Elfriede Dall
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View article: Secondary central nervous system lymphoma (<scp>SCNSL</scp>) in mantle cell lymphoma (<scp>MCL</scp>): Characteristics and risk factors in a Danish nationwide population‐based study
Secondary central nervous system lymphoma (<span>SCNSL</span>) in mantle cell lymphoma (<span>MCL</span>): Characteristics and risk factors in a Danish nationwide population‐based study Open
Summary Secondary central nervous system (CNS) lymphoma (SCNSL) in mantle cell lymphoma (MCL) is associated with dismal outcomes, and risk factors are not well documented. This population‐based study reports the incidence of SCNSL, risk fa…
View article: Real-world outcomes with ibrutinib in relapsed or refractory mantle cell lymphoma: a Danish population-based study
Real-world outcomes with ibrutinib in relapsed or refractory mantle cell lymphoma: a Danish population-based study Open
Ibrutinib was approved for relapsed/refractory (R/R) mantle cell lymphoma (MCL) based on high response rates in clinical trials, but it is unclear how effective ibrutinib is in the real-world setting. This study provides population-based r…
View article: Conformational and Functional Regulation of SET by Legumain Cleavage
Conformational and Functional Regulation of SET by Legumain Cleavage Open
The cysteine protease legumain typically localizes to the endolysosomal system, where it is an important player in the immune system. However, in the context of Alzheimer's disease (AD), legumain has been shown to be translocated to the cy…
View article: Conformational and Functional Regulation of SET by Legumain Cleavage
Conformational and Functional Regulation of SET by Legumain Cleavage Open
The cysteine protease legumain typically localizes to the endolysosomal system, where it is an important player in the immune system. However, in the context of Alzheimer’s disease (AD), legumain has been shown to be translocated to the cy…
View article: Real-World Outcomes for Patients Treated with Ibrutinib for Relapsed/Refractory Mantle Cell Lymphoma in Denmark
Real-World Outcomes for Patients Treated with Ibrutinib for Relapsed/Refractory Mantle Cell Lymphoma in Denmark Open
Introduction In 2013 promising response rates led to accelerated approval of ibrutinib for relapsed/refractory (R/R) mantle cell lymphoma (MCL) by the FDA. The approval was withdrawn in 2023 due to lack of overall survival (OS) benefit in …
View article: <i>Arabidopsis thaliana</i> Phytocystatin 6 Forms Functional Oligomer and Amyloid Fibril States
<i>Arabidopsis thaliana</i> Phytocystatin 6 Forms Functional Oligomer and Amyloid Fibril States Open
Cystatins encode a high functional variability not only because of their ability to inhibit different classes of proteases but also because of their propensity to form oligomers and amyloid fibrils. Phytocystatins, essential regulators of …
View article: <i>Arabidopsis thaliana</i>phytocystatin 6 forms functional oligomer and amyloid fibril states
<i>Arabidopsis thaliana</i>phytocystatin 6 forms functional oligomer and amyloid fibril states Open
Cystatins not only encode a high functional variability because of their ability to inhibit different classes of proteases but also because of their propensity to form oligomers and amyloid fibrils. Phytocystatins, essential regulators of …
View article: Phytocystatin 6 is a context‐dependent, tight‐binding inhibitor of <i>Arabidopsis thaliana</i> legumain isoform β
Phytocystatin 6 is a context‐dependent, tight‐binding inhibitor of <i>Arabidopsis thaliana</i> legumain isoform β Open
SUMMARY Plant legumains are crucial for processing seed storage proteins and are critical regulators of plant programmed cell death. Although research on legumains boosted recently, little is known about their activity regulation. In our s…
View article: Phytocystatin 6 is a context-dependent, tight-binding inhibitor of<i>Arabidopsis thaliana</i>legumain isoform β
Phytocystatin 6 is a context-dependent, tight-binding inhibitor of<i>Arabidopsis thaliana</i>legumain isoform β Open
Plant legumains are crucial for processing seed storage proteins and are critical regulators of plant programmed cell death. Although research on legumains boosted recently, little is known about their activity regulation. In our study, we…
View article: Legumain Functions as a Transient TrkB Sheddase
Legumain Functions as a Transient TrkB Sheddase Open
While primarily found in endo-lysosomal compartments, the cysteine protease legumain can also translocate to the cell surface if stabilized by the interaction with the RGD-dependent integrin receptor αVβ3. Previously, it has been shown tha…
