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View article: MON-601 Recent Strides In Diabetes Technology Utilization Among Individuals With Type 1 Diabetes
MON-601 Recent Strides In Diabetes Technology Utilization Among Individuals With Type 1 Diabetes Open
Disclosure: E.M. Everett: None. R. Tiu: None. I. Melgoza: None. J. Graham: None. G. Villanueva: None. J. Menjivar Cruz: None. A. Rivas Deras: None. K. Udeze: None. J. Cushing: None. B. Escobar Barrios: None. J. Mendez: None. E. Shaw: None.…
View article: Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries
Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries Open
Summary Background Polygenic risk scores (PRSs) improve type 2 diabetes (T2D) prediction beyond clinical risk factors but perform poorly in non-European populations, where T2D burden is often higher, undermining their global clinical utili…
View article: Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL
Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL Open
Central obesity is a leading health concern with a great burden carried by ethnic minority populations, especially Hispanics/Latinos. Genetic factors contribute to the obesity burden overall and to inter-population differences. We aimed to…
View article: Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits—The Hispanic/Latino Anthropometry Consortium
Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits—The Hispanic/Latino Anthropometry Consortium Open
Hispanic/Latinos have been underrepresented in genome-wide association studies (GWAS) for anthropometric traits despite their notable anthropometric variability, ancestry proportions, and high burden of growth stunting and overweight/obesi…
View article: Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies Open
Chronic kidney disease (CKD) affects ~10% of the global population, with considerable ethnic differences in prevalence and aetiology. We assemble genome-wide association studies of estimated glomerular filtration rate (eGFR), a measure of …
View article: Genome-wide association identifies novel ROP risk loci in a multiethnic cohort
Genome-wide association identifies novel ROP risk loci in a multiethnic cohort Open
We conducted a genome-wide association study (GWAS) in a multiethnic cohort of 920 at-risk infants for retinopathy of prematurity (ROP), a major cause of childhood blindness, identifying 1 locus at genome-wide significance level (p < 5×10 …
View article: Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas
Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas Open
Chronic kidney disease is a leading cause of death and disability globally and impacts individuals of African ancestry (AFR) or with ancestry in the Americas (AMS) who are under-represented in genome-wide association studies (GWASs) of kid…
View article: Genome-wide association identifies novel ROP risk loci in a multi-ethnic cohort
Genome-wide association identifies novel ROP risk loci in a multi-ethnic cohort Open
We conducted a genome-wide association study (GWAS) in a multiethnic cohort of 920 at-risk infants for retinopathy of prematurity (ROP), a major cause of childhood blindness, identifying 2 loci at genome-wide significance level (p<5×10-8) …
View article: LBODP048 Barriers To Diabetic Retinopathy Screening In Hospitalized Patients With Diabetes
LBODP048 Barriers To Diabetic Retinopathy Screening In Hospitalized Patients With Diabetes Open
Diabetic retinopathy (DR) is a leading cause of preventable vision loss in the in the U. S., and DR screening is essential to prevent blindness. Yet minority populations have consistently lower DR screening rates than Non-Hispanic Whites a…
View article: Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits—The Hispanic/Latino Anthropometry Consortium
Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits—The Hispanic/Latino Anthropometry Consortium Open
[This corrects the article DOI: 10.1016/j.xhgg.2022.100099.].
