Eli Mohapatra
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View article: Symbolic regression and interpretable ensemble learning approach in determining early onset of diabetic peripheral neuropathy
Symbolic regression and interpretable ensemble learning approach in determining early onset of diabetic peripheral neuropathy Open
The detrimental consequences of diabetic peripheral neuropathy (DPN), a prevalent comorbidity of type 2 diabetic mellitus, include heightened morbidity and mortality, as well as a reduced quality of life. Unfortunately, this condition has …
View article: Thyroid Dysfunction and Inflammatory Biomarkers as Prognostic Indicators of Mortality in Hospitalized COVID-19 Patients: A Retrospective Observational Study
Thyroid Dysfunction and Inflammatory Biomarkers as Prognostic Indicators of Mortality in Hospitalized COVID-19 Patients: A Retrospective Observational Study Open
Background: Coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2, is a systemic disease with significant endocrine implications, particularly affecting thyroid function. Non-thyroidal illness syndrome (NTIS) is frequently observed in …
View article: SARS-CoV-2 sero-surveillance among healthcare workers at a tertiary care reference centre in Central India: A cross-sectional study
SARS-CoV-2 sero-surveillance among healthcare workers at a tertiary care reference centre in Central India: A cross-sectional study Open
Introduction: Health care workers (HCW), as the primary caregivers in the management of COVID-19 cases, are at a higher risk of acquiring infection. As such, they are associated with challenges to themselves including adverse health outcom…
View article: Cytokine and immune cell interaction in immune-inflammatory response during crisis event in sickle cell disease
Cytokine and immune cell interaction in immune-inflammatory response during crisis event in sickle cell disease Open
Background: The present study focused on evaluating serum cytokines in SCD cases and understanding these mediators' interplay with immune cells and their impact on disease severity score(DSscore).Methods: The study population of eighty-eig…
View article: Endocan expression and correlation with other endothelial determinants in developing a score for early identification of diabetic peripheral neuropathy
Endocan expression and correlation with other endothelial determinants in developing a score for early identification of diabetic peripheral neuropathy Open
Diabetic peripheral neuropathy is a common complication of diabetes mellitus that has dire outcomes, affecting the economic profile of a country. Despite the multifactorial background of the pathogenesis of this disease, the mechanism unde…
View article: Prevalence, Phenotypes, and Comorbidities of Polycystic Ovary Syndrome Among Indian Women
Prevalence, Phenotypes, and Comorbidities of Polycystic Ovary Syndrome Among Indian Women Open
Importance The prevalence of polycystic ovary syndrome (PCOS) varies across the globe. Indian studies on PCOS are limited by poor design, small sizes, regional representations, and varying methods. Objectives To estimate the nationwide pre…
View article: RBD mutations at the residues K417, E484, N501 reduced immunoreactivity with antisera from vaccinated and COVID-19 recovered patients
RBD mutations at the residues K417, E484, N501 reduced immunoreactivity with antisera from vaccinated and COVID-19 recovered patients Open
Introduction: It is unclear whether induced spike protein-specific antibodies due to infections with SARS-CoV-2 or to the prototypic Wuhan isolate-based vaccination can immune-react with the emerging variants of SARS-CoV-2. Aim/objectives:…
View article: Evaluation of lipid profile in systemic lupus erythematosus and relation with interleukin-10
Evaluation of lipid profile in systemic lupus erythematosus and relation with interleukin-10 Open
Objectives: To detect pattern of dyslipidemia in patients of SLE and clarify the correlation between lipid profile with disease activity, inflammatory factors, and cytokines. Materials and Methods: Blood collected from 65 SLE patients and …
View article: Incidence of Yq Microdeletion among Chattishgarh Population and Cast based distribution
Incidence of Yq Microdeletion among Chattishgarh Population and Cast based distribution Open
Background: Millions of individuals in their reproductive years are affected by infertility on a global scale, potentially exerting a significant influence on their lives and family dynamics. The coexistence of abnormal seminogram and Yq m…
View article: An Approach to Re-evaluate the Reference Cutoff of the Parameters of Newborn Screening: An Observational Study
An Approach to Re-evaluate the Reference Cutoff of the Parameters of Newborn Screening: An Observational Study Open
Background Unless a cutoff level of the parameters of newborn screening (NBS) is defined, a screening test's results would end in high recall rates and apprehensive parents. The study aimed to establish a cutoff level of the healthy term n…
View article: Rhinosporidiosis- Epidemiological, Clinicoradiological, Immunological Profile.
