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Post-transcriptional control of HIF-1α by MBNL1 restrains hypoxia-driven stemness in GBM Open
MBNL1 binds the HIF-1α 3'UTR to promote rapid mRNA decay, thereby limiting HIF-1 activity and hypoxia-induced stemness in glioblastoma. Using patient-derived glioma stem cells, we show that MBNL1 loss stabilizes HIF-1α mRNA and increases H…
TMET-33. Systemic Cyst(e)inase administration induces Ferroptosis and synergizes with Temozolomide in Glioblastoma Open
Glioblastoma (GBM), an aggressive primary brain cancer, exhibits therapeutic resistance because of tumor heterogeneity and highly plastic glioma stem cells (GSCs). This study targets the metabolic vulnerability of GSCs to cysteine depletio…
TMIC-71. MBNL1: A key regulator of HIF-1α mRNA stability, hypoxia memory, and hypoxia-induced stemness in Glioblastoma Open
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, characterized by profound heterogeneity and a dismal prognosis. A key driver of GBM aggressiveness is the subpopulation of glioma stem cells (GSCs), which exhibit enh…
Heterotrimeric and monomeric G proteins interactions that regulate the yeast mating response. Open
Heterotrimeric and monomeric G proteins interactions that regulate the yeast mating response.
Exploiting genetic and environmental vulnerabilities to target DHODH in CNS tumors Open
This review explores innovative therapeutic strategies for treating central nervous system (CNS) tumors by targeting their unique metabolic dependencies. This approach marks a significant departure from traditional cytotoxic treatments, fo…
Supplementary Figures S1-S3 from BRAF Activation Induces Transformation and Then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model Open
Supplementary Figures S1-S3 from BRAF Activation Induces Transformation and Then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model
View article: Data from The Alternative Splicing Factor, MBNL1, Inhibits Glioblastoma Tumor Initiation and Progression by Reducing Hypoxia-Induced Stemness
Data from The Alternative Splicing Factor, MBNL1, Inhibits Glioblastoma Tumor Initiation and Progression by Reducing Hypoxia-Induced Stemness Open
Muscleblind-like proteins (MBNL) belong to a family of tissue-specific regulators of RNA metabolism that control premessenger RNA splicing. Inactivation of MBNL causes an adult-to-fetal alternative splicing transition, resulting in the dev…
View article: Supplementary Data from The Alternative Splicing Factor, MBNL1, Inhibits Glioblastoma Tumor Initiation and Progression by Reducing Hypoxia-Induced Stemness
Supplementary Data from The Alternative Splicing Factor, MBNL1, Inhibits Glioblastoma Tumor Initiation and Progression by Reducing Hypoxia-Induced Stemness Open
Supplementary Figures 1-8 S1. MBNL1 expression in Glioblastoma by subtype S2. MBNL1 target gene splicing S3. MBNL1 expression in cultured GSCs S4. MBNL1 activity is monitored with RG6 splicing reporter minigene S5. Effect of induced MBNL1 …
Supplementary figures 1-4 from Targetable T-type Calcium Channels Drive Glioblastoma Open
Supplementary figures: 1): molecular structure of mibefradil, 2) Mibefradil effects on HIFs, 3) effects of sh-RNA inhibition of Cav3.2 in GSCs, 4) Schematic summary of the findings.
Data from BRAF Activation Induces Transformation and Then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model Open
Purpose: BRAF is frequently activated by gene fusion or point mutation in pilocytic astrocytoma, the most common pediatric brain tumor. We investigated the functional effect of constitutive BRAF activation in normal human neural stem and p…
Supplementary Figure 1 from Prolonged Inhibition of Glioblastoma Xenograft Initiation and Clonogenic Growth following <i>In Vivo</i> Notch Blockade Open
PDF file - 54K, MRK003 slows growth of HSR-GBM1 XG2 glioblastoma xenografts.
