Eli Arama
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View article: The Initiator Caspase Dronc Drives Compensatory Proliferation of Apoptosis-Resistant Cells During Epithelial Tissue Regeneration After Ionizing Radiation
The Initiator Caspase Dronc Drives Compensatory Proliferation of Apoptosis-Resistant Cells During Epithelial Tissue Regeneration After Ionizing Radiation Open
Caspases, well-known for their role in executing apoptosis, also participate in various non-apoptotic processes. Despite this, their involvement in promoting compensatory proliferation - a key aspect of tissue regeneration following extens…
View article: Egg multivesicular bodies elicit an LC3-associated phagocytosis-like pathway to degrade paternal mitochondria after fertilization
Egg multivesicular bodies elicit an LC3-associated phagocytosis-like pathway to degrade paternal mitochondria after fertilization Open
Mitochondria are maternally inherited, but the mechanisms underlying paternal mitochondrial elimination after fertilization are far less clear. Using Drosophila , we show that special egg-derived multivesicular body vesicles promote patern…
View article: Egg MVBs elicit an antimicrobial pathway to degrade paternal mitochondria after fertilization
Egg MVBs elicit an antimicrobial pathway to degrade paternal mitochondria after fertilization Open
Mitochondria are maternally inherited, but the mechanisms underlying paternal mitochondrial elimination (PME) after fertilization are far less clear. Using Drosophila , we show that special egg-derived multivesicular bodies (MVBs) promote …
View article: Issue Information
Issue Information Open
Dissected trachea from hypoxia-treated wild-type (blue) and LUBEL-mutant (white) Drosophila larvae.M1-ubiquitination is induced in response to hypoxia in wild-type flies.
View article: Editor Profile: Eli Arama
Editor Profile: Eli Arama Open
In this special interview series, we profile members of The FEBS Journal editorial board to highlight their research focus, perspectives on the journal and future directions in their field. Eli Arama is an Associate Professor at the Weizma…
View article: DNase II mediates a parthanatos-like developmental cell death pathway in Drosophila primordial germ cells
DNase II mediates a parthanatos-like developmental cell death pathway in Drosophila primordial germ cells Open
During Drosophila embryonic development, cell death eliminates 30% of the primordial germ cells (PGCs). Inhibiting apoptosis does not prevent PGC death, suggesting a divergence from the conventional apoptotic program. Here, we demonstrate …
View article: Issue Information
Issue Information Open
A human k-opioid receptor, a member of a group of inhibitory G protein-coupled receptors with opioids as ligands.
View article: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Open
When I invite authors to submit a punctum to Autophagy, my e-mail includes the following: “Note for international authors: I would like to point out that I personally edit all the puncta for accuracy, but also for English grammar and spell…
View article: Non‐lethal message from the Holy Land: The first international conference on nonapoptotic roles of apoptotic proteins
Non‐lethal message from the Holy Land: The first international conference on nonapoptotic roles of apoptotic proteins Open
Apoptosis is a major form of programmed cell death (PCD) that eliminates unnecessary and potentially dangerous cells in all metazoan organisms, thus ensuring tissue homeostasis and many developmental processes. Accordingly, defects in the …
View article: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Open
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View article: International conference on Cell Death in Cancer and Toxicology 2018 (CDCT-2018)
International conference on Cell Death in Cancer and Toxicology 2018 (CDCT-2018) Open
The International Conference on Cell Death in Cancer and Toxicology 2018 (February 20-22, 2018) provided an international forum for scientific collaborations across multiple disciplines in cancer, cell death, and toxicology. During the thr…
View article: Proceedings of International Conference on Cell Death in Cancer and Toxicology
Proceedings of International Conference on Cell Death in Cancer and Toxicology Open
Apoptotic cells can produce signals to instruct cells in their local environment, including factors that stimulate proliferation.This apoptosis-induced proliferation has been shown to play important roles in tissue regeneration, tumor grow…
View article: p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis
p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis Open
The importance of regulated necrosis in pathologies such as cerebral stroke and myocardial infarction is now fully recognized. However, the physiological relevance of regulated necrosis remains unclear. Here, we report a conserved role for…
View article: Controlling caspase activity in life and death
Controlling caspase activity in life and death Open
Every day, billions of human cells terminate their normal activities and launch intrinsic suicide pathways.Timely cell death is orchestrated by destructive functions encoded by dying cells, such as caspase proteases in the case of apoptoti…
View article: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Open
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new t…