View article: Artificial Intelligence Detection of Diabetic Retinopathy
Artificial Intelligence Detection of Diabetic Retinopathy Open
The AI system had a higher sensitivity for detecting mtmDR than either general ophthalmologists or retina specialists compared with the clinical reference standard. It can potentially serve as a low-cost point-of-care diabetic retinopathy …
View article: Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits—The Hispanic/Latino Anthropometry Consortium
Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits—The Hispanic/Latino Anthropometry Consortium Open
Hispanic/Latinos have been underrepresented in genome-wide association studies (GWAS) for anthropometric traits despite their notable anthropometric variability, ancestry proportions, and high burden of growth stunting and overweight/obesi…
View article: Diabetic Retinopathy and Insulin Insufficiency: Beta Cell Replacement as a Strategy to Prevent Blindness
Diabetic Retinopathy and Insulin Insufficiency: Beta Cell Replacement as a Strategy to Prevent Blindness Open
Diabetic retinopathy (DR) is a potentially devastating complication of diabetes because it puts patients at risk of blindness. Diabetes is a common cause of blindness in the U.S. and worldwide and is dramatically increasing in global preva…
View article: Pivotal Evaluation of an Artificial Intelligence System for Autonomous Detection of Referrable and Vision-Threatening Diabetic Retinopathy
Pivotal Evaluation of an Artificial Intelligence System for Autonomous Detection of Referrable and Vision-Threatening Diabetic Retinopathy Open
This prospective multicenter cross-sectional diagnostic study noted safety and accuracy with use of the EyeArt Automated DR Detection System in detecting both mtmDR and, for the first time, vtDR, without physician assistance. These finding…
View article: A Clinical Conundrum: Intensifying Glycemic Control in the Presence of Advanced Diabetic Retinopathy
A Clinical Conundrum: Intensifying Glycemic Control in the Presence of Advanced Diabetic Retinopathy Open
Diabetic retinopathy (DR) is a potentially devastating complication of diabetes because of the risk of developing blindness. While therapies to prevent blindness are improving, in much of the world visual impairment continues to occur and …
View article: Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL
Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL Open
Central obesity is a leading health concern with a great burden carried by ethnic minority populations, especially Hispanics/Latinos. Genetic factors contribute to the obesity burden overall and to inter-population differences. We aimed to…
View article: Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium
Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium Open
Hispanic/Latinos have been underrepresented in genome-wide association studies (GWAS) for anthropometric traits despite notable anthropometric variability with ancestry proportions, and a high burden of growth stunting and overweight/obesi…
View article: Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL Study
Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL Study Open
Central obesity is a leading health concern with a great burden carried by ethnic minority populations, and especially Hispanics/Latinos. Genetic factors contribute to the obesity burden overall and to inter-population differences. We aim …
View article: Erratum. Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. Diabetes 2019;68:441—456
Erratum. Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. Diabetes 2019;68:441—456 Open
In the article cited above, in the first paragraph of results, a link to the full set of results was given as https://www.ncbi.nlm.nih.gov/gap. Due …
View article: Genome-wide association study of iron traits and relation to diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): potential genomic intersection of iron and glucose regulation?
Genome-wide association study of iron traits and relation to diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): potential genomic intersection of iron and glucose regulation? Open
Genetic variants contribute to normal variation of iron-related traits and may also cause clinical syndromes of iron deficiency or excess. Iron overload and deficiency can adversely affect human health. For example, elevated iron storage i…
View article: SUN-686 Diabetic Retinopathy in Latinos with Type 2 Diabetes: Temperance Is Protective
SUN-686 Diabetic Retinopathy in Latinos with Type 2 Diabetes: Temperance Is Protective Open
Diabetic retinopathy (DR) is a duration-dependent complication of diabetes (DM). Yet some people with DM do not develop DR despite long disease duration. We evaluated such a group in search of novel factors that might signal protection fro…
View article: Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control
Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control Open
To identify genetic variants associated with diabetic retinopathy (DR), we performed a large multiethnic genome-wide association study. Discovery included eight European cohorts (n = 3,246) and seven African American cohorts (n = 2,611). W…
View article: Trans-ethnic genome-wide association study of kidney function provides novel insight into effector genes and causal effects on kidney-specific disease aetiologies
Trans-ethnic genome-wide association study of kidney function provides novel insight into effector genes and causal effects on kidney-specific disease aetiologies Open
Chronic kidney disease (CKD) affects ∼10% of the global population, with considerable ethnic differences in prevalence and aetiology. We assembled genome-wide association studies (GWAS) 1-3 of estimated glomerular filtration rate (eGFR), a…
View article: Comparative Effectiveness of a Technology-Facilitated Depression Care Management Model in Safety-Net Primary Care Patients With Type 2 Diabetes: 6-Month Outcomes of a Large Clinical Trial
Comparative Effectiveness of a Technology-Facilitated Depression Care Management Model in Safety-Net Primary Care Patients With Type 2 Diabetes: 6-Month Outcomes of a Large Clinical Trial Open
Both the technology-facilitated care and supported care delivery models showed potential to improve 6-month depression and functional disability outcomes. The technology-facilitated care model has a greater likelihood to improve depression…