 disease in females Open

Marcello Scala, Evelien Zonneveld‐Huijssoon, Marianna Brienza, Oriano Mecarelli, Annemarie H. van der Hout , et al. · 2020

Reply to ‘Delirium, sleep, COVID-19 and melatonin’ Open

Armando D’Agostino, Elena Zambrelli · 2020

Delirium and sleep disturbances in COVID–19: a possible role for melatonin in hospitalized patients? Open

Elena Zambrelli, Mariapaola Canevini, Orsola Gambini, Armando D’Agostino · 2020

Antiepileptic Drug Teratogenicity and De Novo Genetic Variation Load Open

Piero Perucca, Alison Anderson, Dana Jazayeri, Alison Hitchcock, Janet Graham , et al. · 2020

Objective The mechanisms by which antiepileptic drugs (AEDs) cause birth defects (BDs) are unknown. Data suggest that AED‐induced BDs may result from a genome‐wide increase of de novo variants in the embryo, a mechanism that we investigate…

Declining malformation rates with changed antiepileptic drug prescribing Open

Torbjörn Tomson, Dina Battino, Erminio Bonizzoni, John Craig, Dick Lindhout , et al. · 2019

There have been major changes in AED prescription patterns over the years covered by the study. In parallel, we observed a significant 27% decrease in the prevalence of MCMs. The results of adjusting the trend analysis for MCMs for changes…

Level of empowerment and decision-making style of women with epilepsy in childbirth age Open

Katherine Turner, Ilaria Cutica, Silvia Riva, Elena Zambrelli, Maria Paola Canevini , et al. · 2019

Defining the electroclinical phenotype and outcome of PCDH19‐related epilepsy: A multicenter study Open

Marina Trivisano, Nicola Pietrafusa, Antonio Terracciano, Carla Marini, Davide Mei , et al. · 2018

Summary Objective PCDH 19‐related epilepsy is an epileptic syndrome with infantile onset, characterized by clustered and fever‐induced seizures, often associated with intellectual disability ( ID ) and autistic features. The aim of this st…

Chronobiology, sleep-related risk factors and light therapy in perinatal depression: the “Life-ON” project Open

Simone Baiardi, Fabio Cirignotta, Alessandro Cicolin, Corrado Garbazza, Armando D’Agostino , et al. · 2016

Laryngeal motility alteration: A missing link between sleep apnea and vagus nerve stimulation for epilepsy Open

Elena Zambrelli, Alberto Maria Saibene, Francesca Furia, Valentina Chiesa, Aglaia Vignoli , et al. · 2015

Summary This study aimed to evaluate the prevalence and the relationship of sleep breathing disorders ( SBD s) and laryngeal motility alterations in patients with drug‐resistant epilepsy after vagus nerve stimulator ( VNS ) implantation. T…

Narcolepsy Type 1 and Idiopathic Generalized Epilepsy: Diagnostic and Therapeutic Challenges in Dual Cases Open

Simone Baiardi, Stefano Vandi, Fabio Pizza, Lara Alvisi, Lucia Toscani , et al. · 2015

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