Rhinosporidiosis- Epidemiological, Clinicoradiological, Immunological Profile. Open
Rhinosporidiosis has a definite epidemiological and clinical-radiological profile. A clear association with exposure to contaminated water is present which could not be further associated with disease duration or recurrence. The immunologi…
View article: Clinical implication of changes in serum cations and anions on clinical severity in sickle cell disease: A case–control study in a tertiary center
Clinical implication of changes in serum cations and anions on clinical severity in sickle cell disease: A case–control study in a tertiary center Open
Objectives: Vaso-occlusive crisis in sickle cell disease (SCD) is related to disproportionate serum ions distribution. The objective was to evaluate the influence of changes in serum cations and anions on clinical severity in SCD patients.…
View article: Serological Evaluation of Antibody Titers After Vaccination Against COVID-19 in 18-44-Year-Old Individuals at a Tertiary Care Center
Serological Evaluation of Antibody Titers After Vaccination Against COVID-19 in 18-44-Year-Old Individuals at a Tertiary Care Center Open
Background The evaluation of the effectiveness of the vaccines (ChAdOx1-nCOV; Covishield and BBV-152; Covaxin) against coronavirus disease 2019 (COVID-19) is necessary to assess their efficacy. Because most antibodies that neutralize the c…
View article: Normative range of various serum hormonal parameters among Indian women of reproductive age: ICMR-PCOS task force study outcome
Normative range of various serum hormonal parameters among Indian women of reproductive age: ICMR-PCOS task force study outcome Open
The study was financially supported by the grant-in-aid from ICMR vide file No:5/7/13337/2015-RBMH.
View article: Effect of the Angiotensin-Converting Enzyme (ACE) (I/D) Polymorphism in COVID-19 Patients and Their Healthy Contacts
Effect of the Angiotensin-Converting Enzyme (ACE) (I/D) Polymorphism in COVID-19 Patients and Their Healthy Contacts Open
Introduction The quest to understand the pathophysiology behind the deleterious effects of the coronavirus disease 2019 (COVID-19) outbreak took a turn when involvement of the angiotensin converting enzyme (ACE) receptors in different orga…
View article: Association of Methylenetetrahydrofolate Reductase Gene Polymorphism in Mothers With Adverse Clinical Outcomes in Neonates
Association of Methylenetetrahydrofolate Reductase Gene Polymorphism in Mothers With Adverse Clinical Outcomes in Neonates Open
Mothers with C677T and A1298C SNPs are highly susceptible to adverse outcomes in their neonates. Hence, screening the SNPs during the antenatal period can purposefully serve as a better predictive marker, following which proper clinical ma…
View article: Predictive Effect of Methylene Tetrahydrofolate Reductase Variants on Vascular Related Crisis
Predictive Effect of Methylene Tetrahydrofolate Reductase Variants on Vascular Related Crisis Open
BACKGROUND: Homocysteinemia is regarded as potential predictor for vaso-occlusive phenomenon often observed in sickle cell hemoglobinopathy. The objective was to determine the relationship of these genotypes with homocysteinemia and the pr…
View article: A pilot study to evaluate the changes in venous blood gas parameters and hypoxia biomarkers in health care workers using different kinds of masks
A pilot study to evaluate the changes in venous blood gas parameters and hypoxia biomarkers in health care workers using different kinds of masks Open
Background: The study is aimed to investigate the metabolic alterations and changes in biochemical parameters associated with extended mask. Methods: It was a prospective comparative study conducted on 129 participants comprised of 37 heal…
View article: Correlation of Vitamin D Levels with Markers of Bone Metabolism in COVID-19 Patients
Correlation of Vitamin D Levels with Markers of Bone Metabolism in COVID-19 Patients Open