View article: ACBN Newsletter #5 Jul-Dec 2022
ACBN Newsletter #5 Jul-Dec 2022 Open
This newsletter highlights two interesting new projects recently started within ACBN: One of them is based on a highly prestigious START grant, the first one to be acquired by ACBN members! Another story features our activities within the …
View article: Legumain Activity Is Controlled by Extended Active Site Residues and Substrate Conformation
Legumain Activity Is Controlled by Extended Active Site Residues and Substrate Conformation Open
Legumain is a lysosomal cysteine protease with strict specificity for cleaving after asparagine residues. By sequence comparison, legumain belongs to MEROPS clan CD of the cysteine proteases, which indicates its structural and mechanistic …
View article: Structural and functional studies of legumain–mycocypin complexes revealed a competitive, exosite-regulated mode of interaction
Structural and functional studies of legumain–mycocypin complexes revealed a competitive, exosite-regulated mode of interaction Open
Under pathophysiologic conditions such as Alzheimer's disease and cancer, the endolysosomal cysteine protease legumain was found to translocate to the cytosol, the nucleus, and the extracellular space. These noncanonical localizations dema…
View article: The Peptide Ligase Activity of Human Legumain Depends on Fold Stabilization and Balanced Substrate Affinities
The Peptide Ligase Activity of Human Legumain Depends on Fold Stabilization and Balanced Substrate Affinities Open
Protein modification by enzymatic breaking and forming of peptide bonds significantly expands the repertoire of genetically encoded protein sequences. The dual protease-ligase legumain exerts the two opposing activities within a single pro…
View article: Laser‐facilitated epicutaneous immunotherapy with hypoallergenic beta‐glucan neoglycoconjugates suppresses lung inflammation and avoids local side effects in a mouse model of allergic asthma
Laser‐facilitated epicutaneous immunotherapy with hypoallergenic beta‐glucan neoglycoconjugates suppresses lung inflammation and avoids local side effects in a mouse model of allergic asthma Open
Background Allergen‐specific immunotherapy via the skin targets a tissue rich in antigen‐presenting cells, but can be associated with local and systemic side effects. Allergen‐polysaccharide neoglycogonjugates increase immunization efficac…
View article: Cruzain structures: apocruzain and cruzain bound to <i>S</i>-methyl thiomethanesulfonate and implications for drug design
Cruzain structures: apocruzain and cruzain bound to <i>S</i>-methyl thiomethanesulfonate and implications for drug design Open
Chagas disease, which is caused by Trypanosoma cruzi , affects more than six million people worldwide. Cruzain is the major cysteine protease involved in the survival of this parasite. Here, the expression, purification and crystallization…
View article: Crystal Structure of Plant Legumain Reveals a Unique Two-Chain State with pH-Dependent Activity Regulation
Crystal Structure of Plant Legumain Reveals a Unique Two-Chain State with pH-Dependent Activity Regulation Open
The vacuolar cysteine protease legumain can cleave and selectively rebuild peptide bonds, thereby vastly expanding the sequential repertoire of biomolecules. In this context, plant legumains have recently attracted particular interest. Fur…
View article: Two Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S
Two Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S Open
Birch pollen allergy affects more than 20% of the European allergic population. On a molecular level, birch pollen allergy can be linked to the two dominant allergens Bet v 1 and Bet v 2. Bet v 2 belongs to the profilin family, which is ab…
View article: Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations
Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations Open
The cysteine protease enzyme legumain hydrolyzes peptide bonds with high specificity after asparagine and under more acidic conditions after aspartic acid [Baker E. N.J. Mol. Biol.1980, 141, 441-484; Baker E. N.; J. Mol. Biol.1977, 111, 20…
View article: Comparing Proteolytic Fingerprints of Antigen-Presenting Cells during Allergen Processing
Comparing Proteolytic Fingerprints of Antigen-Presenting Cells during Allergen Processing Open
Endolysosomal processing has a critical influence on immunogenicity as well as immune polarization of protein antigens. In industrialized countries, allergies affect around 25% of the population. For the rational design of protein-based al…