Elham Nasri
YOU?
Author Swipe
View article: A Rare Case of <i>CIC‐DUX4</i> Sarcoma in a Mediastinal Lymph Node Diagnosed by Fine Needle Aspiration Cytology
A Rare Case of <i>CIC‐DUX4</i> Sarcoma in a Mediastinal Lymph Node Diagnosed by Fine Needle Aspiration Cytology Open
CIC ‐rearranged sarcomas (CDS) are rare, aggressive undifferentiated small round cell tumors recently classified as a distinct entity by the World Health Organization. These tumors are defined by CIC gene fusions, most commonly CIC::DUX4 ,…
View article: Revisiting <i>CDKN2A</i> dysregulation in Ewing sarcoma
Revisiting <i>CDKN2A</i> dysregulation in Ewing sarcoma Open
Ewing sarcoma (EwS) is a rare and aggressive malignancy, which frequently affects children. One of the few recurrent genomic variants in EwS is genomic copy number deletion of CDKN2A ; however, the clinical consequences of dysregulation of…
View article: Complete clinical remission of malignant peritoneal mesothelioma with systemic pemetrexed and bevacizumab in a patient with a BAP1 mutation
Complete clinical remission of malignant peritoneal mesothelioma with systemic pemetrexed and bevacizumab in a patient with a BAP1 mutation Open
Malignant peritoneal mesothelioma (MPeM) is a rare malignancy with historically poor prognosis. Recent research has started to reveal increasingly prevalent genetic mutations seen in this malignancy. Here, we report a case of complete clin…
View article: Gene partners of the EWSR1 fusion may represent molecularly distinct entities
Gene partners of the EWSR1 fusion may represent molecularly distinct entities Open
EWSR1 fusions are highly promiscuous and are associated with unique malignancies, clinical phenotypes, and molecular subtypes. However, rare fusion partners (RFP) of EWSR1 has not been well described. Here, we conducted a cross-sectional, …
View article: First-in-class multifunctional TYMS nonclassical antifolate inhibitor with potent in vivo activity that prolongs survival
First-in-class multifunctional TYMS nonclassical antifolate inhibitor with potent in vivo activity that prolongs survival Open
Although thymidylate synthase (TYMS) inhibitors have served as components of chemotherapy regimens, the currently available inhibitors induce TYMS overexpression or alter folate transport/metabolism feedback pathways that tumor cells explo…
View article: Aneurysmal bone cyst: a review
Aneurysmal bone cyst: a review Open
Aneurysmal bone cyst (ABC) is a benign locally destructive bone neoplasm composed of multi-loculated blood-filled cystic spaces. The most common sites of involvement are the meta-diaphysis of the long bones and posterior elements of the ve…
View article: Myofibroma mimicking peripheral nerve sheath tumour with ulnar nerve compression symptoms
Myofibroma mimicking peripheral nerve sheath tumour with ulnar nerve compression symptoms Open
We report a case of myofibroma encasing the ulnar nerve on the medial aspect of the left arm with motor and sensory deficit secondary to compression. Initially, the tumour appeared to be a benign peripheral nerve sheath tumour based on pre…
View article: Metastatic malignant peripheral nerve sheath tumour in a patient with neurofibromatosis 1 and review of contemporary systemic treatments
Metastatic malignant peripheral nerve sheath tumour in a patient with neurofibromatosis 1 and review of contemporary systemic treatments Open
Malignant peripheral nerve sheath tumours are rare soft tissue sarcomas commonly seen in patients with neurofibromatosis type 1. They typically manifest in the fibrous sheaths of major nerve trunks in the extremities or in an axial locatio…
View article: Arthroscopic treatment for intra-articular fibroma of the tendon sheath in a teenager
Arthroscopic treatment for intra-articular fibroma of the tendon sheath in a teenager Open
An adolescent female patient presented with atraumatic left knee pain and limited flexion. MRI demonstrated evidence of a soft tissue lesion abutting the posterior cruciate ligament. Differential diagnosis included pigmented villonodular s…
View article: Complex Reconstruction for Acetabular Pathologic Fracture in Unusual Chondroblastoma With Aneurysmal Bone Cyst
Complex Reconstruction for Acetabular Pathologic Fracture in Unusual Chondroblastoma With Aneurysmal Bone Cyst Open
Treating bone loss with complex arthroplasty poses a significant challenge for the arthroplasty surgeon. When considering a reconstructive case after pathologic fracture and oncologic excision, a multidisciplinary approach with reliance on…
View article: Basal cell carcinoma of the oral cavity: A case report
Basal cell carcinoma of the oral cavity: A case report Open
Background: Basal Cell Carcinoma (BCC) is commonly diagnosed in the cutaneous head and neck; however, the oral cavity is a rare primary site. Case presentation: An 82-year-old female presented with a lesion of the retromolar trigone. Biops…
View article: Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model
Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model Open
Toward the treatment of osteoarthritis (OA), the authors have been investigating self-complementary adeno-associated virus (scAAV) for intra-articular delivery of therapeutic gene products. As OA frequently affects weight-bearing joints, p…
View article: Self-Complementary Adeno-Associated Virus–Mediated Interleukin-1 Receptor Antagonist Gene Delivery for the Treatment of Osteoarthritis: Test of Efficacy in an Equine Model
Self-Complementary Adeno-Associated Virus–Mediated Interleukin-1 Receptor Antagonist Gene Delivery for the Treatment of Osteoarthritis: Test of Efficacy in an Equine Model Open
The authors are investigating self-complementary adeno-associated virus (scAAV) as a vector for intra-articular gene-delivery of interleukin-1 receptor antagonist (IL-1Ra), and its therapeutic capacity in the treatment of osteoarthritis (O…
View article: 233 GI Pathology Residency Education: Barrett Esophagus (BE) Biopsy Evaluation
233 GI Pathology Residency Education: Barrett Esophagus (BE) Biopsy Evaluation Open
Incidence of Barrett esophagus (BE) neoplasia has increased, and its management has changed dramatically. Assessment of dysplasia in BE is a diagnostic challenge in gastrointestinal pathology practice and residency education. This study ai…