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View article: A rare splenic and pancreatic inflammatory myofibroblastic tumour with left‑sided portal hypertension and gastric varices: A case report
A rare splenic and pancreatic inflammatory myofibroblastic tumour with left‑sided portal hypertension and gastric varices: A case report Open
Left-sided portal hypertension or segmental portal hypertension is a rare cause of upper gastrointestinal bleeding. The present study reports a case of isolated gastric variceal haemorrhage and hypersplenism, due to left-sided portal hyper…
View article: Isolated Leptomeningeal Carcinomatosis in Triple-Negative Breast Cancer: A Case Report
Isolated Leptomeningeal Carcinomatosis in Triple-Negative Breast Cancer: A Case Report Open
Introduction: Leptomeningeal carcinomatosis (LC) is a rare but devastating complication that can arise from various cancers, particularly breast cancer. Case Presentation: We present the case of a female patient with early onset triple-neg…
View article: Serum Proteomic Signatures of Pregnancy-associated Breast Cancer
Serum Proteomic Signatures of Pregnancy-associated Breast Cancer Open
Differential proteomic expression was detected in PABC-derived serum samples, implying distinct PABC molecular features that require further investigation. The identification of PABC proteomic signatures provides significant insight into P…
View article: Molecular Prognostic Factors in Uterine Serous Carcinomas: A Systematic Review
Molecular Prognostic Factors in Uterine Serous Carcinomas: A Systematic Review Open
Uterine serous carcinomas are an aggressive minority of endometrial cancers. They are characterized by mutations in TP53 and extensive copy number alterations and are primarily classified in the copy number-high/p53abn molecular prognostic…
View article: Prevalence and Genotype Distribution of High-Risk HPV Genotypes Among Women in Greece: A Retrospective Analysis of 3500 Women
Prevalence and Genotype Distribution of High-Risk HPV Genotypes Among Women in Greece: A Retrospective Analysis of 3500 Women Open
Background/Objectives: Persistent infection with high-risk (HR) HPV genotypes is the main risk factor for the development of cervical cancer. The present analysis provides recent trends on HR-HPV infection rates and the distribution of HR-…
View article: Expression of DNA Repair Genes in Ewing Sarcoma
Expression of DNA Repair Genes in Ewing Sarcoma Open
Background/Aim: Ewing sarcoma is an aggressive mesenchymal malignancy commonly affecting children and young adolescents. The molecular basis of this neoplasia is well reported with the formation of the EWSR1/FLI1 fusion gene being the most…
View article: 120P Discovery of prognostic biomarkers in Ewing sarcoma
120P Discovery of prognostic biomarkers in Ewing sarcoma Open
Several data indicate that Ewing Sarcoma (ES) is susceptible to DNA-damaging agents. We hypothesize that the two major repair pathways that can restore double-strand breaks (DSBs), nonhomologous end joining (NHEJ) and homologous recombinat…
View article: The Immunohistochemical Expression of REV-7 in Various Human Cancer Pathology Specimens: A Systematic Review
The Immunohistochemical Expression of REV-7 in Various Human Cancer Pathology Specimens: A Systematic Review Open
The purpose of this systematic review is to summarize all existing evidence, regarding the immunohistochemical expression of REV-7 in different human cancer pathology specimens. Moreover, the association of REV-7 expression with disease se…
View article: Mutation Profile of HPV16 L1 and L2 Genes in Different Geographic Areas
Mutation Profile of HPV16 L1 and L2 Genes in Different Geographic Areas Open
The causal relationship between HPV and cervical cancer in association with the high prevalence of high risk HPV genotypes led to the design of HPV vaccines based on the major capsid L1 protein. In recent years, capsid protein L2 has also …
View article: Baseline Ang-2 Serum Levels as a Predictive Factor for Survival in NSCLC and SCLC
Baseline Ang-2 Serum Levels as a Predictive Factor for Survival in NSCLC and SCLC Open
Angiopoietin-2 (Ang-2) has been implicated in the development of several types of cancer, including lung malignancy. In the present study, we examined the impact of Ang-2 serum concentration on the development, dissemination, and 5-year ov…
View article: Germline and somatic variants in ovarian carcinoma: A next-generation sequencing (NGS) analysis
Germline and somatic variants in ovarian carcinoma: A next-generation sequencing (NGS) analysis Open
Background Germline BRCA1/2 mutations are identified in 13-15% of ovarian cancers, while an additional 5-7% of ovarian cancers harbor somatic BRCA1/2 mutations. Beyond these mutations, germline or somatic aberrations in genes of the homolo…
View article: Circulating miRNA Expression Profiling in Breast Cancer Molecular Subtypes: Applying Machine Learning Analysis in Bioinformatics
Circulating miRNA Expression Profiling in Breast Cancer Molecular Subtypes: Applying Machine Learning Analysis in Bioinformatics Open