Introduction: Low serum Vitamin D levels are common in orthopedic patients in India. Low serum Vitamin D levels are implicated in COVID-19 worsening the illness. With this background, we assessed serum Vitamin D levels in COVID-19 patients…
View article: Influence of laboratory biomarkers on inflammatory indices for assessing severity progression in COVID-19 cases
Influence of laboratory biomarkers on inflammatory indices for assessing severity progression in COVID-19 cases Open
Background and Objective: This study explored the role of various laboratory biomarkers on inflammatory indices for predicting disease progression toward severity in COVID-19 patients. Methods: This retrospective study was conducted on 123…
View article: Plasma Interleukin-33 Cannot Predict Hip Osteonecrosis in Patients With Sickle Cell Disease: A Case-Control Study
Plasma Interleukin-33 Cannot Predict Hip Osteonecrosis in Patients With Sickle Cell Disease: A Case-Control Study Open
Background Plasma interleukin-33 (IL-33), a cytokine associated with inflammatory and autoimmune disease, has been described to be significantly raised in osteonecrosis of the femoral head (ONFH) and hence was recommended for use as a mark…
View article: A study of Apolipoprotein A1(ApoA1) And Interleukin-10(IL-10) In Diabetes With Foot Ulcers
A study of Apolipoprotein A1(ApoA1) And Interleukin-10(IL-10) In Diabetes With Foot Ulcers Open
In the light of this study, ApoA1 has the potential to predict DFU. The finding proposes IL-10 (b = -0.37, p < 0.001) could be considered in stratifying DFU as per its severity.
View article: Early Biochemical Markers in Predicting the Clinical Outcome of COVID-19 Patients Admitted in Tertiary Care Hospital
Early Biochemical Markers in Predicting the Clinical Outcome of COVID-19 Patients Admitted in Tertiary Care Hospital Open
Introduction An array of routinely accessible serum biomarkers was assessed to explore their overall impact on severity and mortality in coronavirus disease 2019. Materials and Methods A retrospective analysis of 1,233 adults was conducted…
View article: First-Trimester Reference Intervals for Thyroid Function Testing among Women Screened at a Tertiary Care Hospital in India
First-Trimester Reference Intervals for Thyroid Function Testing among Women Screened at a Tertiary Care Hospital in India Open
Objectives Due to differences in the method of assay and population-specific factors, each laboratory needs to establish its own gestation-specific reference intervals (GRIs) for thyroid hormones. Materials and Methods Three-hundred forty-…
View article: Newborn Thyroid-Stimulating Hormone Dynamicity as per the Antenatal and Perinatal Factors
Newborn Thyroid-Stimulating Hormone Dynamicity as per the Antenatal and Perinatal Factors Open
Background: Recent surge in the diagnoses of congenital hypothyroidism (CH) has necessitated the measurement of newborn TSH levels and understanding of the way various antenatal and perinatal factors influence its dynamicity. It is a cross…
View article: Thyroid Peroxidase Antibodies as a Marker of Iodine Status in Healthy Euthyroid Women in First Trimester of Pregnancy Visiting a Tertiary Care Hospital in Raipur, India
Thyroid Peroxidase Antibodies as a Marker of Iodine Status in Healthy Euthyroid Women in First Trimester of Pregnancy Visiting a Tertiary Care Hospital in Raipur, India Open
BACKGROUND The importance of adequate iodine status in pregnancy is undoubted as its deficiency is associated with adverse pregnancy outcomes for the mother as well as the foetus and neonate. Although median urine iodine concentration can …
View article: Interactions of Combined Haplotypes of Methylenetetrahydrofolate Reductase on Clinical Events in Children with Sickle Cell Disorder
Interactions of Combined Haplotypes of Methylenetetrahydrofolate Reductase on Clinical Events in Children with Sickle Cell Disorder Open
BACKGROUND Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C variants are considered as potential genetic risk factors for vaso-occlusive complications in sickle cell disorder (SCD). The purpose of the study was to determine the…