Supplementary Figure 4 from Notch Signaling Promotes Growth and Invasion in Uveal Melanoma Open
PDF file - 2.5MB
View article: Supplementary Data from The Alternative Splicing Factor, MBNL1, Inhibits Glioblastoma Tumor Initiation and Progression by Reducing Hypoxia-Induced Stemness
Supplementary Data from The Alternative Splicing Factor, MBNL1, Inhibits Glioblastoma Tumor Initiation and Progression by Reducing Hypoxia-Induced Stemness Open
Supplementary Figures 1-8 S1. MBNL1 expression in Glioblastoma by subtype S2. MBNL1 target gene splicing S3. MBNL1 expression in cultured GSCs S4. MBNL1 activity is monitored with RG6 splicing reporter minigene S5. Effect of induced MBNL1 …
Supplementary Figure 3 from Notch Signaling Promotes Growth and Invasion in Uveal Melanoma Open
PDF file - 1.5MB
Supplementary Figure 4 from Notch Signaling Promotes Growth and Invasion in Uveal Melanoma Open
PDF file - 2.5MB
Supplementary Tables 1-2 from Notch Signaling Promotes Growth and Invasion in Uveal Melanoma Open
PDF file - 36K
Supplementary Data from The Notch Target Hes1 Directly Modulates Gli1 Expression and Hedgehog Signaling: A Potential Mechanism of Therapeutic Resistance Open
Supplementary Figures S1-S3; Supplementary Tables S1-S2.
Supplementary Figure 5 from Notch Signaling Promotes Growth and Invasion in Uveal Melanoma Open
PDF file - 369K
Data from Prolonged Inhibition of Glioblastoma Xenograft Initiation and Clonogenic Growth following <i>In Vivo</i> Notch Blockade Open
Purpose: To examine the effects of clinically relevant pharmacologic Notch inhibition on glioblastoma xenografts.Experimental Design: Murine orthotopic xenografts generated from temozolomide-sensitive and -resistant glioblastoma neurospher…
Supplementary Figure Legends 1-5, Table Legends 1-2 from Notch Signaling Promotes Growth and Invasion in Uveal Melanoma Open
PDF file - 69K
Supplementary Figure 5 from Notch Signaling Promotes Growth and Invasion in Uveal Melanoma Open
PDF file - 369K
Data from Notch Signaling Promotes Growth and Invasion in Uveal Melanoma Open
Purpose: To determine whether uveal melanoma, the most common primary intraocular malignancy in adults, requires Notch activity for growth and metastasis.Experimental Design: Expression of Notch pathway members was characterized in primary…
View article: Data from The Alternative Splicing Factor, MBNL1, Inhibits Glioblastoma Tumor Initiation and Progression by Reducing Hypoxia-Induced Stemness
Data from The Alternative Splicing Factor, MBNL1, Inhibits Glioblastoma Tumor Initiation and Progression by Reducing Hypoxia-Induced Stemness Open
Muscleblind-like proteins (MBNL) belong to a family of tissue-specific regulators of RNA metabolism that control premessenger RNA splicing. Inactivation of MBNL causes an adult-to-fetal alternative splicing transition, resulting in the dev…
Supplementary Figure 1 from Prolonged Inhibition of Glioblastoma Xenograft Initiation and Clonogenic Growth following <i>In Vivo</i> Notch Blockade Open
PDF file - 54K, MRK003 slows growth of HSR-GBM1 XG2 glioblastoma xenografts.
Supplementary Figure 3 from Prolonged Inhibition of Glioblastoma Xenograft Initiation and Clonogenic Growth following <i>In Vivo</i> Notch Blockade Open
PDF file - 127K, Cell cycle analysis was performed in triplicate on HSR-GBM1 XG2-derived neurospheres and analyzed on a Guava PCA.
Data from BRAF Activation Induces Transformation and Then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model Open
Purpose: BRAF is frequently activated by gene fusion or point mutation in pilocytic astrocytoma, the most common pediatric brain tumor. We investigated the functional effect of constitutive BRAF activation in normal human neural stem and p…
Data from The Notch Target Hes1 Directly Modulates Gli1 Expression and Hedgehog Signaling: A Potential Mechanism of Therapeutic Resistance Open
Purpose: Multiple developmental pathways including Notch, Hedgehog, and Wnt are active in malignant brain tumors such as medulloblastoma and glioblastoma (GBM). This raises the possibility that tumors might compensate for therapy directed …