Eleni Zingkou
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View article: Proteolytic activities of extracellular vesicles attenuate A-synuclein aggregation
Proteolytic activities of extracellular vesicles attenuate A-synuclein aggregation Open
View article: Deletion of the Epidermal Protease KLK5 Aggravates the Symptoms of Congenital Ichthyosis CDSN-nEDD
Deletion of the Epidermal Protease KLK5 Aggravates the Symptoms of Congenital Ichthyosis CDSN-nEDD Open
Congenital ichthyoses, now grouped under the acronym EDD (Epidermal Differentiation Disorders), include nonsyndromic forms (nEDD) that may be caused by loss-of-function mutations in the CDSN gene encoding corneodesmosin (CDSN-nEDD, formerl…
View article: Cytocompatibility Study of Stainless Steel 316l Against Differentiated SH-SY5Y Cells
Cytocompatibility Study of Stainless Steel 316l Against Differentiated SH-SY5Y Cells Open
Stainless steel (SS) 316l constitutes a popular biomaterial with various applications as implants in cardiovascular and orthopedic surgery, as well as in dentistry. Nevertheless, its cytocompatibility against neuronal cells has not been in…
View article: Essential oil-in-water microemulsions for topical application: structural study, cytotoxic effect and insect repelling activity
Essential oil-in-water microemulsions for topical application: structural study, cytotoxic effect and insect repelling activity Open
View article: Novel specific activity-based probes validate KLK proteases as druggable targets
Novel specific activity-based probes validate KLK proteases as druggable targets Open
KEYWORDS: activity-based probesABPskallikrein-related peptidasesKLKsKLK-ABPsKLK proteolytic cascadesactivographytheranostic ABPs
View article: Activity-Based Probes for Proteases Pave the Way to Theranostic Applications
Activity-Based Probes for Proteases Pave the Way to Theranostic Applications Open
Proteases are important enzymes in health and disease. Their activities are regulated at multiple levels. In fact, proteases are synthesized as inactive proenzymes (zymogens) that are activated by proteolytic removal of their pro-peptide s…
View article: Reconstructing the epidermal proteolytic cascades in health and disease
Reconstructing the epidermal proteolytic cascades in health and disease Open
The epidermis is the outer stratified epithelium of the skin, forming the physical barrier that is indispensable for homeostasis. Epidermal proteolysis, mainly but not exclusively executed by kallikrein‐related peptidases (KLKs), is tightl…
View article: A chemogenomic approach is required for effective treatment of amyotrophic lateral sclerosis
A chemogenomic approach is required for effective treatment of amyotrophic lateral sclerosis Open
ALS is a fatal untreatable disease involving degeneration of motor neurons. Μultiple causative genes encoding proteins with versatile functions have been identified indicating that diverse biological pathways lead to ALS. Chemical entities…
View article: Keratinocyte differentiation and proteolytic pathways in skin (patho) physiology
Keratinocyte differentiation and proteolytic pathways in skin (patho) physiology Open
The epidermis is a stratified epithelium that forms the barrier between the organism and its environment. It is mainly composed of keratinocytes at various stages of differentiation. The stratum corneum is the outermost layer of the epider…
View article: Kallikreins emerge as new regulators of viral infections
Kallikreins emerge as new regulators of viral infections Open
View article: Forschen für die Praxis: Die Rolle epidermaler Proteasen in der Progression der rezessiven dystrophen Epidermolysis bullosa
Forschen für die Praxis: Die Rolle epidermaler Proteasen in der Progression der rezessiven dystrophen Epidermolysis bullosa Open
Zusammenfassung Die rezessiv dystrophe Epidermolysis bullosa (RDEB) ist eine unheilbare schwere Hautkrankheit durch den Verlust von Kollagen VII, eines extrazellulären Proteins, das die Hautkohäsion sichert. RDEB manifestiert sich mit Blas…
View article: Research in practice: Towards deciphering the role of epidermal proteases in recessive dystrophic epidermolysis bullosa progression
Research in practice: Towards deciphering the role of epidermal proteases in recessive dystrophic epidermolysis bullosa progression Open
Summary Recessive dystrophic epidermolysis bullosa (RDEB) is an incurable severe skin disease caused by loss of collagen VII, an extracellular protein that ensures skin cohesion. It manifests in skin blistering and unresolved cycles of wou…
View article: Redirecting drug repositioning to discover innovative cosmeceuticals
Redirecting drug repositioning to discover innovative cosmeceuticals Open
Skin appearance is essential for self‐esteem and quality of life; consequently, skin care products represent a huge market. In particular, cosmeceuticals constitute a hybrid category of skin care formulations, at the interphase of cosmetic…
View article: Generation of a quenched phosphonate activity-based probe for labelling the active KLK7 protease
Generation of a quenched phosphonate activity-based probe for labelling the active KLK7 protease Open
A mixed alkyl aryl phosphonate qABP for KLK7 was developed where the internally-quenching system is realeased upon binding of the qABP to the active enzyme.
View article: A novel theranostic activity-based probe targeting kallikrein 7 for the diagnosis and treatment of skin diseases
A novel theranostic activity-based probe targeting kallikrein 7 for the diagnosis and treatment of skin diseases Open
Enzyme specific inhibitors can be designed based on endogenous substrate peptide motifs and modified to yield specific activity-based probes (ABPs). The development/validation of a theranostic ABP-inhibitor prototype for KLK7 protease is p…
View article: Treatment of keratinocytes with 4-phenylbutyrate in epidermolysis bullosa: Lessons for therapies in keratin disorders
Treatment of keratinocytes with 4-phenylbutyrate in epidermolysis bullosa: Lessons for therapies in keratin disorders Open
View article: Biochemical pathways mediated by <scp>KLK</scp>6 protease in breast cancer
Biochemical pathways mediated by <span>KLK</span>6 protease in breast cancer Open
Kallikrein‐related peptidase 6 ( KLK 6) is a serine protease normally expressed in mammary tissue and aberrantly regulated in breast cancer. At physiological levels, KLK 6 functions as a suppressor of breast cancer, while its aberrant over…
View article: Activography reveals aberrant proteolysis in desquamating diseases of differing backgrounds
Activography reveals aberrant proteolysis in desquamating diseases of differing backgrounds Open
The role of epidermal proteolysis in overdesquamation was revealed in Netherton syndrome, a rare ichthyosis due to genetic deficiency of the LEKTI inhibitor of serine proteases. Recently, we developed activography, a new histochemical meth…
View article: KLK6 protease accelerates skin tumor formation and progression
KLK6 protease accelerates skin tumor formation and progression Open
Kallikrein-related peptidase 6 (KLK6) is a serine protease that is aberrantly altered in various types of cancer, but its role in non-melanoma skin cancer has not been investigated. KLK6 is active in epidermis and has been linked to normal…
View article: Enhanced Proteolytic Activities in Acral Peeling Skin Syndrome: A Role of Transglutaminase 5 in Epidermal Homeostasis
Enhanced Proteolytic Activities in Acral Peeling Skin Syndrome: A Role of Transglutaminase 5 in Epidermal Homeostasis Open