Background/Aim: Breast cancer is a leading worldwide cause of female cancer-related morbidity and mortality. Since molecular characteristics increasingly guide disease management, demystifying breast tumor miRNA signature emerges as an ess…
View article: Targeting Both Autophagy and Immunotherapy in Breast Cancer Treatment
Targeting Both Autophagy and Immunotherapy in Breast Cancer Treatment Open
As clinical efforts towards breast-conserving therapy and prolonging survival of those with metastatic breast cancer increase, innovative approaches with the use of biologics are on the rise. Two areas of current focus are cancer immunothe…
View article: Prognostic Value of Circulating Tumor DNA (ctDNA) in Oncogene-Driven NSCLC: Current Knowledge and Future Perspectives
Prognostic Value of Circulating Tumor DNA (ctDNA) in Oncogene-Driven NSCLC: Current Knowledge and Future Perspectives Open
As we enter an unprecedented era of personalized medicine, molecular targeted therapies have the potential to induce improved survival outcome in patients with non-small cell lung cancer (NSCLC). However, a significant percentage of oncoge…
View article: PD-L1 Gene Polymorphisms rs822336 G>C and rs822337 T>A: Promising Prognostic Markers in Triple Negative Breast Cancer Patients
PD-L1 Gene Polymorphisms rs822336 G>C and rs822337 T>A: Promising Prognostic Markers in Triple Negative Breast Cancer Patients Open
Background and Objectives: Triple-negative breast cancer (TNBC) is a highly heterogeneous subtype that is associated with unresponsiveness to therapy and hence with high mortality rates. In this study we aimed to investigate the prognostic…
View article: Multi-Gene Mutation Profiling by Targeted Next-Generation Sequencing in Premenopausal Breast Cancer
Multi-Gene Mutation Profiling by Targeted Next-Generation Sequencing in Premenopausal Breast Cancer Open
Breast cancer has distinct etiology, prognoses, and clinical outcomes at premenopausal ages. Determination of the frequency of germline and somatic mutations will refine our understanding of the genetic contribution to premenopausal breast…
View article: High-throughput Proteomic Profiling of Male Breast Cancer Tissue
High-throughput Proteomic Profiling of Male Breast Cancer Tissue Open
Differential proteomic expression was found in MBC tissue, leading to improved understanding of MBC pathology and highlighting the need for personalized management of male patients.
View article: Chasing Hippos: Implications of YAP1 and TAZ Expression in Pregnancy-associated Breast Cancer Tumorigenesis
Chasing Hippos: Implications of YAP1 and TAZ Expression in Pregnancy-associated Breast Cancer Tumorigenesis Open
The Hippo pathway is de-regulated in a subset of PABC patients, highlighting the complex molecular background of the disease, which certainly requires further investigation.
View article: BRCA1/2 Mutation Types Do Not Affect Prognosis in Ovarian Cancer Patients
BRCA1/2 Mutation Types Do Not Affect Prognosis in Ovarian Cancer Patients Open
Background: High grade serous ovarian carcinoma (HGSOC) is the most lethal type of epithelial ovarian cancer, with a prevalence of germline BRCA1/2 mutations as high as 20%. Our objective is to determine whether the location of mutations i…
View article: Update Overview of the Role of Angiopoietins in Lung Cancer
Update Overview of the Role of Angiopoietins in Lung Cancer Open
Angiogenesis is a biological process that involves the formation of new blood vessels from the existing vasculature, and it plays a fundamental role in the development and progression of several types of cancer, including lung cancer. The …
View article: MicroRNAs as Potential Predictors of Response to CDK4/6 Inhibitor Treatment
MicroRNAs as Potential Predictors of Response to CDK4/6 Inhibitor Treatment Open
Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have emerged as novel treatment options in the management of advanced or metastatic breast cancer. MicroRNAs are endogenous non-coding 19–22-nucleotide-long RNAs that regulate gene expression…
View article: Inducible 70kDa Heat Shock Protein and Autophagy-related Protein P62 Levels in Women With Breast Cancer: an Exploratory Investigation
Inducible 70kDa Heat Shock Protein and Autophagy-related Protein P62 Levels in Women With Breast Cancer: an Exploratory Investigation Open
Background: Peripheral blood mononuclear cells (PBMCs) respond to altered physiological conditions to alleviate the threat. The inducible 70kDa heat shock protein (HSPA1A) protects proteins from degradation. Autophagy is an intracellular p…
View article: Immunotherapy in HER2-Positive Breast Cancer: A Systematic Review
Immunotherapy in HER2-Positive Breast Cancer: A Systematic Review Open
Introduction: The clinical outcome of HER2-positive breast cancer patients changed with the use of anti-Her therapies, though it still remains an aggressive and fatal disease. Implementation of immune checkpoint inhibitors in HER2-positive…